azoxystrobin: a methoxyacrylate analog; a strobilurin fungicide; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
azoxystrobin : An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 3034285 |
| CHEMBL ID | 230001 |
| CHEBI ID | 40909 |
| SCHEMBL ID | 55087 |
| SCHEMBL ID | 18823 |
| MeSH ID | M0232164 |
| Synonym |
|---|
| methyl (e)-2-(2-(6-(2-cyanopheoxy)pyrimidin-4-yloxy)phenyl)-3-methoxypropenoate |
| bankit |
| icia-5504 |
| amistar |
| heritage |
| quadris |
| ici-a 5504 |
| hsdb 7017 |
| einecs annex i index 607-256-00-x |
| benzeneacetic acid, 2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene)-, methyl ester, (e)- |
| azoxystrobin |
| NCGC00163818-01 |
| 131860-33-8 |
| methyl (2e)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyacrylate |
| NCGC00163818-02 |
| DB07401 |
| dndi1511705 |
| chebi:40909 , |
| CHEMBL230001 |
| TCMDC-125883 , |
| methyl (e)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxyprop-2-enoate |
| A806322 |
| (e)-2-[2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]phenyl]-3-methoxy-2-propenoic acid methyl ester |
| NCGC00163818-04 |
| NCGC00163818-03 |
| NCGC00163818-05 |
| azoxy-strobin |
| methyl (2e)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate |
| 215934-32-0 |
| C18558 |
| benzeneacetic acid, 2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene)-, methyl ester, (alphae)- |
| unii-nyh7y08ipm |
| azoxystrobin [iso] |
| nyh7y08ipm , |
| tox21_400087 |
| dtxcid8012520 |
| cas-131860-33-8 |
| dtxsid0032520 , |
| methyl (e)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yl]oxyphenyl]-3-methoxy -prop-2-enoate |
| methyl (e)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylate |
| methyl (2e)-2-(2-{[6-(2-cyanophenoxy)pyrimidin-4-yl]oxy}phenyl)-3-methoxyprop-2-enoate |
| (alphae)-2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-alpha-(methoxymethylene) benzeneacetic acid methyl ester |
| AKOS015900562 |
| azoxystrobin [hsdb] |
| methyl (.alpha.e)-2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-.alpha.-(methoxymethylene)benzeneacetate |
| azoxystrobin [mi] |
| ici-a-5504 |
| (.alpha.e)-2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-.alpha.-(methoxymethylene)benzeneacetic acid methyl ester |
| SCHEMBL55087 |
| SCHEMBL18823 |
| 1SQB |
| methyl (e)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate |
| (e)-methyl 2-[2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)pheny]-3-methoxypropenoate |
| methyl (e)-2-{2-[6-(2-cyano-phenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate |
| (e)-methyl 2-[2-(6- (2-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate |
| (e)-methyl 2-[2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate |
| azoxystrobin, certified reference material, tracecert(r) |
| azoxystrobine x |
| KS-5365 |
| methyl (2e)-2-(2-{[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy}phenyl)-3-methoxyacrylate |
| AC-24498 |
| J-519625 |
| mfcd08277047 |
| azoxystrobin, pestanal(r), analytical standard |
| bdbm50487147 |
| F20623 |
| azoxystrobin 10 microg/ml in cyclohexane |
| benzeneacetic acid, 2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-alpha-(methoxymethylene)-, methyl ester, (alphae)- |
| J-006072 |
| (e)-methyl 2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate |
| bankit; cruiser extreme;ici-a 5504 |
| Q2013860 |
| CS-0012863 |
| AMY3587 |
| HY-B0849 |
| azoxystrobin 1000 microg/ml in acetone |
| azoxystrobin 1000 microg/ml in toluene |
| 40 - fungicides |
| (alphae)-2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene) benzeneacetic acid methyl ester |
| methyl (e)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate |
| methyl (2e)-2-(2-((6-(2-cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyprop-2-enoate |
| usepa/opp pesticide code: 128810 |
| methyl (alphae)-2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene)benzeneacetate |
| methyl(e)-2-(2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl)-3-methoxyacrylate |
| (alphae)-2-((6-(2-cyanophenoxy)-4-pyrimidinyl)oxy)-alpha-(methoxymethylene)benzeneacetic acid methyl ester |
| annex i index 607-256-00-x |
Azoxystrobin is a broad-spectrum, systemic and soil-applied fungicide used for crop protection against the four major classes of pathogenic fungi. It was recently added to mold- and mildew-resistant wallboards.
Azoxystrobin has been widely used since 1996 to control rice blast caused by Pyricularia oryzae.
Azoxystrobin treatments (125 or 250 g AI ha-1) were applied at various stages of the infection process under controlled conditions. No significant effect on relative Tri5 expression or DON quantity.
