ascorbic-acid and Rhinitis--Allergic--Seasonal

The effect of acute oral administration of 2 g vitamin C on bronchial responsiveness to inhaled histamine in 16 patients with allergic rhinitis was compared with placebo on two consecutive days in a double-blind, crossover design. The PC15FEV1 was significantly increased one hour after treatment with vitamin C but not after placebo.

Topics: Administration, Inhalation; Adult; Ascorbic Acid; Bronchi; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Maximal Expiratory Flow Rate; Rhinitis, Allergic, Seasonal

The effect of ascorbic acid (AA) on the skin wheal and flare response to histamine and allergen and on the nasal response to allergen was evaluated in eight adults with seasonal allergic rhinitis. The above parameters were measured after 3 days of AA administration (2 gm/day) and again after 3 days of a similar-appearing lactose placebo. An additional study was conducted in which six subjects took 0 (placebo), 1, 2, and 4 gm/day of AA to determine the dose-response effect of AA on histamine skin tests. Overall there was no difference in skin or nasal reactivity between AA and placebo regimens. The findings in this study suggest that AA in relatively high doses would have no beneficial effects on symptoms resulting from allergen exposure and that AA in doses of up to 4 gm/day will not suppress the histamine skin response.

Topics: Adult; Airway Resistance; Allergens; Ascorbic Acid; Dose-Response Relationship, Drug; Female; Histamine; Humans; Male; Middle Aged; Morphine; Placebos; Rhinitis, Allergic, Seasonal; Skin Tests

Topics: Administration, Oral; Adolescent; Adult; Aged; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Ascorbic Acid; Capsules; Child; Child, Preschool; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Nasal Decongestants; Nylidrin; Piperidines; Rhinitis; Rhinitis, Allergic, Seasonal; Rutin

Topics: Administration, Oral; Adult; Aged; Ascorbic Acid; Aspirin; Asthma; Drug Combinations; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperazines; Respiratory Insufficiency; Rhinitis, Allergic, Seasonal; Triamcinolone

Topics: Ascorbic Acid; Humans; Rhinitis, Allergic, Seasonal

Topics: Ascorbic Acid; Caffeine; Common Cold; Diphenhydramine; Humans; Immune Tolerance; Nasal Decongestants; Pheniramine; Phenylephrine; Rhinitis; Rhinitis, Allergic, Seasonal; Vasoconstrictor Agents