Roles > vulnerary
Page last updated: 2024-08-05 14:35:17

vulnerary

A drug used in treating and healing of wounds.

ChEBI ID: 73336

Members (10)

MemberDefinitionClass
acetylcysteineAn N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.N-acetyl-L-cysteine
allantoinAn imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.allantoin
auraptenA member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.auraptene
ginsenoside rdA ginsenoside found in Panax ginseng and Panax japonicus var. major that is (20S)-ginsenoside Rg3 in which the hydroxy group at position 20 has been converted to its beta-D-glucopyranoside.ginsenoside Rd
glycyl-histidyl-lysineA tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence.Gly-His-Lys
madecassosideA triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.madecassoside
neurotensinA 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.neurotensin
piperonylic acidA member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a carboxy group at position 5. It is a natural product isolated from several plant species. It is a selective mechanism-based inactivator of the trans-cinnamate 4-hydroxylase enzyme and exhibits antifungal and skin wound healing properties.piperonylic acid
plaunotolA diterpenoid that is geranylgeraniol carrying an additional hydroxy substituent at position 18.plaunotol
thioglycerolA thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.monothioglycerol

Research

Studies (19,446)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19903,288 (16.91)18.7374
1990's3,268 (16.81)18.2507
2000's5,125 (26.36)29.6817
2010's6,060 (31.16)24.3611
2020's1,705 (8.77)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,177 (5.75%)5.53%
Reviews1,359 (6.64%)6.00%
Case Studies532 (2.60%)4.05%
Observational34 (0.17%)0.25%
Other17,351 (84.83%)84.16%

Protein Targets (171)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency33.552012
15-lipoxygenase, partialHomo sapiens (human)Potency0.025111
acetylcholinesteraseHomo sapiens (human)Potency31.653811
acid sphingomyelinaseHomo sapiens (human)Potency31.622811
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency29.032714
alpha-galactosidaseHomo sapiens (human)Potency14.125411
Alpha-synucleinHomo sapiens (human)Potency5.623411
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency15.848911
AR proteinHomo sapiens (human)Potency9.248155
arylsulfatase AHomo sapiens (human)Potency37.933011
Ataxin-2Homo sapiens (human)Potency11.220211
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency26.854511
Bloom syndrome protein isoform 1Homo sapiens (human)Potency1.000022
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency56.234111
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency29.594713
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency1.412511
Chain A, HADH2 proteinHomo sapiens (human)Potency31.622811
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency67.197813
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency7.079511
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency40.397312
Chain B, HADH2 proteinHomo sapiens (human)Potency31.622811
chromobox protein homolog 1Homo sapiens (human)Potency56.234111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency39.810722
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency19.497111
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency14.299911
D(1A) dopamine receptorHomo sapiens (human)Potency5.804511
DNA polymerase eta isoform 1Homo sapiens (human)Potency89.125111
dopamine D1 receptorHomo sapiens (human)Potency0.020611
estrogen nuclear receptor alphaHomo sapiens (human)Potency37.193158
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency24.089211
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency14.338814
farnesoid X nuclear receptorHomo sapiens (human)Potency28.183811
flap endonuclease 1Homo sapiens (human)Potency26.679511
GABA theta subunitRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency39.810711
gemininHomo sapiens (human)Potency5.920722
GLI family zinc finger 3Homo sapiens (human)Potency17.944423
glp-1 receptor, partialHomo sapiens (human)Potency19.952611
glucocerebrosidaseHomo sapiens (human)Potency31.622811
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency4.244022
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency49.052011
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.118711
heat shock protein beta-1Homo sapiens (human)Potency33.488911
lamin isoform A-delta10Homo sapiens (human)Potency17.782811
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency31.622811
LuciferasePhotinus pyralis (common eastern firefly)Potency37.933011
Microtubule-associated protein tauHomo sapiens (human)Potency20.665013
mitogen-activated protein kinase 1Homo sapiens (human)Potency39.810712
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency12.589311
NFKB1 protein, partialHomo sapiens (human)Potency4.466822
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency62.309111
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency7.079511
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency79.432811
ParkinHomo sapiens (human)Potency44.668411
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency40.533411
phosphopantetheinyl transferaseBacillus subtilisPotency35.481311
PINK1Homo sapiens (human)Potency44.668411
pregnane X receptorRattus norvegicus (Norway rat)Potency31.622811
progesterone receptorHomo sapiens (human)Potency61.752811
RAR-related orphan receptor gammaMus musculus (house mouse)Potency13.333211
regulator of G-protein signaling 4Homo sapiens (human)Potency0.237611
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency36.027222
retinoid X nuclear receptor alphaHomo sapiens (human)Potency9.211111
RGS12Homo sapiens (human)Potency12.589311
serine-protein kinase ATM isoform aHomo sapiens (human)Potency22.387211
Smad3Homo sapiens (human)Potency35.481311
survival motor neuron protein isoform dHomo sapiens (human)Potency1.584911
TAR DNA-binding protein 43Homo sapiens (human)Potency10.000011
TDP1 proteinHomo sapiens (human)Potency23.724622
ThrombopoietinHomo sapiens (human)Potency31.622822
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency41.077622
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.562311
USP1 protein, partialHomo sapiens (human)Potency48.022422
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency1.122011
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency89.125111
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency49.052011