The toxic effects of azoxystrobin on zebrafish (Danio rerio) were investigated. The study was carried out on earthworms (Eisenia fetida) in three different natural soils.
| Excerpt | Reference | Relevance |
|---|---|---|
| "In the past few decades, extensive application of azoxystrobin has led to great concern regarding its adverse effects on aquatic organisms." | ( Reproductive toxicity of azoxystrobin to adult zebrafish (Danio rerio). Cao, F; Li, H; Qiu, L; Wang, C; Yu, S; Zhu, L, 2016) | 0.99 |
| " In the present work, the toxic effects of azoxystrobin on zebrafish (Danio rerio) were investigated." | ( Genotoxicity and oxidative stress induced by the fungicide azoxystrobin in zebrafish (Danio rerio) livers. Han, Y; Liu, T; Wang, J; Zhang, C; Zhu, L, 2016) | 0.94 |
| " Risk assessments revealed that the acceptable daily intake percentage is substantially below the risk level of consumption at day 0 (in both areas), thus encouraging its safe consumption." | ( Dynamic residual pattern of azoxystrobin in Swiss chard with contribution to safety evaluation. Abd El-Aty, AM; Chang, BJ; Chung, HS; Farha, W; Jeon, JS; Kabir, MH; Lee, HS; Rahman, MM; Shim, JH; Shin, HC; Wang, J, 2018) | 0.77 |
| " To assess the ecological risk of azoxystrobin in real soil environments, we performed a study on the toxic effects of azoxystrobin on earthworms (Eisenia fetida) in three different natural soils (fluvo-aquic soil, black soil and red clay soil) and an artificial soil." | ( Ecotoxicity evaluation of azoxystrobin on Eisenia fetida in different soils. Allen, SC; Du, Z; Hou, K; Li, B; Li, W; Wang, J; Xu, Y; Zhu, L, 2021) | 1.2 |
| " In view of the adverse toxic effects of both on the mammalian liver, it is necessary to conduct a cumulative risk assessment of their dietary exposure to consumers." | ( Dissipation and Residue of Metalaxyl-M and Azoxystrobin in Scallions and Cumulative Risk Assessment of Dietary Exposure to Hepatotoxicity. Chai, Y; Du, X; Liu, R; Yuan, L, 2022) | 0.98 |
| " Still, adverse environmental and human health effects resulting from its application have been reported." | ( Recommended rates of azoxystrobin and tebuconazole seem to be environmentally safe but ineffective against target fungi. Aguiar, N; Alves, A; Gonçalves, FJM; Pereira, JL; Pereira, P; Queirós, L, 2023) | 1.23 |
Little is known about the bioavailability of azoxystrobin in the soil-vegetable system. In the current study we investigated the effect of BC onBioavailability of the fungicide azoxy Strobin.
The results demonstrated that the safety of using azoxystrobin at the recommended agriculture dosage to protect bananas from diseases. Their physico-chemical properties suggest difenoconazole and azoxy Strobin should be stable in bananas and soil. Both decreased to safe concentrations by the minimum harvest time after spraying the mixture.
| Role | Description |
|---|---|
| mitochondrial cytochrome-bc1 complex inhibitor | null |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| antifungal agrochemical | Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties. |
| quinone outside inhibitor | A mitochondrial cytochrome-bc1 complex inhibitor that acts at the Quinone 'outer' (Qo) binding site of the cytochrome-bc1 complex. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| nitrile | A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it. |
| aryloxypyrimidine | |
| enoate ester | An alpha,beta-unsaturated carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) in which the ester C=O function is conjugated to a C=C double bond at the alpha,beta position. |
| enol ether | Ethers ROR' where R has a double bond adjacent to the oxygen of the ether linkage. |
| methyl ester | Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol. |
| methoxyacrylate strobilurin antifungal agent | Any strobilurin antifungal agent that contains a methoxyacrylate group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 89.3584 | 0.0025 | 41.7960 | 15,848.9004 | AID1347398 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 0.0251 | 27.9203 | 501.1870 | AID651751 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 58.6042 | 3.1890 | 29.8841 | 59.4836 | AID1224846 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 1.0171 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521; AID1159523 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 42.5933 | 0.1737 | 34.3047 | 61.8120 | AID1346859; AID1346924 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 14.1254 | 0.0030 | 8.7949 | 48.0869 | AID1347053 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 42.5933 | 0.1737 | 34.3047 | 61.8120 | AID1346859; AID1346924 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.2301 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.5669 | 0.0007 | 14.5928 | 83.7951 | AID1259369; AID1259392 |
| AR protein | Homo sapiens (human) | Potency | 13.3385 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID588515; AID743035; AID743042; AID743054; AID743063 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 65.6259 | 0.0006 | 57.9133 | 22,387.1992 | AID1259377; AID1259378 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 10.7030 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839 |
| progesterone receptor | Homo sapiens (human) | Potency | 52.9111 | 0.0004 | 17.9460 | 75.1148 | AID1346784; AID1346795 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 20.0048 | 0.0123 | 7.9835 | 43.2770 | AID1645841 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 26.0395 | 0.0002 | 14.3764 | 60.0339 | AID588533; AID720691; AID720692 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 6.3465 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159553; AID1159555 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 39.8427 | 0.0008 | 17.5051 | 59.3239 | AID1159527; AID1159531; AID588546 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 6.6504 | 0.0015 | 30.6073 | 15,848.9004 | AID1224819; AID1224820; AID1224821; AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 38.1187 | 0.3758 | 27.4851 | 61.6524 | AID588526; AID743217; AID743220 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 2.3335 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982; AID720659 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.5522 | 0.0002 | 29.3054 | 16,493.5996 | AID1259244; AID1259248; AID588513; AID588514; AID743069; AID743075; AID743078; AID743079; AID743080; AID743091 |
