Page last updated: 2024-08-05 14:56:30
water-soluble vitamin (role)
Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.
ChEBI ID: 27314
Members (2)
| Member | Definition | Class |
|---|---|---|
| levocarnitine | The (R)-enantiomer of carnitine. | (R)-carnitine |
| pqq cofactor | A pyrroloquinoline having oxo groups at the 4- and 5-positions and carboxy groups at the 2-, 7- and 9-positions. | pyrroloquinoline quinone |
Research
Studies (693)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 94 (13.56) | 18.7374 |
| 1990's | 170 (24.53) | 18.2507 |
| 2000's | 140 (20.20) | 29.6817 |
| 2010's | 198 (28.57) | 24.3611 |
| 2020's | 91 (13.13) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 8 (1.13%) | 5.53% |
| Reviews | 80 (11.33%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 618 (87.54%) | 84.16% |
Protein Targets (9)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 24.8344 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 1.4125 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 12.9953 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carnitine O-palmitoyltransferase 1, muscle isoform | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| Carnitine O-palmitoyltransferase 2, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 0.3060 | 2 | 2 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| G-protein coupled receptor 35 | Homo sapiens (human) | EC50 | 0.0710 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carnitine O-acetyltransferase | Homo sapiens (human) | Km | 300.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Mus musculus (house mouse) | Km | 0.0619 | 1 | 1 |