Page last updated: 2024-08-05 15:39:31
adenosine A3 receptor agonist
An agonist at the adenosine A3 receptor.
ChEBI ID: 73319
Members (1)
| Member | Definition | Class |
|---|---|---|
| n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine | A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and one of the hydrogens of the exocyclic amino function is substituted by a 3-iodobenzyl group. | 3-iodobenzyl-5'-N-methylcarboxamidoadenosine |
Research
Studies (210)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 39 (18.57) | 18.2507 |
| 2000's | 97 (46.19) | 29.6817 |
| 2010's | 62 (29.52) | 24.3611 |
| 2020's | 12 (5.71) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 5 (2.34%) | 5.53% |
| Reviews | 16 (7.48%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 193 (90.19%) | 84.16% |
Protein Targets (34)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 5.1042 | 4 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 16.9441 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 39.8107 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.2240 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.9879 | 2 | 3 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 1.0800 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 5.4200 | 2 | 2 |
| Adenosine receptor A1 | Bos taurus (cattle) | Ki | 0.0226 | 2 | 2 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 0.1908 | 15 | 15 |
| Adenosine receptor A1 | Mus musculus (house mouse) | Ki | 0.0059 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 5 | 6 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 1.6926 | 18 | 18 |
| Adenosine receptor A2a | Mus musculus (house mouse) | Ki | 1.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 0.0560 | 7 | 8 |
| Adenosine receptor A2b | Homo sapiens (human) | Ki | 6.5200 | 2 | 2 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 0.0560 | 1 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.0017 | 19 | 19 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.0506 | 37 | 37 |
| Adenosine receptor A3 | Mus musculus (house mouse) | Ki | 0.0001 | 1 | 1 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 12 | 12 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0560 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | Ki | 0.0540 | 1 | 1 |
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 2.1002 | 2 | 2 |
| Thyroid hormone receptor beta | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 1 | 2 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A2b | Homo sapiens (human) | EC50 | 11.0000 | 1 | 1 |
| Adenosine receptor A2b | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | EC50 | 0.0012 | 5 | 5 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A3 | Homo sapiens (human) | ED50 | 0.0280 | 1 | 1 |