| G | Vesicular stomatitis virus | Potency | 1.2622 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 31.7055 | 0.0010 | 8.3798 | 61.1304 | AID1645840 |
| polyprotein | Zika virus | Potency | 14.1254 | 0.0030 | 8.7949 | 48.0869 | AID1347053 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 54.7233 | 0.0010 | 24.5048 | 61.6448 | AID588535; AID743212; AID743215 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 26.1483 | 0.0010 | 19.4141 | 70.9645 | AID588536; AID588537; AID743094; AID743140; AID743191 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 27.4244 | 0.0237 | 23.2282 | 63.5986 | AID743222; AID743223 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 7.6959 | 0.0007 | 23.0674 | 1,258.9301 | AID743085 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 32.6741 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 59.7406 | 0.0016 | 28.0151 | 77.1139 | AID1224843; AID1259385; AID1259395 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 1.0962 | 0.1434 | 27.6121 | 59.8106 | AID1159516 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 9.2881 | 19.7391 | 45.9784 | 64.9432 | AID1159509 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 65.7549 | 0.0578 | 21.1097 | 61.2679 | AID1159526 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 15.9623 | 0.0391 | 47.5451 | 146.8240 | AID1224845 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0126 | 0.0100 | 39.5371 | 1,122.0200 | AID588547 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 0.5666 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743067 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 6.9009 | 0.0006 | 27.2152 | 1,122.0200 | AID651741; AID743202; AID743219 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 5.1785 | 0.0015 | 57.7890 | 15,848.9004 | AID1259244 |
| Interferon beta | Homo sapiens (human) | Potency | 14.1454 | 0.0033 | 9.1582 | 39.8107 | AID1347407; AID1645842 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 1.2622 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 1.6376 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 5.1785 | 0.0015 | 51.7393 | 15,848.9004 | AID1259244 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 19.9526 | 0.0158 | 23.5273 | 44.6684 | AID651778 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 1.2622 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 1.2622 | 0.0123 | 8.9648 | 39.8107 | AID1645842 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain C, Cytochrome b | Bos taurus (cattle) | IC50 (µMol) | 0.0112 | 0.0112 | 0.0112 | 0.0112 | AID977608 |
| Chain C, Cytochrome b | Bos taurus (cattle) | IC50 (µMol) | 0.0112 | 0.0112 | 0.0112 | 0.0112 | AID977608 |
| Cytochrome b | Sus scrofa (pig) | Ki | 0.2976 | 0.0033 | 0.1535 | 0.2976 | AID1091872 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1112830 | Fungicidal activity against Magnaporthe oryzae assessed as germination of conidia at 1 mg/l at 26 degC measured after 7 days | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID297517 | Antimicrobial activity against Fusarium solani at 0.3 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1367218 | Antifungal activity against Botrytis cinerea assessed as inhibition of mycelium growth at 5 ug/ml after 48 hrs relative to control | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Synthesis, antifungal and antitumor activity of two new types of imidazolin-2-ones. |
| AID1090505 | Antifungal activity against Colletotrichum acutatum assessed as growth inhibition at 2 uL in 2 mM acetone by direct bioautography | 2006 | Journal of agricultural and food chemistry, Sep-06, Volume: 54, Issue:18 | Chemical composition and antifungal activity of Salvia macrochlamys and Salvia recognita essential oils. |
| AID1112835 | Fungicidal activity against Magnaporthe oryzae assessed as inhibition of sporulation at 26 degC measured after 7 days | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1091304 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1091295 | Fungicidal activity against Blumeria graminis infected wheat plants exposed to compound treatment 1 day post infection assessed as disease curative activity at 1.56 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1091299 | Fungicidal activity against Podosphaera fuliginea infected compound pre-treated cucumber plants assessed as disease preventive activity at 0.78 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1080482 | Antifungal activity against Colletotrichum gloeosporioides assessed as as appearance of diffuse zone of inhibition at 2 mM in 2 uL solution by direct bio-autography assay | 2009 | Journal of agricultural and food chemistry, Jan-28, Volume: 57, Issue:2 | Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity. |
| AID297518 | Antimicrobial activity against Fusarium solani at 0.3 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1111110 | Antifungal activity against Pseudoperonospora cubensis infected cucumber leaves assessed as disease control at 400 mg/l after 5 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID297519 | Antimicrobial activity against Fusarium oxysporum at 3 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1111109 | Antifungal activity against Pseudoperonospora cubensis infected cucumber leaves assessed as disease control at 25 mg/l after 5 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID611600 | Competitive inhibition of pig heart Cytochrome b-c1 complex using DBH2 as substrate in absence of lauryl maltoside by Line-weaverBurk plot analysis | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc₁ complex inhibitors. |
