| ID Source | ID |
|---|---|
| PubMed CID | 3002190 |
| CHEMBL ID | 1136 |
| CHEBI ID | 29688 |
| SCHEMBL ID | 5100 |
| MeSH ID | M0278116 |
| Synonym |
|---|
| nsc 758940 |
| ki8h7h19wl , |
| unii-ki8h7h19wl |
| telithromycin [usan:inn:ban] |
| (3as,4r,7r,9r,10r,11r,13r,15r,15ar)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-(4-(4-(pyridin-3-yl)-1h-imidazol-1-yl)butyl)-10-((3,4,6-trideoxy-3-(dimethylamino)-b-d-xylo-hexopyranosyl)oxy)octahydro-2h-oxacyclotetradecino(4,3-d)oxazole-2,6,8,14(1h,7h |
| (1r,2r,4r,6r,7r,8r,10r,13r,14s)-7-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetr |
| 11,12-dideoxy-3-des(2,6-dideoxy-3-c,3-o-dimethyl-alpha-l-altropyranosyloxy)-6-o-methyl-3-oxo-12,11-(oxycarbonylimino)-n11-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]erythromycin a |
| erythromycin, 3-de[(2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy]-11,12-dideoxy-6-o-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1h-imidazol-1-yl]butyl]imino]]- |
| ketek |
| hmr3647 |
| DB00976 |
| ru 66647 |
| hmr 3647 |
| hsdb 7359 |
| erythromycin, 3-de((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyl)oxy)-11,12-dideoxy-6-o-methyl-3-oxo-12,11-(oxycarbonyl((4-(4-(3-pyridinyl)-1h-imidazol-1-yl)butyl)imino))- |
| CHEMBL1136 |
| nsc-758940 |
| tox21_112203 |
| dtxsid3046455 , |
| tox21_111454 |
| dtxcid1026455 |
| cas-191114-48-4 |
| bdbm50378137 |
| telithromycin [jan] |
| telithromycin [hsdb] |
| telithromycin [vandf] |
| telithromycin [orange book] |
| erythromycin,3-de((2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy)-11,12-dideoxy-6-o-methyl-3-oxo-12,11-(oxycarbonyl((4-(4-(3-pyridinyl)-1h-imidazol-1-yl)butyl)imino)- |
| telithromycin [usan] |
| telithromycin [mi] |
| telithromycin [ema epar] |
| telithromycin [inn] |
| telithromycin [mart.] |
| telithromycin [who-dd] |
| HY-A0062 |
| SCHEMBL5100 |
| CHEBI:29688 |
| (3as,4r,7r,9r,10r,11r,13r,15r,15ar)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-{4-[4-(pyridin-3-yl)-1h-imidazol-1-yl]butyl}tetradecahydro-2h-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-he |
| hmr-3647;ru-66647 |
| Q2736135 |
| 2h-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1h,7h,9h)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1h-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl]oxy]-, (3as,4r,7r,9r,10r, |
| (1s,2r,5r,7r,8r,9r,11r,13r,14r)-8-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-15-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone |
| telithromycinum |
| erythromycin,3-de((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyl)oxy)-11,12-dideoxy-6-o-methyl-3-oxo-12,11-(oxycarbonyl((4-(4-(3-pyridinyl)-1h-imidazol-1-yl)butyl)imino)- |
| (1s,2r,5r,7r,8r,9s,11r,13r,14r)-8-((2s,3r,4s,6r)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-15-(4-(4-pyridin-3-ylimidazol-1-yl)butyl)-3,17-dioxa-15-azabicyclo(12.3.0)heptadecane-4,6,12,16-tetrone |
| telithromycine |
| j01fa15 |
| 3-de((2,6-didexyl-3-c-methyl-3-o-methyl-alpha-l-ribohexopyranosyl)oxy)-11,12-dideoxy-6-o-methyl-3-oxo-12,11-(oxycarbonyl((4-(4-(3-pyridinyl)-1h-imidazol-1-yl)butyl)imino))erythromycin |
| telitromicina |
| telithromycin (mart.) |
HMR 3647 appears to be a very promising agent for the treatment of respiratory infections and is currently in clinical trials.
| Excerpt | Reference | Relevance |
|---|---|---|
| "HMR 3647 appears to be a very promising agent for the treatment of respiratory infections and is currently in clinical trials." | ( Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. Agouridas, C; Auger, JM; Benedetti, Y; Bonnefoy, A; Bretin, F; Chantot, JF; D'Ambrières, SG; Denis, A; Dussarat, A; Fromentin, C; Lachaud, S; Laurin, P; Le Martret, O; Loyau, V; Pejac, JM; Perron, S; Tessot, N, 1999) | 1.29 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | ( Developing structure-activity relationships for the prediction of hepatotoxicity. Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) | 0.36 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " To assess this, the pharmacokinetic parameters of telithromycin were compared after intravenous and oral administration (50 mg/kg)." | ( Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. Cho, YK; Jung, YS; Kim, YC; Lee, JH; Lee, MG, 2008) | 0.35 |
| " pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data." | ( Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Lombardo, F; Obach, RS; Waters, NJ, 2008) | 0.35 |
| " It has good preclinical pharmacokinetic properties across multiple species and potent in vitro and in vivo activity against respiratory tract infection pathogens, including Haemophilus influenzae, atypical organisms (e." | ( Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. Jiang, LJ; Or, YS; Wang, M, 2009) | 0.35 |
| " The objective of the present study was to determine the plasma and intrapulmonary pharmacokinetic parameters of orally administered S-013420 in healthy volunteers." | ( Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. Furuie, H; Saisho, Y; Shimada, J; Yoshikawa, T, 2010) | 0.36 |
| "Synthesis, antibacterial activity and pharmacokinetic properties of a novel class of macrolide antibiotics-macrolones-derived from azithromycin, comprising oxygen atom(s) in the linker and either free or esterified quinolone 3-carboxylic group, are reported." | ( Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. Alihodžić, S; Antolović, R; Eraković Haber, V; Fajdetić, A; Filić, D; Jakopović, IP; Kapić, S; Košutić-Hulita, N; Modrić, M; Mutak, S; Padovan, J; Paljetak, HČ; Schoenfeld, ZI; Spaventi, R; Vinter, A, 2011) | 0.37 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Human oral bioavailability is an important pharmacokinetic property, which is directly related to the amount of drug available in the systemic circulation to exert pharmacological and therapeutic effects." | ( Hologram QSAR model for the prediction of human oral bioavailability. Andricopulo, AD; Moda, TL; Montanari, CA, 2007) | 0.34 |
| " The isopropyl ester, compound 35, and a macrolone derivative with an elongated linker 29 showed the best oral bioavailability in rats, both accompanied with an excellent overall microbiology profile addressing inducible and constitutive MLSb as well as efflux mediated macrolide resistance in streptococci, while compound 29 is more potent against staphylococci." | ( Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. Alihodžić, S; Antolović, R; Eraković Haber, V; Fajdetić, A; Filić, D; Jakopović, IP; Kapić, S; Košutić-Hulita, N; Modrić, M; Mutak, S; Padovan, J; Paljetak, HČ; Schoenfeld, ZI; Spaventi, R; Vinter, A, 2011) | 0.37 |
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| Excerpt | Relevance | Reference |
|---|---|---|
| ", 100-, 200-, 400-, 800-, or 1,200-mg dosing groups) consisting of eight subjects (six active and two placebo) each." | ( Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. Jiang, LJ; Or, YS; Wang, M, 2009) | 0.35 |
| " Twenty-eight healthy Japanese male subjects who never smoked were randomly allocated to seven groups of four subjects each who underwent bronchoalveolar lavage (BAL) at different times after dosing (2, 4, 6, 8, 10, 12, or 24 h)." | ( Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. Furuie, H; Saisho, Y; Shimada, J; Yoshikawa, T, 2010) | 0.36 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| TDP1 protein | Homo sapiens (human) | Potency | 10.3646 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| AR protein | Homo sapiens (human) | Potency | 25.0801 | 0.0002 | 21.2231 | 8,912.5098 | AID743035; AID743042; AID743054; AID743063 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 0.5012 | 0.0123 | 7.9835 | 43.2770 | AID1346984 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 0.7943 | 0.0054 | 28.0263 | 1,258.9301 | AID1346985 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 19.4896 | 0.0002 | 29.3054 | 16,493.5996 | AID743075; AID743079; AID743080; AID743091 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.8493 | 0.0007 | 23.0674 | 1,258.9301 | AID743085; AID743122 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 0.1000 | 9.1916 | 31.6228 | AID1346983 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 21.1317 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743067 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 0.6315 | 4.4531 | 9.3000 | AID1473740 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 (µMol) | 7.1000 | 0.2000 | 5.6774 | 10.0000 | AID1473741 |
| Bile salt export pump | Homo sapiens (human) | IC50 (µMol) | 13.0000 | 0.1100 | 7.1903 | 10.0000 | AID1443980; AID1443986; AID1473738 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 (µMol) | 40.0000 | 0.0001 | 0.7298 | 10.0000 | AID440649 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0009 | 1.9014 | 10.0000 | AID440649 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 (µMol) | 133.0000 | 2.4100 | 6.3433 | 10.0000 | AID1473739 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 (µMol) | 5.8884 | 0.1047 | 2.7195 | 7.0795 | AID977603 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 (µMol) | 3.4674 | 0.0500 | 2.3797 | 9.7000 | AID977600 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| 30S ribosomal protein S6 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S7 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L15 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L10 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L11 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L7/L12 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L19 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L1 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L20 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L27 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L28 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L29 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L31 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L31 type B | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L32 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L33 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L34 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L35 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L36 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S10 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S11 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S12 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S13 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S16 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S18 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S19 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S20 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S2 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S3 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S4 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S5 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S8 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S9 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L13 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L14 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L16 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L23 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S15 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L17 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L21 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L30 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L6 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S14 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S17 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S1 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L18 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | EC50 (µMol) | 132.0000 | 0.0070 | 3.4540 | 10.0000 | AID1646215 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | EC50 (µMol) | 132.0000 | 0.0070 | 2.2587 | 9.4000 | AID1646215 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Kd | 0.0064 | 0.0002 | 1.2965 | 10.0000 | AID1164325 |
| 50S ribosomal protein L2 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L3 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L24 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L4 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L22 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L5 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 30S ribosomal protein S21 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L25 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| 50S ribosomal protein L36 2 | Escherichia coli K-12 | Kd | 0.0064 | 0.0006 | 0.0231 | 0.0840 | AID1164325 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID86119 | In vitro antibacterial activity against Haemophilus influenzae GYR1435 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID1549373 | Selectivity ratio of MBC to MIC for Streptococcus pneumoniae 07P390 expressing constitutive ermB gene | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID508372 | Antibacterial activity against Streptococcus pneumoniae harboring erm(B) and mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1549371 | Selectivity ratio of MBC to MIC for penicillin-susceptible Streptococcus pneumoniae PU 09 expressing mef gene | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID531454 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID369437 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID528731 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID499552 | Antibacterial activity against efflux-resistant Staphylococcus aureus B0331 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID1549364 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC49619 assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID261781 | Antibacterial activity against Streptococcus pneumoniae ATCC 6301 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID508382 | Antibacterial activity against Streptococcus pyogenes harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1691388 | Antibacterial activity against Erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 assessed as reduction in microbial growth | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID519205 | Antibacterial activity against Streptococcus pneumoniae by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID781260 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 11-20 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID562612 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1439721 | Ratio of MBC to MIC for penicillin-susceptible Streptococcus pneumoniae PU09 | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID283557 | Antimicrobial activity against Streptococcus pneumoniae R6 with L4 69GTG71 to TPS mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID1443986 | Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-taurocholic acid uptake in to vesicles preincubated for 5 mins followed by ATP/AMP addition measured after | 2014 | Hepatology (Baltimore, Md.), Sep, Volume: 60, Issue:3 | Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. |
