diallyl tetrasulfide profile

Diallyl tetrasulfide (DATS) is an organosulfur compound found naturally in garlic. It is a yellow-colored oily liquid with a strong garlic odor. DATS has been shown to possess various biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. It is synthesized from diallyl disulfide (DADS) by a series of reactions involving sulfur. Research interest in DATS stems from its potential therapeutic applications, particularly in the prevention and treatment of cardiovascular disease, cancer, and Alzheimer's disease. The compound has shown promise in reducing blood pressure, cholesterol levels, and platelet aggregation. Furthermore, studies have demonstrated its ability to inhibit the growth and proliferation of cancer cells and to protect neurons from damage. The precise mechanisms underlying DATS's pharmacological effects are still being elucidated. However, its antioxidant and anti-inflammatory properties are thought to play a significant role.'

ID Source	ID
PubMed CID	75552
CHEMBL ID	1947232
CHEBI ID	177763
SCHEMBL ID	389609
MeSH ID	M0394415

Synonym
diallyltetrasulfane
2444-49-7
CHEBI:177763
3-(prop-2-enyltetrasulanyl)prop-1-ene
unii-wrp12iw1d7
wrp12iw1d7 ,
diallyl tetrasulfide
einecs 219-485-7
tetrasulfide, di-2-propenyl
diallyl tetrasulphide
dially tetrasulfide
3-(allyltetrasulfanyl)prop-1-ene
3-(prop-2-enyltetrasulfanyl)prop-1-ene
nsc750226
nsc-750226
diallyltetrasulfide
CHEMBL1947232
tetrasulfide, diallyl
fema no. 3533, tetrasulfide
allyl tetrasulfide
SCHEMBL389609
1,4-diallyltetrasulfane #
RMKCQUWJDRTEHE-UHFFFAOYSA-N
DTXSID70179196
bis(prop-2-en-1-yl)tetrasulfane
di-2-propenyl tetrasulfide
allyl tetrasulfide, 8ci
4,5,6,7-tetrathia-1,9-decadiene
1,4-diallyltetrasulfane
di-allyl-tetrasulfide
Q27292795
AKOS040755018

Class	Description
organosulfur compound	An organosulfur compound is a compound containing at least one carbon-sulfur bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID644231	Cytotoxicity against human HCT116 cells expressing p53 assessed as reduction in cell viability at 50 uM from 24 to 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4	Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (37.50)	29.6817
2010's	9 (56.25)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.03	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
allyl sulfide allyl sulfide: essence of garlic; inhibits CYP2E1	2.44	2	organic sulfide
diallyl trisulfide [no description available]	2.99	4	organic trisulfide	anti-inflammatory agent; antilipemic drug; antineoplastic agent; antioxidant; antiprotozoal drug; apoptosis inducer; estrogen receptor antagonist; insecticide; platelet aggregation inhibitor; vasodilator agent
diallyl disulfide diallyl disulfide: major constituent of garlic oil. diallyl disulfide : An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.	3.18	5	organic disulfide	antifungal agent; antineoplastic agent; plant metabolite
cadmium Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.	7.45	2	cadmium molecular entity; zinc group element atom
cadmium chloride Cadmium Chloride: A cadmium halide in the form of colorless crystals, soluble in water, methanol, and ethanol. It is used in photography, in dyeing, and calico printing, and as a solution to precipitate sulfides. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). cadmium dichloride : A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.	2.95	4	cadmium coordination entity
dibenzyl trisulfide dibenzyl trisulfide: structure in first source; an antiproliferative agent	2.15	1
thiobarbituric acid thiobarbituric acid: RN given refers to parent cpd. 2-thiobarbituric acid : A barbiturate, the structure of which is that of barbituric acid in which the oxygen at C-2 is replaced by sulfur.	2.03	1	barbiturates	allergen; reagent
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.17	1	chalcogen; nonmetal atom	macronutrient
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.17	1	cysteinium	fundamental metabolite
s-allylcysteine S-allylcysteine: structure in first source; RN given refers to (L)-isomer. S-allylcysteine : An S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity.	2.17	1	L-alpha-amino acid zwitterion; S-hydrocarbyl-L-cysteine	antineoplastic agent; metabolite
bn82002 BN82002: inhibitor of CDC25 phosphatases; structure in first source	2.07	1
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.06	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent

Condition	Relationship Strength	Studies
Colorectal Cancer [description not available]	2.15	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.15	1
Hematologic Malignancies [description not available]	2.1	1
Hematologic Neoplasms Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.	2.1	1
Testicular Diseases Pathological processes of the TESTIS.	2.06	1
Breast Cancer [description not available]	2.06	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.06	1
Diffuse Large B-Cell Lymphoma [description not available]	2.07	1
Lymphoma, Large B-Cell, Diffuse Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.	2.07	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.03	1
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	2.03	1
Acute Liver Injury, Drug-Induced [description not available]	2.03	1
Liver Dysfunction [description not available]	2.03	1
Liver Diseases Pathological processes of the LIVER.	2.03	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.03	1

diallyl tetrasulfide

Cross-References

Synonyms (32)

Drug Classes (1)

Bioassays (1)

Research

Studies (16)

Market Indicators

Research Demand Index: 22.41

Study Types