Page last updated: 2024-08-05 10:46:35

dipeptide

Any molecule that contains two amino-acid residues connected by peptide linkages.

ChEBI ID: 46761

Members (168)

MemberDefinitionRole
4-aminobenzoylglutamic acidA dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid.N-(4-aminobenzoyl)-L-glutamic acid
abt-267A dipeptide derivative which is used which is in combination with dasabuvir sodium hydrate, paritaprevir and ritonavir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.ombitasvir
Ala-LysA dipeptide obtained by formal condensation of the carboxy group of L-alanine with the alpha-amino group of L-lysine.Ala-Lys
alaceprilAlacepril
alanylalanineAlanyl-alanine
alanylalanineA dipeptide consisting of two L-alanine units joined by a peptide linkage.Ala-Ala zwitterion; L-alanyl-L-alanine
alanylglutamic acidA dipeptide consisting of L-glutamic acid having an L-alanyl attached to its alpha-amino groupL-alanyl-L-glutamic acid
alanylglutamineA dipeptide formed from L-alanyl and L-glutamine residues.Ala-Gln zwitterion; Ala-Gln
alanylglycineA dipeptide formed from L-alanyl and glycine residues.Ala-Gly zwitterion; Ala-Gly
alanylphenylalanineA dipeptide formed from L-alanyl and L-phenylalanine residues.Ala-Phe
alanylprolineA dipeptide composed of L-alanine and L-proline joined by a peptide linkage.Ala-Pro zwitterion; Ala-Pro
alanyltyrosineA dipeptide composed of L-alanine and L-tyrosine joined by a peptide linkage.Ala-Tyr
alanyltyrosineA dipeptide formed from L-tyrosine and L-alanine residues.Tyr-Ala
alitameAlitame
alpha-aspartylalanineA dipeptide formed from L-alpha-aspartyl and L-valine residues.Asp-Ala
alpha-glutamyltryptophanA dipeptide composed of L-glutamic acid and L-tryptophan joined by a peptide linkage.Glu-Trp
alpha-glutamyltryptophanA dipeptide formed from L-tryptophan and L-glutamic acid residues.Trp-Glu
anserineA dipeptide comprising of beta-alanine and 3-methyl-L-histidine units.anserine zwitterion; anserine
arginyl-glutamineA dipeptide formed from L-arginyl and L-glutamine residues.Arg-Gln
arginylarginineA dipeptide formed from two L-arginine residues.Arg-Arg
arginyllysineA dipeptide formed from L-arginyl and L-leucine residues.Arg-Lys
arginylprolineA dipeptide obtained by formal condensation of the carboxy group of L-arginine with the amino group of L-proline.Arg-Pro
aspartameA dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener.aspartame zwitterion; aspartame
aspartyl-aspartic acidA dipeptide formed from two L-aspartic acid units.Asp-Asp
aspartyl-phenylalanineA dipeptide formed from L-alpha-aspartyl and L-phenylalanine residues. It is obtained after the hydrolysis of aspartame in intestinal lumen.Asp-Phe
aspartyl-prolineAsp-Pro
aspartylglutamateA dipeptide formed from L-alpha-aspartyl and L-glutamic acid residues.Asp-Glu
aspartylglycineA dipeptide composed of L-aspartic acid and glycine joined by a peptide linkage.Asp-Gly
aspartyllysineA dipeptide formed from L-alpha-aspartyl and L-lysine residues.Asp-Lys
b 581A dipeptide obtained from the tetrapeptide Cys-Val-Phe-Met by reduction of the amide carbonyl groups of the Cys and Val residues.B 581
bentiromideThe dipeptide obtained by condensation of N-benzoyl-L-tyrosine with 4-aminobenzoic acid. Used as a noninvasive screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy, it is given by mouth: the amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.bentiromide
Benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(1,3-thiazol-2-yl)propan-2-yl]amino]pentan-2-yl]amino]-1-oxobutan-2-yl]carbamateBenzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(1,3-thiazol-2-yl)propan-2-yl]amino]pentan-2-yl]amino]-1-oxobutan-2-yl]carbamate
beta-aspartylglycineL-beta-aspartylglycine
birinapantBirinapant
brevianamide fA pyrrolopyrazine that is hexahydropyrrolo[1,2-a]pyrazine-1,4-dione bearing an indol-3-ylmethyl substituent at position 3 (the 3S,8aS-diastereomer, obtained by formal cyclocondensation of L-tryptophan and L-proline).brevianamide F
carbobenzoxyvalylphenylalanine aldehydeA dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpain I and II, and is also a gamma-secretase inhibitor.Z-Val-Phe-H
carbocysteine-lysinecarbocysteine-lysine
carnosineA dipeptide that is the N-(beta-alanyl) derivative of L-histidine.carnosine zwitterion; carnosine