| AID1105339 | Antifungal activity against Sclerotinia sclerotiorum assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID1081082 | Inhibition of intact mycelial respiration of Phytophthora capsici assessed as superpose rate of oxygen consumption at 10 ug/mL in presence of malonic acid | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici. |
| AID1091307 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 3.12 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1081292 | Fungicidal activity against Rhizoctonia solani assessed as inhibition of intact mycelia respiration at 10 ug/mL by cell membrane permeability assay | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Primary study on mode of action for macrocyclic fungicide candidates (7B3, D1) against Rhizoctonia solani Kuhn. |
| AID611602 | Competitive inhibition of pig heart Cytochrome b-c1 complex using DBH2 as substrate by Line-weaverBurk plot analysis | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc₁ complex inhibitors. |
| AID1081086 | Inhibition of intact mycelial respiration of Phytophthora capsici at 10 ug/mL in presence of sodium phosphate | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici. |
| AID1091301 | Fungicidal activity against Podosphaera fuliginea infected compound pre-treated cucumber plants assessed as disease preventive activity at 1.56 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID346925 | Inhibition of Phytophthora infestans cytochrome bc1 complex inoculated in tomato plant assessed as lowest drug concentration required to control 100% disease applied to leaf 1 hr prior inoculation measured after 6 to 9 days | 2008 | Bioorganic & medicinal chemistry, Dec-15, Volume: 16, Issue:24 | The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D. |
| AID297521 | Antimicrobial activity against Fusarium solani at 3 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID297520 | Antimicrobial activity against Fusarium oxysporum at 3 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID376577 | Antifungal activity against Colletotrichum fragariae assessed as zone of inhibition | 2000 | Journal of natural products, Aug, Volume: 63, Issue:8 | A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens. |
| AID1111614 | Fungicidal activity against Pseudoperonospora cubensis at 6.25 mg/L relative to untreated control | 2011 | Pest management science, Jun, Volume: 67, Issue:6 | Design, synthesis and structure-activity relationship of novel coumarin derivatives. |
| AID1081081 | Inhibition of intact mycelial respiration of Phytophthora capsici assessed as superpose rate of oxygen consumption at 10 ug/mL in presence of iodoacetic acid | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici. |
| AID1091300 | Fungicidal activity against Podosphaera fuliginea infected compound pre-treated cucumber plants assessed as disease preventive activity at measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1081041 | Antifungal activity against Magnaporthe oryzae assessed as inhibition at 25 mg/L relative to control | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and biological activity of new (E)-alpha-(Methoxyimino)benzeneacetate derivatives containing a substituted pyrazole ring. |
| AID611599 | Non-competitive inhibition of pig heart succinate-cytochrome c reductase (Electron transport protein complex 2/3) using cytochrome c as substrate by Line-weaverBurk plot analysis | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc₁ complex inhibitors. |
| AID1111105 | Antifungal activity against Blumeria graminis f. sp. tritici infected seven-day-old wheat seedlings assessed as disease control at 12.5 mg/l after 7 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID1882204 | Antifungal activity against sunflower Sclerotinia rot at 50 ug/ml relative to control | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Natural and synthetic β-carboline as a privileged antifungal scaffolds. |
| AID1081088 | Inhibition of intact mycelial respiration of Phytophthora capsici at 10 ug/mL in presence of malonic acid | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici. |
| AID1112836 | Fungicidal activity against Magnaporthe oryzae assessed as inhibition of mycelium growth at 26 degC measured after 7 days | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1112831 | Fungicidal activity against Magnaporthe oryzae assessed as germination of conidia at 0.01 mg/l at 26 degC measured after 7 days | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1111112 | Antifungal activity against Magnaporthe oryzae infected 12 day old rice plant assessed as disease control at 400 mg/l after 6 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID1111108 | Antifungal activity against Pseudoperonospora cubensis infected cucumber leaves assessed as disease control at 6.25 mg/l after 5 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID297544 | Antimicrobial activity against Fusarium proliferatum at 0.3 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1090802 | Antifungal activity against Colletotrichum acutatum assessed as diffuse inhibitory zone at concentration of 2 mM in volume of 2 ul of EtOH measured after 4 days by TLC based direct bioautography assay | 2007 | Journal of agricultural and food chemistry, Oct-17, Volume: 55, Issue:21 | Chemical composition and antifungal activity of Arnica longifolia, Aster hesperius, and Chrysothamnus nauseosus essential oils. |
