Roles > EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
Page last updated: 2024-08-05 15:46:16

EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor

An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of purine nucleoside phosphorylase (EC 2.4.2.1).

ChEBI ID: 63090

Members (3)

MemberDefinitionClass
6-methylpurinePurine bearing a methyl substituent at position 6.6-methylpurine
azaguanineA triazolopyrimidine that consists of 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively.8-azaguanine
didanosineA purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.didanosine

Research

Studies (2,757)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990774 (28.07)18.7374
1990's1,112 (40.33)18.2507
2000's632 (22.92)29.6817
2010's213 (7.73)24.3611
2020's26 (0.94)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials461 (15.74%)5.53%
Reviews194 (6.63%)6.00%
Case Studies169 (5.77%)4.05%
Observational2 (0.07%)0.25%
Other2,102 (71.79%)84.16%

Protein Targets (51)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency0.003211
67.9K proteinVaccinia virusPotency23.221026
activating transcription factor 6Homo sapiens (human)Potency0.067411
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.622811
AR proteinHomo sapiens (human)Potency31.622811
aryl hydrocarbon receptorHomo sapiens (human)Potency68.589611
BRCA1Homo sapiens (human)Potency11.220211
Cellular tumor antigen p53Homo sapiens (human)Potency36.358122
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency10.000011
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency7.943311
chromobox protein homolog 1Homo sapiens (human)Potency89.125111
cytochrome P450 2D6Homo sapiens (human)Potency6.165511
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency6.917811
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency27.973013
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency5.799724
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency6.447135
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.000011
estrogen nuclear receptor alphaHomo sapiens (human)Potency47.016122
EWS/FLI fusion proteinHomo sapiens (human)Potency34.295444
farnesoid X nuclear receptorHomo sapiens (human)Potency44.668411
gemininHomo sapiens (human)Potency7.436022
GLI family zinc finger 3Homo sapiens (human)Potency29.849311
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency17.298422
Glycoprotein hormones alpha chainHomo sapiens (human)Potency2.818411
hemoglobin subunit betaHomo sapiens (human)Potency1.653122
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency0.089112
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency7.943322
IDH1Homo sapiens (human)Potency0.517411
Integrin alpha-IIbHomo sapiens (human)Potency10.000011
Integrin beta-3Homo sapiens (human)Potency10.000011
lamin isoform A-delta10Homo sapiens (human)Potency12.589311
mitogen-activated protein kinase 1Homo sapiens (human)Potency19.952611
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency17.448822
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency37.215822
Smad3Homo sapiens (human)Potency10.613613
TAR DNA-binding protein 43Homo sapiens (human)Potency5.623411
TDP1 proteinHomo sapiens (human)Potency6.7792210
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency0.840822
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency39.723422
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency21.872411

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 3AHomo sapiens (human)IC50100.000011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC50133.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Reverse transcriptase/RNaseH Human immunodeficiency virus 1IC506.260022
Transcriptional activator protein LasRPseudomonas aeruginosa PAO1IC500.640011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AlbuminHomo sapiens (human)Kd44.000011
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_aHomo sapiens (human)EC5091.170011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Hypoxanthine-guanine phosphoribosyltransferaseHomo sapiens (human)Km72.000011
Microphthalmia-associated transcription factorHomo sapiens (human)AC500.875033