Compounds > 2,2'-biphenol
Page last updated: 2024-12-05

2,2'-biphenol

Description

2,2'-Biphenol is a white crystalline solid organic compound with the formula C12H10O2. It is an important industrial chemical that finds applications in the synthesis of polymers, pharmaceuticals, and other organic chemicals. Its synthesis typically involves the oxidative coupling of phenol, a reaction that can be catalyzed by various metal complexes. 2,2'-Biphenol exhibits antioxidant properties and is used in the production of antioxidants for various industrial applications, including the stabilization of plastics and rubbers. Its biological activities include potential anticancer, antibacterial, and anti-inflammatory effects. 2,2'-Biphenol has also been investigated for its potential as a building block in the development of new materials with interesting optical and electronic properties.'

biphenyl-2,2'-diol : A member of the class of hydroxybiphenyls carrying hydroxy groups at positions 2 and 2'. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID15731
CHEMBL ID183874
CHEBI ID28970
SCHEMBL ID28574
MeSH IDM0116500

Synonyms (60)

Synonym
BIDD:ER0397
4-06-00-06645 (beilstein handbook reference)
pm2r53i3c9 ,
unii-pm2r53i3c9
CHEBI:28970 ,
2,2'-dihydroxy-1,1'-biphenyl
2,2'-dihydroxydiphenyl
2,2'-biphenol
o,o'-biphenol
nsc37068
o,o'-diphenol
2,2'-biphenyldiol
o-dihydroxydiphenyl
wln: qr br bq
1806-29-7
nsc-37068
o,o'-dihydroxybiphenyl
einecs 217-303-0
(1,1'-biphenyl)-2,2'-diol
nsc 37068
brn 1638363
ccris 2980
biphenyl-2,2'-diol
[1,1'-biphenyl]-2,2'-diol
inchi=1/c12h10o2/c13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14/h1-8,13-14
C03209
2,2'-dihydroxybiphenyl
2,2'-biphenol, 99%
B0813
2-(2-hydroxyphenyl)phenol
CHEMBL183874
A812554
FT-0609156
AM84630
AKOS015890248
SCHEMBL28574
1,1'-bi-2-phenol
2,2'-bisphenol
2,2'-dihydroxy-biphenyl
DTXSID6051809
J-200141
2,2'-biphenyldiol,
biphenyl, 2,2'-dihydroxy
2,2-biphenol
5vl ,
mfcd00002210
LT0037
2,2 inverted exclamation mark -biphenol
0,0'-biphenol
F0001-0654
2,2`-dihydroxybiphenyl
Q27103998
AS-17348
BCP13947
CS-W016899
D71070
SY048537
2,2/'-biphenol
EN300-171748
biphenol, 2,2'-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydroxybiphenylsAny member of the class of biphenyls that has one or more hydroxy groups attached to the benzenoid ring system.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
2,2'-dihydroxybiphenyl degradation318

