Roles > emetic
Page last updated: 2024-08-05 15:26:56

emetic

Any agent that induces nausea and vomiting.

ChEBI ID: 149552

Members (5)

MemberDefinitionClass
apomorphineapomorphine
copper sulfateA metal sulfate compound having copper(2+) as the metal ion.copper(II) sulfate
emetineA pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.emetine
emetine dihydrochlorideThe dihydrochloride salt of emetine.emetine dihydrochloride
xylazineA methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.xylazine

Research

Studies (14,239)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19906,895 (48.42)18.7374
1990's2,797 (19.64)18.2507
2000's2,289 (16.08)29.6817
2010's1,772 (12.44)24.3611
2020's486 (3.41)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials582 (3.83%)5.53%
Reviews513 (3.38%)6.00%
Case Studies332 (2.19%)4.05%
Observational13 (0.09%)0.25%
Other13,737 (90.51%)84.16%

Protein Targets (175)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency3.981111
acetylcholinesteraseHomo sapiens (human)Potency37.062133
activating transcription factor 6Homo sapiens (human)Potency2.798712
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency30.300112
AR proteinHomo sapiens (human)Potency8.3190719
aryl hydrocarbon receptorHomo sapiens (human)Potency4.308022
arylsulfatase AHomo sapiens (human)Potency2.685511
ATAD5 protein, partialHomo sapiens (human)Potency0.779122
Ataxin-2Homo sapiens (human)Potency6.873424
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency12.589311
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency5.581025
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency37.933011
Bloom syndrome protein isoform 1Homo sapiens (human)Potency17.782822
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency100.000011
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency68.798911
caspase-3Cricetulus griseus (Chinese hamster)Potency30.731411
caspase-3Homo sapiens (human)Potency68.798911
Caspase-7Cricetulus griseus (Chinese hamster)Potency30.731411
Cellular tumor antigen p53Homo sapiens (human)Potency6.723024
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency15.714222
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency35.481311
Chain A, HADH2 proteinHomo sapiens (human)Potency12.569422
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency13.784225
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency22.334211
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency0.281811
Chain B, HADH2 proteinHomo sapiens (human)Potency12.569422
cytochrome P450 2C19 precursorHomo sapiens (human)Potency10.000011
cytochrome P450 2C9 precursorHomo sapiens (human)Potency31.622811
cytochrome P450 2D6Homo sapiens (human)Potency15.487112
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency20.800013
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency2.510924
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency2.597023
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency11.324213
estrogen nuclear receptor alphaHomo sapiens (human)Potency7.1478822
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency10.205513
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency9.1834921
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency24.000614
farnesoid X nuclear receptorHomo sapiens (human)Potency15.345313
flap endonuclease 1Homo sapiens (human)Potency29.934911
GABA theta subunitRattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency2.510912
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency2.510912
gemininHomo sapiens (human)Potency12.679044
GLI family zinc finger 3Homo sapiens (human)Potency5.387337
GLS proteinHomo sapiens (human)Potency19.952611
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency5.774323
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency4.072713
heat shock protein beta-1Homo sapiens (human)Potency0.618811
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency19.174225
Histone H2A.xCricetulus griseus (Chinese hamster)Potency17.140124
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency10.878813
Integrin alpha-IIbHomo sapiens (human)Potency25.118911
Integrin beta-3Homo sapiens (human)Potency25.118911
Interferon betaHomo sapiens (human)Potency0.559924
lamin isoform A-delta10Homo sapiens (human)Potency17.944224
lethal factor (plasmid)Bacillus anthracis str. A2012Potency25.118911
LuciferasePhotinus pyralis (common eastern firefly)Potency11.423911
Microtubule-associated protein tauHomo sapiens (human)Potency22.936424
mitogen-activated protein kinase 1Homo sapiens (human)Potency23.735822
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency13.347722
neuropeptide S receptor isoform AHomo sapiens (human)Potency2.511911
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency58.047911
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency16.442326
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency30.106511
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency18.338724
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency0.100011
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency10.891239
ParkinHomo sapiens (human)Potency9.200011
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency14.381811
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency0.075711
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency11.227425
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency21.258013
phosphopantetheinyl transferaseBacillus subtilisPotency44.964712
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency0.501211
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency20.811412
PPM1D proteinHomo sapiens (human)Potency0.658412
pregnane X nuclear receptorHomo sapiens (human)Potency0.013912
progesterone receptorHomo sapiens (human)Potency11.548824
RAR-related orphan receptor gammaMus musculus (house mouse)Potency6.311525
ras-related protein Rab-9AHomo sapiens (human)Potency10.952212
regulator of G-protein signaling 4Homo sapiens (human)Potency0.094711
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency8.355639
retinoid X nuclear receptor alphaHomo sapiens (human)Potency0.011011
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency3.530622
SMAD family member 2Homo sapiens (human)Potency10.682211
SMAD family member 3Homo sapiens (human)Potency10.682211
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency1.394812
survival motor neuron protein isoform dHomo sapiens (human)Potency0.281811
TDP1 proteinHomo sapiens (human)Potency8.076528
thioredoxin reductaseRattus norvegicus (Norway rat)Potency2.369912
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency8.409426
thyroid stimulating hormone receptorHomo sapiens (human)Potency35.989445
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency26.972411
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency26.832511
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency5.586812
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency19.149812
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency4.072713