chrysobactinA catechol-type siderophore with a structure of D-lysyl-L-serine substituted on N(2) of the lysyl residue by a 2,3-dihydroxybenzoyl group. It is produced by the Gram-negative bacillus Dickeya dadantii (previously known as Erwinia chrysanthem). Only the catecholate hydroxyl groups participate in metal coordination, so chrysobactin cannot provide full 1:1 coordination of Fe(III); at neutral pH and concentrations of about 0.1 mM, ferric chrysobactin exists as a mixture of bis and tris complexes.chrysobactin
cyclo(leucyl-prolyl)A homodetic cyclic peptide composed from leucyl and prolyl residues.cyclo(L-Leu-L-Pro)
cysteinylcysteineA dipeptide formed from two L-cysteine residues.Cys-Cys
cysteinylglycineA dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism.L-cysteinylglycine zwitterion; L-cysteinylglycine
cysteinylprolineA dipeptide composed of L-cysteine and L-proline joined by a peptide linkage.Cys-Pro
cysteinyltyrosineCys-Tyr
enalaprilA dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).enalapril
enalaprilat anhydrousEnalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is given by intravenous injection, usually as the dihydrate.enalaprilat (anhydrous)
epelsibanEpelsiban
Ethyl (E,4S)-4-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-3-phenylpropanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoateEthyl (E,4S)-4-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-3-phenylpropanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
gamma-glu-aspgamma-Glutamylaspartic acid
gamma-glutamylglutamateA dipeptide obtained by formal condensation of the gamma-carboxy group of glutamic acid with the amino group of another glutamic acid.gamma-Glu-Glu
gamma-glutamylglutamineA dipeptide obtained by formal condensation of the gamma-carboxy group of glutamic acid with the amino group of glutaminegamma-Glu-Gln
gamma-glutamylphenylalanineA dipeptide obtained by formal condensation of the side-chain carboxy group of L-glutamic acid with the amino group of L-phenylalanine.gamma-Glu-Phe
gamma-glutamyltyrosineA dipeptide composed of L-glutamic acid and L-tyrosine joined by a peptide linkage.gamma-Glu-Tyr
gap 134danegaptide
gliotoxinA pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.gliotoxin
glutaminyl-glycineA dipeptide formed from L-glutamine and glycine residues.Gln-Gly
glutamyl-glutamic acidA dipeptide composed of two L-glutamic acid units joined by a peptide linkage.Glu-Glu
glutamylalanineA dipeptide formed from L-alpha-glutamyl and L-alanine residues.Glu-Ala
glutaurineA dipeptide resulting from the formal condensation of the amino group of taurine with the gamma-carboxy group of L-glutamic acid. It was initially found in the parathyroid in 1980 and later in the brain of mammals.glutaurine zwitterion; glutaurine
glycyl-l-phenylalanineA dipeptide formed from glycine and L-phenylalanine residues.Gly-Phe zwitterion; Gly-Phe
glycylaspartic acidA dipeptide formed from glycyl and L-aspartic acid residues.Gly-Asp
glycylglutamineA dipeptide formed from glycine and L-glutamine residues.Gly-Gln zwitterion; Gly-Gln
glycylglycineA dipeptide formed from glycine residues.glycylglycine zwitterion; glycylglycine
glycylhistidineA dipeptide composed of glycine and L-histidine joined by a peptide linkage.Gly-His zwitterion; Gly-His
glycylleucineA dipeptide composed of glycine and L-leucine joined by a peptide linkage.Gly-Leu; glycyl-L-leucine zwitterion
glycyllysineA dipeptide formed from glycine and L-lysine residues.Gly-Lys
glycylphenylalanine 2-naphthylamideAn N-(2-naphthyl)carboxamide obtained by formal condensation of the carboxy group of glycyl-L-phenylalanine with the amino group of 2-naphthylamine.glycyl-L-phenylalanine 2-naphthylamide
glycylprolineA dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group.Gly-Pro zwitterion; Gly-Pro
glycylsarcosineA dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine.glycylsarcosine zwitterion; glycylsarcosine
glycyltryptophanA dipeptide formed from glycine and L-tryptophan residues.Gly-Trp
glycyltyrosineA dipeptide composed of glycine and L-tyrosine joined by a peptide linkage.Gly-Tyr
glycylvalineA dipeptide formed from glycine and L-valine residues.Gly-Val
golotimodGolotimod
gsk221149aRetosiban
histidinoalanineA dipeptide formed from L-histidine and L-alanine residues.His-Ala zwitterion; His-Ala
histidyl-proline diketopiperazineA homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH).cyclo(L-His-L-Pro)
histidylglycineA dipeptide formed from L-histidine and glycine residues.His-Gly
histidylhistidineA dipeptide formed from two L-histidine residues.His-His