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1059430Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 using L-tryptophan as substrate at 1 mM after 1 hr relative to control2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).
AID1306194Downregulation of c-Myc gene expression in human HT-29 cells assessed as gene expression levels at 3 ug/ml after 48 hrs by RT-qPCR analysis relative to control2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306176Downregulation of VEGFA-165 secretion in human HT-29 cells assessed as protein secretion levels at 3 ug/ml after 72 hrs by ELISA relative to control2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1859357Inhibition of His-tagged SUMO1/SUMO E1 /GST-tagged Aos1/Uba2/His-tagged Ubc9 (unknown origin)-mediated recombinant His/T7-tagged RanGAP1-C-terminal fragment SUMOylation assessed as change in chemical shift perturbation by 1H,15N HSQC NMR spectroscopy anal2022European journal of medicinal chemistry, Apr-05, Volume: 233Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.
AID1552550Partition coefficient, log P of the compound2019Bioorganic & medicinal chemistry, 08-15, Volume: 27, Issue:16
Anti-proliferative activity and structure-activity relationship of honokiol derivatives.
AID1436342Inhibition of mushroom tyrosinase assessed as reduction in caffeic acid oxidation measured after 6 mins by UV-Vis spectrophotometric method2017European journal of medicinal chemistry, Jan-27, Volume: 126Hydroxylated biphenyls as tyrosinase inhibitor: A spectrophotometric and electrochemical study.
AID1306182Downregulation of VEGFA gene expression in human HT-29 cells assessed as gene expression levels at 3 ug/ml after 48 hrs by RT-qPCR analysis relative to control2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306175Therapeutic index, ratio of IC50 for HEK293 cells to IC50 for human MCF7 cells2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306174Therapeutic index, ratio of IC50 for HEK293 cells to IC50 for human HT-29 cells2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306171Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306173Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1436343Inhibition of immobilized mushroom tyrosinase diphenolase activity assessed as reduction in caffeic acid oxidation at 50 uM by amperometric tyrosinase biosensor method2017European journal of medicinal chemistry, Jan-27, Volume: 126Hydroxylated biphenyls as tyrosinase inhibitor: A spectrophotometric and electrochemical study.
AID247905Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined2005Bioorganic & medicinal chemistry letters, Jan-03, Volume: 15, Issue:1
Cytotoxic neolignans: an SAR study.
AID1306188Downregulation of TERT gene expression in human HT-29 cells assessed as gene expression levels at 3 ug/ml after 48 hrs by RT-qPCR analysis relative to control2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306172Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (6.67)18.7374
1990's4 (13.33)18.2507
2000's8 (26.67)29.6817
2010's12 (40.00)24.3611
2020's4 (13.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.39 (24.57)
Research Supply Index3.47 (2.92)
Research Growth Index4.96 (4.65)
Search Engine Demand Index34.57 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.23%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (96.77%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2,3-dihydroxybenzoic acid
2,3-dihydroxybenzoic acid: RN given refers to parent cpd. dihydroxybenzoic acid : Any member of the class of hydroxybenzoic acids carrying two phenolic hydroxy groups on the benzene ring and its derivatives.. 2,3-dihydroxybenzoic acid : A dihydroxybenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.		1.9810dihydroxybenzoic acidhuman xenobiotic metabolite;
plant metabolite
4-hydroxybenzaldehyde
[no description available]		2.0810hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
ammonium hydroxide
azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.		2.2510azane;
gas molecular entity;
mononuclear parent hydride		EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant
catechol
[no description available]		2.4220catecholsallelochemical;
genotoxin;
plant metabolite
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		2.0810monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
hydroquinone
[no description available]		210benzenediol;
hydroquinones		antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent
phenol
[no description available]		2.7230phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
pyrogallol
benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.		1.9810benzenetriol;
phenolic donor		plant metabolite
streptonigrin
[no description available]		3.5110pyridines;
quinolone		antimicrobial agent;
antineoplastic agent
triclosan
[no description available]		1.9910aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
cyanides
Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.		2.0310pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
benzoxazolone
benzoxazolone: RN given refers to parent cpd; structure. 2-benzoxazolinone : A member of the class of benzoxazoles that is 2,3-dihydro-1,3-benzoxazole carrying an oxo group at position 2.		2.0810benzoxazoleallelochemical;
phytoalexin
4-nitrobenzoic acid
4-nitrobenzoic acid: RN given refers to parent cpd. 4-nitrobenzoic acid : A nitrobenzoic acid having the nitro group at the 4-position.		2.0810nitrobenzoic acid
dinitrofluorobenzene
Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.. 1-fluoro-2,4-dinitrobenzene : The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.		1.9710C-nitro compound;
organofluorine compound		agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent
azobis(isobutyronitrile)