| AID523012 | Ratio of Kcat to Km for macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID501300 | Antibacterial activity against inducible resistance to macrolide, licosamide and streptogramin Streptococcus pyogenes 2 Finland by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID519988 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID508401 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 3665 harboring mef(A) gene after 14 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID519329 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT04 carrying duplication in the carboxy-terminal region of L22 ribosomal protein | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID1245713 | Antimicrobial activity against azithromycin-susceptible and ampicillin-resistant Haemophilus influenzae 11P037 incubated for 20 to 24 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID539507 | Antibacterial activity against efflux-resistant Staphylococcus aureus B0331 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID562363 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1549387 | Antibacterial activity against Streptococcus pyogenes 12-207 expressing mef gene assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1550836 | Antimicrobial activity against inducibly erythromycin-resistant and methicillin resistant Staphylococcus aureus PU32 expressing i-ermA incubated in CAMHB medium for 20 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID283553 | Antimicrobial activity against Streptococcus pneumoniae PC13 isolate with L4 mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID261479 | Antibacterial activity against Streptococcus pneumoniae Mef 3449 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID567806 | Antibacterial activity against erythromycin-susceptible Haemophilus influenzae 07O339 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID508407 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1076 harboring erm(B) and mef(A) gene after 18 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID717684 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 09A011 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID1549379 | Bactericidal activity against MLS/methicillin-resistant Staphylococcus aureus PU 32 expressing inducible ermA gene pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID674453 | Antibacterial activity against macrolide-resistant Staphylococcus aureus ATCC 33591 constitutively expressing ermA | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and antibacterial activity of desosamine-modified macrolide derivatives. |
| AID528714 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus capitis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID423236 | Antibacterial activity against Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID428138 | Antimicrobial activity against telithromycin-resistant Streptococcus pneumoniae isolate P1501016 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID519994 | Antimicrobial activity against Streptococcus pneumoniae harboring erm(B) gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID270430 | Antibacterial activity against Streptococcus pyogenes 8668 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID132625 | The compound was tested in vivo for antibacterial activity against AmpR beta(-) Haemophilus influenza 351TO19 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID528723 | Antibacterial activity against Streptococcus constellatus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID283555 | Antimicrobial activity against Streptococcus pneumoniae R6 transformants | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID539506 | Antibacterial activity against erythromycin A-susceptible Streptococcus pneumoniae B0541 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID429065 | Antiplasmodial activity after 96 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID508370 | Antibacterial activity against Streptococcus pneumoniae harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID572272 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6301 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1459108 | Antibacterial activity against constitutively macrolide/lincosamide/streptogramin B-resistant Streptococcus pneumoniae by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID369229 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent resistant isolates by CLSI breakpoint method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID508470 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2011 harboring mef(A) gene after 35 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID132635 | The compound was tested in vivo for antibacterial activity against inducibly erythromycin resistant Streptococcus pneumoniae 030RO1 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID558087 | Antimicrobial activity against Ureaplasma parvum isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID735597 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes A3 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID528732 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus saprophyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID475105 | Antibacterial activity against Haemophilus influenzae 3 after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID244992 | Minimum inhibitory concentration of compound against Ery-R Staphylococcus aureus 96:11480 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID261503 | Antibacterial activity against Streptococcus pneumoniae Erm 8919 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1245711 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus PU32 expressing inducible ermA incubated for 20 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID261467 | Antibacterial activity against Haemophilus influenzae 49247 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID637558 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 162 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID270429 | Antibacterial activity against Enterococcus faecalis bc11148-2 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID440643 | Antibacterial activity against multidrug-resistant Streptococcus pyogenes 1079 harboring ermB gene by NCCLS method | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID531461 | Antibacterial activity against Streptococcus pneumoniae serotype 22 assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID508371 | Antibacterial activity against Streptococcus pneumoniae harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1550825 | Antimicrobial activity against Staphylococcus epidermidis E1 incubated in CAMHB medium for 20 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID1459127 | Volume of distribution at steady state in Han Wistar rat at 10 mg/kg, iv by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID422687 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3413 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID555117 | Distribution half life in healthy human at 400 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID245669 | Minimum inhibitory concentration of the compound against 3 erythromycin-susceptible Streptococcus pneumoniae OC4421 with an mef(A) efflux-mediated resistance was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID501675 | Antimicrobial activity against Streptococcus pneumoniae 58 spain by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID567804 | Antibacterial activity against erythromycin-susceptible Haemophilus influenzae ATCC 49247 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID508373 | Antibacterial activity against Streptococcus pneumoniae harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID508384 | Antibacterial activity against Streptococcus pyogenes harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID572270 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 13709 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID508393 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 1077 after 29 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID558593 | Antimicrobial activity against Streptococcus pneumoniae 5 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID510558 | Antimicrobial activity against Chlamydia trachomatis after 72 hrs by fluorescence assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. |
| AID518992 | Nonrenal clearance in Sprague-Dawley rat at 50 mg/kg, iv pretreated with Escherichia coli lipopolysaccharide (Rvb=27.2 +/- 5.02 ml/min/kg) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID299385 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus OC4172 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID440650 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae 1095 harboring ermB infected in po dosed mouse respiratory tract model assessed as survival administered 18 hrs postinfection BID for 2 days measured on day 10 postinfection | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID79583 | In Vitro antibacterial activity against H. flu DILL (Amp-R strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID520397 | Antibacterial activity against erm(B) and mef(E)-positive Streptococcus pneumoniae isolate Spain 6B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID372548 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b with an amino acid substitution in variable mutated locus Asn-526 or Arg-517 of ftsI gene by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID261500 | Antibacterial activity against Streptococcus pneumoniae Erm 7985 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID425978 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 24 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1549380 | Selectivity ratio of MBC to MIC for MLS/methicillin-resistant Staphylococcus aureus PU 32 expressing inducible ermA gene | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID244994 | Minimum inhibitory concentration of compound against Ery-S Streptococcus pneumoniae 3773 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID423099 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID528737 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID261786 | Antibacterial activity against macrolide resistant Streptococcus pneumoniae ATCC 700906 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID1439739 | Ratio of MBC to MIC against erythromycin-susceptible Moraxella catarrhalis 11B366 | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID1691389 | Bactericidal activity against Erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID1439742 | Ratio of MBC to MIC against erythromycin-susceptible Moraxella catarrhalis 13L332 | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID572487 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae ATCC 700677 infected in po dosed BALB/c mouse administered twice daily for 3 days | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1439724 | Ratio of MBC to MIC for Streptococcus pyogenes 01-968 expressing inducible ermA | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID244965 | Minimum inhibitory concentration of compound against Ery-R Streptococcus pyogenes 3262 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID520395 | Antibacterial activity against erm(B) and mef(E)-positive Streptococcus pneumoniae isolate Sweden 15A-25 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID508365 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1868039 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID712423 | Antibacterial activity against wild type Escherichia coli DK/pKK3535 in presence of ethanol | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID425335 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID425964 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3274 after 48 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID562361 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID299386 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae OC9132 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID208145 | In vivo antibacterial activity against Streptococcus pneumoniae strain 6396 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID1498832 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 11G364 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID1245712 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus PU20 expressing constitutive ermC incubated for 20 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID499559 | Antibacterial activity against efflux-resistant Streptococcus pyogenes B0545 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID260949 | Antibacterial activity against Haemophilus influenzae OC4882 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID1550839 | Antimicrobial activity against erythromycin-susceptible Moraxella catarrhalis 13L332 incubated in CAMHB medium for 20 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID519992 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium nosocomial isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID554542 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC958 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID508366 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID440648 | Inhibition of CYP3A in human liver microsomes assessed as hydroxymidazolam formation by time dependent inhibition assay | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID1164325 | Binding affinity to Escherichia coli ribosomes after 2 hrs by fluorescence polarization assay in presence of BODIPY-labeled erythromycin A | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9 | Desmethyl macrolides: synthesis and evaluation of 4-desmethyl telithromycin. |
| AID372547 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-susceptible Haemophilus influenzae type b without amino acid substitutions in ftsI gene and bla gene by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID423104 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID261498 | Antibacterial activity against Streptococcus pneumoniae Erm 5415 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID642855 | Antibacterial activity against constitutive MLS resistant Staphylococcus aureus by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID508375 | Antibacterial activity against quinolone-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID508423 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2686 harboring mutation in L4 ribosomal protein after 25 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID206750 | In vitro antibacterial activity against Staphylococcus aureus strain ATCC 6538P. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID519990 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID429069 | Relative activity against Plasmodium falciparum 3D7 as IC50 ratio after 48 and 96 hrs | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID519998 | Antimicrobial activity against Streptococcus pyogenes | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID261515 | Oral bioavailability in Sprague-Dawley rat at 100 mg/kg, po | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID270428 | Antibacterial activity against Enterococcus faecalis 29212 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID555113 | AUC (0 to infinity) in healthy human at 400 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID523010 | Activity at macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID528711 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus saprophyticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID429071 | Antiplasmodial activity against Plasmodium falciparum 3D7 as late trophozoite to early schizont arrest at IC50 after 48-120 hrs by giemsa stain | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID501671 | Antimicrobial activity against Streptococcus pneumoniae SP030 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID263391 | Antibacterial activity against Haemophilus influenzae OC4882 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID508436 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 3009 harboring mutation in 23S rRNA after 20 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1245708 | Antimicrobial activity against Streptococcus pneumoniae 07P390 expressing constitutive ermB incubated for 20 to 24 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID300824 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 1068 in mouse soft tissue infection model assessed as reduction in bacterial count at 100 mg/kg, po after 24 hrs | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Novel tethers in ketolide antibiotics. |
| AID425337 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID1868049 | Intrinsic clearance in human liver microsomes at 1 uM by LC-MS/MS analysis | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID508368 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID531450 | Antibacterial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1439731 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus PU20 expressing constitutive ermC after 20 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID499551 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Staphylococcus aureus B0330 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID518964 | Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZalpha reporter plasmid at 1.5 mg/ml after 36 hrs at 37 degC by disc-based beta-galactosidase reporter gene assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID483700 | Antimicrobial activity against inducible macrolide and constitutive lincosamide, streptogramin-resistant Streptococcus pyogenes 166 GR-micro | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID562406 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID669598 | Antibacterial activity against wild type Escherichia coli DK/pKK3535 | 2012 | ACS medicinal chemistry letters, Mar-08, Volume: 3, Issue:3 | Desmethyl Macrolides: Synthesis and Evaluation of 4,10-Didesmethyl Telithromycin. |
