Aortitis, Syphilitic

Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.

Synonyms(4)

Synonym
Syphilitic Aortitis
Aortitis, Syphilitic
Syphilis, Cardiovascular
Cardiovascular Syphilis

Research Excerpts

Research

Studies (88)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	66 (75.00)	23.3326
1990's	2 (2.27)	12.5806
2000's	9 (10.23)	18.1394
2010's	10 (11.36)	28.8240
2020's	1 (1.14)	9.53

Drug	Relationship Strength	Studies
carbon monoxide	low	1
iodine	low	5
niacin	low	1
atenolol	low	1
lidocaine	low	1
nitroglycerin	low	4
phenylbutazone	low	1
probenecid	low	1
procainamide	low	1
procaine	low	1
nikethamide	low	1
triamterene	low	1
trihexyphenidyl	low	1
prednisolone	low	1
cephaloridine	low	1
spironolactone	low	1
aldosterone	low	1
penicillin g	low	10
metaraminol	low	1
chloramphenicol	low	1
cyanides	low	2
ampicillin	low	2
pentaerythritol tetranitrate	low	1
dehydrocholic acid	low	1
methylprednisolone	low	1
benzathine	low	1
aminophylline	low	1
n-pentyl nitrite	low	1
mercuric cyanide	low	2
erythromycin	low	5
mercury	low	5
gadolinium	low	1
urobilinogen	low	1
cephalexin	low	1
iodine	low	2
cephapirin	low	1
amoxicillin	low	1
chlorsulfuron	low	2
cephalosporin c	low	1
fluorodeoxyglucose f18	low	5
simplexin	low	1
atropine	low	1
cortisone	low	1
lanatosides	low	1
quinidine	low	1
digitoxin	low	1
arsphenamine	low	2
propylthiouracil	low	1
digoxin	low	1
17-ketosteroids	low	1
bilirubin	low	1
phenylephrine hydrochloride	low	1
erythrityl tetranitrate	low	1
bismuth	low	10
arsenic	low	3
cysteine	low	1
phosphorus	low	1
enerbol	low	1
phosphatidylcholines	low	1
chondroitin	low	2
ascorbic acid	low	1
tetracycline	low	5
chlortetracycline	low	1
oxytetracycline, anhydrous	low	1
technetium tc 99m bicisate	low	1