histidylleucineA dipeptide formed from L-histidine and L-leucine residues.His-Leu zwitterion; His-Leu
histidylphenylalanineA dipeptide obtained by formal condensation of the carboxy group of L-histidine with the amino group of L-phenylalanine.His-Phe
histidylprolineA dipeptide formed from L-histidine and L-proline residues.His-Pro zwitterion; His-Pro
homocarnosineA homocarnosine that has S configuration.L-homocarnosine zwitterion; L-homocarnosine
idIsoleucyl-Aspartate
imidaprilA member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure.imidapril
imidaprilImidapril hydrochloride
imidaprilatA member of the class of imidazolidines that is imidapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of imidapril used to treat hypertension.imidaprilat
isoleucyl-tyrosineA dipeptide formed from L-isoleucine and L-tyrosine residues.Ile-Tyr
isoleucylvalineA dipeptide formed from L-isoleucine and L-valine residues.Ile-Val
isospaglumic acidA dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.Ac-Asp-Glu
kyotorphinA dipeptide composed of L-tyrosine and L-arginine joined by a peptide linkage.Tyr-Arg
l-ala-gamma-d-glu-meso-diaminopimelic acidL-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate
leucyl-alanineA dipeptide composed of L-leucine and L-alanine joined by a peptide linkage.Leu-Ala
leucyl-phenylalanineA dipeptide formed from L-leucine and L-phenylalanine residues.Leu-Phe
leucylarginineA dipeptide composed of L-leucine and L-arginine joined by peptide linkages.Leu-Arg
leucylleucineA dipeptide formed from two L-leucine residues.Leu-Leu zwitterion; Leu-Leu
leucylprolineA dipeptide formed from L-leucine and L-proline residues.Leu-Pro zwitterion; Leu-Pro
leucyltyrosineA dipeptide formed from L-leucine and L-tyrosine residues.Leu-Tyr
leukotriene d4A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R).leukotriene D4
leukotriene f-4A leukotriene composed of (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid having (5S)-hydroxy and (6R)-(L-gamma-glutamyl-L-cystein-S-yl) substituents.leukotriene F4
libenzaprillibenzapril
lisinoprillisinopril
lysylglutamic acidA dipeptide formed from L-lysine and L-glutamic acid residues.Lys-Glu
lysylglycineA dipeptide formed from L-lysine and glycine residues.Lys-Gly
lysyllysineA dipeptide formed from two L-lysine residues.Lys-Lys
lysylprolineA dipeptide formed from L-lysine and L-proline residues.Lys-Pro
maculosinA homodetic cyclic peptide that is a dipeptide composed of L-proline and L-tyrosine joined by peptide linkages.maculosin
methionylglutamic acidA dipeptide formed from L-methionine and L-glutamic acid residues.Met-Glu
methionylglycineA dipeptide formed from L-methionine and glycine residues.Met-Gly
methionyltryptophanA dipeptide formed from L-methionine and L-tryptophan residues.Met-Trp
moexipril hydrochlorideMoexipril hydrochloride
n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl esterA dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. A gamma-secretase inhibitor.DAPT
n-acetyl-beta-glucosaminyl-n-acetylmuramyl-alanylisoglutamineglucosaminylmuramyl dipeptide
n-acetylcarnosineA dipeptide that is the N-acetyl derivative of carnosine.N-acetylcarnosine
n-acetylglutaminylglutamine amideN2-Acetyl-L-glutaminyl-L-glutamamide
n-glycylalanineA dipeptide formed from glycine and L-alanine residues.Gly-Ala
n-glycylglutamic acidA dipeptide formed from glycyl and L-glutamic acid residues.Gly-Glu
neotameA dipeptide composed of N-(3,3-dimethylbutyl)-L-aspartic acid and methyl L-phenylalanate units joined by a peptide linkage.neotame
omapatrilatomapatrilat
perindoprilatA dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril.perindoprilat
Phe-TyrA dipeptide formed from L-phenylalanine and L-tyrosine residues.Phe-Tyr
phenylalanyl-valineA dipeptide formed from L-valine and L-phenylalanine residues.Val-Phe
phenylalanyl-valineA dipeptide formed from L-phenylalanine and L-valine residues.Phe-Val
phenylalanylalanineA dipeptide formed from L-phenylalanine and L-alanine residues.Phe-Ala zwitterion; Phe-Ala
phenylalanylarginineA dipeptide composed of L-phenylalanine and L-arginine joined by a peptide linkage.Phe-Arg
phenylalanylglutamateA dipeptide formed from L-phenylalanine and L-glutamic acid residues.Phe-Glu
phenylalanylglycineA dipeptide formed from L-phenylalanine and glycine residues.Phe-Gly
phenylalanylleucineA dipeptide obtained by formal condensation of the carboxy group of L-phenylalanine with the amino group of L-leucine.Phe-Leu zwitterion; Phe-Leu
