A role borne by a molecule that acts to counteract or neutralize the deleterious effects of cyanide.
ChEBI ID: 90749
| Member | Definition | Class |
|---|---|---|
| 3-mercaptopyruvic acid | A 2-oxo monocarboxylic acid that is pyruvic acid substituted by a sulfanyl group at position 3. | 3-mercaptopyruvic acid |
| sodium nitrite | An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning. | sodium nitrite |
| sodium thiosulfate | An inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio. | sodium thiosulfate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 764 (30.00) | 18.7374 |
| 1990's | 452 (17.75) | 18.2507 |
| 2000's | 424 (16.65) | 29.6817 |
| 2010's | 670 (26.31) | 24.3611 |
| 2020's | 237 (9.31) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 90 (3.13%) | 5.53% |
| Reviews | 130 (4.52%) | 6.00% |
| Case Studies | 253 (8.81%) | 4.05% |
| Observational | 4 (0.14%) | 0.25% |
| Other | 2,396 (83.40%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 31.6228 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 54.5654 | 2 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 6.9167 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 57.4177 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 47.3079 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 68.2410 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 19.3913 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 6,800.0000 | 3 | 3 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 63,800.0000 | 1 | 1 |
| Carbonic anhydrase | Pseudomonas aeruginosa PAO1 | Ki | 940.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 8,400.0000 | 8 | 8 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 63,000.0000 | 18 | 18 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 30,800.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 16,000.0000 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 63,000.0000 | 1 | 1 |