A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
ChEBI ID: 35942
| Member | Definition | Class |
|---|---|---|
| acamprosate | An organosulfonic acid that is propane-1-sulfonic acid substituted by an acetylamino group at position 3. | acamprosate |
| ambenonium chloride | A symmetrical oxalamide-based bis-quaternary ammonium salt having ethyl and 2-chlorobenzyl groups attached to the nitrogens. | ambenonium chloride |
| angiotensin i | A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids. | angiotensin I dizwitterion; angiotensin I |
| angiotensin i, ile(5)- | A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids. | angiotensin I dizwitterion; angiotensin I |
| n-methylaspartate | An aspartic acid derivative having an N-methyl substituent and D-configuration. | N-methyl-D-aspartic acid |
| strychnine | A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position. | strychnine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4,283 (22.34) | 18.7374 |
| 1990's | 5,855 (30.53) | 18.2507 |
| 2000's | 4,739 (24.71) | 29.6817 |
| 2010's | 3,453 (18.01) | 24.3611 |
| 2020's | 846 (4.41) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 337 (1.67%) | 5.53% |
| Reviews | 1,084 (5.37%) | 6.00% |
| Case Studies | 176 (0.87%) | 4.05% |
| Observational | 6 (0.03%) | 0.25% |
| Other | 18,599 (92.07%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 19.4092 | 4 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.1199 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.4871 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 7.7619 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 21.1923 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.2048 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 2.5929 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 5.3538 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0141 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 78.1171 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 2 | 2 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 2 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 11.1400 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 6.2000 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 11.1400 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 6.2000 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 11.1400 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 6.2000 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 11.1400 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 6.2000 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 11.1400 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 6.2000 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 11.1400 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 6.2000 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 11.1400 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 6.2000 | 2 | 2 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 0.1843 | 14 | 20 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | Ki | 0.0503 | 3 | 3 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Glycine receptor subunit beta | Homo sapiens (human) | IC50 | 0.2871 | 6 | 9 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 35.0267 | 6 | 6 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | EC50 | 52.2867 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | EC50 | 34.6200 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | EC50 | 34.9533 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | EC50 | 30.0533 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | EC50 | 40.9300 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | EC50 | 40.9300 | 2 | 2 |
| Taste receptor type 2 member 10 | Homo sapiens (human) | EC50 | 22.5000 | 2 | 2 |
| Taste receptor type 2 member 46 | Homo sapiens (human) | EC50 | 0.6900 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit rho-1 | Homo sapiens (human) | Kb | 69.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit rho-2 | Homo sapiens (human) | Kb | 69.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit rho-3 | Homo sapiens (human) | Kb | 69.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | ED50 | 15.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | ED50 | 15.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | ED50 | 15.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | ED50 | 15.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | ED50 | 15.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | ED50 | 15.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | ED50 | 15.0000 | 1 | 1 |
| Renin | Homo sapiens (human) | Km | 50.0000 | 1 | 1 |
| Taste receptor type 2 member 10 | Homo sapiens (human) | Activity | 1.5500 | 2 | 2 |