Any bacterial metabolite produced by metabolism of a xenobiotic compound in bacteria.
| Member | Definition | Class |
|---|
| 1-hydroxy-2-naphthoic acid | A naphthoic acid with the carboxy group at position 2 and carrying a hydroxy substituent at the 1-position. It is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms. | 1-hydroxy-2-naphthoic acid |
| 1-naphthoic acid | A naphthoic acid carrying a carboxy group at position 1. | 1-naphthoic acid |
| 1,2-dihydroxy-1,2-dihydronaphthalene | A member of the class of naphthalenediols that is 1,2-dihydronaphthalene substituted by hydroxy groups at positions 1 and 2 respectively. | 1,2-dihydronaphthalene-1,2-diol |
| 1,3,4-butanetriol | A triol that is butane carrying three hydroxy substituents at position 1, 2 and 4. | 1,2,4-butanetriol |
| 10-hydroxystearic acid | A hydroxy fatty acid that is octadecanoic acid carrying a hydroxy group at position 10. | 10-hydroxyoctadecanoic acid |
| 11-hydroxytestosterone | An androstanoid that is testosterone carrying an additional hydroxy substituent at the 11beta-position. | 11beta-hydroxytestosterone |
| 12-hydroxy stearic acid | A hydroxy fatty acid that is stearic acid bearing a hydroxy substituent at position 12. | 12-hydroxyoctadecanoic acid |
| 2-ethylhexanal | A saturated fatty aldehyde that is heptane in which one of the hydrogens at position 3 has been replaced by a formyl group. It is a metabolite of the plasticisers di-2-ethylhexyl phthalate (DEHP) and di-2-ethylhexyl adipate (DEHA). | 2-ethylhexanal |
| 2-furoic acid | A furoic acid having the carboxylic acid group located at position 2. | 2-furoic acid |
| 2-pinene oxide | An epoxide of alpha-pinene. | alpha-pinene oxide |
| 2,4-dinitrophenol | A dinitrophenol having the nitro groups at the 2- and 4-positions. | 2,4-dinitrophenol |
| 2,5-dichlorohydroquinone | A dichlorohydroquinone that is hydroquinone substituted by chloro groups at positions 2 and 5 respectively. | 2,5-dichlorohydroquinone |
| 2,6-dichlorobenzoic acid | A chlorobenzoic acid carrying two chloro groups at positions 2 and 6 respectively. | 2,6-dichlorobenzoic acid |
| 3-methylcatechol | A methylcatechol carrying a methyl substituent at position 3. It is a xenobiotic metabolite produced by some bacteria capable of degrading nitroaromatic compounds present in pesticide-contaminated soil samples. | 3-methylcatechol |
| 3-methylsalicylic acid | A monohydroxybenzoic acid consisting of salicylic acid carrying a methyl group at the 3-position. | 3-methylsalicylic acid |
| 3-oxoadipic acid | An oxo dicarboxylic acid consisting of adipic acid having a single oxo group at the 3-position. | 3-oxoadipic acid |
| 3-phenylbutyric acid | A monocarboxylic acid that is butanoic acid substituted by a phenyl group at position 3. | 3-phenylbutyric acid |
| 4-chlorobenzoic acid | A monochlorobenzoic acid carrying a chloro substituent at position 4. | 4-chlorobenzoic acid |
| 4-chlorocatechol | A chlorocatechol that is catechol substituted by a chloro group at position 4. | 4-chlorocatechol |
| 4-fluorobenzoic acid | A fluorobenzoic acid carrying a fluoro substituent at position 4. | 4-fluorobenzoic acid |
| 4-nitroaniline | A nitroaniline carrying a nitro group at position 4. | 4-nitroaniline |
| 5-chloromuconolactone | A 5-oxo-2-furylacetic acid that is muconolactone substituted at position 5 by a chloro group. | 5-chloromuconolactone |
| 5-hydroxymethyl-2-furoic acid | A member of the class of furoic acids that is 2-furoic acid substituted at position 5 by a hydroxymethyl group. | 5-hydroxymethyl-2-furoic acid |
| 6-deisopropylatrazine | A diamino-1,3,5-triazine that is N-ethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6. | deisopropylatrazine |
| 6-hydroxyhexanoic acid | An omega-hydroxy fatty acid comprising hexanoic acid having a hydroxy group at the 6-position. | 6-hydroxyhexanoic acid |
| 9,11-linoleic acid | An octadeca-9,11-dienoic acid having 9-trans,11-trans-stereochemistry. | (9E,11E)-octadecadienoic acid |
| benzohydrol | A secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1. | diphenylmethanol |
| benzylsuccinic acid | A dicarboxylic acid consisting of succinic acid carrying a 2-benzyl substituent. | 2-benzylsuccinic acid |
| carbostyril | A monohydroxyquinoline carrying a hydroxy substituent at position 2. It is an intermediate metabolite produced duting the microbial degradation of quinoline. | quinolin-2-ol; quinolin-2(1H)-one |
| cellodextrin | A glucotriose consisting of three | cellotriose |
| dimethyl sulfide | A methyl sulfide in which the sulfur atom is substituted by two methyl groups. It is produced naturally by some marine algae. | dimethyl sulfide |
| dimethylselenide | An organoselenium compound of two methyl groups covalently bound to a selenium. | dimethylselenide |
| duroquinol | A member of the class of hydroquinones that is benzene-1,4-diol carrying four methyl groups at positions 2, 3, 5 and 6. | durohydroquinone |
| edda | An ethylenediamine derivative in which two of the four amine protons of ethylenediamine are replaced by carboxymethyl groups. | ethylenediaminediacetic acid |
| hydromethylthionine | A member of the class of phenothiazines that is 10H-phenothiazine in which the ring hydrogens at positions 3 and 7 have been replaced by dimethylamino groups. | leucomethylene blue |
| hydroxylamine | The simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria. | hydroxylamine |
| maleamic acid | A dicarboxylic acid monoamide of maleamic acid. | maleamic acid |
| maleoylacetic acid | A 4-oxohex-2-enedioic acid with a Z-configuration. | maleylacetic acid |
| melilotic acid | A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 3 is substituted by a 2-hydroxyphenyl group. | 3-(2-hydroxyphenyl)propanoic acid |
| n-methylglutamate | A N-methyl-L-alpha-amino acid with L-glutamic acid as the amino acid component. | N-methyl-L-glutamic acid |
| oripavine | A morphinane alkaloid with formula C18H19NO3. It is the major metabolite of thebaine. | oripavine |
