Page last updated: 2024-09-27

Signs and Symptoms

Clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient.

Synonyms(1)

Synonym
Signs and Symptoms

Research

Studies (151)

TimeframeStudies, This Condition (%)All Conditions %
pre-199096 (63.58)23.3326
1990's55 (36.42)12.5806
2000's0 (0.00)18.1394
2010's0 (0.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gossypol0low10
lynestrenol0low30
estrone0low10
ethinyl estradiol0low190
norethindrone0low110
norethynodrel0low20
medroxyprogesterone acetate0low130
mestranol0low50
dimethisterone0low10
nonoxynol0low10
ethynodiol diacetate0low30
chlormadinone acetate0low30
cyproterone acetate0low30
megestrol acetate0low50
levonorgestrel0low100
silver0low10
cetylpyridinium chloride anhydrous0low420
mifepristone0low40
nsc-1727550low10
oxytocin0low50
retinol0low20
diethylstilbestrol0low20
enclomiphene0low10
ascorbic acid0low10
contraceptives, postcoital0low60
norgestrel0low30
exudates0low30
eye0low30

Protein Targets (390)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase6006
RAR-related orphan receptor gamma180018
GLI family zinc finger 3170017
AR protein200020
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 4150015
glucocorticoid receptor [Homo sapiens]190019
retinoic acid nuclear receptor alpha variant 1180018
estrogen-related nuclear receptor alpha180018
estrogen nuclear receptor alpha190019
vitamin D (1,25- dihydroxyvitamin D3) receptor160016
IDH15005
euchromatic histone-lysine N-methyltransferase 27007
chromobox protein homolog 16006
nuclear factor erythroid 2-related factor 2 isoform 27007
thyroid hormone receptor beta isoform 2180018
nuclear factor erythroid 2-related factor 2 isoform 1170017
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin140014
lethal factor (plasmid)3003
lamin isoform A-delta10110011
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0617
Spike glycoprotein9009
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Ferritin light chain5005
hypoxia-inducible factor 1 alpha subunit6006
SMAD family member 2110011
USP1 protein, partial9009
SMAD family member 3110011
TDP1 protein180018
Microtubule-associated protein tau7007
caspase 7, apoptosis-related cysteine protease4004
estrogen receptor 2 (ER beta)140014
nuclear receptor subfamily 1, group I, member 3170017
progesterone receptor160016
retinoid X nuclear receptor alpha160016
farnesoid X nuclear receptor140014
67.9K protein5005
peroxisome proliferator-activated receptor delta120012
peroxisome proliferator activated receptor gamma120012
caspase-34004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a140014
activating transcription factor 69009
thyrotropin-releasing hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)120012
vitamin D3 receptor isoform VDRA8008
heat shock protein beta-19009
mitogen-activated protein kinase 15005
nuclear receptor ROR-gamma isoform 1100010
survival motor neuron protein isoform d7007
Voltage-dependent calcium channel gamma-2 subunit9009
Cellular tumor antigen p53130013
Glutamate receptor 29009
Caspase-20011
Inositol monophosphatase 14004
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, Cruzipain7007
ATAD5 protein, partial8008
aldehyde dehydrogenase 1 family, member A16006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
pregnane X nuclear receptor150015
G150015
bromodomain adjacent to zinc finger domain 2B5005
thyroid stimulating hormone receptor110011
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a100010
nuclear receptor subfamily 1, group I, member 25005
thyroid hormone receptor beta isoform a4004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor6006
transcriptional regulator ERG isoform 33003
importin subunit beta-1 isoform 11001
snurportin-11001
peripheral myelin protein 228008
neuropeptide S receptor isoform A6006
Interferon beta150015
HLA class I histocompatibility antigen, B alpha chain 150015
Glucocorticoid receptor118324
Glycine receptor subunit alpha-1018018
Androgen receptor024024
Glycine receptor subunit beta018018
Glycine receptor subunit alpha-2018018
Glycine receptor subunit alpha-3018018
Cytochrome P450 2C190202
Inositol hexakisphosphate kinase 1150015
cytochrome P450 2C9, partial150015
Chain A, Beta-lactamase6006
thioredoxin reductase4004
pregnane X receptor6006
Smad34004
thyroid stimulating hormone receptor4004
aryl hydrocarbon receptor1001