| AID283554 | Antimicrobial activity against Streptococcus pneumoniae PC13 isolate with L4 69GTG71 to TPS mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID276841 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4051 containing erm(B) | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID523011 | Inhibition of macrolide 2'-phosphotransferase 1 by PK/LDH-coupled assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | Nucleotide selectivity of antibiotic kinases. |
| AID1164319 | Antimicrobial activity against Escherichia coli SQ171/2058G harboring ribosome A2058G mutant | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9 | Desmethyl macrolides: synthesis and evaluation of 4-desmethyl telithromycin. |
| AID1439730 | Ratio of MBC to MIC for azithromycin susceptible/ampicillin-resistant Haemophilus influenzae 11P307 | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID369435 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID502240 | Antibacterial activity against inducible resistance to macrolide and constitutive resistance to lincosamide Streptococcus pneumoniae 134 GR M by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID206554 | In vivo antibacterial activity against Staphylococcus aureus strain 10649 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID208605 | The compound was tested in vitro for antibacterial activity against inducibly erythromycin resistant Streptococcus pneumoniae 030J5i. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID263388 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 6301 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID528735 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus capitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID558589 | Antimicrobial activity against Streptococcus pneumoniae 1 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID501297 | Antibacterial activity against efflux-mediated macrolide-resistance Streptococcus pyogenes 2 Finland by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID508471 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2011 harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID510554 | Antimicrobial activity against Chlamydophila pneumoniae infected in human Hep2 cells after 72 hrs by fluorescence assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | |||
| AID508381 | Antibacterial activity against macrolide-susceptible Streptococcus pyogenes after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID582683 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 assessed as concentration required to no apparent bacterial growth after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID717678 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 09H071 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID567791 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID508399 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 24 harboring erm(B) gene after 14 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID747243 | Antibacterial activity against drug-resistant Staphylococcus epidermidis by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID781250 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 12-14 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID1459111 | Antibacterial activity against constitutively macrolide/lincosamide/streptogramin B-resistant Staphylococcus aureus by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID1550828 | Bactericidal activity against mef-encoded erythromycin resistant Streptococcus pneumoniae PU09 assessed as reduction in colony formation incubated in CAMHB medium for 20 to 24 hrs followed by 24 hrs subculturing in the medium without test compound | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID562408 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID519203 | Antibacterial activity against Streptococcus pneumoniae assessed as susceptible isolates by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID531449 | Antibacterial activity against Streptococcus pneumoniae serotype 23A assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID261800 | Antibacterial activity against Haemophilus influenzae EH003 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID369446 | Antimicrobial activity against Streptococcus group A after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1646211 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae | 2020 | Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12 | Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics. |
| AID528736 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus auricularis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID717675 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 09U070 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID422655 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 after 14 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID567795 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 07R066 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID425988 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 29 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID528708 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1498840 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis ATCC 12228 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID557651 | Antimicrobial activity against Mycobacterium abscessus isolate MC879 at day 7 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID422644 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 after 44 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1549386 | Selectivity ratio of MBC to MIC for MLS-resistant Streptococcus pyogenes 12-206 expressing constitutive ermA gene | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1459141 | Protein binding in mouse plasma at 1 ug/ml by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID1691390 | Ratio of MBC to MIC against Erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID519993 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID422690 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3413 after 30 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1498839 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID501287 | Antibacterial activity against Moraxella catarrhalis ATCC 23246 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID520393 | Antibacterial activity against mef-positive Streptococcus pneumoniae isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID775001 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis ATCC 12228 by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. |
| AID519334 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT11 carrying rplD and rplV mutant genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID588209 | Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset | 2010 | Chemical research in toxicology, Jul-19, Volume: 23, Issue:7 | Developing structure-activity relationships for the prediction of hepatotoxicity. |
| AID539505 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pneumoniae B0627 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID637568 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 5051 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | |||
| AID132632 | The compound was tested in vivo for antibacterial activity against erythromycin susceptible Streptococcus pneumoniae 032UC1 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID425340 | Antibacterial activity against quinolone-susceptible Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID669597 | Antibacterial activity against Escherichia coli SQ171 harboring 23S rRNA A2058G mutant | 2012 | ACS medicinal chemistry letters, Mar-08, Volume: 3, Issue:3 | Desmethyl Macrolides: Synthesis and Evaluation of 4,10-Didesmethyl Telithromycin. |
| AID208143 | In vivo antibacterial activity against Streptococcus pneumoniae strain 5649 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID245598 | Minimum inhibitory concentration of the compound against erythromycin-susceptible Staphylococcus aureus Smith OC4172 in 50% mouse serum was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID425985 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 20 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID210385 | In vitro antibacterial activity against Streptococcus pneumoniae 5979 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID369438 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1549395 | Systemic plasma clearance in Sprague-Dawley rat at 20 mg/kg, po after 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID206352 | The compound has been evaluated for the antibacterial activity against Staphylococcus aureus EryRc 011CB20 strains | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID781263 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 12-32 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID519204 | Antibacterial activity against Streptococcus pneumoniae assessed as resistant isolates by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | In vitro activity of AR-709 against Streptococcus pneumoniae. |
| AID735589 | Antibacterial activity against methicillin-resistant, coagulase-negative, MLS-resistant (inducible) Staphylococcus epidermidis E3 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID131226 | Mouse protection tests for effective dose against Streptococcus pneumoniae 6303 ((erythromycin susceptible strain)) infected mice | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID425336 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID519000 | Drug excretion in Sprague-Dawley rat urine assessed as unchanged drug at 50 mg/kg, iv after 24 hrs pretreated with Escherichia coli lipopolysaccharide (Rvb=16.5 +/- 2.32 %) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID475095 | Antibacterial activity against Streptococcus pneumoniae 7 expressing constitutive ermB methylase after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID518994 | AUC in Sprague-Dawley rat at 50 mg/kg, po pretreated with Escherichia coli lipopolysaccharide (Rvb=609 +/- 323 ug/min/ml) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID283552 | Antimicrobial activity against Streptococcus pneumoniae PC13 isolate with erm(B) mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID206282 | In vitro antibacterial activity against Staphylococcus aureus 1775 (methicillin-resistant strain(MRSA)) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID261505 | Antibacterial activity against Streptococcus pneumoniae Erm 10279 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID423237 | Antibacterial activity against beta lactamase-positive Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID261517 | Efficacy against Streptococcus pneumoniae Erm in Sprague-Dawley rat lung infection model at 100 mg/kg | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID428240 | Increase in dimethylation at position A2058 of 23S rRNA of Streptococcus pneumoniae isolate P1501016 at 0.008 ug/ml by phosphorimager scanning relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID1459136 | Tmax in Han Wistar rat at 20 mg/kg, po by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID206743 | In vitro antibacterial activity against Staphylococcus aureus NCTC 10649M strain | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID300908 | Antibacterial activity against erm containing Streptococcus pyogenes 1079 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID674452 | Antibacterial activity against macrolide-susceptible Staphylococcus aureus ATCC 29213 | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14 | Synthesis and antibacterial activity of desosamine-modified macrolide derivatives. |
| AID781254 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 12-1 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID567801 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID1245730 | Ratio of MBC to MIC against methicillin-resistant Staphylococcus aureus PU20 expressing constitutive ermC | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID637566 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 5099 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID717686 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 09L075 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID502378 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 8902 expressing ermB by the broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | A new series of macrolide derivatives with 4''-O-saccharide substituents. |
| AID322975 | Cmax in mouse serum at 15 mg/kg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID1439726 | Bactericidal activity against Streptococcus pyogenes 12-207 expressing mef incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID1498833 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 11 J011 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID261480 | Antibacterial activity against Streptococcus pneumoniae Mef 3855 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1169033 | Antibacterial activity against macrolide lincosamide- streptogramin B inducibly-resistant Streptococcus pyogenes by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID261466 | Antibacterial activity against Streptococcus pneumoniae Mef S 3427 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID508464 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2094 harboring erm(A) gene after 22 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID276838 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus Smith OC4172 in presence of 50% mouse serum | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID261489 | Antibacterial activity against Streptococcus pneumoniae Erm S 4297 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1550824 | Antimicrobial activity against inducibly erythromycin resistant Staphylococcus aureus PU64 expressing i-ermA incubated in CAMHB medium for 20 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID1498834 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 11L264 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID502238 | Antibacterial activity against efflux-mediated macrolide-resistance Staphylococcus aureus PK1 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID261456 | Antibacterial activity against Staphylococcus epidermidis 14990 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID508460 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2094 harboring erm(A) gene after 5 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID372549 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b with an amino acid substitution in highly mutated locus Ser-385 of ftsI gene by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID422683 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 37 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID424319 | Antimicrobial activity against Dialister pneumosintes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID300914 | Antibacterial activity against erm containing Staphylococcus aureus 1095 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID1691392 | Bactericidal activity against penicillin-susceptible Streptococcus pneumoniae PU09 harboring mef gene | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID519327 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT01 carrying duplication in the carboxy-terminal region of L22 ribosomal protein | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID429064 | Antiplasmodial activity after 72 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID475097 | Antibacterial activity against Streptococcus pneumoniae 9 expressing inducible ermB methylase after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID300818 | Antibacterial activity against erythromycin-resistant ermB expressing Streptococcus pneumoniae 1095 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Novel tethers in ketolide antibiotics. |
