Conditions > Dysthymic Disorder
Page last updated: 2024-09-27

Dysthymic Disorder

Chronically depressed mood that occurs for most of the day more days than not for at least 2 years. The required minimum duration in children to make this diagnosis is 1 year. During periods of depressed mood, at least 2 of the following additional symptoms are present: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self-esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. (DSM-IV)

Synonyms(1)

Synonym
Dysthymic Disorder

Research Excerpts

Overview

ExcerptReference
"Dysthymic disorder is a chronic depression that is usually characterized by depression rating scale scores that are lower than those for major depressive disorder."( Bea, C; Budech, CB; Dunner, DL; Hendrickson, HE, 1997)
"Dysthymic disorder is a chronic disorder characterised by the presence of a depressed mood and is classified as a distinct category in DSM-IV, separately from major depression."( Abay, E; Berkarda, S; Cermik, TF; Karaşin, E; Sarikaya, A, 1999)
"Dysthymic disorder is a relatively common illness that is often treated with antidepressants."( Gaynes, BN; Golden, RN; McLeod, MN, 1999)
"Dysthymic disorder is a form of chronic depression which often has its onset in childhood or adolescence and is generally persistent throughout life."( Bea, C; Budech, CB; Dunner, DL; Hendrickson, HE; O'Connor, E, 1999)
"Dysthymic disorder is a chronic depressive condition with considerable psychosocial impairment."( Bogetto, F; Marchiaro, L; Rasetti, R; Rivoira, E; Rocca, P, 2002)

Treatment

ExcerptReference
"An optimal treatment for dysthymic disorder may be combined psychotherapy and pharmacotherapy for a longer period of time."( Bea, C; Becker, J; Dunner, DL; Hendrickson, H; Lehman, A; Schmaling, KB, 1996)
"Many studies of antidepressants in the treatment of dysthymic disorder (DD) have been conducted, but none has included bupropion sustained-release (SR)."( Batchelder, S; Fedak, M; Hellerstein, DJ; Kreditor, D, 2001)

Research

Studies (236)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's66 (27.97)12.5806
2000's126 (53.39)18.1394
2010's42 (17.80)28.8240
2020's2 (0.85)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetylcarnitine0medium22
gamma-aminobutyric acid0medium21
choline0low10
bupropion0medium72
creatine0low10
inositol0low10
picolinic acid0medium11
normetanephrine0low10
amitrole0medium11
homovanillic acid0low10
hydroxyindoleacetic acid0low30
alprazolam0medium11
dan 21630medium127
amitriptyline0medium33
aspirin0low10
buspirone0low10
carbamazepine0low30
chlorpromazine0low10
citalopram0medium116
clonazepam0low10
desipramine0medium22
amphetamine0low10
diazepam0low10
disulfiram0low10
valproic acid0medium42
doxepin0low10
fentanyl0low10
phenelzine0low10
ketamine0low10
methadone0low50
methylphenidate0low30
mianserin0medium82
midazolam0low10
mirtazapine0medium92
moclobemide0medium62
modafinil0medium21
nefazodone0medium74
nortriptyline0medium21
pirenzepine0medium11
propranolol0low10
risperidone0medium41
ritanserin0low10
ropinirole0low10
succinylcholine0low10
sulpiride0medium127
trazodone0medium32
zolpidem0low10
thyroxine0medium11
dextroamphetamine0low20
prednisone0low10
dehydroepiandrosterone0medium22
aspartic acid0low10
carbostyril0low10
tryptophan0low10
cyclohexanol0medium1910
thiophenes0medium53
1-naphthylamine0medium74
thiazoles0low10
methoxyhydroxyphenylglycol0low10
lithium carbonate0medium42
acetylcysteine0low10
dehydroepiandrosterone sulfate0low20
s,n,n'-tripropylthiocarbamate0low30
metanephrine0low10
chromium0medium11
glutamic acid0medium21
amineptin0medium21
paroxetine0medium1612
fenoxycarb0low10
aripiprazole0low10
duloxetine hydrochloride0medium75
venlafaxine hydrochloride0medium1910
n-acetylaspartic acid0low10
triazoles0medium74
fluorodeoxyglucose f180low10
sertraline0medium3526
delta sleep-inducing peptide0low10
homocysteine0low20
pramipexole0low10
