An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19).
ChEBI ID: 20569
| Member | Definition | Class |
|---|---|---|
| glyphosate | A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS). | glyphosate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 277 (5.70) | 18.7374 |
| 1990's | 304 (6.25) | 18.2507 |
| 2000's | 883 (18.16) | 29.6817 |
| 2010's | 2,122 (43.64) | 24.3611 |
| 2020's | 1,277 (26.26) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 108 (2.12%) | 5.53% |
| Reviews | 321 (6.29%) | 6.00% |
| Case Studies | 285 (5.59%) | 4.05% |
| Observational | 33 (0.65%) | 0.25% |
| Other | 4,353 (85.35%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 2-dehydro-3-deoxyphosphooctonate aldolase | Neisseria meningitidis MC58 | Ki | 260.0000 | 1 | 1 |
| Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase | Agrobacterium sp. CP4 | IC50 | 5,580.0000 | 1 | 4 |
| Cytochrome P450 71B1 | Thlaspi arvense | IC50 | 12.0000 | 1 | 1 |
| Glutamine synthetase | Nicotiana tabacum (common tobacco) | IC50 | 100.0000 | 1 | 1 |
| Glutamine synthetase | Spinacia oleracea (spinach) | IC50 | 100.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 71B1 | Thlaspi arvense | Ks | 60.0000 | 1 | 1 |