| AID206464 | The compound has been evaluated for the antibacterial activity against Staphylococcus aureus EryRi 011GO25i strains | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID520392 | Antibacterial activity against mef and erm(B) positive Streptococcus pneumoniae isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID261783 | Antibacterial activity against macrolide resistant Streptococcus pneumoniae ATCC 700676 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID1868050 | Antibacterial activity against erythromycin-susceptible Mycoplasma pneumoniae ATCC 29342 by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID369227 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID425338 | Antibacterial activity against azithromycin-susceptible Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID411680 | Antibacterial activity against macrolide-susceptible Staphylococcus aureus Smith by broth-microdilution method | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID1439727 | Ratio of MBC to MIC for Streptococcus pyogenes 12-207 expressing mef | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID422674 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 21 passages with gemifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID562402 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID422944 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae harboring A2064G transition in domain V of 23S rRNA isolated from pediatric patients with community-acquired pneumonia after 10 to 14 days by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. |
| AID422670 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1076 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID608741 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B resistant Streptococcus pyogenes Finland 11 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID554550 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC879-2 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID555119 | Terminal half life in healthy human at 400 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID276844 | Antibacterial activity against Staphylococcus aureus Smith infected in sc dosed Swiss Webster mouse septicemia model | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID369445 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID244905 | Minimum inhibitory concentration against Staphylococcus aureus OC4172 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID519326 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus RN4220 carrying rplD and rplV genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID1617218 | Cytotoxicity in human HS5 cells assessed as reduction in cell viability at 0.5 to 50 uM incubated up to 72 hrs relative to chloramphenicol | 2019 | Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22 | Structure-Activity Relationship of Peptide-Conjugated Chloramphenicol for Inhibiting |
| AID508398 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 1077 after 49 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID261483 | Antibacterial activity against Streptococcus pneumoniae Mef 6966 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID210384 | In vitro antibacterial activity against Streptococcus pneumoniae 5649 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID582684 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 infected in human THP1 cells assessed as decrease of CFU after 24 hrs relative to initial inoculum | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | |||
| AID300819 | Antibacterial activity against erythromycin-resistant mef expressing Streptococcus pneumoniae 1175 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Novel tethers in ketolide antibiotics. |
| AID1245729 | Ratio of MBC to MIC against methicillin-resistant Staphylococcus aureus PU32 expressing inducible ermA | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID1498845 | Antibacterial activity against extended spectrum beta-lactamases producing Klebsiella pneumoniae ATCC 700603 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID535567 | Antibacterial activity against Salmonella enterica serovar blockley harboring G235A mutation in rlpD gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro activity of azithromycin against nontyphoidal Salmonella enterica. |
| AID554544 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC720 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID210222 | In vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 (an erythromycin-susceptible strain) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID1868051 | Antibacterial activity against erythromycin-resistant Mycoplasma pneumoniae A2058G by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID637554 | Antibacterial activity against Streptococcus pyogenes 19615 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1550845 | Bactericidal activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 assessed as log reduction in bacterial CFU at 1 to 16XMIC incubated for 1 to 24 hrs by broth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID260948 | Antibacterial activity against Mef(A) efflux pump containing Streptococcus pneumoniae OC4438 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID423103 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID261482 | Antibacterial activity against Streptococcus pneumoniae Mef 4331 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID637567 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 3390 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID531446 | Antibacterial activity against Streptococcus pneumoniae serotype 3 assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID510555 | Antimicrobial activity against Chlamydia trachomatis after 72 hrs by twofold serial dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. |
| AID1245727 | Ratio of MBC to MIC against Streptococcus pyogenes 12-207 expressing mef | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID1278827 | Antibacterial activity against efflux mediated macrolide resistant Streptococcus pneumoniae by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID261499 | Antibacterial activity against Streptococcus pneumoniae Erm 5554 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID475104 | Antibacterial activity against Haemophilus influenzae 2 after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID554535 | Antimicrobial activity against Mycobacterium abscessus isolate MC958 on day 4 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID423235 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID502236 | Antibacterial activity against efflux-mediated macrolide-resistance Streptococcus pyogenes 2 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID206747 | In vitro antibacterial activity against Staphylococcus aureus strain A 5177. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID425341 | Antibacterial activity against quinolone-resistant Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID1245728 | Ratio of MBC to MIC against azithromycin-susceptible and ampicillin-resistant Haemophilus influenzae 11P037 | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID539509 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Staphylococcus aureus B0538 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID565810 | Antimicrobial activity against Neisseria meningitidis by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9 | Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. |
| AID519996 | Antimicrobial activity against Streptococcus pneumoniae harboring mef(A) gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID261504 | Antibacterial activity against Streptococcus pneumoniae Erm 8947 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID518962 | Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZ7 lacking codons 2 to 4 with additional mutations leader peptide cistrons reporter plasmid at 25 mg/ml after 36 hrs at 37 degC by disc-based be | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID508451 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 2132 after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID501674 | Antimicrobial activity against Streptococcus pyogenes Finland 2 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID475102 | Antibacterial activity against Streptococcus pyogenes 3 expressing mefA efflux pump after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID508409 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1076 harboring erm(B) and mef(A) gene after 14 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID712422 | Antibacterial activity against Escherichia coli DK/2058G harboring 23S rRNA A2058G mutant in presence of ethanol | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID1459138 | Oral bioavailability in Han Wistar rat at 20 mg/kg by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID422645 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID508413 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1635 harboring erm(A) gene after 14 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID422943 | Antimicrobial activity against macrolide-resistant Mycoplasma pneumoniae harboring A2063G transition in domain V of 23S rRNA isolated from pediatric patients with community-acquired pneumonia after 10 to 14 days by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. |
| AID558085 | Antimicrobial activity against Mycoplasma fermentans isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID582674 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 at pH 5.5 to 7.4 after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID510557 | Antimicrobial activity against Chlamydophila pneumoniae infected in human Hep2 cells after 72 hrs by twofold serial dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. |
| AID197857 | Minimum inhibitory concentration against Staphylococcus aureus 10649 (erythromycin susceptible strain) | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID132633 | The compound was tested in vivo for antibacterial activity against erythromycin susceptible Streptococcus pyogenes 02A1UC1 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID422689 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3413 after 30 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID501669 | Antimicrobial activity against macrolide, licosamide streptogramin-resistant Staphylococcus aureus 90265/97 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID508444 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 7127 harboring S20N mutation in L4 ribosomal protein and A105V mutation in L22 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID558084 | Antimicrobial activity against Mycoplasma genitalium isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID520000 | Antimicrobial activity against Moraxella catarrhalis | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID475096 | Antibacterial activity against Streptococcus pneumoniae 8 expressing inducible ermB methylase after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID565820 | Antimicrobial activity against Chlamydia trachomatis isolates | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10 | Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID300823 | Antibacterial activity against Haemophilus influenzae 1100 in po dosed gerbils | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Novel tethers in ketolide antibiotics. |
| AID508448 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 2132 after 50 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID747245 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID245559 | Minimum inhibitory concentration of the compound againstEnterococcus faecalis ATCC 51299 with an erm(B)-encoded ribosomal methylase was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID717680 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID528729 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID300905 | Antibacterial activity against erythromycin susceptible Staphylococcus aureus 0052 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID311524 | Oral bioavailability in human | 2007 | Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24 | Hologram QSAR model for the prediction of human oral bioavailability. |
| AID508369 | Antibacterial activity against Streptococcus pneumoniae harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID608737 | Antibacterial activity against efflux-mediated macrolide-resistant Streptococcus pneumoniae Ci137 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID1550831 | Bactericidal activity against inducibly erythromycin resistant Streptococcus pyogenes 01-968 expressing i-ermA assessed as reduction in colony formation incubated in CAMHB medium for 20 to 24 hrs followed by 24 hrs subculturing in the medium without test | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID369444 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID642858 | Antibacterial activity against constitutive MLS resistant Streptococcus pneumoniae by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID519987 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID518975 | Induction of erm(C) expression in Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid assessed as increase in A2058 dimethylation in 23S rRNA at 25% MIC after 4 hrs by primer extension assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID260947 | Antibacterial activity against erm(B) ribosomal methylase gene containing Streptococcus pneumoniae OC4051 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID1164322 | Antimicrobial activity against Staphylococcus aureus UCN14 harboring ribosome A2058T mutant | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9 | Desmethyl macrolides: synthesis and evaluation of 4-desmethyl telithromycin. |
| AID423098 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID1245721 | Bactericidal activity against methicillin-resistant Staphylococcus aureus PU32 expressing inducible ermA incubated for 20 hrs followed by sub-culturing for 24 hrs in absence of compound | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID558597 | Antimicrobial activity against Streptococcus pneumoniae 9 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID582681 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 assessed as decrease of CFU after 24 hrs relative to initial inoculum | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID1550857 | MRT in Sprague-Dawley rat at 20 mg/kg, po administered as single dose measured for 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID1549365 | Bactericidal activity against erythromycin-susceptible Streptococcus pneumoniae ATCC49619 pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1439718 | Ratio of MBC to MIC for erythromycin-resistant Streptococcus pneumoniae ATCC 49619 | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID245360 | Minimum inhibitory concentration of the compound against erythromycin-susceptible Streptococcus pneumoniae was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID261782 | Antibacterial activity against Streptococcus pneumoniae ATCC 700671 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID270425 | Antibacterial activity against Staphylococcus aureus 33591 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID263387 | Antibacterial activity against Staphylococcus aureus Smith OC4172 in presence of 50% mouse serum | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID562610 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID285156 | Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID642859 | Antibacterial activity against efflux mediated macrolide resistant Streptococcus pneumoniae by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID637557 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 757 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID508387 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID688518 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19 | Synthesis and structure-activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'. |