reboxetine0medium52
cocaine0low20
thiopental0low10
pica0low10
freedom0low10
fluvoxamine0medium21
naltrexone0low10
hypericum0medium31
technetium tc 99m exametazime0low10
quetiapine fumarate0low10
ascorbic acid0medium11
phenprocoumon0low10
rome0low10
vitamin b 120low20
exudates0low10
folic acid0low20
neopterin0low10
clozapine0low10
olanzapine0medium21
sildenafil citrate0medium21
ego0low20
leptin0low10

Protein Targets (955)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain A, HADH2 protein100010
Chain B, HADH2 protein100010
RAR-related orphan receptor gamma200020
GLI family zinc finger 3270027
AR protein330033
aldehyde dehydrogenase 1 family, member A1180018
thyroid stimulating hormone receptor180018
estrogen receptor 2 (ER beta)170017
nuclear receptor subfamily 1, group I, member 3230023
progesterone receptor200020
glucocorticoid receptor [Homo sapiens]290029
retinoic acid nuclear receptor alpha variant 1290029
estrogen-related nuclear receptor alpha310031
pregnane X nuclear receptor260026
estrogen nuclear receptor alpha400040
aryl hydrocarbon receptor130013
thyroid stimulating hormone receptor110011
activating transcription factor 67007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a120012
v-jun sarcoma virus 17 oncogene homolog (avian)180018
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
thyroid hormone receptor beta isoform 2260026
nuclear factor erythroid 2-related factor 2 isoform 1240024
cytochrome P450 3A4 isoform 1140014
Gamma-aminobutyric acid receptor subunit pi1413330
Voltage-dependent calcium channel gamma-2 subunit110011
Gamma-aminobutyric acid receptor subunit beta-11413330
Gamma-aminobutyric acid receptor subunit delta1413330
Gamma-aminobutyric acid receptor subunit gamma-21413431
Glutamate receptor 2112114
Gamma-aminobutyric acid receptor subunit alpha-51413330
Gamma-aminobutyric acid receptor subunit alpha-31413330
Gamma-aminobutyric acid receptor subunit gamma-11413330
Gamma-aminobutyric acid receptor subunit alpha-21413330
Gamma-aminobutyric acid receptor subunit alpha-41413330
Gamma-aminobutyric acid receptor subunit gamma-31413330
Gamma-aminobutyric acid receptor subunit alpha-61413330
Gamma-aminobutyric acid receptor subunit alpha-11414432
Gamma-aminobutyric acid receptor subunit beta-31413330
Gamma-aminobutyric acid receptor subunit beta-21413431
Kelch-like ECH-associated protein 10011
GABA theta subunit1413330
Gamma-aminobutyric acid receptor subunit epsilon1413330
Histone acetyltransferase KAT80101
Chain A, JmjC domain-containing histone demethylation protein 3A8008
Chain A, 2-oxoglutarate Oxygenase100010
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
acetylcholinesterase160016
dopamine D1 receptor4004
15-lipoxygenase, partial4004
pregnane X receptor4004
phosphopantetheinyl transferase110011
USP1 protein, partial170017
NFKB1 protein, partial110011
Microtubule-associated protein tau9009
Thrombopoietin6006
regulator of G-protein signaling 4150015
retinoid X nuclear receptor alpha170017
farnesoid X nuclear receptor100010
vitamin D (1,25- dihydroxyvitamin D3) receptor160016
arylsulfatase A190019
euchromatic histone-lysine N-methyltransferase 2400040
Bloom syndrome protein isoform 18008
D(1A) dopamine receptor250025
thyroid hormone receptor beta isoform a7007
heat shock protein beta-16006
flap endonuclease 16006
geminin300030
peripheral myelin protein 22200020
survival motor neuron protein isoform d9009
muscarinic acetylcholine receptor M1180018
Histone deacetylase 30404
Solute carrier family 22 member 60202
Histone deacetylase 40404
Guanine nucleotide-binding protein G2002
Histone deacetylase 10404
Histone deacetylase 70404
Histone deacetylase 20404
Polyamine deacetylase HDAC100404
Histone deacetylase 11 0404
Ataxin-2240024
Histone deacetylase 80404
Histone deacetylase 60404
Histone deacetylase 90404
Histone deacetylase 50404
ATP-dependent phosphofructokinase180018
TDP1 protein330033