phenylalanylphenylalanineA dipeptide formed from two L-phenylalanine residues.Phe-Phe zwitterion; Phe-Phe
phenylalanylprolineA dipeptide formed from L-phenylalanine and L-proline residues.Phe-Pro
phenylalanylserineA dipeptide that is the N-(L-phenylalanyl) derivative of L-serine.Phe-Ser
phosphoramidonA dipeptide isolated from the cultures of Streptomyces tanashiensis.phosphoramidon
prolyl-4-hydroxyprolineProlyl-Hydroxyproline
prolyl-prolineA dipeptide formed from two L-proline residues.Pro-Pro
prolyl-serineA dipeptide formed from L-proline and L-serine residues.Pro-Ser
prolyl-tyrosineA dipeptide formed from L-proline and L-tyrosine residues.Pro-Tyr
prolylarginineA dipeptide formed from L-proline and L-arginine residues.Pro-Arg
prolylglutamic acidA dipeptide formed from L-proline and L-glutamic acid residues.Pro-Glu
prolylglycineA dipeptide consisting of glycine having an L-prolyl group attached to its alpha-amino nitrogen.L-prolinylglycine zwitterion; L-prolylglycine
prolylisoleucineA dipeptide formed from L-proline and L-isoleucine residues.Pro-Ile
prolylvalineA dipeptide formed from L-valine and L-proline residues.Val-Pro
pyroglutamylleucinePyroglutamylleucine
ramiprilA dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.ramipril
ramiprilatA dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.ramiprilat
RF9A dipeptide formed from L-arginine and L-phenylalaninamide residues in which a hydrogen attached to the nitrogen of the alpha-amino group of the arginine residue has been replaced by a 1-adamantanecarbonyl group. It has been reported to be a potent and selective antagonist of neuropeptide FF (NPFF) receptors, but more recently found to be an agonist at both NPFF1R and the kisspeptin receptor (KISS1R).RF9
s-nitrosocysteinylglycineA dipeptide resulting from the formal condensation of the carboxylic acid group of S-nitroso-L-cysteine with the amino group of glycine.S-nitroso-L-cysteinylglycine
seryl-histidineA dipeptide formed from L-serine and L-histidine residues.Ser-His
seryl-prolineA dipeptide formed from L-serine and L-proline residues.Ser-Pro
spiraprilspirapril
spiraprilatAn azaspiro compound that is spirapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid group. It is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor spirapril.spiraprilat
syringolin a2-(3-(1-(((4E,10E)-2,9-Dioxo-12-isopropyl-1,8-diazacyclododecane-4,10-diene-3-yl)carbamoyl)-2-methylpropyl)ureido)-3-methylbutyric acid
tabtoxinA monobactam phytotoxic dipeptide produced by Pseudomonas syringae, that causes wildfire disease in tobacco.tabtoxin
temocapriltemocapril
temocapril hydrochlorideTemocapril hydrochloride
trandolaprilA heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.trandolapril
trandolaprilatA heterobicyclic compound that is trandolapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of the prodrug trandolapril.trandolaprilat
Trp-TrpA dipeptide formed from two L-tryptophan residues.Trp-Trp
tryprostatin aA cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at positions 2 and 6 on the indole ring by prenyl and methoxy groups respectively.tryprostatin A
tryprostatin bA cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at position 2 on the indole ring by a prenyl group.tryprostatin B
tryptophylglycineA dipeptide formed from L-tryptophan and glycine residues.Trp-Gly
tyropeptin aTyropeptin A
tyrosyl-prolineTyrosyl-Proline
tyrosylleucineA dipeptide formed from L-tyrosine and L-leucine residues.Tyr-Leu
u-47929ficellomycin
valylleucineA dipeptide formed from L-valine and L-leucine residues.Val-Leu
valyltyrosineA dipeptide formed from L-valine and L-tyrosine residues.Val-Tyr
valylvalineA dipeptide formed from two L-valine residues.Val-Val
vanchrobactinA catechol-type natural product that is composed of 2,3-dihydroxybenzoic acid, D-arginine and L-serine joined in sequence by peptide linkages. It is a siderophore synthesized by the bacterial fish pathogen Vibrio anguillarum.vanchrobactin
vx 765Belnacasan

Research

Studies (20,488)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19903,053 (14.90)18.7374
1990's6,028 (29.42)18.2507
2000's5,762 (28.12)29.6817
2010's4,516 (22.04)24.3611
2020's1,129 (5.51)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials4,352 (17.83%)5.53%
Reviews1,380 (5.65%)6.00%
Case Studies1,210 (4.96%)4.05%
Observational57 (0.23%)0.25%
Other17,406 (71.32%)84.16%