| AID1646214 | Inhibition of human nAChR expressed in human TE671 cells assessed as reduction in nicotine-induced current response by whole-cell patch-clamp method | 2020 | Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12 | Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | |||
| AID775000 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 09-3 by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. |
| AID1498843 | Antibacterial activity against methicillin-resistant Streptococcus pyogenes 12-1 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID270436 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae mef S 3427 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID501672 | Antimicrobial activity against Streptococcus pyogenes 3565 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID539502 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes B0543 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID508378 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID270438 | Antibacterial activity against Haemophilus influenzae 2762 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID567792 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ANS46 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID775005 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. |
| AID735599 | Antibacterial activity against erythromycin-resistant Streptococcus dysgalactiae A1 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID1278825 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID508400 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 24 harboring erm(B) gene after 14 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID553266 | Antibacterial activity against Escherichia coli SQ171/2058G harboring ribosomal A2058G mutant | 2011 | ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1 | Desmethyl Macrolide Analogues to Address Antibiotic Resistance: Total Synthesis and Biological Evaluation of 4,8,10-Tridesmethyl Telithromycin. |
| AID483698 | Antimicrobial activity against inducible macrolide, lincosamide, streptogramin-resistant Streptococcus pneumoniae 134 GRM | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID263389 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4051 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | |||
| AID642853 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID209609 | In vitro antibacterial activity against Streptococcus pyogenes strain PIU 2548. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID132626 | The compound was tested in vivo for antibacterial activity against Haemophilus influenza 351GR1 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID1169034 | Antibacterial activity against efflux-resistant Streptococcus pyogenes by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID531420 | Antibacterial activity against Streptococcus pneumoniae serotype 19F by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1549389 | Selectivity ratio of MBC to MIC for Streptococcus pyogenes 12-207 expressing mef gene | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | |||
| AID1498829 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 11B117 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID567803 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 07P390 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID747246 | Antibacterial activity against Escherichia coli ATCC 35218 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID475103 | Antibacterial activity against Haemophilus influenzae 1 after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID244962 | Minimum inhibitory concentration of compound against Ery-R Streptococcus pyogenes 1721 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID519989 | Antimicrobial activity against coagulase-negative Staphylococcus nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID712420 | Antibacterial activity against Staphylococcus aureus ATCC 33591 harboring ermA mutant in presence of ethanol | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID70129 | The compound was tested in vitro for antibacterial activity against Escherichia coli 250 UCS. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID509005 | Antimicrobial activity against Haemophilus influenzae | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID422942 | Antimicrobial activity against macrolide-susceptible Mycoplasma pneumoniae isolated from pediatric patients with community-acquired pneumonia after 10 to 14 days by microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. |
| AID245427 | Minimum inhibitory concentration of the compound against erythromycin-susceptible Staphylococcus aureus Smith OC4172 was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID270427 | Antibacterial activity against Staphylococcus epidermidis f50654 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID422682 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 after 14 passages with clindamycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID528733 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus hominis subsp. novobiosepticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | |||
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID528730 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID283550 | Antimicrobial activity against Streptococcus pneumoniae BSF-11524 isolate with erm(B) and L4 mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID85810 | The compound was tested in vitro for antibacterial activity against 39 strains of Haemophilus influenza AmpR; Value is 0.6/0.6 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID261493 | Antibacterial activity against Streptococcus pneumoniae Erm 3120 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1459118 | Antibacterial activity against erythromycin susceptible Staphylococcus aureus infected in mouse assessed as increase in mouse survival administered orally 1 hr post infection | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID518996 | Cmax in Sprague-Dawley rat at 50 mg/kg, po pretreated with Escherichia coli lipopolysaccharide (Rvb=2.35 +/- 1.19 ug/ml) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID423102 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID426379 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes 07U084 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID261477 | Antibacterial activity against Streptococcus pneumoniae Mef 2382 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1169027 | Antibacterial activity against macrolide lincosamide- streptogramin B inducibly-resistant Staphylococcus aureus by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID572271 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus NB01021 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID558590 | Antimicrobial activity against Streptococcus pneumoniae 2 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID508386 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID508411 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1635 harboring erm(A) gene after 32 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID558083 | Antimicrobial activity against Mycoplasma pneumoniae isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID1459115 | Antibacterial activity against Mef-mediated macrolide efflux resistant Streptococcus pyogenes by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID423245 | Antibacterial activity against Moraxella catarrhalis isolated from respiratory tract infected patients after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID567796 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 07A066 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID717681 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 09M124 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID735590 | Antibacterial activity against methicillin-resistant, MLS-resistant (constitutive) Staphylococcus epidermidis E2 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID608733 | Antibacterial activity against erythromycin-sensitive Staphylococcus aureus ATCC 13709 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID369443 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID261492 | Antibacterial activity against Streptococcus pneumoniae Erm 2218 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID518966 | Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZalpha reporter plasmid after 36 hrs at 37 degC by disc-based beta-galactosidase reporter gene assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID518990 | Clearance in Sprague-Dawley rat at 50 mg/kg, iv pretreated with Escherichia coli lipopolysaccharide (Rvb=32.4+/- 5.25 ml/min/kg) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID501676 | Antimicrobial activity against Streptococcus pyogenes 166 GR-Micro by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID261462 | Antibacterial activity against Streptococcus pneumoniae 297-749 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID426382 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes 07Z014 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID425969 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 2527 after 20 passages with azithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID518995 | Half life in Sprague-Dawley rat at 50 mg/kg, po pretreated with Escherichia coli lipopolysaccharide (Rvb=123 +/- 63.4 min) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID717677 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 09D016 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID1278826 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B resistant Streptococcus pneumoniae by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID608736 | Antibacterial activity against efflux-mediated macrolide-resistant Staphylococcus aureus PK1 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID425986 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 41 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1164323 | Antimicrobial activity against Staphylococcus aureus ATCC 33591 harboring ermA gene | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9 | Desmethyl macrolides: synthesis and evaluation of 4-desmethyl telithromycin. |
| AID261476 | Antibacterial activity against Streptococcus pneumoniae Mef 1790 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID531444 | Antibacterial activity against Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID261464 | Antibacterial activity against Streptococcus pneumoniae Erm 6849 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID261787 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID1169026 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID528728 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID424320 | Antimicrobial activity against Dialister micraerophilus by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID528727 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID519331 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT06 carrying duplication in the carboxy-terminal region of L22 ribosomal protein | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID1550832 | Ratio of MBC to MIC for inducibly erythromycin resistant Streptococcus pyogenes 01-968 expressing i-ermA | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID508432 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 7127 harboring S20N mutation in L4 ribosomal protein and A105V mutation in L22 ribosomal protein after 38 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1550830 | Antimicrobial activity against inducibly erythromycin resistant Streptococcus pyogenes 01-968 expressing i-ermA incubated in CAMHB medium for 20 to 24 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID206748 | In vitro antibacterial activity against Staphylococcus aureus strain A 5278. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID524825 | Antibacterial activity against erythromycin susceptible Campylobacter sp. by agar plate dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID423097 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID528724 | Antibacterial activity against Streptococcus oralis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID261468 | Antibacterial activity against Haemophilus influenzae 2762 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID422686 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 37 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID283551 | Antimicrobial activity against Streptococcus pneumoniae PC13 transformants | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID642860 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID608740 | Antibacterial activity against inducible macrolide-resistant, constitutive lincosamide, streptogramin-resistant Streptococcus pneumoniae 134 GR M by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID1549363 | Antibacterial activity against MLS-resistant Staphylococcus aureus PU 32 expressing inducible ermA gene assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID131225 | Mouse protection tests for effective dose against Staphylococcus aureus 10649 ((erythromycin susceptible strain)) infected mice | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID426378 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae 05Z006 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID508476 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 237 harboring mutation in L4 ribosomal protein after 50 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID501286 | Antibacterial activity against Haemophilus influenzae ATCC 49247 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID608745 | Antibacterial activity against Haemophilus influenzae ATCC 49247 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID1691397 | Antibacterial activity against MLSB/methicillin/ciprofloxacin-resistant Staphylococcus aureus PU32 harboring ermA gene assessed as reduction in microbial growth | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID132623 | The compound was tested in vitro for antibacterial activity against inducibly erythromycin resistant Staphylococcus aureus 011GO3. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID717688 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 09O077 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID508438 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 3009 harboring mutation in 23S rRNA after 25 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID483697 | Antimicrobial activity against Haemophilus influenzae ATCC 49247 | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID1439734 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus PU32 expressing inducible ermA after 20 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID429063 | Antiplasmodial activity after 48 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID132629 | The compound was tested in vivo for antibacterial activity against constitutively erythromycin resistant Streptococcus pneumoniae 030SJ1 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID1550860 | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins after substrate addition by HPLC analysis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID528726 | Antibacterial activity against Streptococcus mitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1498847 | Antibacterial activity against extended spectrum beta-lactamases non-producing Escherichia coli ATCC 25922 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID261521 | Efficacy against Streptococcus pneumoniae Mef in Sprague-Dawley rat lung infection model at 100 mg/kg | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1439736 | Ratio of MBC to MIC against methicillin-resistant Staphylococcus aureus PU32 expressing inducible ermA | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID608746 | Antibacterial activity against Moraxella catarrhalis ATCC 23246 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID1868053 | Antibacterial activity against erythromycin-resistant Mycoplasma pneumoniae A2058T by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID206483 | The compound was tested in vitro for antibacterial activity against constitutively erythromycin resistant Staphylococcus aureus 011CB20. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID322976 | Tmax in mouse serum at 15 mg/kg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID208144 | In vivo antibacterial activity against Streptococcus pneumoniae strain 6303 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID440642 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae 1175 harboring mefA gene by NCCLS method | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID519001 | Drug excretion in Sprague-Dawley rat urine assessed as unchanged drug at 50 mg/kg, po after 24 hrs pretreated with Escherichia coli lipopolysaccharide (Rvb=4.78 +/- 3.28 %) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID535570 | Antibacterial activity against Salmonella enterica serovar montevideo harboring rlpD GC379T and rlpV G25A mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro activity of azithromycin against nontyphoidal Salmonella enterica. |