peroxisome proliferator activated receptor gamma170017
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a180018
nuclear receptor ROR-gamma isoform 19009
lamin isoform A-delta10300030
Bromodomain-containing protein 40011
Gamma-aminobutyric acid receptor subunit alpha-1010515
Gamma-aminobutyric acid receptor subunit gamma-2010313
Cholecystokinin receptor type A0303
Gamma-aminobutyric acid receptor subunit alpha-5010515
Gamma-aminobutyric acid receptor subunit alpha-3010414
Gamma-aminobutyric acid receptor subunit alpha-2010414
Gamma-aminobutyric acid receptor subunit beta-2010313
Cholecystokinin receptor type A0202
ATPase family AAA domain-containing protein 58008
Luciferase8008
cytochrome P450 family 3 subfamily A polypeptide 4300030
cytochrome P450 2D6280028
peroxisome proliferator-activated receptor delta120012
Snq2p0003
Cellular tumor antigen p53210021
Pleiotropic ABC efflux transporter of multiple drugs0306
thioredoxin reductase240024
GLS protein240024
cytochrome P450 2D6 isoform 1160016
chromobox protein homolog 1200020
atrial natriuretic peptide receptor 2 precursor100010
serine/threonine-protein kinase mTOR isoform 1110011
Solute carrier family 22 member 1 011012
Polyunsaturated fatty acid lipoxygenase ALOX15B9009
ATP-binding cassette sub-family C member 3029029
Multidrug resistance-associated protein 4030032
Voltage-dependent L-type calcium channel subunit alpha-1F0808
5-hydroxytryptamine receptor 4028028
Bile salt export pump041041
Albumin0088
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B1025025
Muscarinic acetylcholine receptor M2024226
Muscarinic acetylcholine receptor M4023124
Muscarinic acetylcholine receptor M10707
Muscarinic acetylcholine receptor M30606
Muscarinic acetylcholine receptor M40606
5-hydroxytryptamine receptor 2C026329
Muscarinic acetylcholine receptor M50808
Muscarinic acetylcholine receptor M5025025
Alpha-2A adrenergic receptor032235
Muscarinic acetylcholine receptor M20606
Muscarinic acetylcholine receptor M1026431
Angiotensin-converting enzyme019019
D(2) dopamine receptor035646
5-hydroxytryptamine receptor 2A028331
Alpha-2B adrenergic receptor029232
Alpha-2C adrenergic receptor028231
5-hydroxytryptamine receptor 1A032437
Muscarinic acetylcholine receptor M3027229
D(1A) dopamine receptor023328
D(1B) dopamine receptor0619
UDP-glucuronosyltransferase 1A40207
Sodium-dependent noradrenaline transporter 043649
Histamine H2 receptor017219
Alpha-1D adrenergic receptor025127
5-hydroxytryptamine receptor 2A038343
5-hydroxytryptamine receptor 2C035237
5-hydroxytryptamine receptor 1B024226
5-hydroxytryptamine receptor 1D012214
5-hydroxytryptamine receptor 1F012214
5-hydroxytryptamine receptor 2B024428
5-hydroxytryptamine receptor 60729
Histamine H1 receptor0808
Sodium-dependent serotonin transporter045752
5-hydroxytryptamine receptor 7 013215
5-hydroxytryptamine receptor 5A0729
5-hydroxytryptamine receptor 5B0729
Histamine H1 receptor028434
D(3) dopamine receptor034545
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 4 subunit alpha0506
UDP-glucuronosyltransferase 1A30002
5-hydroxytryptamine receptor 3A09211
5-hydroxytryptamine receptor 2B033235
Alpha-1A adrenergic receptor028533
Histamine H2 receptor156026
D(1A) dopamine receptor100010
5-hydroxytryptamine receptor 6027130
5-hydroxytryptamine receptor 70606
Voltage-dependent N-type calcium channel subunit alpha-1B0505
Sodium channel protein type 7 subunit alpha0303
Voltage-dependent L-type calcium channel subunit alpha-1D 0808
Sodium-dependent dopamine transporter 033538
Potassium voltage-gated channel subfamily H member 2031031
Voltage-dependent L-type calcium channel subunit alpha-1S0808
Voltage-dependent L-type calcium channel subunit alpha-1C0909
Sodium channel protein type 5 subunit alpha0707
Sodium channel protein type 9 subunit alpha0505
Sigma non-opioid intracellular receptor 10729
5-hydroxytryptamine receptor 4 0729