| AID1091302 | Fungicidal activity against Podosphaera fuliginea infected compound pre-treated cucumber plants assessed as disease preventive activity at 3.12 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1081036 | Antifungal activity against Pseudoperonospora cubensis assessed as inhibition at 25 mg/L relative to control | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and biological activity of new (E)-alpha-(Methoxyimino)benzeneacetate derivatives containing a substituted pyrazole ring. |
| AID1103205 | Antifungal activity against Fusarium graminearum isolate CE135 after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID1112537 | Antifungal activity against Botryotinia fuckeliana SAS56 assessed as inhibition of colony growth | 2012 | Pest management science, Sep, Volume: 68, Issue:9 | Genetic analysis and molecular characterisation of laboratory and field mutants of Botryotinia fuckeliana (Botrytis cinerea) resistant to QoI fungicides. |
| AID1091290 | Fungicidal activity against Podosphaera fuliginea infected cucumber plants exposed to compound treatment 1 day post infection assessed as disease curative activity at 0.78 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID346926 | Inhibition of Plasmopara viticola cytochrome bc1 complex inoculated in vine plant assessed as lowest drug concentration required to control 100% disease applied to leaf 1 hr prior inoculation measured after 6 to 9 days | 2008 | Bioorganic & medicinal chemistry, Dec-15, Volume: 16, Issue:24 | The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D. |
| AID1882203 | Antifungal activity against rape Sclerotinia rot at 50 ug/ml relative to control | 2022 | European journal of medicinal chemistry, Feb-05, Volume: 229 | Natural and synthetic β-carboline as a privileged antifungal scaffolds. |
| AID1081033 | Antifungal activity against Blumeria graminis assessed as inhibition at 6.25 mg/L relative to control | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and biological activity of new (E)-alpha-(Methoxyimino)benzeneacetate derivatives containing a substituted pyrazole ring. |
| AID1091289 | Fungicidal activity against Podosphaera fuliginea infected cucumber plants exposed to compound treatment 1 day post infection assessed as disease curative activity measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1111111 | Antifungal activity against Botryotinia fuckeliana infected cucumber leaves assessed as disease control at 400 mg/l after 4 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID1112834 | Fungicidal activity against Magnaporthe oryzae assessed as inhibition of sporulation at 1 mg/l at 26 degC measured after 7 days | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1111613 | Fungicidal activity against Pseudoperonospora cubensis at 25 mg/L relative to untreated control | 2011 | Pest management science, Jun, Volume: 67, Issue:6 | Design, synthesis and structure-activity relationship of novel coumarin derivatives. |
| AID611606 | Activity of pig heart succinate-cytochrome c reductase (Electron transport protein complex 2/3) using cytochrome c as substrate by Line-weaverBurk plot analysis | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc₁ complex inhibitors. |
| AID1399728 | Antifungal activity against Phytophthora infestans assessed as inhibition of zoospore release after 4 hrs | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis and bioactivities evaluation of l-pyroglutamic acid analogues from natural product lead. |
| AID299150 | Growth inhibition of Verticillium lamellicola at 50 ug/mL | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7 | Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations. |
| AID1091294 | Fungicidal activity against Blumeria graminis infected wheat plants exposed to compound treatment 1 day post infection assessed as disease curative activity measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1090506 | Antifungal activity against Colletotrichum fragariae assessed as growth inhibition at 2 uL in 2 mM acetone by direct bioautography | 2006 | Journal of agricultural and food chemistry, Sep-06, Volume: 54, Issue:18 | Chemical composition and antifungal activity of Salvia macrochlamys and Salvia recognita essential oils. |
| AID297547 | Antimicrobial activity against Fusarium proliferatum at 3 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1091312 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 500 ppm measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1081089 | Inhibition of intact mycelial respiration of Phytophthora capsici at 10 ug/mL | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici. |
| AID1103208 | Antifungal activity against Colletotrichum truncatum CE175 after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID1091303 | Fungicidal activity against Podosphaera fuliginea infected compound pre-treated cucumber plants assessed as disease preventive activity at 6.25 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1090800 | Antifungal activity against Colletotrichum fragariae assessed as size of growth inhibitory zone at concentration of 2 mM in volume of 2 ul of EtOH measured after 4 days by TLC based direct bioautography assay | 2007 | Journal of agricultural and food chemistry, Oct-17, Volume: 55, Issue:21 | Chemical composition and antifungal activity of Arnica longifolia, Aster hesperius, and Chrysothamnus nauseosus essential oils. |
| AID1112534 | Antifungal activity against Botryotinia fuckeliana SAS56 assessed as complete inhibition of colony growth at 3 mg/ml | 2012 | Pest management science, Sep, Volume: 68, Issue:9 | Genetic analysis and molecular characterisation of laboratory and field mutants of Botryotinia fuckeliana (Botrytis cinerea) resistant to QoI fungicides. |
