Compounds > isoaaptamine
Page last updated: 2024-12-08

isoaaptamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

isoaaptamine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID395377
CHEMBL ID301307
SCHEMBL ID7350656
MeSH IDM0375583

Synonyms (8)

Synonym
NCI60_035809
isoaaptamine
CHEMBL301307
SCHEMBL7350656
117173-75-8
bdbm50476977
8-methoxy-1-methyl-1h-benzo[de]1,6-naphthyridin-9-ol
11-methoxy-2-methyl-2,6-diazatricyclo[7.3.1.05,13]trideca-1(13),3,5,7,9,11-hexaen-12-ol

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID355800Antioxidant activity assessed as DPPH free radical scavenging activity by TLC autoradiographic assay2003Journal of natural products, May, Volume: 66, Issue:5
Marine natural products as novel antioxidant prototypes.
AID400885Antimicrobial activity against Micrococcus luteus by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID419045Inhibition of 6-His tagged Staphylococcus aureus recombinant sortase delta N24 expressed in Escherichia coli BL21 (DE3)2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform.
AID400606Antineoplastic activity against human A498 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID381211Cytotoxicity against human KB16 cells after 3 days by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Structures and cytotoxicity relationship of isoaaptamine and aaptamine derivatives.
AID150355Inhibition of murine leukemia P388 cell proliferation2004Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.
AID400887Antimicrobial activity against Stenotrophomonas maltophilia at 64 ug/ml by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID300939Inhibition of Staphylococcus aureus SKM12 adhesion to fibronectin in relative to wild type2007Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19
Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.
AID300936Inhibition of SrtA2007Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19
Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.
AID400888Antimicrobial activity against Neisseria gonorrhoeae by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID381212Cytotoxicity against human A549 cells after 6 days by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Structures and cytotoxicity relationship of isoaaptamine and aaptamine derivatives.
AID400882Antimicrobial activity against Staphylococcus aureus by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400892Antimicrobial activity against Escherichia coli at 64 ug/ml by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID226687Effect on tubulin assembly was determined2004Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.
AID400884Antimicrobial activity against Enterococcus faecalis by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400878Antineoplastic activity against human KM20L2 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400605Antineoplastic activity against human SF295 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID381210Cytotoxicity against mouse P388 cells after 3 days by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Structures and cytotoxicity relationship of isoaaptamine and aaptamine derivatives.
AID300937Antimicrobial activity against Staphylococcus aureus Newman2007Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19
Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.
AID400879Antineoplastic activity against human SK-MEL-5 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID300938Inhibition of Staphylococcus aureus Newman adhesion to fibronectin2007Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19
Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.
AID482936Inhibition of chymotrypsin-like activity of purified 20S proteasome from human erythrocyte2010Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor.
AID355801Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay2003Journal of natural products, May, Volume: 66, Issue:5
Marine natural products as novel antioxidant prototypes.
AID400881Antimicrobial activity against Candida albicans at 64 ug/ml by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID482933Inhibition of chymotrypsin like activity of partially purified rat liver proteasome by spectrofluorimetry2010Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor.
AID400880Antimicrobial activity against Cryptococcus neoformans by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400604Antineoplastic activity against human OVCAR-3 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID482938Cytotoxicity against human HeLa cells after 3 days by MTT assay2010Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor.
AID400877Antineoplastic activity against human NCI-H460 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID482937Inhibition of caspase-like activity of 20S proteasome in human erythrocyte by spectrofluorimetry2010Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor.
AID482934Inhibition of trypsin like activity of partially purified rat liver proteasome by spectrofluorimetry2010Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor.
AID482935Inhibition of caspase like activity of partially purified rat liver proteasome by spectrofluorimetry2010Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor.
AID400603Antineoplastic activity against mouse P388 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400886Antimicrobial activity against Enterobacter cloacae at 64 ug/ml by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400883Antimicrobial activity against Streptococcus pneumoniae by broth microdilution susceptibility assay2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID381213Cytotoxicity against human HT-29 cells after 6 days by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Structures and cytotoxicity relationship of isoaaptamine and aaptamine derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's8 (61.54)29.6817
2010's3 (23.08)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
Berberine chloride (TN)
[no description available]		2.4420organic molecular entity
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		2.0110alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
phosphoric acid, trisodium salt
[no description available]		2.0210sodium phosphate
puupehenone
[no description available]		2.0110
phenyl vinyl sulfone
phenyl vinyl sulfone: RN and structure in first source		2.0510
aaptamine
aaptamine: natural product from sea sponge Aaptos aaptos; structure given in first source; RN from CA Index Guide 1984		3.5480
topsentin a
topsentin A: number of carbony group = 1 for topsentin A and no carbonyl group for nortopsentin B and D; structure in first source		2.0510
curcudiol
curcudiol: RN given for (S)-isomer; structure in first source		2.0110
morin
morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.		2.05107-hydroxyflavonol;
pentahydroxyflavone		angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		2.0510beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
demethyloxyaaptamine
demethyloxyaaptamine: from Hymeniacidon sp.; structure in first source		2.9540
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0110ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.7130
Astrocytoma, Grade IV
[description not available]		02.610
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		07.610
Breast Cancer
[description not available]		02.1710
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1710
Cancer, Embryonal
[description not available]		02.110
Neoplasms, Germ Cell and Embryonal
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.		02.110
Infections, Plasmodium
[description not available]		02.0310
AIDS-Related Opportunistic Infections
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.		02.0310
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.0310