Nuclear receptor subfamily 3 group C member 3 019019
Canalicular multispecific organic anion transporter 1027027
Sodium channel protein type 2 subunit alpha0303
Sigma non-opioid intracellular receptor 1028129
5-hydroxytryptamine receptor 3B09211
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0303
Sodium channel protein type 8 subunit alpha0303
Histamine H3 receptor0808
Sodium channel protein type 10 subunit alpha0303
Integrase 0101
Solute carrier family 22 member 30202
Phenylethanolamine N-methyltransferase0303
Cytochrome P450 2A60202
Substance-P receptor0101
Cytochrome P450 2A50101
Sodium-dependent dopamine transporter022224
Beta-2 adrenergic receptor0315
Sigma non-opioid intracellular receptor 108210
Chain A, TYROSYL-DNA PHOSPHODIESTERASE120012
5-hydroxytryptamine receptor 3E0505
hypoxia-inducible factor 1 alpha subunit8008
SMAD family member 24004
Fumarate hydratase110011
PPM1D protein3003
SMAD family member 34004
EWS/FLI fusion protein140014
G120012
polyprotein110011
67.9K protein5005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)4004
lysosomal alpha-glucosidase preproprotein4004
mu-type opioid receptor isoform MOR-10011
nuclear factor erythroid 2-related factor 2 isoform 28008
potassium voltage-gated channel subfamily H member 2 isoform d190019
transcriptional regulator ERG isoform 34004
histone acetyltransferase KAT2A isoform 1110011
5-hydroxytryptamine receptor 2A0011
neuropeptide S receptor isoform A6006
Solute carrier family 22 member 20506
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 3B0505
Interferon beta140014
HLA class I histocompatibility antigen, B alpha chain 120012
ATP-dependent translocase ABCB1011016
Cytochrome P450 3A4012014
5-hydroxytryptamine receptor 1A0161329
Neuronal acetylcholine receptor subunit alpha-41304
Neuronal acetylcholine receptor subunit beta-21304
Alpha-1B adrenergic receptor025530
D016016
D(4) dopamine receptor017222
Alpha-1D adrenergic receptor022527
D(4) dopamine receptor011011
Histamine H1 receptor0607
5-hydroxytryptamine receptor 7015116
Alpha-1A adrenergic receptor010213
Alpha-1B adrenergic receptor0416
5-hydroxytryptamine receptor 3A0808
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0404
Spike glycoprotein192122
D(2) dopamine receptor026128
Inositol monophosphatase 19009
5-hydroxytryptamine receptor 3D0505
Multidrug and toxin extrusion protein 20404
5-hydroxytryptamine receptor 3C0505
Inositol hexakisphosphate kinase 1120012
Multidrug and toxin extrusion protein 10404
cytochrome P450 2C9, partial120012
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase5005
IDH1120012
lethal(3)malignant brain tumor-like protein 1 isoform I2002
lethal factor (plasmid)8008
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Ferritin light chain6006
cytochrome P450 2C19 precursor100010
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
Carbonic anhydrase 107013
Carbonic anhydrase 207114
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0203
Glutamate receptor ionotropic, NMDA 1 08110
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 08110
Glutamate receptor ionotropic, NMDA 2B09111
Glutamate receptor ionotropic, NMDA 2C08110
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0003
Glutamate receptor ionotropic, NMDA 2D08110
Glutamate receptor ionotropic, NMDA 3B08110
Carbonic anhydrase 40304
Glutamate receptor ionotropic, NMDA 3A08110
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
hypothetical protein, conserved3003
glucocerebrosidase5005
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
DNA polymerase iota isoform a (long)7007
DNA polymerase kappa isoform 15005
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0202
Integrin beta-35117
Myeloperoxidase0303
Prostaglandin G/H synthase 10303
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb5117
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10303
Adenosine receptor A2a0101
Substance-P receptor0202
