ascorbic-acid and Myocarditis

This study performed a meta-analysis to explore the clinical efficacy of creatine phosphate sodium (CPS) and/or vitamin C for viral myocarditis (VMC) in children, to provide guidance for its clinical treatment.. A literature search was performed on PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang databases to obtain published clinical randomized controlled trials (RCTs) on CPS and/or vitamin C for VMC in children, with a time span from 2013 to 2022. Relevant data was extracted and meta-analysis was performed using the statistical software Stata 16.0.. A total of 723 studies were retrieved and 19 studies were finally included for meta-analysis, with a total of 1,957 patients. The meta-analysis results showed that the observation group (conventional treatment + CPS and/or vitamin C) was superior to the control group (conventional treatment alone) in treatment effective rate (OR = 3.60, 95% CI (2.55, 5.07), and. CPS and/or vitamin C treatment could greatly improve the treatment, protect myocardial function, and relieve inflammatory response in children with VMC.

Topics: Ascorbic Acid; Aspartate Aminotransferases; Child; Humans; Myocarditis; Phosphocreatine; Sodium; Treatment Outcome; Virus Diseases

There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in this process. Atrial biopsies from patients with AF have also confirmed the presence of inflammation. Furthermore, there is preliminary evidence to support a number of drug therapies that have the potential to reduce the clinical burden of AF. In this review, we present an overview of the evidence supporting a link between inflammation and AF, and some of the drug therapies, such as the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, steroids, fish oils, and vitamin C, that might be efficacious in the prevention of AF by modulating inflammatory pathways.

Topics: Ascorbic Acid; Atrial Fibrillation; Biomarkers; C-Reactive Protein; Coronary Thrombosis; Cytokines; Fish Oils; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocarditis; Pericarditis; Renin-Angiotensin System; Steroids

Inflammation and oxidative stress have been recently implicated in the pathophysiology of atrial fibrillation (AF). The aim of this study was to examine the potential benefit of vitamin C on the early recurrence rates and on inflammatory indices after successful cardioversion of persistent AF, as well as to investigate the time course of changes in these indices post-cardioversion.. We prospectively studied 44 consecutive patients after successful electrical cardioversion of persistent AF. All patients received standard treatment and were randomised in one to one fashion to either oral vitamin C administration or no additional therapy. We followed-up the patients for 7 days performing successive measurements of white blood cell (WBC) count, C-reactive protein (CRP), fibrinogen, and ferritin levels.. One week after successful cardioversion, AF recurred in 4.5% of patients in the vitamin C group and in 36.3% of patients in the control group (p=0.024). Compared to baseline values, inflammatory indices decreased after cardioversion in patients receiving vitamin C but did not change significantly in the control group. A significant variance was found in the serial measurements of WBC counts (F=5.86, p=0.001) and of fibrinogen levels (F=4.10, p=0.0084) in the two groups. In the vitamin C group CRP levels were lower on the seventh day (p<0.05). CRP and fibrinogen levels were higher in patients who relapsed into AF compared to patients who maintained sinus rhythm (F=2.77, p=0.044 and F=3.51, p=0.017, respectively).. These findings suggest that vitamin C reduces the early recurrence rates after cardioversion of persistent AF and attenuates the associated low-level inflammation. These effects indicate that therapeutic approaches targeting at inflammation and oxidative stress may exert favourable effects on atrial electrical remodeling.

Topics: Administration, Oral; Aged; Antioxidants; Ascorbic Acid; Atrial Fibrillation; Biomarkers; C-Reactive Protein; Echocardiography; Electric Countershock; Electrocardiography; Female; Ferritins; Fibrinogen; Follow-Up Studies; Heart Atria; Humans; Incidence; Inflammation; Leukocyte Count; Male; Myocarditis; Nephelometry and Turbidimetry; Oxidative Stress; Prospective Studies; Secondary Prevention; Treatment Outcome

Topics: Adult; Ascorbic Acid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Infusions, Intravenous; Male; Myocarditis; Phytotherapy; Virus Diseases