| AID297515 | Antimicrobial activity against Fusarium oxysporum at 0.3 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1103201 | Antifungal activity against Fusarium equiseti (CE181) after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID1091291 | Fungicidal activity against Podosphaera fuliginea infected cucumber plants exposed to compound treatment 1 day post infection assessed as disease curative activity at 1.56 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1081087 | Inhibition of intact mycelial respiration of Phytophthora capsici at 10 ug/mL in presence of iodoacetic acid | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici. |
| AID1081080 | Inhibition of intact mycelial respiration of Phytophthora capsici assessed as superpose rate of oxygen consumption at 10 ug/mL in presence of sodium phosphate | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici. |
| AID297526 | Antimicrobial activity against Fusarium solani at 30 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1666591 | Inhibition of porcine succinate-ubiquinone oxidoreductase at 10 uM using succinate and 2,6-dichloroindophenol as substrates by spectrophotometric based assay relative to control | 2020 | Bioorganic & medicinal chemistry, 03-01, Volume: 28, Issue:5 | N-(3,5-Dichloro-4-(2,4,6-trichlorophenoxy)phenyl)benzenesulfonamide: A new dual-target inhibitor of mitochondrial complex II and complex III via structural simplification. |
| AID1105341 | Antifungal activity against Phytophthora parasitica assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID1666589 | Inhibition of porcine succinate-cytochrome c reductase using succinate and cytochrome c as substrates by spectrophotometric based assay | 2020 | Bioorganic & medicinal chemistry, 03-01, Volume: 28, Issue:5 | N-(3,5-Dichloro-4-(2,4,6-trichlorophenoxy)phenyl)benzenesulfonamide: A new dual-target inhibitor of mitochondrial complex II and complex III via structural simplification. |
| AID1112536 | Antifungal activity against Botryotinia fuckeliana SAS405 assessed as inhibition of colony growth | 2012 | Pest management science, Sep, Volume: 68, Issue:9 | Genetic analysis and molecular characterisation of laboratory and field mutants of Botryotinia fuckeliana (Botrytis cinerea) resistant to QoI fungicides. |
| AID1091305 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 0.78 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1091293 | Fungicidal activity against Podosphaera fuliginea infected cucumber plants exposed to compound treatment 1 day post infection assessed as disease curative activity at 6.25 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1105340 | Antifungal activity against Botryotinia fuckeliana assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID1103203 | Antifungal activity against Fusarium graminearum isolate CE169 after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID1090797 | Antifungal activity against Colletotrichum gloeosporioides assessed as diffuse inhibitory zone at concentration of 2 mM in volume of 2 ul of EtOH measured after 4 days by TLC based direct bioautography assay | 2007 | Journal of agricultural and food chemistry, Oct-17, Volume: 55, Issue:21 | Chemical composition and antifungal activity of Arnica longifolia, Aster hesperius, and Chrysothamnus nauseosus essential oils. |
| AID1103204 | Antifungal activity against Fusarium graminearum isolate CE171 after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID297525 | Antimicrobial activity against Fusarium solani at 30 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1112828 | Fungicidal activity against Magnaporthe oryzae in five leaf stage carnaroli plants assessed as decrease in disease incidence at 0.01 to 1 mg/l | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1103206 | Antifungal activity against Fusarium graminearum isolate CE170 after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID1091313 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 100 ppm measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1081034 | Antifungal activity against Pseudoperonospora cubensis assessed as inhibition at 6.25 mg/L relative to control | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and biological activity of new (E)-alpha-(Methoxyimino)benzeneacetate derivatives containing a substituted pyrazole ring. |
| AID1399727 | Antifungal activity against Phytophthora infestans assessed as inhibition of zoospore release at 100 ug/ml after 4 hrs relative to control | 2018 | Bioorganic & medicinal chemistry, 09-01, Volume: 26, Issue:16 | Synthesis and bioactivities evaluation of l-pyroglutamic acid analogues from natural product lead. |
| AID1091298 | Fungicidal activity against Blumeria graminis infected wheat plants exposed to compound treatment 1 day post infection assessed as disease curative activity at 6.25 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID297550 | Fungistatic activity against Fusarium proliferatum at 30 uM after 72 hrs by microtiter plate assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1090504 | Antifungal activity against Colletotrichum gloeosporioides assessed as growth inhibition at 2 uL in 2 mM acetone by direct bioautography | 2006 | Journal of agricultural and food chemistry, Sep-06, Volume: 54, Issue:18 | Chemical composition and antifungal activity of Salvia macrochlamys and Salvia recognita essential oils. |
| AID1103202 | Antifungal activity against Diaporthe longicolla CE117 after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID346928 | Inhibition of cytochrome bc1 complex in bovine heart mitochondria by NADH oxidase assay | 2008 | Bioorganic & medicinal chemistry, Dec-15, Volume: 16, Issue:24 | The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D. |
| AID1367217 | Antifungal activity against Botrytis cinerea assessed as inhibition of spore germination at 5 ug/ml after 6 hrs by microscopic analysis relative to control | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24 | Synthesis, antifungal and antitumor activity of two new types of imidazolin-2-ones. |