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma3003
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Integrin alpha-50101
Acetylcholine receptor subunit beta0101
UDP-glucuronosyltransferase 2B70305
Neuronal acetylcholine receptor subunit beta-20102
UDP-glucuronosyltransferase 1-60203
Cytochrome P450 2B60114
UDP-glucuronosyltransferase 1A1 0304
Neuronal acetylcholine receptor subunit beta-40102
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 2C1908010
UDP-glucuronosyltransferase 2B10 0202
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-40102
Acetylcholine receptor subunit delta0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
cytochrome P450 2C9 precursor9009
Bile salt export pump0808
Beta-2 adrenergic receptor0506
Angiotensin-converting enzyme 0101
Beta-1 adrenergic receptor0517
D(3) dopamine receptor015116
Alpha-2B adrenergic receptor014317
D(2) dopamine receptor0505
Alpha-2C adrenergic receptor014317
Alpha-2A adrenergic receptor014317
D(1B) dopamine receptor0909
Beta-3 adrenergic receptor0404
Alpha-2A adrenergic receptor0101
D0101
5-hydroxytryptamine receptor 2A0101
D0505
Lysosomal alpha-glucosidase0101
Chain A, Beta-lactamase6006
mitogen-activated protein kinase 19009
Vpr2002
Major prion protein0033
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 011012
Cytochrome P450 2J209010
Frizzled-80011
P2X purinoceptor 40202
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, serum paraoxonase0101
Carbonic anhydrase 120306
Carbonic anhydrase 30305
Neutrophil cytosol factor 10101
Carbonic anhydrase 40205
Carbonic anhydrase 60306
Carbonic anhydrase 5A, mitochondrial0317
Carbonic anhydrase 70306
Carbonic anhydrase 90307
Carbonic anhydrase 130202
Poly [ADP-ribose] polymerase tankyrase-20101
Carbonic anhydrase 140205
Carbonic anhydrase 5B, mitochondrial0306
Proteasome subunit beta type-110001
ATAD5 protein, partial160016
Smad39009
caspase 7, apoptosis-related cysteine protease6006
NADPH oxidase 10101
caspase-36006
Adenylate cyclase type 1 0303
Histone H2A.x4004
Caspase-73003
Spike glycoprotein0213
Replicase polyprotein 1ab0213
cellular tumor antigen p53 isoform a6006
vitamin D3 receptor isoform VDRA100010
caspase-33003
histone deacetylase 9 isoform 32002
ras-related protein Rab-9A9009
M-phase phosphoprotein 8100010
Proteasome subunit alpha type-70001
Transmembrane protease serine 20213
Glutamate receptor ionotropic, NMDA 2D0303
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0303
Potassium channel subfamily K member 20202
Albumin0056
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Cytochrome P450 1A20214
Tyrosine-protein kinase Fyn0101
Procathepsin L0213
Replicase polyprotein 1a0213
Replicase polyprotein 1ab0213
Replicase polyprotein 1ab0314
Cys-loop ligand-gated ion channel0101
Calmodulin-10314
Replicase polyprotein 1ab0314
Cytochrome P450 2D6013116
Polyunsaturated fatty acid lipoxygenase ALOX150303
Sphingomyelin phosphodiesterase0202
Proteasome subunit beta type-10001
Substance-K receptor0202
Adenylate cyclase type 30303
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20303
Adenylate cyclase type 40303
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
Trypanothione reductase0202
Melanocortin receptor 40202
Melanocortin receptor 50404
Mu-type opioid receptor011417
Adenylate cyclase type 80303
Proteasome subunit beta type-100001
Delta-type opioid receptor09314
Kappa-type opioid receptor010215
Melanocortin receptor 30202
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
Gastrin/cholecystokinin type B receptor0202
Proteasome subunit alpha type-60012
Calmodulin 0123
Aldehyde oxidase 10101
Adenylate cyclase type 60303
Adenylate cyclase type 50303
Glutamate receptor ionotropic, NMDA 10404
Aldehyde oxidase0202
Glutamate receptor ionotropic, NMDA 2A0404
Glutamate receptor ionotropic, NMDA 2B0404
Glutamate receptor ionotropic, NMDA 2C0303
Adenylyl cyclase 7 0303
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0303