Protein Targets (586)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	1	1	2
5-hydroxytryptamine receptor 1A	0	2	2	4
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	0	1	1
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
AR protein	22	0	0	22
glucocorticoid receptor [Homo sapiens]	18	0	0	18
thyroid hormone receptor beta isoform a	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
geminin	20	0	0	20
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	3	0	3
Mineralocorticoid receptor	0	5	3	9
Androgen receptor	0	6	0	7
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	3
Guanine nucleotide-binding protein G	2	0	0	2
thioredoxin reductase	9	0	0	9
USP1 protein, partial	5	0	0	5
Microtubule-associated protein tau	7	0	0	7
lamin isoform A-delta10	13	0	0	13
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	17
Bile salt export pump	0	22	0	22
Canalicular multispecific organic anion transporter 1	0	17	0	17
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, Beta-lactamase	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
apical membrane antigen 1, AMA1	3	0	0	3
estrogen nuclear receptor alpha	22	0	0	22
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
DNA polymerase kappa isoform 1	5	0	0	5
Bile salt export pump	0	2	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	3
Cytochrome P450 2C9	0	6	1	7
Beta-lactamase	0	0	0	3
Kappa-type opioid receptor	0	0	0	2
Solute carrier family 15 member 1	0	8	0	8
Solute carrier family 15 member 1	0	3	0	3
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	4
Solute carrier family 15 member 2	0	5	0	5
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	6	0	7
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Cruzipain	5	0	0	5
Beta-lactamase	0	0	0	2
acid sphingomyelinase	2	0	0	2
GLS protein	5	0	0	5
GLI family zinc finger 3	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
farnesoid X nuclear receptor	6	0	0	6
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
chromobox protein homolog 1	11	0	0	11
thyroid hormone receptor beta isoform 2	11	0	0	11
DNA polymerase beta	3	0	0	3
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	0	4
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
Spike glycoprotein	5	0	0	5
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	3
Beta-lactamase	0	0	0	3
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	3
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	3
Beta-lactamase VIM-1	0	0	0	2
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	5	0	0	5
RAR-related orphan receptor gamma	12	0	0	12
thioredoxin glutathione reductase	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
estrogen-related nuclear receptor alpha	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
IDH1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	4	0	0	4
Polyphenol oxidase 2	0	2	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
regulator of G-protein signaling 4	6	0	0	6
Beta-1 adrenergic receptor	0	0	1	1
D(1A) dopamine receptor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	5	0	1	6
Fatty acid-binding protein, liver	0	2	0	2
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
Beta-3 adrenergic receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	5	0	1	6
Gamma-aminobutyric acid receptor subunit delta	5	0	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	1	6
Alpha-1D adrenergic receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	1	6
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	1	6
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	0	1	6
Gamma-aminobutyric acid receptor subunit beta-3	5	0	1	6
Gamma-aminobutyric acid receptor subunit beta-2	5	0	1	6
TAR DNA-binding protein 43	3	0	0	3
Beta-2 adrenergic receptor	0	0	1	1
GABA theta subunit	5	0	1	6
Gamma-aminobutyric acid receptor subunit epsilon	5	0	1	6
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
retinoid X nuclear receptor alpha	8	0	0	8
pregnane X nuclear receptor	15	0	0	15
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	4	0	6
5-hydroxytryptamine receptor 4	0	2	0	2
Muscarinic acetylcholine receptor M2	0	5	1	9
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	4	1	7
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	2	0	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
phosphopantetheinyl transferase	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
vitamin D3 receptor isoform VDRA	4	0	0	4
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	3	0	4
Solute carrier organic anion transporter family member 1B1	0	3	0	4
TDP1 protein	17	0	0	17
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
mitogen-activated protein kinase 1	5	0	0	5
Solute carrier family 22 member 6	0	5	0	5
Interferon beta	7	0	0	7
Solute carrier family 22 member 8	0	5	0	6
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
aryl hydrocarbon receptor	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
Beta-lactamase	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase OXA-10	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 6	0	4	0	4
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 7	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 8	0	5	0	6
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 11	0	3	0	4
Solute carrier family 22 member 7	0	3	0	4
interleukin 8	4	0	0	4
EWS/FLI fusion protein	3	0	0	3
G	3	0	0	3
cytochrome P450 2D6	4	0	0	4
peroxisome proliferator activated receptor gamma	13	0	0	13
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
heat shock protein beta-1	4	0	0	4
streptokinase A precursor	0	0	3	3
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
Cellular tumor antigen p53	10	0	0	10
Cytochrome P450 3A4	0	4	0	4
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
50S ribosomal protein L36 2	0	3	1	4
Inositol hexakisphosphate kinase 1	3	0	0	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	3	0	0	3
progesterone receptor	10	0	0	10
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
peroxisome proliferator-activated receptor delta	7	0	0	7
Acetolactate synthase	0	1	0	1
Acetolactate synthase catalytic subunit, mitochondrial	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	3	0	3
endonuclease IV	2	0	0	2
dopamine D1 receptor	1	0	0	1
pregnane X receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
peripheral myelin protein 22 isoform 1	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
flap endonuclease 1	4	0	0	4
survival motor neuron protein isoform d	4	0	0	4
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	5	0	0	5
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	6	0	6
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
SMAD family member 2	5	0	0	5
ATAD5 protein, partial	3	0	0	3
SMAD family member 3	5	0	0	5
STAT3, partial	0	2	0	2
Smad3	5	0	0	5
estrogen receptor 2 (ER beta)	4	0	0	4
67.9K protein	5	0	0	5
thyroid stimulating hormone receptor	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	2	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Replicase polyprotein 1ab	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Glutamate receptor 2	7	0	0	7
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	7	0	0	7
PAX8	0	0	0	2
PPM1D protein	2	0	0	2
alpha-galactosidase	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
cellular tumor antigen p53 isoform a	2	0	0	2
tumor necrosis factor	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Solute carrier organic anion transporter family member 1A4	0	3	0	4
Integrin beta-3	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	6	0	8
Integrin alpha-IIb	2	0	0	2
ATP-dependent translocase ABCB1	0	4	0	4
Nuclear receptor ROR-gamma	1	1	1	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Albumin	0	0	1	1
60 kDa chaperonin	0	1	0	1
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Luciferase	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
histone deacetylase 9 isoform 3	2	0	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	2	0	2
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Macrophage migration inhibitory factor	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
nonstructural protein 1	3	0	0	3
muscleblind-like protein 1 isoform 1	4	0	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
glp-1 receptor, partial	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Amyloid-beta precursor protein	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	4	0	0	4
Cholesteryl ester transfer protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	4	0	0	4
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
Histone H2A.x	5	0	0	5
transcriptional regulator ERG isoform 3	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
importin subunit beta-1 isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
snurportin-1	2	0	0	2
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Solute carrier family 22 member 8	0	2	0	3
Beta-lactamase 1	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Estrogen receptor 1	0	1	0	1
Parkin	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
fMet-Leu-Phe receptor	0	1	0	1
neuropeptide S receptor isoform A	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Cyclooxygenase-2	0	1	0	1
GALC protein	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	2	0	0	2
peripheral myelin protein 22	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	4	1	5
Progesterone receptor	0	4	1	6
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	4	1	5
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	1	4
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
Carbonic anhydrase 9	0	1	0	1
Solute carrier family 22 member 1	0	5	0	6
Canalicular multispecific organic anion transporter 1	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 12	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 2	0	5	0	5
thyroid stimulating hormone receptor	5	0	0	5
cytochrome P450 2C19 precursor	2	0	0	2
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D6	0	4	0	4
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-synuclein	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
Chain A, PAPAIN	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Fumarate hydratase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Hsf1 protein	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
polyprotein	1	0	0	1
glucocerebrosidase	1	0	0	1
putative alpha-glucosidase	1	0	0	1
arylsulfatase A	1	0	0	1
pyruvate kinase	1	0	0	1
caspase-3	1	0	0	1
Janus kinase 2 (a protein tyrosine kinase)	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Cathepsin G	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Cyclin-dependent kinase 4	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Caspase-1	0	1	0	1
Casein kinase I isoform alpha	0	1	0	1
Casein kinase I isoform delta	0	1	0	1
Casein kinase I isoform epsilon	0	1	0	1
Pteridine reductase 1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Aortitis, Syphilitic

Synonyms(4)

Research Excerpts

Research

Studies (88)

Drugs Studied (75)

Protein Targets (586)