| AID1091306 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 1.56 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1111107 | Antifungal activity against Pseudoperonospora cubensis infected cucumber leaves assessed as disease control at 3.12 mg/l after 5 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID1105344 | Antifungal activity against Valsa mali assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID346927 | Inhibition of Puccinia triticina cytochrome bc1 complex inoculated in wheat plant assessed as lowest drug concentration required to control 100% disease applied to leaf 1 hr prior inoculation measured after 6 to 9 days | 2008 | Bioorganic & medicinal chemistry, Dec-15, Volume: 16, Issue:24 | The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D. |
| AID1091310 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 3.1 ppm measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID297555 | Fungistatic activity against Fusarium oxysporum at 30 uM after 72 hrs by microtiter plate assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1111106 | Antifungal activity against Blumeria graminis f. sp. tritici infected seven-day-old wheat seedlings assessed as disease control at 400 mg/l after 7 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID297522 | Antimicrobial activity against Fusarium solani at 3 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1081035 | Antifungal activity against Blumeria graminis assessed as inhibition at 400 mg/L relative to control | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and biological activity of new (E)-alpha-(Methoxyimino)benzeneacetate derivatives containing a substituted pyrazole ring. |
| AID297524 | Antimicrobial activity against Fusarium oxysporum at 30 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1666587 | Inhibition of porcine cytochrome b-c1 complex using DBH2 and cytochrome c as substrates by spectrophotometric based assay | 2020 | Bioorganic & medicinal chemistry, 03-01, Volume: 28, Issue:5 | N-(3,5-Dichloro-4-(2,4,6-trichlorophenoxy)phenyl)benzenesulfonamide: A new dual-target inhibitor of mitochondrial complex II and complex III via structural simplification. |
| AID1091309 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 1.5 ppm measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1091296 | Fungicidal activity against Blumeria graminis infected wheat plants exposed to compound treatment 1 day post infection assessed as disease curative activity at 0.78 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1080483 | Antifungal activity against Colletotrichum acutatum assessed as appearance of diffuse zone of inhibition at 2 mM in 2 uL solution by direct bio-autography assay | 2009 | Journal of agricultural and food chemistry, Jan-28, Volume: 57, Issue:2 | Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity. |
| AID1112826 | Fungicidal activity against Magnaporthe oryzae from perennial ryegrass | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1111104 | Antifungal activity against Blumeria graminis f. sp. tritici infected seven-day-old wheat seedlings assessed as disease control at 1.56 mg/l after 7 days relative to control | 2010 | Pest management science, Jan, Volume: 66, Issue:1 | Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles. |
| AID1091872 | Inhibition of Sus scrofa (pig) heart cytochrome bc1 complex using DBH2 as substrate by spectrophotometric analysis | 2010 | Journal of the American Chemical Society, Jan-13, Volume: 132, Issue:1 | Subnanomolar inhibitor of cytochrome bc1 complex designed by optimizing interaction with conformationally flexible residues. |
| AID1081032 | Antifungal activity against Blumeria graminis assessed as inhibition at 1.56 mg/L relative to control | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and biological activity of new (E)-alpha-(Methoxyimino)benzeneacetate derivatives containing a substituted pyrazole ring. |
| AID297548 | Antimicrobial activity against Fusarium proliferatum at 30 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID611601 | Competitive inhibition of pig heart Cytochrome b-c1 complex using DBH2 as substrate in presence of lauryl maltoside by Line-weaverBurk plot analysis | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc₁ complex inhibitors. |
| AID1105343 | Antifungal activity against Rhizoctonia solani assessed as inhibition of mycelium growth at 50 ug/ml relative to control | 2011 | Molecules (Basel, Switzerland), Oct-25, Volume: 16, Issue:11 | Design, synthesis and antifungal/insecticidal evaluation of novel cinnamide derivatives. |
| AID611607 | Activity of pig heart Cytochrome b-c1 complex using DBH2 as substrate by Line-weaverBurk plot analysis | 2011 | Bioorganic & medicinal chemistry, Aug-01, Volume: 19, Issue:15 | Design, syntheses, and kinetic evaluation of 3-(phenylamino)oxazolidine-2,4-diones as potent cytochrome bc₁ complex inhibitors. |
| AID297545 | Antimicrobial activity against Fusarium proliferatum at 0.3 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1111612 | Fungicidal activity against Cytospora mandshurica Miura under green house condition in presence of 98% compound | 2011 | Pest management science, Jun, Volume: 67, Issue:6 | Design, synthesis and structure-activity relationship of novel coumarin derivatives. |
| AID346924 | Inhibition of Mycosphaerella graminicola cytochrome bc1 complex inoculated in wheat plant assessed as lowest drug concentration required to control 100% disease applied to leaf 1 hr prior inoculation measured after 6 to 9 days | 2008 | Bioorganic & medicinal chemistry, Dec-15, Volume: 16, Issue:24 | The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D. |
| AID1111607 | Fungicidal activity against Cytospora mandshurica Miura at 1000 mg/L of 25% compound under field trials condition relative to untreated control | 2011 | Pest management science, Jun, Volume: 67, Issue:6 | Design, synthesis and structure-activity relationship of novel coumarin derivatives. |