Proteasome subunit beta type-70001
Angiotensin-converting enzyme 2 0213
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0404
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70404
Solute carrier family 22 member 10406
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20305
NPC intracellular cholesterol transporter 1 precursor8008
Sodium-dependent noradrenaline transporter0404
Tryptophan 5-hydroxylase 10404
Aldo-keto reductase family 1 member B10202
Aromatase0101
Sodium-dependent serotonin transporter018221
Sigma intracellular receptor 20606
Sodium-dependent serotonin transporter0404
Sodium-dependent dopamine transporter0606
Transporter022022
Gamma-aminobutyric acid receptor subunit pi0808
Gamma-aminobutyric acid receptor subunit delta0808
Gamma-aminobutyric acid receptor subunit alpha-10304
Gamma-aminobutyric acid receptor subunit beta-10304
Gamma-aminobutyric acid receptor subunit alpha-20304
Gamma-aminobutyric acid receptor subunit alpha-30304
Gamma-aminobutyric acid receptor subunit beta-109110
Gamma-aminobutyric acid receptor subunit alpha-40304
Gamma-aminobutyric acid receptor subunit gamma-20304
Gamma-aminobutyric acid receptor subunit beta-309211
Translocator protein0202
Translocator protein0202
Gastrin/cholecystokinin type B receptor0202
Gamma-aminobutyric acid receptor subunit alpha-409110
Gamma-aminobutyric acid receptor subunit epsilon0808
Gamma-aminobutyric acid receptor subunit alpha-609110
Gamma-aminobutyric acid receptor subunit gamma-10808
Gamma-aminobutyric acid receptor subunit gamma-30808
Gamma-aminobutyric acid receptor subunit theta0808
Beta-1 adrenergic receptor 0214
bromodomain adjacent to zinc finger domain 2B6006
peripheral myelin protein 22 isoform 16006
DNA polymerase beta2002
short transient receptor potential channel 6 isoform 10011
transient receptor potential cation channel subfamily V member 11001
Endothelin receptor type B0303
5-hydroxytryptamine receptor 3A0303
Endothelin receptor type B0303
5-hydroxytryptamine receptor 2C 0404
5-hydroxytryptamine receptor 2A0303
5-hydroxytryptamine receptor 5A0202
D(2) dopamine receptor0101
D(3) dopamine receptor0101
D(2) dopamine receptor0303
5-hydroxytryptamine receptor 2B0303
5-hydroxytryptamine receptor 40101
Transporter0505
5-hydroxytryptamine receptor 1A0202
Histamine H4 receptor0224
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Amyloid-beta precursor protein1203
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Liver carboxylesterase 10102
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Lysosomal Pro-X carboxypeptidase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Leukotriene B4 receptor 10101
Leukotriene B4 receptor 20101
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10303
GALC protein3003
Sex hormone-binding globulin0011
Beta-glucuronidase0101
Corticosteroid-binding globulin0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0303
Alpha-synuclein6006
TAR DNA-binding protein 435005
G-protein coupled bile acid receptor 10022
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Solute carrier organic anion transporter family member 1A40104
Solute carrier organic anion transporter family member 1A50003
Steryl-sulfatase0001
Multidrug resistance-associated protein 1 0001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A20003
Solute carrier organic anion transporter family member 1A30104
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30002
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier organic anion transporter family member 1B10003
huntingtin isoform 25005
Solute carrier family 22 member 30202
Histamine H3 receptor0101
Solute carrier family 22 member 40101
Amine oxidase [flavin-containing] B0303
Amine oxidase [flavin-containing] A0707
Amine oxidase [flavin-containing] B0606
Amine oxidase [flavin-containing] B0303
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Gamma-aminobutyric acid 0112