azobis(isobutyronitrile): blowing agent for elastomers & plastics; initiator for free radical reactions; structure		210
bisphenol a
4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.		2.4720bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
3-methylsalicylic acid
3-methylsalicylic acid : A monohydroxybenzoic acid consisting of salicylic acid carrying a methyl group at the 3-position.		2.0810monohydroxybenzoic acidbacterial xenobiotic metabolite
1,5-dihydroxynaphthalene
[no description available]		2.0810
carbazole
carbazole: structure in first source		7.2510carbazole
5-methylsalicylic acid
[no description available]		2.0810
2-aminodiphenyl
aminobiphenyl : Any member of the class of biphenyls in which the biphenyl skeleton is substituted by at least one amino group.		2.1310
2-phenylphenol
2-phenylphenol: RN given refers to parent cpd; structure. biphenyl-2-ol : A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits.		2.4120hydroxybiphenylsantifungal agrochemical;
environmental food contaminant
4-biphenylamine
4-biphenylamine: used in detection of sulfates, & as a carcinogen in cancer research; RN given refers to parent cpd; structure. biphenyl-4-amine : An aminobiphenyl that is biphenyl substituted by an amino group at position 4.		2.1310aminobiphenylcarcinogenic agent
4-phenylphenol
4-phenylphenol: RN given refers to cpd without isomeric designation. biphenyl-4-ol : A member of the class of hydroxybiphenyls that is biphenyl carrying a hydroxy group at position 4.		2.1310hydroxybiphenyls
4,4'-dihydroxybiphenyl
biphenyl-4,4'-diol : A member of the class of hydroxybiphenyls that is biphenyl with hydroxy groups at positions 4 and 4'.		3.3460hydroxybiphenyls
benzoyl peroxide
Benzoyl Peroxide: A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.		210carbonyl compound
benzothiazole
benzothiazole: structure. benzothiazole : An organic heterobicyclic compound that is a fusion product between benzene and thiazole. The parent of the class of benzothiazoles.		2.0810benzothiazolesenvironmental contaminant;
plant metabolite;
xenobiotic
phenylhydrazine
[no description available]		2.0810phenylhydrazinesxenobiotic
benzoin
[no description available]		1.9910benzoins;
secondary alpha-hydroxy ketone		EC 3.1.1.1 (carboxylesterase) inhibitor
dibenzothiazyl disulfide
dibenzothiazyl disulfide: vulcanizing accelerant. dibenzothiazol-2-yl disulfide : An organic disulfide resulting from the formal oxidative coupling of the thiol groups of two molecules of 1,3-benzothiazole-2-thiol. It is used as an accelerator in the rubber industry.		2.0810benzothiazoles;
organic disulfide		allergen
2-aminobenzothiazole
[no description available]		2.0810benzothiazoles
perylene
Perylene: A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.. perylene : An ortho- and peri-fused polycyclic arene comprising of five benzene rings that is anthracene in which the d,e and k,l sides are fused to benzene rings.		7.0510ortho- and peri-fused polycyclic arene;
perylenes
dibenzo(1,4)dioxin
dibenzo(1,4)dioxin: structure		2.0210dibenzodioxine;
heteranthrene;
mancude organic heterotricyclic parent;
oxacycle;
polycyclic heteroarene
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.2110cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
4-methylcatechol
[no description available]		2.0810methylcatecholantioxidant;
carcinogenic agent;
hapten;
human metabolite;
plant metabolite
ninhydrin
Ninhydrin: 2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.. ninhydrin : A member of the class of indanones that is indane-1,3-dione bearing two additional hydroxy substituents at position 2.		2.0810aromatic ketone;
beta-diketone;
indanones;
ketone hydrate		colour indicator;
human metabolite
hydroxyhydroquinone
benzene-1,2,4-triol : A benzenetriol carrying hydroxy groups at positions 1, 2 and 4.		2.0810benzenetriolmouse metabolite
6-hydroxyquinoline
quinolin-6-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 6.		2.0810monohydroxyquinoline
3-hydroxybiphenyl
3-hydroxybiphenyl: structure given in first source. biphenyl-3-ol : A member of the class of hydroxybiphenyls that is phenol in which the hydrogen at position 3 has been replaced by a phenyl group.		2.1310hydroxybiphenyls
2,7-dihydroxynaphthalene
[no description available]		2.0810
pentafluorobenzoic acid
[no description available]		2.0810perfluorinated compound
1,3-indandione
1,3-indandione : A member of the class of indanones that is indane in which the hydrogens at positions 2 and 4 have been replaced by oxo groups.		2.0810aromatic ketone;
beta-diketone;
indanones
4-methoxybiphenyl
[no description available]		2.1310
5-methylbenzimidazole
5-methylbenzimidazole: structure in first source. 5-methyl-1H-benzimidazole : A member of the class of imidazoles that is 1H-benzimidazole in which the hydrogen at position 5 is substituted by a methyl group.		2.0810imidazoles
2-hydrazinobenzothiazole
[no description available]		2.0810
4,4'-bisphenol f
4,4'-bisphenol F: RN given refers to parent cpd. bisphenol F : A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.		2.610bisphenol;
diarylmethane		environmental food contaminant;
xenoestrogen
3-acetylindole
3-acetylindole: structure in first source		2.0810
cyclopentenone
2-cyclopenten-1-one : An enone that is cyclopentanone having a C=C double bond at position 2.		2.2110alicyclic ketone;
enone		Hsp70 inducer
2-hydroxybenzothiazole
2-hydroxybenzothiazole : Benzothiazole substituted with a hydroxy group at the 2-position.		2.0810benzothiazole
phenylhydroquinone
phenylhydroquinone: major metabolite of o-phenylphenol; cleaves DNA; structure given in first source		2.0810
2-amino-4-methylbenzothiazole
2-amino-4-methylbenzothiazole: structure in first source		2.0810
bisphenol a-glycidyl methacrylate