D(1A) dopamine receptor3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
cytochrome P450 3A4 isoform 17007
Gamma-aminobutyric acid receptor subunit pi7007
Progesterone receptor07514
Androgen receptor16310
Gamma-aminobutyric acid receptor subunit beta-17007
Gamma-aminobutyric acid receptor subunit delta7007
Gamma-aminobutyric acid receptor subunit gamma-27007
Gamma-aminobutyric acid receptor subunit alpha-57007
Gamma-aminobutyric acid receptor subunit alpha-37007
Gamma-aminobutyric acid receptor subunit gamma-17007
Gamma-aminobutyric acid receptor subunit alpha-27007
Adenosine receptor A10213
Gamma-aminobutyric acid receptor subunit alpha-47007
Gamma-aminobutyric acid receptor subunit gamma-37007
Adenosine receptor A2b0101
Gamma-aminobutyric acid receptor subunit alpha-67007
Adenosine receptor A2a0112
Mu-type opioid receptor0808
Nuclear receptor ROR-gamma5005
Gamma-aminobutyric acid receptor subunit alpha-17007
Gamma-aminobutyric acid receptor subunit beta-37007
Gamma-aminobutyric acid receptor subunit beta-27007
GABA theta subunit7007
Gamma-aminobutyric acid receptor subunit epsilon7007
ORF730011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Luciferase3003
interleukin 84004
glp-1 receptor, partial3003
15-lipoxygenase, partial3003
GLS protein3003
regulator of G-protein signaling 43003
cytochrome P450 2D67007
Histone H2A.x7007
cellular tumor antigen p53 isoform a2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
serine/threonine-protein kinase PLK11001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
high affinity choline transporter 1 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
5-hydroxytryptamine receptor 40404
Nuclear receptor subfamily 1 group I member 20101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Estrogen receptor115522
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Integrin beta-32002
Tyrosine-protein kinase Fyn0303
Aldo-keto reductase family 1 member B10808
Integrin alpha-IIb2002
Beta-1 adrenergic receptor0202
Alpha-2A adrenergic receptor0404
Polyunsaturated fatty acid 5-lipoxygenase0101
Adenosine receptor A30606
Muscarinic acetylcholine receptor M10404
Polyunsaturated fatty acid lipoxygenase ALOX150404
D(2) dopamine receptor0202
Alpha-1B adrenergic receptor0606
Alpha-2C adrenergic receptor0404
Muscarinic acetylcholine receptor M30404
Substance-K receptor0404
D(1A) dopamine receptor0202
Acetylcholinesterase0101
Prostaglandin G/H synthase 10303
Sodium-dependent noradrenaline transporter 0808
Thromboxane-A synthase 0101
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
Adenosine receptor A2a0404
Adenosine receptor A10202
Sodium-dependent serotonin transporter012012
D(3) dopamine receptor0404
Vasopressin V1a receptor0415
Alpha-synuclein4206
Delta-type opioid receptor0202
Kappa-type opioid receptor0606
5-hydroxytryptamine receptor 2B0606
Alpha-1A adrenergic receptor0606
Histamine H2 receptor2002
5-hydroxytryptamine receptor 60404
Estrogen-related receptor gamma0011
Disintegrin and metalloproteinase domain-containing protein 173003
Sodium-dependent dopamine transporter 0606
Aldehyde oxidase0202
TAR DNA-binding protein 433003
UDP-glucose 4-epimerase0101
Mitogen-activated protein kinase 140202
Estrogen receptor beta17514
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Cysteinyl leukotriene receptor 10202
chaperonin-containing TCP-1 beta subunit homolog1001
phosphopantetheinyl transferase3003
ubiquitin-conjugating enzyme E2 N0101
protein AF-9 isoform a0001
Epidermal growth factor receptor0101
Receptor tyrosine-protein kinase erbB-20101
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Cytochrome P450 2D60101
Beta-3 adrenergic receptor0202
C-8 sterol isomerase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sigma non-opioid intracellular receptor 10404
endonuclease IV1001
NFKB1 protein, partial1001
GALC protein1001
nonstructural protein 13003
arylsulfatase A2002
Bloom syndrome protein isoform 12002
hexokinase-4 isoform 12002
peripheral myelin protein 22 isoform 11001
glucokinase regulatory protein2002
DNA polymerase iota isoform a (long)7007
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Bile salt export pump0808
Rap guanine nucleotide exchange factor 31001
Sex hormone-binding globulin0044
Corticosteroid-binding globulin0101
Steryl-sulfatase0101
Aromatase0101
