| Assay ID | Title | Year | Journal | Article |
|---|
| AID1285390 | Induction of quinone reductase specific activity in mouse mutant BpRc1 cells expressing defective translocator receptor Arnt using 2,6-DCIP as substrate at 10 uM measured for 1 min relative to control | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID513961 | Induction glutathione-CYP1A1 in rat liver at 15 mg/kg, po qd by EROD assay | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1379240 | Estrogenic activity at estrogen receptor alpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-Nitrophenol phosphate as substrate pretreated for 96 hrs followed by substrate addition measured every 15 secs by scannin | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health. |
| AID1267473 | Cytotoxicity against mouse Hepa-1c1c7 cells assessed as cell viability at 10 uM after 24 hrs by crystal violet staining-based assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
| Bioactive minor components of the total salvianolic acids injection prepared from Salvia miltiorrhiza Bge. |
| AID295385 | Growth inhibition of HT29 cells by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID513959 | Cytotoxicity against human HT-29 cells | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1860353 | Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation at 10 uM in presence of arachidonic acid and NADPH by multi-enzyme assay based LC-MS/MS analysis relative to control | | | |
| AID1354408 | Cytotoxicity against HEK293 cells assessed as reduction in cell viability by CMFDA dye based fluorescence assay | | | |
| AID380758 | Inhibition of mouse Hepa-1c1c7 Bprc1 mutant cells assessed as cell viability | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Quinone reductase induction as a biomarker for cancer chemoprevention. |
| AID1315551 | Induction of quinone reductase-1 in human Hepa-1c1c7 cells assessed as reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide after 48 hrs by crystal violet staining-based assay | 2016 | Journal of natural products, 06-24, Volume: 79, Issue:6
| Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates. |
| AID776774 | Aqueous solubility of the compound | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. |
| AID488653 | Induction of NADPH-dependent quinone reductase activity in mouse Hepa-1c1c7 cells assessed as concentration to double activity after 48 hrs by MTT assay | 2010 | Journal of natural products, Jun-25, Volume: 73, Issue:6
| Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis. |
| AID1237289 | Activation of Quinone reductase-1 in mouse Hepa-1c1c7 cells assessed as concentration required to double enzyme activity after 48 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Synthesis, molecular docking and anticancer studies of peptides and iso-peptides. |
| AID513956 | Induction of quinone reductase activity in rat liver at 15 mg/kg, po qd | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1285389 | Induction of quinone reductase specific activity in mouse Hepa1c1c7 cells using 2,6-DCIP as substrate at 10 uM measured for 1 min relative to control | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID380752 | Induction of antioxidant response element activity in human HepG2 cells at 10 uM by luciferase based chemiluminescence assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Quinone reductase induction as a biomarker for cancer chemoprevention. |
| AID380495 | Induction of ARE in human HepG2 cells by luciferase assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza. |
| AID1192791 | Cytotoxicity against mouse Hepa-1c1c7 cells assessed as cell viability at 10 uM after 10 mins | 2015 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5
| Chemopreventive flavonoids from Millettia pulchra Kurz var-laxior (Dunn) Z.Wei (Yulangsan) function as Michael reaction acceptors. |
| AID776775 | Antiplasmodial activity against chloroquine-resistant blood stage of Plasmodium falciparum W2 infected in human RBC after 48 hrs by flow cytometric analysis | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. |
| AID295386 | Growth inhibition of HK2 cells by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID380757 | Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 Bprc1 mutant cells assessed as drug level required to double specific enzyme activity | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Quinone reductase induction as a biomarker for cancer chemoprevention. |
| AID380748 | Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double specific enzyme activity | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Quinone reductase induction as a biomarker for cancer chemoprevention. |
| AID295382 | Cytotoxicity against human HT29 cells ATCC HTB38 in aerobic condition assessed as survival at 100 uM by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID774398 | Inhibition of human TNKS1 (1030 to 1317) using NAD+ as substrate by fluorescence assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. |
| AID1379243 | Cytotoxicity against mouse Hepa1c1c7 cells after 48 hrs by crystal violet staining based assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health. |
| AID513957 | Cytotoxicity against human MCF7 cells | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID772982 | Induction of quinone reductase-1 activity in mouse Hepa-1c1c7 cells assessed as concentration required to double induction activity by MTT assay | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles. |
| AID513960 | Induction glutathione-S-transferase activity in rat liver at 15 mg/kg, po qd | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1192789 | Induction of NQO1 activity in mouse Hepa-1c1c7 cells assessed as induction ratio at 10 uM after 48 hr by NADPH-dependent MTT assay relative to control | 2015 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 25, Issue:5
| Chemopreventive flavonoids from Millettia pulchra Kurz var-laxior (Dunn) Z.Wei (Yulangsan) function as Michael reaction acceptors. |
| AID1379241 | Cytotoxicity against human Ishikawa cells after 96 hrs by SRB assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health. |
