A depigmentation agent which inhibits the synthesis of melanin.
| Member | Definition | Class |
|---|
| 4,5,6,7-tetrachlorophthalide | A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one in which all or the hydrogens attached to the benzene ring are replaced by chlorines. A fungicide used for the control of rice blast, it is not approved for use within the European Union. | 4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one |
| 5,4'-dihydroxy-7,3'-dimethoxyflavone | A dimethoxyflavone that is luteolin in which the hydroxy groups at positions 7 and 3' are replaced by methoxy groups. | velutin |
| carpropamid | A cyclopropylcarboxamide obtained by formal condensation of the carboxy group of 2,2-dichloro-1-ethyl-3-methylcyclopropanecarboxylic acid with the amino group of 1-(4-chlorophenyl)ethylamine. A rice fungicide with specific action against Pyricularia oryzae. It is not highly toxic to mammals but shows a moderate level of toxicity to birds, fish and earthworms. | carpropamid |
| decaprenoic acid | A polyunsaturated fatty acid that is octa-2,6-dienoic acid bearing two methyl substituents at positions 3 and 7 (the 2E-isomer). | geranic acid |
| monobenzone | The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. | monobenzone |
| N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide | A hydroxamic acid that is N-hydroxy-D-valinamide in which the alpha-amino group has been substituted by isopropoxy and [biphenyl]-4-ylsulfonyl groups. A selective matrix metalloproteinase-2 (MMP-2) inhibitor, it is one of the most potent inducers of autophagy. Its physiological roles include angiogenesis, cancer metastasis, embryogenesis, tissue remodeling in development, and wound healing. | N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide |
| theasinensin a | A biflavonoid that is obtained by coupling of two molecules of (-)-epigallocatechin 3-gallate resulting in a bond between positions C-2 of the hydroxyphenyl ring. It is a natural product found in oolong tea. | theasinensin A |
| tricyclazole | A triazolobenzothiazole that is [1,2,4]triazolo[3,4-b][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union. | tricyclazole |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 51.5879 | 2 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 24.0118 | 6 | 13 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 19.6223 | 2 | 4 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 13.5145 | 2 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 20.7377 | 2 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 4.2355 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 4.2355 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 15.1955 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 10.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 72.3342 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 5.2029 | 1 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 5.8479 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.5853 | 9 | 17 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 16.8617 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 23.9114 | 6 | 11 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 5.0127 | 4 | 4 |
| G | Vesicular stomatitis virus | Potency | 24.5454 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 5.3800 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 14.8464 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 7.2696 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 18.5622 | 2 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 24.5454 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 20.7421 | 2 | 3 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 7,307.8000 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 16.3626 | 4 | 6 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 20.1441 | 3 | 9 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 0.0675 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 5.3099 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 13.2072 | 2 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 33.0560 | 3 | 5 |
| progesterone receptor | Homo sapiens (human) | Potency | 18.9191 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 14.0807 | 2 | 4 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 91.9997 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 37.6858 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 11.9973 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 15.9848 | 2 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 3.6208 | 2 | 2 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 56.2341 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 6.4719 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 26.7239 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 14.8464 | 1 | 2 |