| AID1443992 | Total Cmax in human administered as single dose | 2014 | Hepatology (Baltimore, Md.), Sep, Volume: 60, Issue:3 | Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. |
| AID508377 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID508379 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring erm(B) and mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID422661 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 after 15 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID519997 | Antimicrobial activity against Streptococcus pneumoniae ribosomal mutant | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID261457 | Antibacterial activity against Staphylococcus epidermidis f50654 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID322963 | Antimicrobial activity against macrolide-susceptible Mycobacterium avium by radiometric broth nanodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID423101 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID528710 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID396039 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pACYC184 plasmid by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | |||
| AID208614 | The compound was tested in vitro for antibacterial activity against 32 strains of inducibly erythromycin resistant Streptococcus pneumoniae; Value is 0.005/0.02 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID775003 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 09-6 by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. |
| AID261474 | Antibacterial activity against Streptococcus pneumoniae Mef 1556 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID372555 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b with an amino acid substitution in highly mutated locus Ser-385 of ftsI gene assessed as susceptibility rate by broth microdilution metho | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID1278833 | Antibacterial activity against Moraxella catarrhalis by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID638882 | Antibacterial activity against Streptococcus pneumoniae 6303 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1439723 | Bactericidal activity against Streptococcus pyogenes 01-968 expressing inducible ermA incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID244954 | Minimum inhibitory concentration against Staphylococcus pneumoniae OC4051 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID260945 | Antibacterial activity against Staphylococcus aureus OC4172 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID424331 | Antimicrobial activity against Dialister propionicifaciens assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID508380 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID642865 | Antibacterial activity against Moraxella catarrhalis by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID132624 | The compound was tested in vivo for antibacterial activity against AmpR beta(+) Haemophilus influenza 351RD7 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID270435 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae mef 5654 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID422675 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 25 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID425992 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 29 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1868042 | Antibacterial activity against Streptococcus pyogenes 12-206 by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID1549369 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae PU 09 expressing mef gene assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID369447 | Antimicrobial activity against Streptococcus group B after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID1443995 | Hepatotoxicity in human assessed as drug-induced liver injury | 2014 | Hepatology (Baltimore, Md.), Sep, Volume: 60, Issue:3 | Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. |
| AID440651 | Antibacterial activity against multidrug-susceptible Haemophilus influenzae 1325 infected in po dosed Mongolian gerbil otitis media model assessed as reduction of bacterial infection administered 18 hrs postinfection TID for 2 days measured on day 4 posti | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID567797 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes 07U084 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID528734 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus haemolyticus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID582610 | Drug uptake in human THP1 cells after 24 hrs in presence of verapamil | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID781248 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 12-6 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID518993 | Apparent volume of distribution in Sprague-Dawley rat at 50 mg/kg, iv pretreated with Escherichia coli lipopolysaccharide (Rvb=4,950 +/- 1160 ml/kg) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID245061 | Minimum inhibitory concentration of compound against Ery-S Haemophilus influenzae ATCC 49247 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID717679 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 09H065 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID261496 | Antibacterial activity against Streptococcus pneumoniae Erm 5354 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID428141 | Increase in erm(B) mRNA expression in Streptococcus pneumoniae PC13 transformant harboring 136-bp deletion in erm(B) gene at 0.008 ug/ml by qRT-PCR relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID499558 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes B0544 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID539511 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes B0544 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID519333 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT10 carrying rplD and rplV mutant genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID558088 | Antimicrobial activity against Ureaplasma urealyticum isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID1868040 | Antibacterial activity against Streptococcus pneumoniae 07P390 by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID300820 | Antibacterial activity against erythromycin-resistant ermB expressing Streptococcus pyogenes 1079 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Novel tethers in ketolide antibiotics. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1549392 | Selectivity ratio of MBC to MIC for erythromycin-susceptible Moraxella catarrhalis 13L332 | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | |||
| AID245066 | Minimum inhibitory concentration of compound against Streptococcus pneumoniae ATCC 49619 Ery-S was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID1245726 | Ratio of MBC to MIC against Streptococcus pyogenes 01-968 expressing inducible ermA | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1646215 | Inhibition of human alpha3beta4 nAChR assessed as increase in acetylcholine-induced normalized current at 2 uM (Rvb = 78.5 +/- 10 uM) | 2020 | Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12 | Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics. |
| AID1550853 | AUCinfinity in Sprague-Dawley rat at 20 mg/kg, po administered as single dose measured for 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID1498831 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 11C176 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID1549397 | MRT in Sprague-Dawley rat at 20 mg/kg, po after 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID425339 | Antibacterial activity against azithromycin-resistant Streptococcus pneumoniae ATCC 49619 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1 | In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci. |
| AID555111 | Cmax in healthy human at 400 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID423243 | Antibacterial activity against beta lactamase-positive Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID524824 | Antibacterial activity against erythromycin resistant Campylobacter sp. by agar plate dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3 | Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. |
| AID1245719 | Bactericidal activity against Streptococcus pyogenes 12-207 expressing mef incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID1459109 | Antibacterial activity against erythromycin susceptible Streptococcus pneumoniae by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID483691 | Antimicrobial activity against macrolide-sensitive Staphylococcus aureus ATCC 13709 | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID717676 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 09E427 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID508376 | Antibacterial activity against quinolone-resistant Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID508443 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2686 harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID422673 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 18 passages with levofloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID508405 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 3665 harboring mef(A) gene after 26 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID528738 | Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID582675 | Antibacterial activity against Listeria monocytogenes EGD at pH 5.5 to 7.4 after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID1439722 | Bacteriostatic activity against Streptococcus pyogenes 01-968 expressing inducible ermA after 20 to 24 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID208617 | The compound was tested in vitro for antibacterial activity against 40 strains of constitutively erythromycin resistant Streptococcus pneumoniae; Value is 0.04/0.3 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID245088 | Minimum inhibitory concentration of the compound against Haemophilus influenzae OC4882 was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID422650 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 after 38 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID717683 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 09G291 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID554554 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MAB30 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID428237 | Increase in dimethylation at position A2058 of 23S rRNA of wild type Streptococcus pneumoniae PC13 at 0.25 ug/ml by phosphorimager scanning relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID372553 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-susceptible Haemophilus influenzae type b without amino acid substitutions in ftsI gene and bla gene assessed as susceptibility rate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID572273 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6303 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID572269 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 49951 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID735600 | Antibacterial activity against MLS-resistant (constitutive), penicillin-susceptible Streptococcus pneumoniae PU27 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID558185 | Antimicrobial activity against Mycobacterium abscessus isolate MC1028 at day 7 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID520001 | Antimicrobial activity against Haemophilus influenzae | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID501283 | Antibacterial activity against macrolide, licosamide and streptogramin inducible-resistance Streptococcus pyogenes 11 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID554546 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC958 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID1169031 | Antibacterial activity against efflux-resistant Streptococcus pneumoniae by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID276845 | Antibacterial activity against Staphylococcus aureus Smith infected in orally dosed Swiss Webster mouse septicemia model | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID244983 | Minimum inhibitory concentration of compound against Ery-R Streptococcus pneumoniae 303 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID132631 | The compound was tested in vivo for antibacterial activity against erythromycin susceptible Staphylococcus aureus 011UC4 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID1549366 | Antibacterial activity against azithromycin-susceptible Haemophilus influenzae ATCC 49247 assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID208467 | The compound has been evaluated for the antibacterial activity against Streptococcus pneumoniae EryRc 030PW23c strains | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID206487 | The compound was tested in vitro for antibacterial activity against inducibly erythromycin resistant Staphylococcus aureus 011GO25i. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID638883 | Antibacterial activity against Streptococcus pneumoniae 49619 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID531455 | Antibacterial activity against Streptococcus pneumoniae serotype 3 assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID210386 | In vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID508383 | Antibacterial activity against Streptococcus pyogenes harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID735594 | Antibacterial activity against methicillin-resistant, MLS-resistant (constitutive) Staphylococcus aureus PU 20 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID1245715 | Antimicrobial activity against erythromycin-susceptible Moraxella catarrhalis 11B366 incubated for 20 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID202129 | In Vitro antibacterial ativity against Streptococcus pyogenes 930 (ermB strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID775006 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID425965 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3274 after 48 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID728674 | Antimicrobial activity against wild type Escherichia coli O18:K1:H7 after overnight incubation | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence. |
| AID572274 | Antimicrobial activity against multiple drug-resistant Streptococcus pneumoniae ATCC 700677 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. |
| AID1550822 | Antimicrobial activity against inducibly erythromycin-resistant Staphylococcus aureus PU32 expressing i-ermA incubated in CAMHB medium for 20 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID246975 | Effective dose against Staphylococcus aureus infected murine was tested after peroral injection | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID424330 | Antimicrobial activity against Dialister invisus assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID369228 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent resistant isolates by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID425994 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | |||