glp-1 receptor, partial100010
Alpha-1-acid glycoprotein 10001
Translocator protein0315
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit pi0112
Sphingosine-1-phosphate lyase 10202
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit theta0112
Gamma-aminobutyric acid receptor subunit gamma-10112
Chain A, Cruzipain2002
apical membrane antigen 1, AMA14004
nonstructural protein 13003
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
LacZ protein (plasmid)0011
thyrotropin-releasing hormone receptor1001
beta-2 adrenergic receptor2002
type-1 angiotensin II receptor0101
polyunsaturated fatty acid lipoxygenase ALOX121001
atrial natriuretic peptide receptor 1 precursor1001
runt-related transcription factor 1 isoform AML1b1001
perilipin-50101
glucose-6-phosphate 1-dehydrogenase isoform b0101
perilipin-10101
core-binding factor subunit beta isoform 21001
polypyrimidine tract-binding protein 1 isoform a1001
serine/threonine-protein kinase PLK12002
apelin receptor0101
heat shock protein HSP 90-alpha isoform 20001
histone-lysine N-methyltransferase 2A isoform 2 precursor4004
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
muscleblind-like protein 1 isoform 12002
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
pyruvate kinase PKM isoform b2002
Fatty-acid amide hydrolase 10101
Transient receptor potential cation channel subfamily A member 10011
Carbamate kinase0101
Retinal dehydrogenase 10101
Aldehyde dehydrogenase, mitochondrial0101
Ornithine decarboxylase2002
Fructose-1,6-bisphosphatase 10101
Adenosine receptor A30314
C-X-C chemokine receptor type 20202
Mitogen-activated protein kinase 3 0101
Protein-lysine 6-oxidase0101
Lysine-specific demethylase 5A0101
Caspase-10101
C-C chemokine receptor type 20202
C-C chemokine receptor type 40202
C-C chemokine receptor type 50202
Gasdermin-D0101
Lysyl oxidase homolog 30101
NACHT, LRR and PYD domains-containing protein 3 0101
Lysyl oxidase homolog 40101
Histone-lysine N-methyltransferase EHMT20101
Monoglyceride lipase0101
Gasdermin-D0101
Histone-lysine N-methyltransferase EHMT10101
Lysyl oxidase homolog 20101
heat shock protein 90, putative0001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
Histamine H3 receptor0001
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Nuclear receptor subfamily 1 group I member 20022
Delta-type opioid receptor0618
Delta-type opioid receptor0617
Mu-type opioid receptor0628
Kappa-type opioid receptor0314
Kappa-type opioid receptor0405
Mu-type opioid receptor0315
Mu-type opioid receptor0618
Cytochrome P450 2C80505
Dipeptidyl peptidase 40101
Acetylcholinesterase0202
Potassium voltage-gated channel subfamily C member 10101
Gastrin/cholecystokinin type B receptor 0101
Cytochrome P450 1B10101
Cytochrome P450 1A2 0101
Chain A, Dihydrofolate reductase0011
acid sphingomyelinase1001
alpha-galactosidase3003
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Folylpolyglutamate synthase, mitochondrial0001
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10202
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Sterol O-acyltransferase 10011
Platelet glycoprotein VI0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid type B receptor subunit 10011
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 16006
Metabotropic glutamate receptor 80202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0022
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10202
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
ClpP1001
Solute carrier family 22 member 80001
endonuclease IV2002
Uracil nucleotide/cysteinyl leukotriene receptor0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Envelope glycoprotein0033
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Sodium/myo-inositol cotransporter 20101
Acetylcholinesterase0101
Rap guanine nucleotide exchange factor 33003
Cholinesterase0101
histone-lysine N-methyltransferase NSD2 isoform 10001