Bisphenol A-Glycidyl Methacrylate: The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.		210diarylmethane
3-aminobiphenyl
3-aminobiphenyl: structure given in first source		2.1310
chromium
Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.		2.0710chromium group element atom;
metal allergen		micronutrient
ursolic acid
[no description available]		3.5110hydroxy monocarboxylic acid;
pentacyclic triterpenoid		geroprotector;
plant metabolite
salicylhydroxamic acid
[no description available]		2.0810hydroxamic acid;
phenols		antibacterial drug;
EC 1.11.2.2 (myeloperoxidase) inhibitor;
EC 3.5.1.5 (urease) inhibitor;
trypanocidal drug
5-fluorosalicylic acid
5-fluorosalicylic acid: structure given in first source; product from action of alkaline phosphatase on 5-fluorosalicyl phosphate; forms highly fluorescent terbium ternary complex		2.0810
1,8-diaminonaphthalene
1,8-diaminonaphthalene: structure in first source		2.0810
chavicol
4-allylphenol: an inhibitor of aryl-alcohol oxidase; has free radical scavenging activity. chavicol : A phenylpropanoid that is phenol substituted by a prop-2-enyl group at position 4.		2.0210phenols;
phenylpropanoid
4(5)-phenylimidazole
4(5)-phenylimidazole: tautomeric cpd; cytochrome P450 14alpha-sterol demethylase, CYP51 antagonist		2.0810
biphenyl-2-carboxylic acid
biphenyl-2-carboxylic acid: structure in first source		2.0810
magnolol
[no description available]		2.4820biphenyls
honokiol
[no description available]		2.7830biphenyls
benzylvanillin
benzylvanillin: structure given in first source		1.9910
4-Methoxybenzamide
[no description available]		2.0810benzamides
2-(carboxymethylthio)benzothiazole
2-(carboxymethylthio)benzothiazole: oxidation product of 2-(hydroxyethylthio)benzothiazole; structure given in first source		2.0810
trimethylsilyl cyanide
[no description available]		2.0310
glycyltyrosine
Gly-Tyr : A dipeptide composed of glycine and L-tyrosine joined by a peptide linkage.		1.9610dipeptidemetabolite
2,6-dihydroxynaphthalene
[no description available]		2.0810naphthols
2-hydroxy-1,2-bis(methoxyphenyl)ethanone
2-hydroxy-1,2-bis(methoxyphenyl)ethanone: structure given in first source		1.9910
triptolide
[no description available]		3.5110diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound		antispermatogenic agent;
plant metabolite
titanium isopropoxide
titanium(IV) isopropoxide : A titanium coordination entity consisting of a titanium(IV) cation with four propan-2-olate anions as counterions.		2.0810
4-methoxyhonokiol
4-methoxyhonokiol: an NSAID isolated from Magnolia obovata; structure in first source		2.2110
dehydrodieugenol
dehydrodieugenol: structure in first source		2.0210biphenyls
anacardic acid
anacardic acid: isolated from Anacardium occidentale; monophenol monooxygenase inhibitor. anacardic acid : A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities.		3.5110hydroxy monocarboxylic acid;
hydroxybenzoic acid		anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
apoptosis inducer;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
neuroprotective agent;
plant metabolite
lignin
Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed). lignin : A polyphenylpropanoid derived from three monolignol monomers: trans-p-coumaryl alcohol, coniferol and trans-sinapyl alcohol. There is extensive cross-linking and no defined primary structure.		1.9910
scoparianoside b
scoparianoside B: isolated from the fruit of Japanese Kochia scoparia; structure given in first source		3.5110triterpenoid saponin
kerriamycin b
kerriamycin B: from a streptomycete; structure given in first source		3.5110angucycline antibioticantineoplastic agent
diethylstilbestrol
Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed). diethylstilbestrol : An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.		210olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
1,1-Bis(4-hydroxyphenyl)ethane
[no description available]		2.610diarylmethane
captax
captax: RN given refers to parent cpd. 1,3-benzothiazole-2-thiol : 1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.		2.0810aryl thiol;
benzothiazoles		carcinogenic agent;
metabolite
3,3'-diallyldiethylstilbestrol
3,3'-diallyldiethylstilbestrol: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 12/89		2.2110
4-nitrocatechol
4-nitrocatechol : A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.		2.0810C-nitro compound;
catechols		human xenobiotic metabolite;
lipoxygenase inhibitor
esculetin
esculetin: used in filters for absorption of ultraviolet light; structure. esculetin : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.		2.0810hydroxycoumarinantioxidant;
plant metabolite;
ultraviolet filter
ginkgolic acid
[no description available]		3.5110hydroxybenzoic acid
7-hydroxycoumarin-4-acetic acid
7-hydroxycoumarin-4-acetic acid: pH-indicator dye; structure in first source		2.0810
epicinchonine
epicinchonine: structure in first source. cinchonine : Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.		2.4620cinchona alkaloid
2',3',4'-trihydroxyflavone
2',3',4'-trihydroxyflavone: inhibitor of protein sumoylation; structure in first source		3.5110
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		1.9710ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		1.9810monohydroxybenzoateplant metabolite
hydroxymuconic semialdehyde
(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid : A 2-hydroxy-6-oxohexa-2,4-dienoic acid in which the double bonds at positions 2 and 4 have Z- and E-configuration respectively.. 2-hydroxy-6-oxohexa-2,4-dienoic acid : A muconic semialdehyde having a hydroxy substituent at the 2-position.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		03.3310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.3310
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