A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
| Member | Definition | Class |
|---|
| 6-cyclohexyl-3-furan-2-yl-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazole | A triazolothiadiazole that is [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole which is substituted at positions 3 and 6 by 2-furyl and cyclohexyl groups, respectively. A cardiomyocyte promoter and an inhibitor of Wnt/beta-catenin dependent transcriptional activity, it induces cardiac cell formation in murine stem cells and zebrafish embryos, expanding cardiac progenitor cells. A biphasic modulator of cardiogenesis, it can act as either a promotor or inhibitor of heart formation, depending on the stage of treatment. | cardionogen-1 |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capacity of complex mixtures. | Trolox |
| CCT251545 | A chloropyridine that is 3-chloropyridine substituted by a 1-oxo-2,8-diazaspiro[4.5]decan-8-yl group and a 4-(1-methyl-1H-pyrazol-4-yl)phenyl group at positions 4 and 5, respectively. It is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM) and a potent and selective chemical probe for cyclin-dependent kinases CDK8 and CDK19. | CCT251545 |
| iwr-1 endo | A dicarboximide having an endo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. | IWR-1-endo |
| lgk974 | A carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). | LGK974 |
| toxoflavin | A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. | toxoflavin |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| 4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase | Arabidopsis thaliana (thale cress) | Potency | 1.1873 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 26.2000 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | Potency | 2.3661 | 3 | 3 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 7.2923 | 2 | 2 |
| Caspase-7 | Homo sapiens (human) | Potency | 3.7636 | 3 | 3 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 2.9031 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 15.1652 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 1.5855 | 3 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.1838 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 5.4172 | 3 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 3.0331 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 5.3233 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.0876 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 19.9242 | 4 | 4 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 741.5113 | 2 | 2 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 4.4668 | 1 | 1 |
| galactokinase | Homo sapiens (human) | Potency | 1.1586 | 2 | 2 |
| geminin | Homo sapiens (human) | Potency | 7.3266 | 2 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 9.3336 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | Potency | 3.9811 | 1 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 0.5174 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 0.0370 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 1.2589 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 0.5012 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 11.2202 | 2 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 1.5031 | 3 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 11.2947 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.1836 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 0.5279 | 4 | 4 |
| P53 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 0.7667 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 1.2893 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 49.2885 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.0370 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 1.1220 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 15.9068 | 1 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 26.6320 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 12.5465 | 2 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 48.0224 | 2 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 0.0316 | 1 | 1 |