Decamethylcyclopentasiloxane (D5) is a cyclic siloxane with the formula (CH3)10Si5O5. It is a colorless, odorless, and viscous liquid that is widely used in cosmetics, personal care products, and other industrial applications. D5 is synthesized by the hydrolysis of dimethyldichlorosilane, followed by ring-opening polymerization and ring-closing depolymerization. The compound is known for its excellent spreading and film-forming properties, making it suitable for use as a silicone oil, emollient, and antifoaming agent. Due to its high volatility, D5 can evaporate from skin and products, contributing to its perceived light feel. However, concerns regarding its potential toxicity and environmental impact have led to increased scrutiny. D5 is often studied to understand its environmental fate, potential bioaccumulation, and possible health effects. It is also explored in research on silicone-based materials with improved biocompatibility and degradability.'
| ID Source | ID |
|---|---|
| PubMed CID | 10913 |
| CHEMBL ID | 1885178 |
| CHEBI ID | 191092 |
| SCHEMBL ID | 28497 |
| MeSH ID | M0295835 |
| Synonym |
|---|
| AKOS008901199 |
| decamethylcyclopentasiloxane |
| cyclopentasiloxane, decamethyl- |
| 541-02-6 |
| 2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentoxapentasilecane |
| vs 7158 |
| hsdb 5683 |
| dimethylsiloxane pentamer |
| dow corning 345 |
| dekamethylcyklopentasiloxan [czech] |
| sf 1202 |
| cyclic dimethylsiloxane pentamer |
| brn 1800166 |
| silicon sf 1202 |
| ccris 1328 |
| nuc silicone vs 7158 |
| einecs 208-764-9 |
| kf 995 |
| decamethylcyclopentasiloxane, 97% |
| NCGC00163981-01 |
| FT-0665531 |
| D1890 |
| 2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane |
| CHEBI:191092 |
| dimethylcyclopentasiloxane |
| decamethylcyclopentasiloxane (cyclic monomer) |
| S05475 |
| dtxsid1027184 , |
| cas-541-02-6 |
| tox21_303170 |
| dtxcid907184 |
| NCGC00257224-01 |
| 0tht5pci0r , |
| dekamethylcyklopentasiloxan |
| unii-0tht5pci0r |
| cyclopentasiloxane, 2,2,4,4,6,6,8,8,10,10-decamethyl- |
| d5-sil |
| ec 208-764-9 |
| 4-04-00-04128 (beilstein handbook reference) |
| cyclopentasiloxane |
| d5 |
| kp-545 component cyclomethicone 5 |
| xiameter pmx-0245 |
| cyclomethicone 5 [usp-rs] |
| cyclomethicone 5 [who-dd] |
| kf-995 |
| cyclomethicone d5 |
| cyclopentasiloxane [inci] |
| jeesilc cps-211 |
| decamethylcyclopentasiloxane [hsdb] |
| cyclomethicone 5 |
| octamethylcyclotetrasiloxane (d5) |
| cyclopentasiloxane (d5) |
| ciclopentasiloxane |
| decamethylcyclopentasiloxane [mi] |
| dow corning st cyclomethicone 5 |
| SCHEMBL28497 |
| ddecamethylcyclopentasiloxane |
| CHEMBL1885178 |
| decamethylcylopentasiloxane |
| 2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane # |
| cd3770 |
| XMSXQFUHVRWGNA-UHFFFAOYSA-N |
| d3770 |
| mfcd00046966 |
| c10h30o5si5 |
| decamethylcyclopentasiloxane, analytical standard |
| cyclomethicone 5, united states pharmacopeia (usp) reference standard |
| AS-59731 |
| decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane |
| d5 cyclomethicone, pharmaceutical secondary standard; certified reference material |
| DB11244 |
| BCP15826 |
| Q414350 |
| d5 cyclomethicone |
| decamethyl cyclopentasiloxane |
| D78203 |
| n-propylheptamethyltrisiloxane |
| CS-W009767 |
| 3ce pink im good mascara |
| lightening serum |
| unii: 0tht5pci0r |
| cyclomethicone 5 (usp-rs) |
Decamethylcyclopentasiloxane (D5) is a high-production-volume chemical that is emitted to air in tens of thousands of tonnes each year globally. It is a cyclic polydimethylsiloxane used in the synthesis of silicon-based materials and as a component in consumer products.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Decamethylcyclopentasiloxane (D5) is a high-production-volume chemical that is emitted to air in tens of thousands of tonnes each year globally. " | ( Emissions of decamethylcyclopentasiloxane from Chicago. Bogdal, C; Buser, AM; MacLeod, M; Scheringer, M, 2014) | 2.21 |