| AID608742 | Antibacterial activity against constitutive macrolide, lincosamide, streptogramin-resistant Staphylococcus aureus PK2 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1169028 | Antibacterial activity against macrolide lincosamide- streptogramin B-resistant Staphylococcus aureus by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID244987 | Minimum inhibitory concentration against Staphylococcus haemolyticus OC4545 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID531418 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID424329 | Antimicrobial activity against Dialister propionicifaciens assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID519995 | Antimicrobial activity against Streptococcus pneumoniae harboring erm(B) and mef(A) gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID429074 | Antiplasmodial activity as ED50 against parasite growth after 48 hrs for Plasmodium falciparum 3D7 | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID261502 | Antibacterial activity against Streptococcus pneumoniae Erm 8339 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID501673 | Antimicrobial activity against Streptococcus pneumoniae 134 GR-M by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID369436 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID642862 | Antibacterial activity against constitutive MLS resistant Streptococcus pyogenes by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID508450 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 2132 after 28 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID735595 | Antibacterial activity against methicillin-resistant, MLS-resistant (inducible) Staphylococcus aureus PU 32 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID270431 | Antibacterial activity against Streptococcus pneumoniae 49619 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID558595 | Antimicrobial activity against Streptococcus pneumoniae 7 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID423234 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID554551 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MAB30 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID519999 | Antimicrobial activity against Streptococcus pyogenes harboring mef(A) gene | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID567802 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 07D201 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID508408 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1076 harboring erm(B) and mef(A) gene after 14 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID528717 | Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1550833 | Antimicrobial activity against constitutively erythromycin resistant and methicillin resistant Staphylococcus aureus PU20 expressing c-ermC incubated in CAMHB medium for 20 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID553270 | Antibacterial activity against Staphylococcus aureus ATCC 33591 harboring ermA mutant | 2011 | ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1 | Desmethyl Macrolide Analogues to Address Antibiotic Resistance: Total Synthesis and Biological Evaluation of 4,8,10-Tridesmethyl Telithromycin. |
| AID270434 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae erm 6849 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID499550 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Staphylococcus aureus B0538 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID423244 | Antibacterial activity against beta lactamase-negative Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID369448 | Antimicrobial activity against Streptococcus viridans after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID261797 | Antibacterial activity against Haemophilus influenzae ATCC 49766 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID501278 | Antibacterial activity against efflux-mediated macrolide resistance Staphylococcus aureus PK1 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID508389 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 1077 after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1691422 | Antibacterial activity against MLSB-resistant Streptococcus pyogenes 12-206 harboring ermA gene assessed as reduction in microbial growth | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID562357 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID642854 | Antibacterial activity against Staphylococcus aureus with inducible resistance to MLS by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID531451 | Antibacterial activity against Streptococcus pneumoniae serotype 33 assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID567800 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 01-533 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID428139 | Antimicrobial activity against wild-type Streptococcus pneumoniae PC13 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID1439729 | Bactericidal activity against azithromycin susceptible/ampicillin-resistant Haemophilus influenzae 11P307 incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID261481 | Antibacterial activity against Streptococcus pneumoniae Mef 4126 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1498841 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 13-3 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID300913 | Antibacterial activity against erythromycin susceptible Staphylococcus aureus 1146 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID528709 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1169029 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID501284 | Antibacterial activity against constitutive MLS-resistance Streptococcus pneumoniae 58 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID977600 | pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID642852 | Antibacterial activity against ciprofloxacin-resistant Staphylococcus aureus by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID557652 | Antimicrobial activity against Mycobacterium abscessus isolate MC958 at day 7 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID522935 | Antibacterial activity against Staphylococcus haemolyticus 064-4090A assessed as bacteriostatic by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID717685 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 09N120 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID508454 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2368 harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1439745 | Ratio of MBC to MIC against azithromycin-susceptible Haemophilus influenzae ATCC 49247 | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID1443980 | Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate transport preincubated for 10 mins prior to ATP addition measured after 15 mins in presence of [3H]-tauroch | 2010 | Toxicological sciences : an official journal of the Society of Toxicology, Dec, Volume: 118, Issue:2 | Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. |
| AID276843 | Antibacterial activity against telithromycin-susceptible Haemophilus influenzae ATCC 49766 | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID712415 | Antibacterial activity against Staphylococcus aureus ATCC 33591 harboring ermA mutant in presence of DMSO | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID1245731 | Ratio of MBC to MIC against erythromycin-susceptible Moraxella catarrhalis 11B366 | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID425975 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 24 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID519330 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT05 carrying rplD and rplV mutant genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID774999 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 09-9 by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. |
| AID535569 | Antibacterial activity against Salmonella enterica serovar Typhimurium harboring G235A mutation in rlpD gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro activity of azithromycin against nontyphoidal Salmonella enterica. |
| AID1550840 | Bactericidal activity against erythromycin-susceptible Moraxella catarrhalis 13L332 assessed as reduction in colony formation incubated in CAMHB medium for 20 hrs followed by 24 hrs subculturing in the medium without test compound | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID206485 | The compound was tested in vitro for antibacterial activity against erythromycin susceptible Staphylococcus aureus 011UC4. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID372560 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b with an amino acid substitution in variable mutated locus Asn-526 or Arg-517 of ftsI gene assessed as resistance rate by broth microdilut | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID501281 | Antibacterial activity against macrolide, licosamide and streptogramin inducible-resistance Staphylococcus aureus 90256 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID747244 | Antibacterial activity against drug-resistant Staphylococcus aureus by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID735602 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae PU09 harboring mef gene by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID499557 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes B0543 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID528722 | Antibacterial activity against Streptococcus viridans clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1278829 | Antibacterial activity against inducibly macrolide-lincosamide-streptogramin B resistant Streptococcus pyogenes by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID261486 | Antibacterial activity against Streptococcus pneumoniae Mef 10095 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID501280 | Antibacterial activity against efflux-mediated macrolide resistance Streptococcus pyogenes 2 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID425976 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 24 after 14 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID508434 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 7127 harboring S20N mutation in L4 ribosomal protein and A105V mutation in L22 ribosomal protein after 43 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1691400 | Antibacterial activity against MLSB/methicillin-resistant Staphylococcus aureus 15B196 assessed as reduction in microbial growth | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID261475 | Antibacterial activity against Streptococcus pneumoniae Mef 1566 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID508388 | Antibacterial activity against macrolide-resistant Streptococcus pyogenes harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID519986 | Antimicrobial activity against Streptococcus pneumoniae nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID1550820 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes A3 incubated in CAMHB medium for 20 to 24 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID206740 | In vitro antibacterial activity against Staphylococcus aureus 1775 strain | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID1245710 | Antimicrobial activity against Streptococcus pyogenes 01-968 expressing inducible ermA incubated for 20 to 24 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID1549398 | Tmax in Sprague-Dawley rat at 20 mg/kg, po after 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID411679 | Antibacterial activity against macrolide-resistant Staphylococcus aureus 7701 infected in mouse | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID502233 | Antibacterial activity against Haemophilus influenzae ATCC 49247 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID501679 | Antimicrobial activity against efflux-mediated macrolide-resistant Staphylococcus aureus PK1 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID781256 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes ATCC 19625 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID423240 | Antibacterial activity against beta lactamase-positive Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID519991 | Antimicrobial activity against vancomycin-resistant Enterococcus faecalis nosocomial isolate | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5 | In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. |
| AID508426 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 7127 harboring S20N mutation in L4 ribosomal protein and A105V mutation in L22 ribosomal protein after 16 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID554536 | Antimicrobial activity against Mycobacterium abscessus isolate MC1028 on day 4 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID518997 | Tmax in Sprague-Dawley rat at 50 mg/kg, po pretreated with Escherichia coli lipopolysaccharide (Rvb=180 min) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID508367 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID781259 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 12-5 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID582611 | Drug uptake in human THP1 cells after 24 hrs in presence of gemfibrozil | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID1691426 | Antibacterial activity against MLSB/methicillin-resistant Staphylococcus aureus 15B196 assessed as reduction in microbial growth relative to ciprofloxacin | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID396038 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP2 plasmid containing Enterobacter cloacae acrA gene by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID425984 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1646212 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae | 2020 | Journal of medicinal chemistry, 06-25, Volume: 63, Issue:12 | Differentiating the Pharmacodynamics and Toxicology of Macrolide and Ketolide Antibiotics. |
| AID423100 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID508462 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2094 harboring erm(A) gene after 6 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1459112 | Antibacterial activity against erythromycin susceptible Streptococcus pyogenes by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID524564 | Antibacterial activity against Streptococcus mitis 112-1885A assessed as bactericidal at 4 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID531419 | Antibacterial activity against Streptococcus pneumoniae serotype 3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID261785 | Antibacterial activity against macrolide resistant Streptococcus pneumoniae ATCC 700905 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID519332 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT09 carrying rplD and rplV mutant genes | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID261472 | Antibacterial activity against Streptococcus pneumoniae Mef 953 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID208469 | The compound has been evaluated for the antibacterial activity against Streptococcus pneumoniae EryS 032UC1 strains | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID558086 | Antimicrobial activity against Mycoplasma hominis isolated from human by two fold serial dilution method | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101. |
