Compounds > 4-hydroxybenzylcyanide
Page last updated: 2024-12-06

4-hydroxybenzylcyanide

Description

4-hydroxybenzylcyanide: suicide substrate for dopamine beta-hydroxylase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

(4-hydroxyphenyl)acetonitrile : A hydroxynitrile that is phenylacetonitrile substituted by a hydroxy group at position 4. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID26548
CHEBI ID16667
SCHEMBL ID448467
MeSH IDM0087927

Synonyms (57)

Synonym
HMS1786P20
einecs 238-046-0
brn 1934470
nsc 76080
CHEBI:16667
4-hydroxybenzeneacetonitrile
4-hydroxyphenylacetic acid nitrile
4-hydroxybenzylcyanide
acetonitrile, (p-hydroxyphenyl)-
p-hydroxyphenylacetonitrile
nsc76080
p-hydroxybenzyl cyanide
nsc-76080
(4-hydroxyphenyl)acetonitrile
benzeneacetonitrile, 4-hydroxy-
inchi=1/c8h7no/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10h,5h
acetic acid,(4-hydroxyphenyl),nitrile 4-hydroxy-benzylcyanide
14191-95-8
C03766
4-hydroxyphenylacetonitrile
4-hydroxybenzyl cyanide
4-hydroxyphenylacetonitrile, 98%
acetonitrile, 4-hydroxyphenyl-
AC-10551
7898C7A4-5D46-437F-8474-B1E83F66AFE5
benzeneacetonitrile, 4-hydroxy- (9ci)
BMSE000441
H0657
2-(4-hydroxyphenyl)acetonitrile
AKOS000121408
unii-18q5j224rm
18q5j224rm ,
4-10-00-00554 (beilstein handbook reference)
4-(cyanomethyl)phenol
FT-0618736
FT-0618737
PS-4572
AE-562/40164564
SCHEMBL448467
3aq ,
para-hydroxybenzyl cyanide
p-hydroxy phenyl acetonitrile
alpha-cyano-p-cresol
4-(hydroxy)phenyl acetonitrile
p-hydroxybenzylcyanide
W-108181
STR01465
mfcd00002383
DTXSID90161856
Z90120144
(4-hydroxy-phenyl)-acetonitrile
Q27102019
AM10835
EN300-18729
CS-W016539
HY-W015823
PD158329
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
hydroxynitrileAny nitrile compound which also contains a hydroxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

PathwayProteinsCompounds
taxiphyllin biosynthesis214
dhurrin biosynthesis214
dhurrin biosynthesis114
taxiphyllin biosynthesis014

Bioassays (2)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.48 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzyl alcohol
4-hydroxybenzyl alcohol: the aglycone of gastrodin. p-hydroxybenzyl alcohol : A member of the class of benzyl alcohols that is benzyl alcohol substituted by a hydroxy group at position 4. It has been isolated from Arcangelisia gusanlung.		210benzyl alcohols;
phenols		plant metabolite
catechol
[no description available]		1.9910catecholsallelochemical;
genotoxin;
plant metabolite
choline
[no description available]		210cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
tyramine
[no description available]		1.9610monoamine molecular messenger;
primary amino compound;
tyramines		EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter
trifluoroacetic acid
Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.		210fluoroalkanoic acidhuman xenobiotic metabolite;
NMR chemical shift reference compound;
reagent
potassium cyanide
[no description available]		1.9510cyanide salt;
one-carbon compound;
potassium salt		EC 1.15.1.1 (superoxide dismutase) inhibitor;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
neurotoxin
4-hydroxybenzyl isothiocyanate
4-hydroxybenzyl isothiocyanate: found in white mustard; structure in first source		210phenols
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		210ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
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