| "Decamethylcyclopentasiloxane (D5) is a cyclic siloxane used in the formulation of consumer products as well as an industrial intermediate. " | ( Toxicology of decamethylcyclopentasiloxane (D5). Dekant, W; Klaunig, JE, 2016) | 2.24 |
| "Decamethylcyclopentasiloxane (D5) is a cyclic siloxane used in the production and formulation of consumer products with potential exposure to manufacturing workers, consumer, and the general public. " | ( Biological relevance of decamethylcyclopentasiloxane (D5) induced rat uterine endometrial adenocarcinoma tumorigenesis: Mode of action and relevance to humans. Dekant, W; Klaunig, JE; Plotzke, K; Scialli, AR, 2016) | 2.18 |
| "Decamethylcyclopentasiloxane (D5) is a cyclic polydimethylsiloxane used in the synthesis of silicon-based materials and as a component in consumer products. " | ( Chronic toxicity and oncogenicity of decamethylcyclopentasiloxane in the Fischer 344 Rat. Jean, PA; Plotzke, KP; Scialli, AR, 2016) | 2.15 |
| "Decamethylcyclopentasiloxane (D5) is a low-molecular-weight cyclic siloxane used primarily as an intermediate in the production of several widely-used industrial and consumer products and intentionally added to consumer products, personal products and some dry cleaning solvents. " | ( A global human health risk assessment for Decamethylcyclopentasiloxane (D5). Franzen, A; Gentry, R; Greene, T; Plotzke, K; Van Landingham, C, 2016) | 2.14 |
| "Decamethylcyclopentasiloxane (D5) is a cyclic siloxane used in the production of industrial and consumer products. " | ( Statistical considerations for a chronic bioassay study: Exposure to Decamethylcyclopentasiloxane (D5) and incidence of uterine endometrial adenocarcinomas in a 2-year inhalation study with Fischer rats. Morfeld, P; Young, LJ, 2016) | 2.11 |
| "Decamethylcyclopentasiloxane (D(5)) is a volatile compound used in personal care products that is released to the atmosphere in large quantities. " | ( Concentrations and fate of decamethylcyclopentasiloxane (D(5)) in the atmosphere. Christensen, JH; Hansen, KM; Kierkegaard, A; McLachlan, MS; Skjøth, CA; van Egmond, R, 2010) | 2.1 |
| "Decamethylcyclopentasiloxane (D5) is a cyclic volatile methyl siloxane (cVMS) commonly found in commercially available products. " | ( Ecotoxicity of siloxane D5 in soil. Lessard, ME; Princz, J; Ritchie, E; Scroggins, R; Velicogna, J, 2012) | 1.82 |
| "Decamethylcyclopentasiloxane (D5) is a cyclic siloxane with a wide range of commercial applications. " | ( Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5). Burns-Naas, LA; Choudhuri, S; Gallavan, RH; Madan, A; Mast, RW; McKim, JM; Meeks, RG; Naas, DJ; Parkinson, A; Wilga, PC, 1999) | 1.95 |
| Excerpt | Relevance | Reference |
|---|---|---|
| "8 and 2mg/cm2) and 14C-D5 (10mg/cm2) was topically applied inside a dosing chamber attached to the dorsal area." | ( In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5). Jovanovic, ML; McMahon, JM; McNett, DA; Plotzke, KP; Tobin, JM, 2008) | 0.56 |
| Product Category | Products |
|---|---|
| Beauty & Personal Care | 27 |
| Baby & Kids Products | 2 |
| Class | Description |
|---|---|
| organosilicon compound | An organosilicon compound is a compound containing at least one carbon-silicon bond. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 68.5896 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 76.9588 | 0.0030 | 41.6115 | 22,387.1992 | AID1159553 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 2.7306 | 0.0015 | 30.6073 | 15,848.9004 | AID1224848; AID1224849 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 10.9622 | 0.3758 | 27.4851 | 61.6524 | AID743220 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 1.0000 | 0.0100 | 39.5371 | 1,122.0200 | AID588547 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.17) | 18.2507 |
| 2000's | 15 (16.30) | 29.6817 |
| 2010's | 71 (77.17) | 24.3611 |
| 2020's | 4 (4.35) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (51.31) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (3.26%) | 6.00% |
| Case Studies | 1 (1.09%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 88 (95.65%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||