Compounds > decamethylcyclopentasiloxane
Page last updated: 2024-11-05

decamethylcyclopentasiloxane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Decamethylcyclopentasiloxane (D5) is a cyclic siloxane with the formula (CH3)10Si5O5. It is a colorless, odorless, and viscous liquid that is widely used in cosmetics, personal care products, and other industrial applications. D5 is synthesized by the hydrolysis of dimethyldichlorosilane, followed by ring-opening polymerization and ring-closing depolymerization. The compound is known for its excellent spreading and film-forming properties, making it suitable for use as a silicone oil, emollient, and antifoaming agent. Due to its high volatility, D5 can evaporate from skin and products, contributing to its perceived light feel. However, concerns regarding its potential toxicity and environmental impact have led to increased scrutiny. D5 is often studied to understand its environmental fate, potential bioaccumulation, and possible health effects. It is also explored in research on silicone-based materials with improved biocompatibility and degradability.'

Cross-References

ID SourceID
PubMed CID10913
CHEMBL ID1885178
CHEBI ID191092
SCHEMBL ID28497
MeSH IDM0295835

Synonyms (83)

Synonym
AKOS008901199
decamethylcyclopentasiloxane
cyclopentasiloxane, decamethyl-
541-02-6
2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentoxapentasilecane
vs 7158
hsdb 5683
dimethylsiloxane pentamer
dow corning 345
dekamethylcyklopentasiloxan [czech]
sf 1202
cyclic dimethylsiloxane pentamer
brn 1800166
silicon sf 1202
ccris 1328
nuc silicone vs 7158
einecs 208-764-9
kf 995
decamethylcyclopentasiloxane, 97%
NCGC00163981-01
FT-0665531
D1890
2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane
CHEBI:191092
dimethylcyclopentasiloxane
decamethylcyclopentasiloxane (cyclic monomer)
S05475
dtxsid1027184 ,
cas-541-02-6
tox21_303170
dtxcid907184
NCGC00257224-01
0tht5pci0r ,
dekamethylcyklopentasiloxan
unii-0tht5pci0r
cyclopentasiloxane, 2,2,4,4,6,6,8,8,10,10-decamethyl-
d5-sil
ec 208-764-9
4-04-00-04128 (beilstein handbook reference)
cyclopentasiloxane
d5
kp-545 component cyclomethicone 5
xiameter pmx-0245
cyclomethicone 5 [usp-rs]
cyclomethicone 5 [who-dd]
kf-995
cyclomethicone d5
cyclopentasiloxane [inci]
jeesilc cps-211
decamethylcyclopentasiloxane [hsdb]
cyclomethicone 5
octamethylcyclotetrasiloxane (d5)
cyclopentasiloxane (d5)
ciclopentasiloxane
decamethylcyclopentasiloxane [mi]
dow corning st cyclomethicone 5
SCHEMBL28497
ddecamethylcyclopentasiloxane
CHEMBL1885178
decamethylcylopentasiloxane
2,2,4,4,6,6,8,8,10,10-decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane #
cd3770
XMSXQFUHVRWGNA-UHFFFAOYSA-N
d3770
mfcd00046966
c10h30o5si5
decamethylcyclopentasiloxane, analytical standard
cyclomethicone 5, united states pharmacopeia (usp) reference standard
AS-59731
decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane
d5 cyclomethicone, pharmaceutical secondary standard; certified reference material
DB11244
BCP15826
Q414350
d5 cyclomethicone
decamethyl cyclopentasiloxane
D78203
n-propylheptamethyltrisiloxane
CS-W009767
3ce pink im good mascara
lightening serum
unii: 0tht5pci0r
cyclomethicone 5 (usp-rs)

Research Excerpts

Overview

Decamethylcyclopentasiloxane (D5) is a high-production-volume chemical that is emitted to air in tens of thousands of tonnes each year globally. It is a cyclic polydimethylsiloxane used in the synthesis of silicon-based materials and as a component in consumer products.