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Mas-related G-protein coupled receptor member X20011
Aldehyde oxidase 1 0101
Endothelin-1 receptor0213
Type-2 angiotensin II receptor0303
Angiotensin-converting enzyme0202
5-hydroxytryptamine receptor 3B0202
G-protein coupled receptor 0101
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10101
Amine oxidase [flavin-containing] A 0202
Amine oxidase [flavin-containing] A 0202
Sigma intracellular receptor 20101
Rap guanine nucleotide exchange factor 42002
Histidine decarboxylase0011
Kappa-type opioid receptor0213
Nociceptin receptor0101
UDP-glucuronosyltransferase 1A80001
N-glycosylase/DNA lyase0101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2D40101
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
FAD-linked sulfhydryl oxidase ALR0001
Disintegrin and metalloproteinase domain-containing protein 172002
Quinolone resistance protein NorA0101
Beta-adrenergic receptor kinase 10101
Potassium voltage-gated channel subfamily A member 30101
Beta-adrenergic receptor kinase 10112
Substance-P receptor0101
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50101
G protein-coupled receptor kinase 50101
P2X purinoceptor 40101
Rhodopsin kinase GRK10101
Beta-adrenergic receptor kinase 10001
Lysine-specific histone demethylase 1A0101
Indoleamine 2,3-dioxygenase 10203
Membrane primary amine oxidase0101
Single-stranded DNA cytosine deaminase1001
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Protease 0202
Beta-lactamase 0101
Beta-lactamase 0112
Transmembrane prolyl 4-hydroxylase0101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor DM10101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor0101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M20101
Beta-2 adrenergic receptor0314
Beta-3 adrenergic receptor0314
5-hydroxytryptamine receptor 1B0314
5-hydroxytryptamine receptor 1E0101
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Voltage-dependent calcium channel subunit alpha-2/delta-10203
Voltage-dependent calcium channel subunit alpha-2/delta-20202
Beta-1 adrenergic receptor0213
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Beta-1 adrenergic receptor0101
Vasopressin V1a receptor0112
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Nuclear receptor subfamily 2 group E member 10022
Glycine receptor subunit alpha-10011
DNA polymerase III, partial1001
ubiquitin-conjugating enzyme E2 N0101
Diacylglycerol kinase alpha0101
Sphingosine kinase 20202
Sphingosine kinase 10101
Transcriptional activator protein LuxR0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
nuclear receptor subfamily 1, group I, member 21001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Carbonic anhydrase 130104
Carbonic anhydrase 0002
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase0202
Carbonic anhydrase0203
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0203
Carbonic anhydrase0203
Carbonic anhydrase 0202
Delta carbonic anhydrase0202
Carbonic anhydrase 0203
Carbonic anhydrase 150203
D(2) dopamine receptor0101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
DNA polymerase eta isoform 11001
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, Carbonic anhydrase 10101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Polyunsaturated fatty acid 5-lipoxygenase0101
Arachidonate 5-lipoxygenase-activating protein0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Carbonic anhydrase0102
Carbonic anhydrase 0101
Carbonic anhydrase0102
Androgen receptor0101
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Plasma kallikrein0001
Alkaline phosphatase, tissue-nonspecific isozyme0101
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Tryptophan 2,3-dioxygenase0102
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Monocarboxylate transporter 100001
Phospholipase A-2-activating protein0101
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]