| AID1860355 | Selectivity index, log ratio of Inhibition of CYP450 in human liver microsomes assessed as inhibition of EpETrE formation in presence of arachidonic acid to Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in pres | | | |
| AID1285397 | Chemoprotective index, ratio of IC50 for mouse mutant BpRc1 cells to CD for quinone reductase activity in mouse mutant BpRc1 cells | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID1285398 | Ratio of induction of quinone reductase specific activity in mouse mutant BpRc1 cells to mouse Hepa1c1c7 cells | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID513958 | Cytotoxicity against human TK10 cells | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID1285394 | Chemoprotective index, ratio of IC50 for mouse Hepa1c1c7 cells to CD for quinone reductase activity in mouse Hepa1c1c7 cells | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID1372213 | Induction of QR1 activity in mouse Hepa-1c1c7 cells assessed as drug concentration required to double enzyme activity after 48 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24
| Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1. |
| AID1860354 | Inhibition of CYP450 in human liver microsomes assessed as inhibition of EpETrE formation at 10 uM in presence of arachidonic acid and NADPH by multi-enzyme assay based LC-MS/MS analysis relative to control | | | |
| AID295381 | Cytotoxicity against human MCF7 cells ATCC HTB38 in aerobic condition assessed as survival at 100 uM by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID1267470 | Induction of NQO1 activity in mouse Hepa-1c1c7 cells at 10 uM after 24 hrs by MTT assay relative to control | 2016 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
| Bioactive minor components of the total salvianolic acids injection prepared from Salvia miltiorrhiza Bge. |
| AID772983 | Induction of quinone reductase-1 activity in mouse Hepa-1c1c7 cells assessed as induction ratio at 50 uM by MTT assay relative to DMSO-treated control | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles. |
| AID1354406 | Induction of quinone reductase activity in mouse Hepa1c1c7 cells using menadiol/NADPH as substrate after 48 hrs by MTT assay | | | |
| AID1285391 | Ratio of quinone reductase specific activity in mouse Hepa1c1c7 cells to quinone reductase specific activity in mouse mutant BpRc1 cells | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID295384 | Growth inhibition of MCF7 cells by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID380760 | Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 TAOc1Bprc1 mutant cells assessed as drug level required to double specific enzyme activity | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Quinone reductase induction as a biomarker for cancer chemoprevention. |
| AID650846 | Induction of QR1 in mouse Hepa-1c1c7 cells assessed as concentration required to double QR1 induction by MTT assay | 2012 | Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
| Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. |
| AID1285396 | Induction of quinone reductase activity in mouse mutant BpRc1 cells using 2,6-DCIP as substrate measured for 1 min | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID380750 | Inhibition of mouse Hepa-1c1c7 cells assessed as cell viability | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Quinone reductase induction as a biomarker for cancer chemoprevention. |
| AID1182051 | Induction of quinone reductase 1 in mouse Hepa-1c1c7 cells after 48 hrs by MTT assay | 2014 | Journal of natural products, Jul-25, Volume: 77, Issue:7
| Spongiapyridine and related spongians isolated from an Indonesian Spongia sp. |
| AID1285392 | Cytotoxicity against mouse Hepa1c1c7 cells after 48 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID719275 | Induction of quinone reductase-1 activity in mouse Hepa-1c1c7 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Dec-15, Volume: 20, Issue:24
| Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). |
| AID1285395 | Cytotoxicity against mouse mutant BpRc1 cells after 48 hrs by SRB assay | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID513978 | Toxicity in Sprague-Dawley rat assessed as change in body weight at 250 mg/kg, po | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. |
| AID295380 | Cytotoxicity against human TK10 cells in aerobic condition assessed as survival at 100 uM by sulforhodamine assay | 2007 | Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10
| Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. |
| AID380761 | Inhibition of mouse Hepa-1c1c7 TAOc1Bprc1 mutant cells assessed as cell viability | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Quinone reductase induction as a biomarker for cancer chemoprevention. |
| AID630246 | Induction of quinone reductase 1 in mouse Hepa 1c1c7 cells assessed as concentration of compound required to double enzyme activity by MTT assay | 2011 | Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
| Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. |
| AID380749 | Chemoprevention index, ratio of IC50 for mouse Hepa-1c1c7 cells to drug level required to double specific NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3
| Quinone reductase induction as a biomarker for cancer chemoprevention. |
| AID1285393 | Induction of quinone reductase specific activity in mouse Hepa1c1c7 cells assessed as concentration required to double enzyme specific activity using 2,6-DCIP as substrate measured for 1 min | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons. |
| AID1379242 | Induction of NQO1 activity in mouse Hepa1c1c7 cells after 48 hrs by MTT reduction assay | 2017 | Journal of natural products, 08-25, Volume: 80, Issue:8
| DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health. |
| AID1801003 | Fluorimetric Assay from Article 10.1016/j.bioorg.2014.11.008: \\Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones.\\ | 2015 | Bioorganic chemistry, Feb, Volume: 58 | Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |