Compounds > gamma-tocotrienol
Page last updated: 2024-12-10

gamma-tocotrienol

Description

gamma-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. A vitamin E family member that has potent anti-cancer properties against a wide-range of cancers. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5282349
CHEMBL ID120697
CHEBI ID33277
SCHEMBL ID3272929
SCHEMBL ID16430897
MeSH IDM0061588

Synonyms (54)

Synonym
BIDD:PXR0016
(2r)-2,7,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2h-chromen-6-ol
CHEBI:33277 ,
14101-61-2
(r-(e,e))-3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol
gamma-tocotrienol
d-gamma-tocotrienol
plastochromanol 3
(r)-gamma-tocotrienol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, [r-(e,e)]-
2h-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2r)- (9ci)
2h-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2r)-
6-chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)- (7ci,8ci)
7,8-dimethyltocotrienol
CHEMBL120697
2r,7,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2h-chromen-6-ol
LMPR02020057
(2r)-2,7,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
185qae24tr ,
unii-185qae24tr
2h-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (r-(e,e))-
d-.gamma.-tocotrienol
gamma tocotrienol [who-dd]
(r)-.gamma.-tocotrienol
.gamma.-tocotrienol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-((3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl)-, (2r)-
2h-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-((3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (2r)-
j13.903c ,
SCHEMBL3272929
6-chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-
(r)-2,7,8-trimethyl-2-((3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chroman-6-ol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl]-, (2r)-
3,4-dihydro-2,7,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2h-1-benzopyran-6-ol
HMS3650C14
gama-tocotrienol
SCHEMBL16430897
d-gamma-tocotrienol, analytical reference material
gamma-tocotrienol, analytical standard
(2r)-2,7,8-trimethyl-2-(4',8',12'-trimethyl-trideca-3',7',11'-trienyl)-6-hydroxychroman
2,7,8-trimethyl-2-[(3e,7e,11e,15e,19e,23e,27e)-4,8,12,16,20,24,28,32-o ctamethyl-3,7,11,15,19,23,27,31-tritriacontaoctaenyl]-6-chromanol
SR-01000946268-1
sr-01000946268
Q15633932
DTXSID101019984
plastochromanol
gamma -tocotrienol
2r-gamma-tocotrienol
HY-108694
CS-0029988
gammatocotrienol
gamma tocotrienol
gammatocotrienolplastochromanol
(r)-2,7,8-trimethyl-2-((3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl) chroman-6-ol
AKOS040744431
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (5 Product(s))

Product Categories

Product CategoryProducts
Professional Supplements1
Vitamins & Supplements4

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Dr. Mercola Vitamin E -- 30 CapsulesDr. MercolaProfessional Supplementsd-Beta Tocopherol, d-Alpha-Tocopherol, d-delta tocopherol, d-Gamma Tocopherol, d-Gamma Tocotrienol, Vitamin E, d-Alpha Tocotrienol, d-Beta Tocotrienol, d-Delta Tocotrienol2024-11-29 10:47:42
Jigsaw Health Vitamin K2 + E Complex -- 60 SoftgelsJigsaw HealthVitamins & Supplementsd-beta Tocopherol, d-gamma Tocotrienol, Vitamin K2, Vitamin K2, d-alpha Tocotrienol, d-beta Tocotrienol2024-11-29 10:47:42
MRM Complete E -- 60 SoftgelsMRMVitamins & SupplementsVitamin C, d-Beta Tocopherol, Coenzyme Q10, d-Alpha-Tocopherol, d-delta tocopherol, d-Gamma Tocopherol, d-Gamma Tocotrienol, Vitamin E, glycerin, Phytosterols, Alpha-Lipoic Acid, d-Alpha Tocotrienol2024-11-29 10:47:42
NutriCology Tocomin SupraBio Tocotrienols -- 200 mg - 60 SoftgelsNutriCologyVitamins & SupplementsVitamin E, d-Gamma Tocotrienol, Vitamin E, glycerin, d-Alpha Tocotrienol, d-Beta Tocotrienol, d-delta tocotrienol2024-11-29 10:47:42
Olympian Labs Tocomin Vitamin E Complete -- 60 SoftgelsOlympian LabsVitamins & Supplementsd-Beta Tocopherol, Vitamin E, d-delta tocopherol, d-Gamma Tocopherol, d-Gamma Tocotrienol, Vitamin E, Phytosterols, d-Alpha Tocotrienol, d-Beta Tocotrienol, d-delta tocotrienol2024-11-29 10:47:42

Roles (6)

RoleDescription
antioxidantA substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
radiation protective agentAny compound that is able to protect normal cells from the damage caused by radiation therapy.
apoptosis inducerAny substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
hepatoprotective agentAny compound that is able to prevent damage to the liver.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
tocotrienolA tocol in which the hydrocarbon chain at position 2 contains three double bonds.
vitamin EAny member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
vitamin E biosynthesis (tocotrienols)113

Bioassays (95)

Assay IDTitleYearJournalArticle
AID745932Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound-healing assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745938Antiproliferative activity against human MCF7 cells by MTT assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745934Antiproliferative activity against human MCF10A cells by MTT assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745858Growth inhibition of human NCI-H322M cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID51576Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for total cholesterol (dose 15 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745935Antiproliferative activity against human MDA-MB-231 cells by MTT assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID690597Antioxidant activity assessed as ferric ion reducing power by FRAP method2011Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
Tocotrienamines and tocopheramines: reactions with radicals and metal ions.
AID745835Growth inhibition of human UACC257 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50641picomoles of mevalonic acid synthesized per minute per mg of microsomal protein1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745951Growth inhibition of human CAKI-1 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745845Growth inhibition of human SNB19 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745957Growth inhibition of human OVCAR8 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745847Growth inhibition of human SF295 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745837Growth inhibition of human SK-MEL-28 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745855Growth inhibition of human COLO205 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745962Growth inhibition of human UACC62 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID194998Compound is evaluated for the inhibition of cholesterol biosynthesis in isolated rat hepatocytes at the concentration 125 (ug/mL)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID50634Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for HDL cholesterol (dose 30 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID195009Percent inhibition at 250 ug/mL of binary mixtures of compound and alpha-tocotrienol on cholesterol synthesis in rat hepatocytes1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID195001Compound is evaluated for the inhibition of cholesterol biosynthesis in isolated rat hepatocytes at the concentration 500 ug/mL1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745859Growth inhibition of human NCI-H23 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745852Growth inhibition of human HCT15 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745949Growth inhibition of human SN12C cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID51430Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for total cholesterol1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745960Growth inhibition of human OVCAR3 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID194996Inhibitory concentration required to inhibit cholesterol synthesis in isolated rat Hepatocytes1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745863Growth inhibition of human EKVX cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745842Growth inhibition of human LOXIMVI cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745839Growth inhibition of human MDA-MB-435 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745857Growth inhibition of human NCI-H460 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745947Growth inhibition of human UO31 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745950Growth inhibition of human RXF393 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745856Growth inhibition of human NCI-H522 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745954Growth inhibition of human 786-0 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745948Growth inhibition of human TK10 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745840Growth inhibition of human M14 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745956Growth inhibition of human NCI-ADR-RES cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID537457Cytotoxicity against mouse +SA cells after 24 hrs by MTT assay2010Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors.
AID194999Compound is evaluated for the inhibition of cholesterol biosynthesis in isolated rat hepatocytes at the concentration 250 (ug/mL)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745851Growth inhibition of human HT-29 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745844Growth inhibition of human SNB75 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745838Growth inhibition of human SK-MEL-2 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID690612Antioxidant activity assessed as ABTS+ free radical scavenging activity by TEAC assay2011Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
Tocotrienamines and tocopheramines: reactions with radicals and metal ions.
AID745868Growth inhibition of human K562 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745943Growth inhibition of human MDA-MB-231 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745854Growth inhibition of human HCC2998 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745946Growth inhibition of human PC3 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID51432Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for total cholesterol (dose 30 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID50653Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for LDL cholesterol1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID86699Compound evaluated for Percent inhibition of cholesterol synthesis from [14C]acetate in HepG2 cell1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID86698Compound evaluated for Percent inhibition of cholesterol synthesis from HMG-CoA Reductase in HepG2 cell1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745860Growth inhibition of human NCI-H226 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745933Selectivity index, ratio of IC50 for human MCF10A cells to ratio of IC50 for mouse +SA cells2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745942Growth inhibition of human Hs 578T cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745931Antitumor activity against mouse +SA cells allografted in BALB/c mouse assessed as reduction in tumor volume at 0.5 mg, iv administered on day 40 post challenge for 14 days2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745936Toxicity in BALB/c mouse allografted with mouse +SA cells assessed as body weight change at 0.5 mg, iv administered on day 40 post challenge for 14 days2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50635Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for HDL cholesterol (dose 45 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID457739Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.
AID745843Growth inhibition of human U251 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50642picomoles of mevalonic acid synthesized per minute per mg of microsomal protein (dose 15 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID50654Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for LDL cholesterol (dose 15 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID51433Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for total cholesterol (dose 45 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745961Growth inhibition of human IGROV1 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745846Growth inhibition of human SF539 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745940Growth inhibition of human T47D cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745941Growth inhibition of human BT549 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50632Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for HDL cholesterol1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID50644picomoles of mevalonic acid synthesized per minute per mg of microsomal protein(dose 45 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID457738Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.
AID457735Inhibition of EGF-dependent mouse +SA cells growth2010Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2
Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.
AID745865Growth inhibition of human SR cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745952Growth inhibition of human ACHN cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50633Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for HDL cholesterol (dose 15 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745869Growth inhibition of human HL-60(TB) cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745958Growth inhibition of human OVCAR5 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID690600Antioxidant activity assessed as DPPH free radical scavenging activity2011Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
Tocotrienamines and tocopheramines: reactions with radicals and metal ions.
AID745862Growth inhibition of human HOP62 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745944Growth inhibition of human MCF7 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745939Growth inhibition of human MDA-MB-468 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745841Growth inhibition of human MALME-3M cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745864Growth inhibition of human A549/ATCC cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745867Growth inhibition of human MOLT4 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745836Growth inhibition of human SK-MEL-5 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745861Growth inhibition of human HOP92 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745866Growth inhibition of human RPMI8226 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745945Growth inhibition of human DU145 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745850Growth inhibition of human KM12 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50643picomoles of mevalonic acid synthesized per minute per mg of microsomal protein(dose 30 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745870Growth inhibition of human CCRF-CEM cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50655Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for LDL cholesterol (dose 30 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745848Growth inhibition of human SF268 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID50657Compound is evaluated for the effect on lipid metabolism in 6-week-old male chickens at a concentration of 20 ppm in the diet and measured for LDL cholesterol (dose 45 p.p.m.)1992Journal of medicinal chemistry, Oct-02, Volume: 35, Issue:20
Hypocholesterolemic activity of synthetic and natural tocotrienols.
AID745959Growth inhibition of human OVCAR4 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745849Growth inhibition of human SW620 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
AID745853Growth inhibition of human HCT116 cells assessed as cell growth at 10 uM after 48 hrs by sulforhodamine B assay2013European journal of medicinal chemistry, Jan, Volume: 59Optimization of tocotrienols as antiproliferative and antimigratory leads.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.23 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index63.46 (26.88)
Search Engine Supply Index3.91 (0.95)

This Compound (30.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		3.3320alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
tocopherols
[no description available]		2.8910
delta-tocopherol
[no description available]		2.0610tocopherol;
vitamin E		food antioxidant;
plant metabolite
gamma-tocopherol
gamma-Tocopherol: A natural tocopherol with less antioxidant activity than ALPHA-TOCOPHEROL. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. As in BETA-TOCOPHEROL, it also has three methyl groups on the 6-chromanol nucleus but at different sites.. gamma-tocopherol : A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.		2.0610tocopherol;
vitamin E		algal metabolite;
food antioxidant;
plant metabolite
2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman
2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman: natriuretic metabolite of gamma-tocopherol; structure in first source		2.0610benzopyranantioxidant
tocotrienol, alpha
alpha-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.		3.8640tocotrienol;
vitamin E		ferroptosis inhibitor;
human metabolite;
neuroprotective agent;
plant metabolite
tocotrienol, delta
delta-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2 and 8 and a farnesyl chain at position 2.		4.0550tocotrienol;
vitamin E		anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
bone density conservation agent;
NF-kappaB inhibitor;
plant metabolite;
radiation protective agent;
Saccharomyces cerevisiae metabolite
tocotrienols
tocotrienol : A tocol in which the hydrocarbon chain at position 2 contains three double bonds.		2.8910diterpenoid
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.7630
Invasiveness, Neoplasm
[description not available]		02.0510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.7630
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0810
chemdatabank.com