EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor

An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of sphingomyelin phosphodiesterase (EC 3.1.4.12).

ChEBI ID: 76811

Members (2)

Member	Definition	Class
desipramine	A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.	desipramine
su 11652	A member of the class of pyrrolecarboxamides obtained by formal condensation of the carboxy group of 5-[(Z)-(5-chloro-2-oxo-1,2-dihydroindol-3-ylidene)methyl]-2,4-dimethylpyrrole-3-carboxylic acid with the primary amino group of N(1),N(1)-diethylethane-1,2-diamine.	SU11652

Research

Studies (5,512)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	2,979 (54.05)	18.7374
1990's	1,296 (23.51)	18.2507
2000's	753 (13.66)	29.6817
2010's	430 (7.80)	24.3611
2020's	54 (0.98)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	487 (8.41%)	5.53%
Reviews	182 (3.14%)	6.00%
Case Studies	234 (4.04%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4,886 (84.40%)	84.16%

Protein Targets (98)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
arylsulfatase A	Homo sapiens (human)	Potency	21.3313	1	1
Ataxin-2	Homo sapiens (human)	Potency	14.1254	1	1
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	16.4816	1	1
cytochrome P450 2D6	Homo sapiens (human)	Potency	5.3547	1	1
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	14.5500	1	2
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	16.2710	2	4
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	16.9330	1	1
D(1A) dopamine receptor	Homo sapiens (human)	Potency	6.5278	2	2
D(1A) dopamine receptor	Sus scrofa (pig)	Potency	14.6892	1	1
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	33.5875	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	16.2710	1	2
geminin	Homo sapiens (human)	Potency	14.3194	1	1
GLS protein	Homo sapiens (human)	Potency	12.5893	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	12.5893	1	4
huntingtin isoform 2	Homo sapiens (human)	Potency	35.4813	1	1
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	0.0079	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	1.5673	2	2
NFKB1 protein, partial	Homo sapiens (human)	Potency	10.0000	2	2
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	0.2751	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	12.5893	1	2
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	20.4054	2	2
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	8.4368	1	1
Thrombopoietin	Homo sapiens (human)	Potency	12.5893	2	2

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Ki	0.0803	2	2
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 3A	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 3B	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 4	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 5A	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 5B	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 6	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
5-hydroxytryptamine receptor 7	Cavia porcellus (domestic guinea pig)	IC50	56.8000	1	2
5-hydroxytryptamine receptor 7	Rattus norvegicus (Norway rat)	IC50	0.3500	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.0002	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.0034	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	IC50	0.0002	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	IC50	0.0002	1	1
Alpha-2C adrenergic receptor	Homo sapiens (human)	IC50	0.0002	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50	27.8497	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	Ki	22.8166	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	139.4667	3	3
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	50.0000	1	1
Cytochrome P450 2J2	Homo sapiens (human)	IC50	50.0000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	10.5328	4	6
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	4.1074	3	5
Histamine H1 receptor	Rattus norvegicus (Norway rat)	IC50	0.0008	1	2
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	IC50	3.8000	1	1
Histamine H3 receptor	Homo sapiens (human)	Ki	5.0000	1	1
Histamine H3 receptor	Rattus norvegicus (Norway rat)	Ki	5.0000	1	1
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	IC50	0.0100	1	1
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	IC50	0.7600	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	133.0000	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	IC50	27.8497	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	Ki	22.8166	1	1
Platelet-derived growth factor receptor alpha	Mus musculus (house mouse)	IC50	0.0850	2	2
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	3.3151	5	7
Platelet-derived growth factor receptor beta	Mus musculus (house mouse)	IC50	0.0850	2	2
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	4.7093	7	8
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	Ki	22.8166	1	1
Prostaglandin G/H synthase 1	Ovis aries (sheep)	Ki	0.1600	1	1
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	IC50	8.0000	1	1
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	IC50	1.5200	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	IC50	7.8000	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	Ki	7.0000	2	2
Sodium-dependent dopamine transporter	Homo sapiens (human)	IC50	41.6000	5	5
Sodium-dependent dopamine transporter	Homo sapiens (human)	Ki	0.7504	2	4
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	IC50	0.0031	16	16
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Ki	0.0405	14	15
Sodium-dependent serotonin transporter	Homo sapiens (human)	IC50	0.1961	4	4
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50	20.0000	1	1
Sodium-dependent serotonin transporter	Homo sapiens (human)	Ki	0.0200	1	1
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	Ki	0.1630	1	1
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	IC50	17.5000	1	1
Solute carrier family 22 member 1	Rattus norvegicus (Norway rat)	Ki	2.8000	1	1
Solute carrier family 22 member 1	Homo sapiens (human)	IC50	32.9900	2	2
Solute carrier family 22 member 1	Homo sapiens (human)	Ki	5.3600	1	1
Solute carrier family 22 member 2	Rattus norvegicus (Norway rat)	IC50	10.0000	1	1
Solute carrier family 22 member 2	Homo sapiens (human)	Ki	16.0000	1	1
Solute carrier family 22 member 3	Rattus norvegicus (Norway rat)	IC50	68.0000	1	1
Solute carrier family 22 member 3	Homo sapiens (human)	Ki	14.0000	1	1
Solute carrier family 22 member 4	Rattus norvegicus (Norway rat)	IC50	80.0000	1	1
Transporter	Rattus norvegicus (Norway rat)	IC50	10.6500	2	2
Transporter	Rattus norvegicus (Norway rat)	Ki	0.0074	2	3
Tryptophan 5-hydroxylase 1	Rattus norvegicus (Norway rat)	Ki	0.0005	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	3.8752	4	6
Voltage-dependent N-type calcium channel subunit alpha-1B	Homo sapiens (human)	IC50	11.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Albumin	Homo sapiens (human)	Kd	851.1380	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Kd	0.0008	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	K0.5	0.0454	1	7