ExcerptReferenceRelevance
"Decamethylcyclopentasiloxane (D5) is a high-production-volume chemical that is emitted to air in tens of thousands of tonnes each year globally. "( Emissions of decamethylcyclopentasiloxane from Chicago.
Bogdal, C; Buser, AM; MacLeod, M; Scheringer, M, 2014)		2.21
"Decamethylcyclopentasiloxane (D5) is a cyclic siloxane used in the formulation of consumer products as well as an industrial intermediate. "( Toxicology of decamethylcyclopentasiloxane (D5).
Dekant, W; Klaunig, JE, 2016)		2.24
"Decamethylcyclopentasiloxane (D5) is a cyclic siloxane used in the production and formulation of consumer products with potential exposure to manufacturing workers, consumer, and the general public. "( Biological relevance of decamethylcyclopentasiloxane (D5) induced rat uterine endometrial adenocarcinoma tumorigenesis: Mode of action and relevance to humans.
Dekant, W; Klaunig, JE; Plotzke, K; Scialli, AR, 2016)		2.18
"Decamethylcyclopentasiloxane (D5) is a cyclic polydimethylsiloxane used in the synthesis of silicon-based materials and as a component in consumer products. "( Chronic toxicity and oncogenicity of decamethylcyclopentasiloxane in the Fischer 344 Rat.
Jean, PA; Plotzke, KP; Scialli, AR, 2016)		2.15
"Decamethylcyclopentasiloxane (D5) is a low-molecular-weight cyclic siloxane used primarily as an intermediate in the production of several widely-used industrial and consumer products and intentionally added to consumer products, personal products and some dry cleaning solvents. "( A global human health risk assessment for Decamethylcyclopentasiloxane (D5).
Franzen, A; Gentry, R; Greene, T; Plotzke, K; Van Landingham, C, 2016)		2.14
"Decamethylcyclopentasiloxane (D5) is a cyclic siloxane used in the production of industrial and consumer products. "( Statistical considerations for a chronic bioassay study: Exposure to Decamethylcyclopentasiloxane (D5) and incidence of uterine endometrial adenocarcinomas in a 2-year inhalation study with Fischer rats.
Morfeld, P; Young, LJ, 2016)		2.11
"Decamethylcyclopentasiloxane (D(5)) is a volatile compound used in personal care products that is released to the atmosphere in large quantities. "( Concentrations and fate of decamethylcyclopentasiloxane (D(5)) in the atmosphere.
Christensen, JH; Hansen, KM; Kierkegaard, A; McLachlan, MS; Skjøth, CA; van Egmond, R, 2010)		2.1
"Decamethylcyclopentasiloxane (D5) is a cyclic volatile methyl siloxane (cVMS) commonly found in commercially available products. "( Ecotoxicity of siloxane D5 in soil.
Lessard, ME; Princz, J; Ritchie, E; Scroggins, R; Velicogna, J, 2012)		1.82
"Decamethylcyclopentasiloxane (D5) is a cyclic siloxane with a wide range of commercial applications. "( Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5).
Burns-Naas, LA; Choudhuri, S; Gallavan, RH; Madan, A; Mast, RW; McKim, JM; Meeks, RG; Naas, DJ; Parkinson, A; Wilga, PC, 1999)		1.95