| AID297523 | Antimicrobial activity against Fusarium oxysporum at 30 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1720719 | Inhibition of porcine heart Succinate-cytochrome c reductase complex 2 by measuring decrease in DCIP at 10 uM relative to control | 2020 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 30, Issue:16 | Design and synthesis of potent inhibitors of bc |
| AID1112829 | Fungicidal activity against Magnaporthe oryzae assessed as reduction of appressorium diameter of conidia at 0.01 to 1 mg/l at 26 degC measured after 7 days | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1091308 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 6.25 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1081038 | Antifungal activity against Pseudoperonospora cubensis assessed as inhibition at 400 mg/L relative to control | 2010 | Journal of agricultural and food chemistry, Mar-10, Volume: 58, Issue:5 | Synthesis and biological activity of new (E)-alpha-(Methoxyimino)benzeneacetate derivatives containing a substituted pyrazole ring. |
| AID297546 | Antimicrobial activity against Fusarium proliferatum at 3 uM after 48 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1091297 | Fungicidal activity against Blumeria graminis infected wheat plants exposed to compound treatment 1 day post infection assessed as disease curative activity at 3.12 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID299156 | Effect on growth of Raphanus sativus assessed as length of hypocotyl at 50 ug/mL by seed germination assay | 2007 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7 | Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations. |
| AID297516 | Antimicrobial activity against Fusarium oxysporum at 0.3 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID346923 | Inhibition of Blumeria graminis f. sp. Tritici cytochrome bc1 complex inoculated in wheat plant assessed as lowest drug concentration required to control 100% disease applied to leaf 1 hr prior inoculation measured after 6 to 9 days | 2008 | Bioorganic & medicinal chemistry, Dec-15, Volume: 16, Issue:24 | The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D. |
| AID1112825 | Fungicidal activity against Magnaporthe grisea | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1103207 | Antifungal activity against Macrophomina phaseolina isolate CE173 after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID297549 | Antimicrobial activity against Fusarium proliferatum at 30 uM after 72 hrs by microtiter assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1112827 | Fungicidal activity against Magnaporthe oryzae in five leaf stage carnaroli plants assessed as decrease in frequency of type 3 lesions at 0.01 to 1 mg/l | 2013 | Pest management science, Feb, Volume: 69, Issue:2 | Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae. |
| AID1103209 | Antifungal activity against Alternaria alternata (CE172) after 48 to 72 hr | 2004 | Journal of agricultural and food chemistry, Jun-02, Volume: 52, Issue:11 | Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. |
| AID1091292 | Fungicidal activity against Podosphaera fuliginea infected cucumber plants exposed to compound treatment 1 day post infection assessed as disease curative activity at 3.12 mg/L measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1091311 | Fungicidal activity against Blumeria graminis infected compound pre-treated wheat plants assessed as disease preventive activity at 6.2 ppm measured after 1 or 2 weeks | 2008 | Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15 | Synthesis and fungicidal activities of novel bis(trifluoromethyl)phenyl-based strobilurins. |
| AID1080485 | Antifungal activity against Colletotrichum fragariae assessed as inhibition of fungal growth at 2 mM in 2 uL solution by direct bio-autography assay | 2009 | Journal of agricultural and food chemistry, Jan-28, Volume: 57, Issue:2 | Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity. |
| AID297552 | Fungistatic activity against Fusarium solani at 30 uM after 72 hrs by microtiter plate assay | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347084 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Confirmatory Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347081 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Confirmatory Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347087 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Confirmatory Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347088 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): Viability assay - Alamar blue signal for LCMV Confirmatory Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1159585 | Biochemical screen of P. falciparum CDPK1 | 2016 | PloS one, , Volume: 11, Issue:3 | Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID1159586 | Biochemical screen of P. falciparum PK6 | 2016 | PloS one, , Volume: 11, Issue:3 | Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID1159589 | Biochemical screen of P. falciparum MAPK2 | 2016 | PloS one, , Volume: 11, Issue:3 | Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID1159588 | Biochemical screen of P. falciparum CDPK4 | 2016 | PloS one, , Volume: 11, Issue:3 | Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID1159587 | Biochemical screen of P. falciparum PK7 | 2016 | PloS one, , Volume: 11, Issue:3 | Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2004 | Journal of molecular biology, Jul-30, Volume: 341, Issue:1 | Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.29) | 18.2507 |
| 2000's | 68 (20.00) | 29.6817 |
| 2010's | 171 (50.29) | 24.3611 |
| 2020's | 100 (29.41) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (48.05) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 6 (1.75%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 336 (98.25%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||