Page last updated: 2024-12-05

2,2'-biphenol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,2'-Biphenol is a white crystalline solid organic compound with the formula C12H10O2. It is an important industrial chemical that finds applications in the synthesis of polymers, pharmaceuticals, and other organic chemicals. Its synthesis typically involves the oxidative coupling of phenol, a reaction that can be catalyzed by various metal complexes. 2,2'-Biphenol exhibits antioxidant properties and is used in the production of antioxidants for various industrial applications, including the stabilization of plastics and rubbers. Its biological activities include potential anticancer, antibacterial, and anti-inflammatory effects. 2,2'-Biphenol has also been investigated for its potential as a building block in the development of new materials with interesting optical and electronic properties.'

biphenyl-2,2'-diol : A member of the class of hydroxybiphenyls carrying hydroxy groups at positions 2 and 2'. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID15731
CHEMBL ID183874
CHEBI ID28970
SCHEMBL ID28574
MeSH IDM0116500

Synonyms (60)

Synonym
BIDD:ER0397
4-06-00-06645 (beilstein handbook reference)
pm2r53i3c9 ,
unii-pm2r53i3c9
CHEBI:28970 ,
2,2'-dihydroxy-1,1'-biphenyl
2,2'-dihydroxydiphenyl
2,2'-biphenol
o,o'-biphenol
nsc37068
o,o'-diphenol
2,2'-biphenyldiol
o-dihydroxydiphenyl
wln: qr br bq
1806-29-7
nsc-37068
o,o'-dihydroxybiphenyl
einecs 217-303-0
(1,1'-biphenyl)-2,2'-diol
nsc 37068
brn 1638363
ccris 2980
biphenyl-2,2'-diol
[1,1'-biphenyl]-2,2'-diol
inchi=1/c12h10o2/c13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14/h1-8,13-14
C03209
2,2'-dihydroxybiphenyl
2,2'-biphenol, 99%
B0813
2-(2-hydroxyphenyl)phenol
CHEMBL183874
A812554
FT-0609156
AM84630
AKOS015890248
SCHEMBL28574
1,1'-bi-2-phenol
2,2'-bisphenol
2,2'-dihydroxy-biphenyl
DTXSID6051809
J-200141
2,2'-biphenyldiol,
biphenyl, 2,2'-dihydroxy
2,2-biphenol
5vl ,
mfcd00002210
LT0037
2,2 inverted exclamation mark -biphenol
0,0'-biphenol
F0001-0654
2,2`-dihydroxybiphenyl
Q27103998
AS-17348
BCP13947
CS-W016899
D71070
SY048537
2,2/'-biphenol
EN300-171748
biphenol, 2,2'-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydroxybiphenylsAny member of the class of biphenyls that has one or more hydroxy groups attached to the benzenoid ring system.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
2,2'-dihydroxybiphenyl degradation318

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1059430Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 using L-tryptophan as substrate at 1 mM after 1 hr relative to control2013Bioorganic & medicinal chemistry, Dec-15, Volume: 21, Issue:24
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).
AID1306194Downregulation of c-Myc gene expression in human HT-29 cells assessed as gene expression levels at 3 ug/ml after 48 hrs by RT-qPCR analysis relative to control2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306176Downregulation of VEGFA-165 secretion in human HT-29 cells assessed as protein secretion levels at 3 ug/ml after 72 hrs by ELISA relative to control2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1859357Inhibition of His-tagged SUMO1/SUMO E1 /GST-tagged Aos1/Uba2/His-tagged Ubc9 (unknown origin)-mediated recombinant His/T7-tagged RanGAP1-C-terminal fragment SUMOylation assessed as change in chemical shift perturbation by 1H,15N HSQC NMR spectroscopy anal2022European journal of medicinal chemistry, Apr-05, Volume: 233Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.
AID1552550Partition coefficient, log P of the compound2019Bioorganic & medicinal chemistry, 08-15, Volume: 27, Issue:16
Anti-proliferative activity and structure-activity relationship of honokiol derivatives.
AID1436342Inhibition of mushroom tyrosinase assessed as reduction in caffeic acid oxidation measured after 6 mins by UV-Vis spectrophotometric method2017European journal of medicinal chemistry, Jan-27, Volume: 126Hydroxylated biphenyls as tyrosinase inhibitor: A spectrophotometric and electrochemical study.
AID1306182Downregulation of VEGFA gene expression in human HT-29 cells assessed as gene expression levels at 3 ug/ml after 48 hrs by RT-qPCR analysis relative to control2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306175Therapeutic index, ratio of IC50 for HEK293 cells to IC50 for human MCF7 cells2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306174Therapeutic index, ratio of IC50 for HEK293 cells to IC50 for human HT-29 cells2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306171Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306173Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1436343Inhibition of immobilized mushroom tyrosinase diphenolase activity assessed as reduction in caffeic acid oxidation at 50 uM by amperometric tyrosinase biosensor method2017European journal of medicinal chemistry, Jan-27, Volume: 126Hydroxylated biphenyls as tyrosinase inhibitor: A spectrophotometric and electrochemical study.
AID247905Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined2005Bioorganic & medicinal chemistry letters, Jan-03, Volume: 15, Issue:1
Cytotoxic neolignans: an SAR study.
AID1306188Downregulation of TERT gene expression in human HT-29 cells assessed as gene expression levels at 3 ug/ml after 48 hrs by RT-qPCR analysis relative to control2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
AID1306172Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay2016Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (6.67)18.7374
1990's4 (13.33)18.2507
2000's8 (26.67)29.6817
2010's12 (40.00)24.3611
2020's4 (13.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.39 (24.57)
Research Supply Index3.47 (2.92)
Research Growth Index4.96 (4.65)
Search Engine Demand Index34.57 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.23%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (96.77%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]