EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor

An EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor that interferes with the action of dipeptidyl-peptidase II (EC 3.4.14.2).

ChEBI ID: 76893

Members (1)

Member	Definition	Class
puromycin	An aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome.	puromycin

Research

Studies (5,649)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	4,491 (79.50)	18.7374
1990's	449 (7.95)	18.2507
2000's	371 (6.57)	29.6817
2010's	268 (4.74)	24.3611
2020's	70 (1.24)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	1 (0.02%)	5.53%
Reviews	140 (2.40%)	6.00%
Case Studies	3 (0.05%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5,684 (97.53%)	84.16%

Protein Targets (65)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	23.9185	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	9.5221	1	1
G	Vesicular stomatitis virus	Potency	23.9185	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	23.9185	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	23.9185	1	2
Interferon beta	Homo sapiens (human)	Potency	23.9185	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
30S ribosomal protein S1	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S10	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S11	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S12	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S13	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S14	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S15	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S16	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S17	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S18	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S19	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S2	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S20	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S21	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S3	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S4	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S5	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S6	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S7	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S8	Escherichia coli K-12	IC50	0.9000	1	1
30S ribosomal protein S9	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L1	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L10	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L11	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L13	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L14	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L15	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L16	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L17	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L18	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L19	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L2	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L20	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L21	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L22	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L23	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L24	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L25	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L27	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L28	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L29	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L3	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L30	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L31	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L31 type B	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L32	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L33	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L34	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L35	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L36	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L36 2	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L4	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L5	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L6	Escherichia coli K-12	IC50	0.9000	1	1
50S ribosomal protein L7/L12	Escherichia coli K-12	IC50	0.9000	1	1
Aminopeptidase N	Homo sapiens (human)	IC50	41.0000	1	1
Aminopeptidase N	Sus scrofa (pig)	IC50	100.0000	1	1
Puromycin-sensitive aminopeptidase	Homo sapiens (human)	IC50	6.0750	2	2
Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)	IC50	18,000.0000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
30S ribosomal protein S1	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S10	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S11	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S12	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S13	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S14	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S15	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S16	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S17	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S18	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S19	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S2	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S20	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S21	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S3	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S4	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S5	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S6	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S7	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S8	Escherichia coli K-12	Km	234.0000	1	1
30S ribosomal protein S9	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L1	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L10	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L11	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L13	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L14	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L15	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L16	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L17	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L18	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L19	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L2	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L20	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L21	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L22	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L23	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L24	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L25	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L27	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L28	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L29	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L3	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L30	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L31	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L31 type B	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L32	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L33	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L34	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L35	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L36	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L36 2	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L4	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L5	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L6	Escherichia coli K-12	Km	234.0000	1	1
50S ribosomal protein L7/L12	Escherichia coli K-12	Km	234.0000	1	1