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Acyl carrier protein, mitochondrialHomo sapiens (human)IC5014.500022
Amine oxidase [flavin-containing] AMus musculus (house mouse)IC500.000011
Amine oxidase [flavin-containing] BMus musculus (house mouse)IC500.300022
Beta-secretase 1Homo sapiens (human)IC50345.100011
Complex I intermediate-associated protein 30, mitochondrialHomo sapiens (human)IC5014.500022
Cytochrome c oxidase subunit NDUFA4Homo sapiens (human)IC5014.500022
DNA topoisomerase 1Homo sapiens (human)IC50250.000011
DNA topoisomerase 2-alphaHomo sapiens (human)IC50250.000011
Histone deacetylase 1Homo sapiens (human)IC503,160.000011
Histone deacetylase 11 Homo sapiens (human)IC503,160.000011
Histone deacetylase 2Homo sapiens (human)IC503,160.000011
Histone deacetylase 3Homo sapiens (human)IC503,160.000011
Histone deacetylase 4Homo sapiens (human)IC503,160.000011
Histone deacetylase 5Homo sapiens (human)IC503,160.000011
Histone deacetylase 6Homo sapiens (human)IC503,160.000011
Histone deacetylase 7Homo sapiens (human)IC503,160.000011
Histone deacetylase 8Homo sapiens (human)IC503,160.000011
Histone deacetylase 9Homo sapiens (human)IC503,160.000011
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)IC50250.000011
Melatonin receptor type 1AHomo sapiens (human)Ki1.900011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 subunit C2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 1Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 2Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 3Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 4Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 4LHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 5Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 6Homo sapiens (human)IC5014.500022
Neurotensin receptor type 1Homo sapiens (human)IC500.00131111
Neurotensin receptor type 1Homo sapiens (human)Ki0.001766
Neurotensin receptor type 1Rattus norvegicus (Norway rat)Ki0.001422
Neurotensin receptor type 2Rattus norvegicus (Norway rat)IC500.058233
Neurotensin receptor type 2Homo sapiens (human)Ki0.004633
Neurotensin receptor type 2Rattus norvegicus (Norway rat)Ki0.022633
Polyamine deacetylase HDAC10Homo sapiens (human)IC503,160.000011
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)IC5023.900011
Solute carrier family 15 member 2Homo sapiens (human)Ki3,095.150012
Solute carrier family 22 member 6Rattus norvegicus (Norway rat)Ki2,000.000011
SortilinHomo sapiens (human)IC500.360011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5'-AMP-activated protein kinase catalytic subunit alpha-2Homo sapiens (human)EC500.016811
5'-AMP-activated protein kinase subunit beta-1Homo sapiens (human)EC500.016811
5'-AMP-activated protein kinase subunit gamma-1Homo sapiens (human)EC500.016811
Myelin basic proteinMus musculus (house mouse)Kd0.000611
Neurotensin receptor type 1Homo sapiens (human)EC500.063255
Neurotensin receptor type 1Mus musculus (house mouse)EC500.002011
Neurotensin receptor type 1Rattus norvegicus (Norway rat)EC500.000011
Neurotensin receptor type 1Homo sapiens (human)Kd0.000622
Neurotensin receptor type 2Homo sapiens (human)EC500.110011
Neurotensin receptor type 2Rattus norvegicus (Norway rat)EC500.100011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Neurotensin receptor type 1Homo sapiens (human)Activity0.000211
Neurotensin receptor type 2Homo sapiens (human)Activity0.001111