| s-chloromethylglutathione | An S-substituted glutathione that is glutathione in which the mercapto hydrogen has been replaced by a chloromethyl group. | S-(chloromethyl)glutathione |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 30.3001 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 26.2000 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 19.9526 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 71.5008 | 3 | 9 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 11.3567 | 1 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 33.0084 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 36.4774 | 11 | 27 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 53.2135 | 2 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 6.4596 | 1 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.0120 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 6.4328 | 2 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 89.1251 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 55.9334 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 55.9334 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 14.5614 | 1 | 4 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.4822 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 82.3993 | 1 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.8114 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 56.1880 | 2 | 3 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 89.3584 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 47.9478 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 34.9395 | 10 | 32 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 25.3836 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 27.8067 | 8 | 29 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 35.0364 | 2 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 6.2582 | 1 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 21.6153 | 2 | 12 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 20.3866 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 28.7430 | 4 | 10 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 48.2049 | 1 | 4 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 50.0249 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 22.0243 | 1 | 4 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 31.1027 | 2 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 41.2383 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 89.3584 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0282 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 42.0416 | 3 | 11 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 27.2582 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4980 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 16.4648 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 31.4879 | 3 | 8 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 27.0214 | 3 | 10 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 14.6631 | 3 | 7 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 70.7946 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 66.9080 | 2 | 3 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 50.1187 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 52.0289 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 22.8227 | 2 | 12 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 41.8982 | 3 | 9 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19.4640 | 3 | 7 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 49.2215 | 2 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 51.8714 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 51.8714 | 2 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 11.9048 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.4480 | 2 | 4 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 100.0000 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 50.2907 | 3 | 11 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0962 | 3 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 19.5408 | 4 | 8 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 38.7373 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 12.2469 | 2 | 5 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 31.7542 | 2 | 6 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 48.2049 | 1 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Calcium release-activated calcium channel protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 3,070.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 2,860.6150 | 4 | 4 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.0930 | 3 | 3 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 0.0650 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 0.0360 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 4,700.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 2,745.0000 | 4 | 4 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 0.5700 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 0.3600 | 2 | 2 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 0.4100 | 2 | 2 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 0.7500 | 2 | 2 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 0.0330 | 2 | 2 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.4200 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.0820 | 3 | 3 |
| Carboxypeptidase A1 | Bos taurus (cattle) | Ki | 0.5000 | 1 | 1 |
| Carboxypeptidase B | Helicoverpa zea (corn earworm) | Ki | 11.9000 | 1 | 1 |
| Carboxypeptidase B | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carboxypeptidase B2 | Homo sapiens (human) | Ki | 0.4500 | 1 | 1 |
| Chain A, Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 0.0331 | 1 | 1 |
| Chain A, serum paraoxonase | Oryctolagus cuniculus (rabbit) | Ki | 2.0000 | 1 | 1 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| L-lactate dehydrogenase A chain | Rattus norvegicus (Norway rat) | IC50 | 500.0000 | 1 | 1 |
| L-lactate dehydrogenase B chain | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Mast cell carboxypeptidase A | Homo sapiens (human) | Ki | 0.4500 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.2860 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 100.0000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 1,000.0000 | 1 | 1 |
| Neutrophil cytosol factor 1 | Homo sapiens (human) | Ki | 2,000.0000 | 1 | 1 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Protein orai-2 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Protein orai-3 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Thiopurine S-methyltransferase | Homo sapiens (human) | IC50 | 186.2090 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 850.0000 | 1 | 1 |