ascorbic-acid and alliin

ascorbic-acid has been researched along with alliin* in 2 studies

Other Studies

2 other study(ies) available for ascorbic-acid and alliin

Article	Year
S-alkenyl cysteine sulfoxide and its antioxidant properties from Allium cepa var. tropeana (red onion) seeds. Journal of natural products, 2008, Volume: 71, Issue:12 A new cysteine sulfoxide, (S(S)R(C))-S-(3-pentenyl)-L-cysteine sulfoxide (1), was identified from the seeds of Allium cepa var. tropeana, together with the known methiin, etiin, alliin, isoalliin, propiin, and butiin. The structure of compound 1 was established by analysis of its physical and spectroscopic data. The antioxidant activity of an extract containing cysteine sulfoxides and compound 1 was evaluated using the FRAP and DPPH tests. Topics: Antioxidants; Biphenyl Compounds; Cysteine; Italy; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Onions; Picrates; Seeds; Sulfoxides	2008
Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutrition and cancer, 2005, Volume: 53, Issue:1 Alliin, a compound derived from garlic, demonstrated dose-dependent inhibition of fibroblast growth factor-2 (FGF2)-induced human endothelial cell (EC) tube formation and angiogenesis in the chick chorioallantoic membrane (CAM) model. Additionally, alliin demonstrated potent inhibition of vascular endothelial growth factor (VEGF)-induced angiogenesis in the CAM model. The antioxidant vitamins C and E significantly (P < 0.001) enhanced the inhibitory efficacy of alliin on FGF2-induced EC tube formation and angiogenesis. Alliin significantly increased (P < 0.01) nitric oxide (NO) release into the CAM fluid, which was further enhanced by vitamins C and E. The NO synthesis inhibitor nitro-L-arginine methyl ester (L-NAME) reversed the anti-angiogenesis efficacy of alliin in the CAM model. Vitamins C and E significantly enhanced the anticancer efficacy of alliin in inhibiting colon and fibrosarcoma tumor growth. Alliin significantly inhibited both FGF2 and VEGF secretion from human fibrosarcoma cells in a concentration-dependent manner. Additionally, alliin up-regulated the p53 production in FGF2-stimulated EC. These data indicated a synergistic effect of antioxidants on the anti-angiogenesis and anticancer efficacy of alliin. These data also suggest the implication of cellular NO and p53 as mediators of anti-angiogenesis and anticancer effects of alliin. Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Chick Embryo; Chorioallantoic Membrane; Cysteine; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Growth Factors; Endothelium, Vascular; Garlic; Humans; Models, Animal; Nitric Oxide; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin E	2005

Article

Year

S-alkenyl cysteine sulfoxide and its antioxidant properties from Allium cepa var. tropeana (red onion) seeds.

Journal of natural products, 2008, Volume: 71, Issue:12

A new cysteine sulfoxide, (S(S)R(C))-S-(3-pentenyl)-L-cysteine sulfoxide (1), was identified from the seeds of Allium cepa var. tropeana, together with the known methiin, etiin, alliin, isoalliin, propiin, and butiin. The structure of compound 1 was established by analysis of its physical and spectroscopic data. The antioxidant activity of an extract containing cysteine sulfoxides and compound 1 was evaluated using the FRAP and DPPH tests.

Topics: Antioxidants; Biphenyl Compounds; Cysteine; Italy; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Onions; Picrates; Seeds; Sulfoxides

2008

Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53.

Nutrition and cancer, 2005, Volume: 53, Issue:1

Alliin, a compound derived from garlic, demonstrated dose-dependent inhibition of fibroblast growth factor-2 (FGF2)-induced human endothelial cell (EC) tube formation and angiogenesis in the chick chorioallantoic membrane (CAM) model. Additionally, alliin demonstrated potent inhibition of vascular endothelial growth factor (VEGF)-induced angiogenesis in the CAM model. The antioxidant vitamins C and E significantly (P < 0.001) enhanced the inhibitory efficacy of alliin on FGF2-induced EC tube formation and angiogenesis. Alliin significantly increased (P < 0.01) nitric oxide (NO) release into the CAM fluid, which was further enhanced by vitamins C and E. The NO synthesis inhibitor nitro-L-arginine methyl ester (L-NAME) reversed the anti-angiogenesis efficacy of alliin in the CAM model. Vitamins C and E significantly enhanced the anticancer efficacy of alliin in inhibiting colon and fibrosarcoma tumor growth. Alliin significantly inhibited both FGF2 and VEGF secretion from human fibrosarcoma cells in a concentration-dependent manner. Additionally, alliin up-regulated the p53 production in FGF2-stimulated EC. These data indicated a synergistic effect of antioxidants on the anti-angiogenesis and anticancer efficacy of alliin. These data also suggest the implication of cellular NO and p53 as mediators of anti-angiogenesis and anticancer effects of alliin.

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Chick Embryo; Chorioallantoic Membrane; Cysteine; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Growth Factors; Endothelium, Vascular; Garlic; Humans; Models, Animal; Nitric Oxide; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin E

2005