Dosage Studied

ExcerptRelevanceReference
"8 and 2mg/cm2) and 14C-D5 (10mg/cm2) was topically applied inside a dosing chamber attached to the dorsal area."( In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5).
Jovanovic, ML; McMahon, JM; McNett, DA; Plotzke, KP; Tobin, JM, 2008)		0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organosilicon compoundAn organosilicon compound is a compound containing at least one carbon-silicon bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AR proteinHomo sapiens (human)Potency68.58960.000221.22318,912.5098AID1259243
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency76.95880.003041.611522,387.1992AID1159553
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency2.73060.001530.607315,848.9004AID1224848; AID1224849
farnesoid X nuclear receptorHomo sapiens (human)Potency10.96220.375827.485161.6524AID743220
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency1.00000.010039.53711,122.0200AID588547
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (92)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (2.17)18.2507
2000's15 (16.30)29.6817
2010's71 (77.17)24.3611
2020's4 (4.35)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 51.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index51.31 (24.57)
Research Supply Index4.53 (2.92)
Research Growth Index5.46 (4.65)
Search Engine Demand Index79.19 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (51.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (3.26%)6.00%
Case Studies1 (1.09%)4.05%
Observational0 (0.00%)0.25%
Other88 (95.65%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
octane
Octanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. octane : A straight chain alkane composed of 8 carbon atoms.		2.0110alkanexenobiotic
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.0110aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.		2.830benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
isopropyl myristate
isopropyl myristate: used for microemulsions; structure		2.1510fatty acid ester
squalane
[no description available]		2.1510
2,2,4-trimethylpentane
2,2,4-trimethylpentane: nephrotoxic. isooctane : An alkane that consists of pentane bearing two methyl substituents at position 2 and a single methyl substituent at position 4.		2.0110alkane;
volatile organic compound		fuel additive;
nephrotoxin;
non-polar solvent
dodecamethylcyclohexasiloxane
[no description available]		9.71260organosilicon compound
hexamethylcyclotrisiloxane
[no description available]		3.3660organosilicon compound
octamethylcyclotetrasiloxane
octamethylcyclotetrasiloxane: structure. octamethylcyclotetrasiloxane : A cyclosiloxane that is the octamethyl derivative of cyclotetrasiloxane.		5.18430cyclosiloxane;
organosilicon compound
limonene
Limonene: A naturally-occurring class of MONOTERPENES which occur as a clear colorless liquid at room temperature. Limonene is the major component in the oil of oranges which has many uses, including as flavor and fragrance. It is recognized as safe in food by the Food and Drug Administration (FDA).. limonene : A monoterpene that is cyclohex-1-ene substituted by a methyl group at position 1 and a prop-1-en-2-yl group at position 4 respectively.		3.2710cycloalkene;
p-menthadiene		human metabolite
fluorosulfonic acid
perfluorosulfonic acid: sulfonated tetrafluoroethylene-based fluoropolymer–copolymer		2.1710sulfur oxoacidNMR solvent
hexamethyldisiloxane
dimethicone: a linear silicone; an ingredient of SIMETHICONE; lotion of dimeticone in a volatile silicone base has been used to treat LICE		7.7530organosiloxane
ozone
Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).. ozone : An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.		7.0510elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen		antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer
2,4,5,2',4',5'-hexachlorobiphenyl
[no description available]		2.110hexachlorobiphenyl
pcb 180
PCB 180: C12-H3-Cl7		2.5220polychlorobiphenyl
pergolide
Pergolide: A long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.. pergolide : A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.		2.1510diamine;
methyl sulfide;
organic heterotetracyclic compound		antiparkinson drug;
dopamine agonist
colforsin
Colforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.		2.610acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
trimethylsilanol
[no description available]		2.1310
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.		2.1310oxygen hydride;
oxygen radical;
reactive oxygen species
squalene
Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate		2.1510triterpenehuman metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
3-(4-methoxyphenyl)-2-propenoic acid 3-methylbutyl ester
3-(4-methoxyphenyl)-2-propenoic acid 3-methylbutyl ester: RN given in first source		2.0410
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		2.0810chalcogen;
nonmetal atom		macronutrient
kaolinite
Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: high ridge), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed). kaolin : An aluminosilicate soft white mineral named after the hill in China (Kao-ling) from which it was mined for centuries. In its natural state kaolin is a white, soft powder consisting principally of the mineral kaolinite, and varying amounts of other minerals such as muscovite, quartz, feldspar, and anatase. It is used in the manufacture of china and porcelain and also widely used in the production of paper, rubber, paint, drying agents, and many other products.		2.1310aluminosilicate mineral;
mixture		antidiarrhoeal drug;
excipient
ConditionIndicatedRelationship StrengthStudiesTrials
Glue Abuse
[description not available]		03.0910
Cancer of the Uterus
[description not available]		02.1510
Uterine Neoplasms
Tumors or cancer of the UTERUS.		02.1510
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		07.5420
Adenocarcinoma, Basal Cell
[description not available]		03.9640
Cancer of Endometrium
[description not available]		03.9640
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		03.9640
Endometrial Neoplasms
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.		03.9640
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.4620
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0810
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.4220