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 1AHomo sapiens (human)Ki0.251244
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 2AHomo sapiens (human)Ki0.120011
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 4 Rattus norvegicus (Norway rat)IC507.116733
5-hydroxytryptamine receptor 5ARattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 5BRattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 6Rattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)IC5020.800012
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)IC5010.000022
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)Ki0.188033
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC507.750011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC507.750011
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)IC507.750011
Alpha-2A adrenergic receptorHomo sapiens (human)IC500.038011
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)IC500.063011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki0.014011
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)IC500.063011
Alpha-2C adrenergic receptorHomo sapiens (human)IC500.182011
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)IC500.063011
Alpha-2C adrenergic receptorHomo sapiens (human)Ki0.026011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
ATP-dependent translocase ABCB1Homo sapiens (human)IC5072.757177
Bile salt export pumpHomo sapiens (human)IC50291.250036
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
DBos taurus (cattle)IC500.33851113
DRattus norvegicus (Norway rat)IC500.47441212
DBos taurus (cattle)Ki0.003711
DMus musculus (house mouse)Ki0.101011
DRattus norvegicus (Norway rat)Ki0.386288
D(1A) dopamine receptorHomo sapiens (human)IC500.025011
D(1A) dopamine receptorHomo sapiens (human)Ki0.326688
D(1B) dopamine receptorHomo sapiens (human)IC500.025011
D(1B) dopamine receptorRattus norvegicus (Norway rat)IC500.143277
D(1B) dopamine receptorHomo sapiens (human)Ki0.015011
D(2) dopamine receptorBos taurus (cattle)IC500.33851113
D(2) dopamine receptorHomo sapiens (human)IC500.014622
D(2) dopamine receptorRattus norvegicus (Norway rat)IC500.08131619
D(2) dopamine receptorBos taurus (cattle)Ki0.101922
D(2) dopamine receptorHomo sapiens (human)Ki0.05982020
D(2) dopamine receptorRattus norvegicus (Norway rat)Ki0.02441112
D(3) dopamine receptorHomo sapiens (human)IC500.025011
D(3) dopamine receptorRattus norvegicus (Norway rat)IC500.143277
D(3) dopamine receptorHomo sapiens (human)Ki0.009444
D(4) dopamine receptorHomo sapiens (human)IC500.025011
D(4) dopamine receptorRattus norvegicus (Norway rat)IC500.143277
D(4) dopamine receptorHomo sapiens (human)Ki0.008911
Dihydroorotate dehydrogenase Leishmania majorIC501,037.000012
E3 ubiquitin-protein ligase Mdm2Homo sapiens (human)IC5010.136733
Endothelial PAS domain-containing protein 1Homo sapiens (human)IC500.096522
Glucose transporterLeishmania mexicanaIC500.081011
Hexose transporter 1 Plasmodium falciparum (malaria parasite P. falciparum)IC500.090011
Hypoxia-inducible factor 1-alphaHomo sapiens (human)IC500.096522
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000012
Serine hydrolase RBBP9Homo sapiens (human)IC507.800011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC5010.000011
Solute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)IC500.108011
Solute carrier family 22 member 1 Homo sapiens (human)IC5020.800011
Tryptophan 5-hydroxylase 1Rattus norvegicus (Norway rat)IC500.220011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Angiotensin-converting enzyme 2 Homo sapiens (human)EC500.032512
D(1A) dopamine receptorHomo sapiens (human)EC500.184646
D(1A) dopamine receptorHomo sapiens (human)Kd0.680011
D(2) dopamine receptorHomo sapiens (human)EC500.05441012
D(2) dopamine receptorRattus norvegicus (Norway rat)EC500.017155
D(2) dopamine receptorHomo sapiens (human)Kd0.024011
D(2) dopamine receptorRattus norvegicus (Norway rat)Kd0.760045
D(3) dopamine receptorHomo sapiens (human)EC500.007011
D(4) dopamine receptorHomo sapiens (human)EC500.004322
D(4) dopamine receptorRattus norvegicus (Norway rat)EC500.004233
NS5 Zika virusEC500.030822
Procathepsin LHomo sapiens (human)EC500.032512
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusEC500.032512
Replicase polyprotein 1abBetacoronavirus England 1EC500.032512
Replicase polyprotein 1abHuman coronavirus 229EEC500.032512
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2EC500.032512
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusEC500.032512
Spike glycoproteinBetacoronavirus England 1EC500.032512
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusEC500.032512
Transmembrane protease serine 2Homo sapiens (human)EC500.032512

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-dependent translocase ABCB1Homo sapiens (human)Km6.000011
D(1A) dopamine receptorHomo sapiens (human)ID500.039011
D(1A) dopamine receptorHomo sapiens (human)KL0.206011
D(1B) dopamine receptorHomo sapiens (human)ID500.039011
D(2) dopamine receptorHomo sapiens (human)ID500.039011
D(2) dopamine receptorHomo sapiens (human)KL0.166522
D(3) dopamine receptorHomo sapiens (human)ID500.039011
D(4) dopamine receptorHomo sapiens (human)ID500.039011
Endothelial PAS domain-containing protein 1Homo sapiens (human)MIC0.300011
Hypoxia-inducible factor 1-alphaHomo sapiens (human)MIC0.300011