17-beta-hydroxysteroid dehydrogenase type 10203
Mu-type opioid receptor0011
Solute carrier organic anion transporter family member 1A10101
Mu-type opioid receptor0011
Cytochrome P450 1B10101
Ghrelin O-acyltransferase0101
Fumarate hydratase3003
PPM1D protein2002
polyprotein3003
lysosomal alpha-glucosidase preproprotein2002
Vpr1001
Solute carrier family 22 member 20101
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Cytochrome P450 2B10101
Cytochrome P450 3A40303
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Cytochrome P450 2B60101
UDP-glucuronosyltransferase 1A1 0102
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Sulfotransferase 1A10214
Nuclear receptor subfamily 1 group I member 3 0101
Multidrug and toxin extrusion protein 20101
Canalicular multispecific organic anion transporter 10505
Multidrug and toxin extrusion protein 10101
ATP-dependent phosphofructokinase3003
Amine oxidase [flavin-containing] A0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Mcl-10101
Estrogen receptor 10101
DNA polymerase III, partial1001
PINK12002
EWS/FLI fusion protein2002
Parkin2002
Caspase-71001
cytochrome P450 2D6 isoform 11001
galactokinase1001
NPC intracellular cholesterol transporter 1 precursor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
caspase-31001
huntingtin isoform 22002
DNA polymerase beta3003
atrial natriuretic peptide receptor 2 precursor2002
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 11001
ras-related protein Rab-9A1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase mTOR isoform 12002
tyrosine-protein kinase Yes1001
eukaryotic translation initiation factor 4E isoform 10101
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 12002
histone acetyltransferase KAT2A isoform 13003
caspase-1 isoform alpha precursor1001
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase1001
Prolyl endopeptidase0101
L-lactate dehydrogenase A chain0101
Malate dehydrogenase, mitochondrial0101
Beta-lactamase0101
L-lactate dehydrogenase B chain0101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Apoptosis regulator Bcl-20213
Muscarinic acetylcholine receptor M20101
Solute carrier family 2, facilitated glucose transporter member 10101
Malate dehydrogenase, cytoplasmic0101
Aldo-keto reductase family 1 member B10101
L-lactate dehydrogenase B chain0101
DNA-3-methyladenine glycosylase0101
Caspase-11102
DNA repair protein RAD52 homolog0101
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 70101
Kinesin-like protein KIF110101
Caspase-71001
BH3-interacting domain death agonist0101
Type 1 InsP3 receptor isoform S2 1001
E3 ubiquitin-protein ligase Mdm20101
Bcl-2-like protein 10213
Induced myeloid leukemia cell differentiation protein Mcl-10213
Peroxisome proliferator-activated receptor alpha1001
L-lactate dehydrogenase0101
Aspartyl/asparaginyl beta-hydroxylase0101
L-lactate dehydrogenase0101
L-lactate dehydrogenase B chain0101
L-lactate dehydrogenase0101
Bcl-2-like protein 20101
Bcl2-associated agonist of cell death 0101
Inosine-5'-monophosphate dehydrogenase 0101
Solute carrier organic anion transporter family member 1B30202
Histamine H3 receptor1001
Solute carrier organic anion transporter family member 1B10202
phosphoglycerate kinase1001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Mineralocorticoid receptor 1316
Androgen receptor0011
Histamine H2 receptor0202
5-hydroxytryptamine receptor 1B0101
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G2002
Aldo-keto reductase family 1 member C10101
bioA0001
Cytochrome P450 2C9 0202
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
Cannabinoid receptor 10202
Chain A, PROGESTERONE RECEPTOR0101
Glucocorticoid receptor 0101
dopamine D1 receptor1001
apical membrane antigen 1, AMA11001
hypothetical protein, conserved1001
Prostaglandin G/H synthase 10101
Tegument protein VP160011
Glucocorticoid receptor0113
Glucocorticoid receptor0101
Coagulation factor VII0101
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Tissue factor0101
5-hydroxytryptamine receptor 1A0101
ATP-dependent translocase ABCB10011
Substance-P receptor0101
Progesterone receptor0011
Glucocorticoid receptor0101
Estrogen receptor0011
Estrogen receptor beta0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
Potassium voltage-gated channel subfamily H member 20101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]