To evaluate the effect of intravenous immunoglobulin (IVIG) and vitamin C on the progression of experimental autoimmune myocarditis(EAM).. Fifty-two Balb/c mice were randomized into six groups: The blank group received no treatment, the remaining 5 groups were immunized with 100mug emulsified porcine myosin at d 1 and d 7. Different agents were injected from d 1, SVitC group:150 mg/kg*d(-1)vitamin C; LVitC group: 300 mg/kg*d(-1)vitamin C; IVIG group: 1 g/kg*d(-1)IVIG; IVIG+VitC group: 1 g/kg*d(-1)IVIG and 150 mg/kg*d(-1)vitamin C; The control group same volume of normal saline. All mice were sacrificed at d 21, and serum TNF-alpha levels were detected with enzyme linked immunosorbent assay (ELISA). The ratio of heart to body weight(C/W), spleen to body weight(S/W) and kidney to body weigh(R/W) were calculated. The spleens and heart were examined pathologically and/or immunohistochemically.. Compared with those of control group, inflammatory cells infiltration in the myocardium and calcification in the pericardiume in SVitC and LVitC groups were extenuated. There were inflammatory cells infiltrating in the myocardium sparely and no calcification in the pericardium in IVIG and IVIG+VitC groups. The size of spleens enlarged especially in IVIG and IVIG+VitC groups. White and red pulps of spleens were hyperplastic microscopically. The C/W of treatment groups decreased significantly compared with that of control group. The S/W of therapy groups and control group was significantly higher than that of blank group; and the S/W of IVIG and IVIG + VitC groups was significantly higher than that of SVitC and LVitC groups. The R/W in each groups had no significant difference. The TNF-alpha level in SVitC and LVitC groups was a little lower than that in control group; TNF-alpha level in IVIG and IVIG+VitC groups was significantly lower than that of control group. Wide fluorescence stripe was found along extracellular matrix surrounding the damaged cardiomyocytes of control group. Both density and intensity of fluorescence in SVitC and LVitC groups were lower than those of control group. There were much wider fluorescence stripe and strengthened intensity in IVIG and IVIG + VitC groups. The myofilaments were in wild disorder and sarcomere had severe breakage in control group. Moreover, chondriosome hypertrophy and vacuolar degeneration were found. The damage lessened in SVitC and LVitC groups. Both myofilaments and sarcomeres in IVIG and IVIG + VitC groups were almost normal, and the chondriosome was normal.. IVIG and vitamin C have some protective and therapeutic effect on the progression of EAM by decreasing pathological damage of myocardium and depressing TNF-alpha production, and IVIG combined with vitamin C is more effective.

Topics: Animals; Ascorbic Acid; Autoimmune Diseases; Drug Therapy, Combination; Female; gamma-Globulins; Immunoglobulins, Intravenous; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Myocarditis; Random Allocation; Tumor Necrosis Factor-alpha

The aim was to evaluate the efficacy of intravenous-immunoglobulin (IVIG) and vitamin C (VC) on the progression of experimental autoimmune myocarditis (EAM).. Fifty-two Balb/c mice were randomized into six groups: blank, small-dosage VC, large-dosage VC, IVIG, IVIG+VC, and a control group. All mice were sacrificed 21 days later. The level of tumor necrosis factor alpha (TNF-alpha), the ratios of the heart, spleen, and kidney to body weight (C/W, S/W, K/W), and pathological changes in the hearts and spleens were evaluated.. VC could extenuate inflammatory cell infiltration in the myocardium and calcification in the pericardium. IVIG or IVIG+VC could extenuate the pathological change more effectively. The C/W of each therapy group decreased significantly compared with that of control group. The TNF-alpha levels in the small- and large-dosage VC groups were a little lower than in the control group; the levels in the IVIG and IVIG+VC groups were significantly lower than in controls. Electron microscopic observation of the myocardium showed that VC could extenuate the damage to the myocardium. The myocardium in IVIG and IVIG+VC groups were almost normal.. IVIG and vitamin C have some protective and therapeutic effect on the progression of EAM by decreasing pathological damage to the myocardium and depressing TNF-alpha production. Especially IVIG combined with vitamin C are more effective as they can stimulate the immune reaction and increase IgG deposition in the myocardium.

Topics: Animals; Ascorbic Acid; Autoimmune Diseases; Female; Immunoglobulins, Intravenous; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Myocarditis; Myocardium; Tumor Necrosis Factor-alpha

Topics: Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Atrial Fibrillation; C-Reactive Protein; Electric Countershock; Humans; Inflammation; Myocarditis

Topics: Animals; Ascorbic Acid; Coxsackievirus Infections; Male; Mice; Mice, Inbred BALB C; Myocarditis; Superoxide Dismutase; Survival Rate

Topics: Adolescent; Adult; Ascorbic Acid; Drug Therapy, Combination; Female; Humans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Middle Aged; Myocarditis; Plant Extracts; Plants, Medicinal; Virus Diseases

Topics: Animals; Ascorbic Acid; Chlorides; Dermatologic Agents; Keto Acids; Muscle Proteins; Myocarditis; Myocardium; Myofibrils; Oxidoreductases; Pyruvates; Rabbits; RNA; Stimulation, Chemical; Tannins; Thiamine; Thiamine Pyrophosphate; Time Factors; Transferases

Topics: Antitoxins; Ascorbic Acid; Electrocardiography; Myocarditis; Niacin; Pharmacology; Rats; Research; Riboflavin; Staphylococcal Infections; Testosterone; Testosterone Propionate; Toxicology; Toxins, Biological

Topics: Animals; Ascorbic Acid; Caffeine; Epinephrine; Histocytochemistry; Myocarditis; Myocardium; Pharmacology; Rabbits; Research; Toxicology