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barbiturates
Members of the class of pyrimidones consisting of pyrimidine-2,4,6(1H,3H,5H)-trione (barbituric acid) and its derivatives. Largest group of the synthetic sedative/hypnotics, sharing a characteristic six-membered ring structure.
ChEBI ID: 22693
Members (37)
Member | Definition | Role |
---|---|---|
2-[2,5-dimethyl-3-[(2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]-1-pyrrolyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid ethyl ester | 2-[2,5-dimethyl-3-[(2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]-1-pyrrolyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid ethyl ester | |
4-hydroxyphenobarbital | 4-Hydroxyphenobarbital | |
5-(3-methylbutyl)-5-(2-pyridin-4-ylethyl)-1,3-diazinane-2,4,6-trione | 5-(3-methylbutyl)-5-(2-pyridin-4-ylethyl)-1,3-diazinane-2,4,6-trione | |
5-(thiophen-2-ylmethyl)-1,3-diazinane-2,4,6-trione | 5-(thiophen-2-ylmethyl)-1,3-diazinane-2,4,6-trione | |
5-[[5-(diethylamino)-2-furanyl]methylidene]-1,3-dimethyl-2-sulfanylidene-1,3-diazinane-4,6-dione | 5-[[5-(diethylamino)-2-furanyl]methylidene]-1,3-dimethyl-2-sulfanylidene-1,3-diazinane-4,6-dione | |
5-[2-methyl-1-(phenylmethyl)-6-(trifluoromethyl)-4-pyridinylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione | 5-[2-methyl-1-(phenylmethyl)-6-(trifluoromethyl)-4-pyridinylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione | |
allobarbital | allobarbital | |
allylpropymal | A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by an isopropyl and a prop-1-en-3-yl group at position 5. | aprobarbital |
amobarbital | A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hypnotic properties. | amobarbital |
barbital | A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid). | 5,5-diethylbarbituric acid |
barbituric acid | A barbiturate, the structure of which is that of perhydropyrimidine substituted at C-2, -4 and -6 by oxo groups. Barbituric acid is the parent compound of barbiturate drugs, although it is not itself pharmacologically active. | barbituric acid |
bucolome | 5-butyl-1-cyclohexylbarbituric acid | |
butalbital | A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. Frequently combined with other medicines, such as aspirin, paracetamol and codeine, it is used for treatment of pain and headache. | butalbital |
buthalital | buthalital | |
butobarbital | butobarbital | |
cyclobarbital | cyclobarbital | |
dialuric acid | A member of the class of barbiturates that is barbituric acid in which a hydrogen attached to a ring carbon is replaced by a hydroxy group. | dialuric acid |
eterobarb | eterobarb | |
febarbamate | febarbamate | |
heptabarbital | Heptabarbital | |
hexobarbital | A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups. | hexobarbital |
mephobarbital | A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by ethyl and phenyl groups. | mephobarbital |
methitural | Methitural | |
methohexital | A barbiturate, the structure of which is that of barbituric acid substituted at N-1 by a methyl group and at C-5 by allyl and 1-methylpent-2-ynyl groups. | methohexital |
pentobarbital | A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups. | pentobarbital |
phenobarbital | A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. | phenobarbital |
phenobarbital sodium | A barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups). | phenobarbital sodium |
phetharbital | phetharbital | |
pronarcon | Narcobarbital | |
propallylonal | propallylonal | |
proxibarbal | proxibarbal | |
secbutabarbital | butabarbital | |
secobarbital | A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by prop-2-en-1-yl and pentan-2-yl groups. | secobarbital |
talbutal | talbutal | |
thiamylal | A member of the class of barbiturates that is 2-thioxodihydropyrimidine-4,6(1H,5H)-dione substituted by a pentan-2-yl and prop-2-en-1-yl group at position 5. | thiamylal |
thiobarbituric acid | A barbiturate, the structure of which is that of barbituric acid in which the oxygen at C-2 is replaced by sulfur. | 2-thiobarbituric acid |
thiopental | A barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups. | thiopental |
Research
Studies (40,481)
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 28,528 (70.47) | 18.7374 |
1990's | 6,052 (14.95) | 18.2507 |
2000's | 3,307 (8.17) | 29.6817 |
2010's | 2,086 (5.15) | 24.3611 |
2020's | 508 (1.25) | 2.80 |
Study Types
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 2,330 (4.86%) | 5.53% |
Reviews | 1,352 (2.82%) | 6.00% |
Case Studies | 1,956 (4.08%) | 4.05% |
Observational | 47 (0.10%) | 0.25% |
Other | 42,209 (88.13%) | 84.16% |