An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the function of histone acetyltransferase (EC 2.3.1.48).
ChEBI ID: 76395
| Member | Definition | Class |
|---|---|---|
| anacardic acid | A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities. | anacardic acid |
| cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl]hydrazone | A member of the class of 1,3-thiazole bearing 2-cyclopentylidenehydrazino and 4-chlorophenyl substituents at positions 2 and 4 respectively. | cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl]hydrazone |
| hydrazinocurcumin | A pyrazole obtained by cyclocodensation of the two carbonyl groups of curcumin with hydrazine. | hydrazinocurcumin |
| pentamidine | A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. | pentamidine |
| procyanidin b3 | A proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 8' in alpha-configuration. It can be found in red wine, in barley, in beer, in peach or in Jatropha macrantha, the Huanarpo Macho. | procyanidin B3 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 526 (20.92) | 18.7374 |
| 1990's | 840 (33.41) | 18.2507 |
| 2000's | 424 (16.87) | 29.6817 |
| 2010's | 573 (22.79) | 24.3611 |
| 2020's | 151 (6.01) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 137 (5.13%) | 5.53% |
| Reviews | 222 (8.31%) | 6.00% |
| Case Studies | 352 (13.17%) | 4.05% |
| Observational | 1 (0.04%) | 0.25% |
| Other | 1,960 (73.35%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 11.1906 | 4 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 20.8212 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 20.8212 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 175.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 1.6390 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.4680 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 3.2780 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 1.7170 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 3.2780 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 1.7170 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 175.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 175.0000 | 2 | 2 |
| Acrosin | Sus scrofa (pig) | Ki | 2.3000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.2140 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.1960 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.3750 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.5160 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 126.8000 | 1 | 1 |
| Amiloride-sensitive amine oxidase [copper-containing] | Homo sapiens (human) | Ki | 0.2900 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 5.0658 | 2 | 3 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 0.2625 | 1 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 6.2920 | 3 | 3 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 15.7215 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 12.8802 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 422.6667 | 3 | 3 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (human) | IC50 | 3.6450 | 4 | 4 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Coagulation factor X | Homo sapiens (human) | IC50 | 10.4000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 19.8667 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 75.0000 | 3 | 3 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 3.9980 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 1.3580 | 1 | 1 |
| Diamine acetyltransferase 1 | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | IC50 | 0.7200 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | IC50 | 0.7200 | 1 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Histone acetyltransferase KAT2B | Homo sapiens (human) | IC50 | 19.4500 | 4 | 4 |
| Histone acetyltransferase KAT5 | Homo sapiens (human) | IC50 | 64.0000 | 1 | 1 |
| Histone acetyltransferase KAT8 | Homo sapiens (human) | IC50 | 43.0000 | 1 | 1 |
| Histone acetyltransferase KAT8 | Homo sapiens (human) | Ki | 64.0000 | 1 | 1 |
| Histone acetyltransferase p300 | Homo sapiens (human) | IC50 | 7.4125 | 4 | 4 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 19.4000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 1.7033 | 3 | 3 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 6.5500 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.4250 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.5070 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.5800 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.2200 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 2.8850 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 2.0730 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 29.8000 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 29.8000 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 15.7215 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 12.8802 | 1 | 1 |
| Plasminogen | Homo sapiens (human) | IC50 | 28.4000 | 3 | 5 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 0.1618 | 5 | 5 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 7.3000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 15.8054 | 4 | 4 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 12.8802 | 1 | 1 |
| Probable linoleate 9S-lipoxygenase 5 | Solanum tuberosum (potato) | IC50 | 43.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 9.7000 | 1 | 1 |
| Protein arginine N-methyltransferase 1 | Homo sapiens (human) | IC50 | 81.0000 | 2 | 2 |
| Protein arginine N-methyltransferase 5 | Homo sapiens (human) | IC50 | 582.0000 | 1 | 1 |
| Protein S100-B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 1 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 2 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 3 | Homo sapiens (human) | IC50 | 35.8333 | 3 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 8.9200 | 2 | 2 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 51.9000 | 1 | 1 |
| Signal transducer and activator of transcription 3 | Homo sapiens (human) | IC50 | 16.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 9.7000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 3.1590 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 2.5100 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.2140 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.1960 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 22.1000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 9.5000 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 430.0000 | 1 | 1 |
| SUMO-activating enzyme subunit 1 | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Suppressor of tumorigenicity 14 protein | Homo sapiens (human) | Ki | 1.1600 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 29.8000 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 43.3333 | 1 | 3 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | IC50 | 43.3333 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 | 3.5000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 17.0000 | 1 | 1 |
| Protein kinase C delta type | Homo sapiens (human) | EC50 | 14.9700 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | EC50 | 18.8100 | 1 | 1 |
| Protein kinase C theta type | Homo sapiens (human) | EC50 | 7.2500 | 1 | 1 |
| Protein S100-B | Homo sapiens (human) | Kd | 1.0000 | 1 | 1 |
| Protein S100-B | Rattus norvegicus (Norway rat) | Kd | 47.0000 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 3.9800 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | DC50 | 1.4700 | 1 | 1 |
| Histone acetyltransferase KAT8 | Homo sapiens (human) | K0.5 | 205.0000 | 3 | 3 |
| Histone acetyltransferase KAT8 | Homo sapiens (human) | Km | 1.7667 | 3 | 3 |
| Histone acetyltransferase p300 | Homo sapiens (human) | INH | 8.5000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | DC50 | 17.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Emax | 68.0000 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | K0.5 | 514.0000 | 1 | 1 |