dihydroavenanthramide d profile

dihydroavenanthramide D: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	10334118
SCHEMBL ID	4330597
MeSH ID	M0525984

Synonym
2-[3-(4-hydroxyphenyl)propanoylamino]benzoic acid
SCHEMBL4330597
697235-49-7
benzoic acid, 2-[[3-(4-hydroxyphenyl)-1-oxopropyl]amino]-
unii-25krt26h77
symcalmin 143535
25krt26h77 ,
dihydroavenanthramide d
benzoic acid, 2-((3-(4-hydroxyphenyl)-1-oxopropyl)amino)-
hydroxyphenyl propamidobenzoic acid
2-((3-(4-hydroxyphenyl)-1-oxopropyl)amino)benzoic acid
hydroxyphenyl propamidobenzoic acid [inci]
DTXSID80220022
2-[[3-(4-hydroxyphenyl)-1-oxopropyl]amino]benzoic acid
2-[[3-(4-hydroxyphenyl)-1-oxopropyl]amino]-benzoic acid,
dihydroavenanthramide d;hydroxyphenyl propamidobenzoic acid
2-(3-(4-hydroxyphenyl)propanamido)benzoic acid
BCP29907
2-[3-(4-hydroxyphenyl)propanamido]benzoic acid
2-[[3-(4-hydroxyphenyl)-1-oxopropyl]amino]-benzoic acid
AMY42003
E78298
Q27253970
A930262
AS-81958
mfcd26131465

Research Excerpts

Overview

Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenAnthramide, which is the active component of oat.

Excerpt	Reference	Relevance
"Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component in oats."	( Dihydroavenanthramide D prevents UV-irradiated generation of reactive oxygen species and expression of matrix metalloproteinase-1 and -3 in human dermal fibroblasts. Hwang, BM; Hwang, JK; Kim, HJ; Kim, JM; Kim, JS; Kim, MS; Kwon, KB; Lee, JH; Lee, W; Lee, YR; Noh, EM; You, YO, 2013)	2.55
"Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component of oat. "	( Dihydroavenanthramide D protects pancreatic beta-cells from cytokine and streptozotocin toxicity. Choi, HN; Kwon, KB; Lee, YR; Lv, N; Park, BH; Park, JW; Song, MY, 2009)	3.24
"Dihydroavenanthramide D (DHAvD) is a synthetic analog to naturally occurring avenanthramide, which is the active component of oat. "	( Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression. Han, JH; Hur, H; Hwang, JK; Jung, JY; Jung, SH; Kim, BS; Kim, JM; Kim, JS; Lee, SH; Lee, YR; Noh, EM; Oh, HJ; Park, BH; Park, CS; Park, JW; Youn, HJ, 2011)	3.25

Compound-Compound Interactions

Daily use of a detergent containing dihydroavenanthramide D 5% combined with a moisturizer containing 1% of menthol improves chronic pruritus associated with xerosis.

Excerpt	Reference	Relevance
" The aim of our study was to evaluate the efficacy of a detergent containing dihydroavenanthramide D 5% combined with a moisturizer containing 1% of menthol for the treatment of chronic pruritus associated with xerosis in elderly KS patients."	( Efficacy of a detergent combined with a moisturizer for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi's sarcoma. Brambilla, L; Consonni, D; Genovese, G; Tourlaki, A, 2020)	0.79
"Daily use of a detergent containing dihydroavenanthramide D 5% combined with a moisturizer containing 1% of menthol improves chronic pruritus associated with xerosis in elderly adults with KS."	( Efficacy of a detergent combined with a moisturizer for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi's sarcoma. Brambilla, L; Consonni, D; Genovese, G; Tourlaki, A, 2020)	0.83

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (12.50%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (87.50%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	3.51	1	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	3.51	1	1	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
propylene glycol Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.. propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.	2.04	1	0	glycol; propane-1,2-diols	allergen; human xenobiotic metabolite; mouse metabolite; protic solvent
menthol Menthol: A monoterpene cyclohexanol produced from mint oils.	2.25	1	0	p-menthane monoterpenoid; secondary alcohol	volatile oil component
pantothenic acid Pantothenic Acid: A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.. pantothenic acid : A member of the class of pantothenic acids that is an amide formed from pantoic acid and beta-alanine.. vitamin B5 : Any member of a group of vitamers that belong to the chemical structural class called pantothenic acids that exhibit biological activity against vitamin B5 deficiency. Deficiency of vitamin B5 is rare due to its widespread distribution in whole grain cereals, legumes and meat. Symptoms associated with vitamin B5 deficiency are difficult to asses since they are subtle and resemble those of other B vitamin deficiencies. The vitamers include (R)-pantothenic acid and its ionized and salt forms.. (R)-pantothenate : A pantothenate that is the conjugate base of (R)-pantothenic acid, obtained by deprotonation of the carboxy group.. (R)-pantothenic acid : A pantothenic acid having R-configuration.	3.51	1	1	pantothenic acid; vitamin B5	antidote to curare poisoning; geroprotector; human blood serum metabolite
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.06	1	0	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
substance p [no description available]	2.15	1	0	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent
dexpanthenol dexpanthenol: The alcohol of pantothenic acid	3.51	1	1	amino alcohol; monocarboxylic acid amide	cholinergic drug; provitamin

Condition	Relationship Strength	Studies	Trials
Itching [description not available]	2.59	2	0
Kaposi Sarcoma [description not available]	2.25	1	0
Dermatoses [description not available]	2.25	1	0
Pruritus An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.	2.59	2	0
Sarcoma, Kaposi A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.	2.25	1	0
Skin Diseases Diseases involving the DERMIS or EPIDERMIS.	2.25	1	0
Skin Aging The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.	2.08	1	0
Recrudescence [description not available]	3.51	1	1
Complications of Diabetes Mellitus [description not available]	3.51	1	1
Candidiasis, Genital [description not available]	3.51	1	1
Candidiasis, Vulvovaginal Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.	3.51	1	1
Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	3.51	1	1
Dyspareunia Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.	3.51	1	1
Vulvovaginitis Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.	3.51	1	1
Chronic Illness [description not available]	2.15	1	0
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.15	1	0
Breast Cancer [description not available]	7.06	1	0
Invasiveness, Neoplasm [description not available]	2.06	1	0
Breast Neoplasms Tumors or cancer of the human BREAST.	2.06	1	0

dihydroavenanthramide d

Description

Cross-References

Synonyms (26)

Research Excerpts

Overview

Compound-Compound Interactions

Research

Studies (8)

Market Indicators

Research Demand Index: 24.00

Study Types

dihydroavenanthramide d

Description

Cross-References

Synonyms (26)

Research Excerpts

Overview

Compound-Compound Interactions

Research

Studies (8)

Market Indicators

Research Demand Index: 24.00

Study Types

Related Drugs (8)

Related Conditions (19)