| AID582682 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 assessed as decrease of CFU after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID717674 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 09Q149 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID1550858 | Tmax in Sprague-Dawley rat at 20 mg/kg, po administered as single dose measured for 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID499560 | Antibacterial activity against Moraxella catarrhalis B0324 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID261460 | Antibacterial activity against Streptococcus pyogenes 8668 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1549378 | Selectivity ratio of MBC to MIC for MLS-resistant Streptococcus pyogenes 01-968 expressing inducible ermB gene | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1498837 | Antibacterial activity against azithromycin-resistant Haemophilus influenzae 11Q373 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID244955 | Minimum inhibitory concentration against Staphylococcus pneumoniae OC4421 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID203435 | The compound was tested in vitro for antibacterial activity against 23 strains of constitutively erythromycin resistant Staphylococci; Value is 40/40 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID244993 | Minimum inhibitory concentration of compound against Ery-R Streptococcus pneumoniae 5032 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID1549368 | Antibacterial activity against Streptococcus pneumoniae 07P390 expressing constitutive ermB gene assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID261463 | Antibacterial activity against Streptococcus pneumoniae 280-962 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID554548 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC720 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID209867 | In vivo antibacterial activity against Streptococcus pneumoniae strain 6396 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID735596 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus ATCC 29213 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID1278830 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B resistant Streptococcus pyogenes by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID637553 | Antibacterial activity against Streptococcus pneumoniae 994 expressing mef gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID518969 | Induction of erm(C) expression in Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid assessed as increase in A2058 dimethylation in 23S rRNA at 0.4 ug/ml after 4 hrs by primer extension assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID567799 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 03-233 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID562359 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID712418 | Antibacterial activity against wild type Escherichia coli DK/pKK3535 in presence of DMSO | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID528725 | Antibacterial activity against Streptococcus intermedius clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID261491 | Antibacterial activity against Streptococcus pneumoniae Erm 867 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID775002 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 09-13 by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. |
| AID245693 | Minimum inhibitory concentration of the compound against 3 erythromycin-susceptible Streptococcus pneumoniae OC4051 with an erm(B)-ribosomal methylase-mediated resistance was determined | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. |
| AID424332 | Antimicrobial activity against Dialister invisus assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID499561 | Antibacterial activity against Haemophilus influenzae B0529 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID1549394 | AUC (0 to t) in Sprague-Dawley rat at 20 mg/kg, po after 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID428236 | Increase in dimethylation at position A2058 of 23S rRNA of wild type Streptococcus pneumoniae PC13 at 0.008 ug/ml by phosphorimager scanning relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID508468 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2011 harboring mef(A) gene after 50 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID202134 | In Vitro antibacterial ativity against Streptococcus pyogenes EES61 (Ery-S strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID396040 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP3 plasmid containing Enterobacter aerogenes acrR gene by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID501301 | Antibacterial activity against constitutive MLS resistance Streptococcus pneumoniae 58 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID501678 | Antimicrobial activity against macrolide-resistant Streptococcus pyogenes Finland 2 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID508442 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1635 harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID637555 | Antibacterial activity against Haemophilus influenzae 38 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID276837 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus Smith OC4172 | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID531422 | Antibacterial activity against Streptococcus pneumoniae serotype 23A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1691425 | Antibacterial activity against MLSB/methicillin/ciprofloxacin-resistant Staphylococcus aureus PU32 harboring ermA gene assessed as reduction in microbial growth relative to ciprofloxacin | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID1459143 | Protein binding in human plasma at 1 ug/ml by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID1550834 | Bactericidal activity against constitutively erythromycin resistant and methicillin-resistant Staphylococcus aureus PU20 expressing c-ermC assessed as reduction in colony formation incubated in CAMHB medium for 20 hrs followed by 24 hrs subculturing in th | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID206298 | In vitro antibacterial activity against Staphylococcus aureus NCTC 10649 (erythromycin-susceptible strain) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID261455 | Antibacterial activity against Staphylococcus aureus 33591 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID501279 | Antibacterial activity against efflux-mediated macrolide resistance Streptococcus pneumoniae Ci137 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID735603 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID85809 | The compound was tested in vitro for antibacterial activity against Haemophilus influenza 351HT3. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID508391 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 1077 after 43 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1245709 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae PU09 incubated for 20 to 24 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID483695 | Antimicrobial activity against inducible macrolide, lincosamide, streptogramin-resistant Streptococcus pyogenes Finland 11 | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID1868047 | Stability in rat liver microsomes assessed as unchanged drug level at 1 uM after 60 mins by LC-MS/MS analysis | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID261470 | Antibacterial activity against Streptococcus pneumoniae Mef S 3435 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID508473 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 237 harboring mutation in L4 ribosomal protein after 20 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID425987 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 33 passages with azithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID501680 | Antimicrobial activity against macrolide-resistant Streptococcus pneumoniae Ci137 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID244915 | Minimum inhibitory concentration against Haemophilus influenzae OC4482 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID531452 | Antibacterial activity against Streptococcus pneumoniae serotype 22 assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID422665 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID261494 | Antibacterial activity against Streptococcus pneumoniae Erm 4290 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID637556 | Antibacterial activity against Moraxella catarrhalis 8176 by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1473739 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID424324 | Antimicrobial activity against Dialister micraerophilus assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID425980 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 after 14 passages with azithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID712416 | Antibacterial activity against Staphylococcus aureus UCN14 harboring ribosomal A2058T mutant in presence of DMSO | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID608734 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae SP030 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID1868043 | Antibacterial activity against Staphylococcus aureus 15B196 by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID1691403 | Antibacterial activity against azithromycin-susceptible Haemophilus influenzae ATCC 49247 assessed as reduction in microbial growth | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID422649 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID429067 | Antiplasmodial activity against Plasmodium falciparum 3D7 as delayed first replication cycle at IC50 after 48-120 hrs by giemsa stain | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID1473738 | Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1549400 | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in metabolite formation using midazolam as substrate incubated for 10 mins in presence of NADPH by HPLC based mass spectrometric method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID499549 | Antibacterial activity against erythromycin A-resistant Staphylococcus aureus B0329 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID276839 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae OC9132 | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID567794 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis 07T202 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID1549393 | AUCinfinity in Sprague-Dawley rat at 20 mg/kg, po after 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID712421 | Antibacterial activity against Staphylococcus aureus UCN14 harboring ribosomal A2058T mutant in presence of ethanol | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID1550816 | Antimicrobial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 incubated in CAMHB medium for 20 to 24 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID1169030 | Antibacterial activity against macrolide lincosamide- streptogramin B inducibly-resistant Streptococcus pneumoniae by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID440640 | Antibacterial activity against multidrug-susceptible Streptococcus pneumoniae 1016 by NCCLS method | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID300906 | Antibacterial activity against erm containing Staphylococcus aureus 1117 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID642864 | Antibacterial activity against Haemophilus influenzae B0529 by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID524565 | Antibacterial activity against Streptococcus mitis 112-1885A assessed as bactericidal at 8 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID426380 | Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes 07U086 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID270426 | Antibacterial activity against Staphylococcus epidermidis 14990 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID423233 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID1278821 | Antibacterial activity against erythromycin-susceptible Staphylococcus aureus by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID1459107 | Antibacterial activity against constitutively macrolide/lincosamide/streptogramin B-resistant Streptococcus pyogenes by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID508477 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 237 harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1459123 | AUC(0 to infinity) in Han Wistar rat at 10 mg/kg, iv by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID539504 | Antibacterial activity against efflux-resistant Streptococcus pneumoniae B0326 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID1278822 | Antibacterial activity against inducibly macrolide-lincosamide-streptogramin B resistant Staphylococcus aureus by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID202102 | In Vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 (Ery-S strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID524563 | Antibacterial activity against Streptococcus mitis 112-1885A assessed as bactericidal at 2 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID369234 | Antibacterial activity Streptococcus pneumoniae expressing erm(B) and/or mef genes at 0.25 ug/ml by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID422680 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID637559 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 2840 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID1691394 | Antibacterial activity against MLSB-resistant Streptococcus pneumoniae 07P390 harboring ermB gene assessed as reduction in microbial growth | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID747241 | Antibacterial activity against drug-resistant Klebsiella pneumoniae by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID518998 | Renal clearance in Sprague-Dawley rat at 50 mg/kg, po pretreated with Escherichia coli lipopolysaccharide (Rvb=4.21 +/- 1.81 ml/min/kg) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID1868045 | Antibacterial activity against Haemophilus influenzae ATCC 49247 by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID508430 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 7127 harboring S20N mutation in L4 ribosomal protein and A105V mutation in L22 ribosomal protein after 15 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID429073 | Antiplasmodial activity against Plasmodium falciparum 3D7 as 2xnuclei schizont arrest at IC50 after 96 hrs by transmission electron microscopy | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID422652 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID276840 | Antibacterial activity against erythromycin resistant Staphylococcus haemolyticus OC3882 containing erm(C) | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID1245723 | Bactericidal activity against erythromycin-susceptible Moraxella catarrhalis 11B366 incubated for 20 hrs followed by sub-culturing for 24 hrs in absence of compound | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID501296 | Antibacterial activity against efflux-mediated macrolide-resistance Streptococcus pneumoniae Ci137 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID263386 | Antibacterial activity against Staphylococcus aureus Smith OC4172 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID428238 | Increase in dimethylation at position A2058 of 23S rRNA of Streptococcus pneumoniae PC13 transformant harboring 136-bp deletion in erm(B) gene at 0.008 ug/ml by phosphorimager scanning relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID440646 | Metabolic stability in human liver cytosol assessed as compound turnover at 1 uM after 60 mins | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | |||
| AID735598 | Antibacterial activity against MLS-resistant (constitutive) Streptococcus pyogenes A2 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID508441 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1076 harboring erm(B) and mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID539513 | Antibacterial activity against Moraxella catarrhalis B0324 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID1439732 | Bactericidal activity against methicillin-resistant Staphylococcus aureus PU20 expressing constitutive ermC incubated for 20 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID717687 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 09U035 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID1459110 | Antibacterial activity against inducibly macrolide/lincosamide/streptogramin B-resistant Staphylococcus aureus by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID508396 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 1077 after 15 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID424327 | Antimicrobial activity against Dialister propionicifaciens by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID712419 | Antibacterial activity against Escherichia coli SQ171/2058G harboring 23S rRNA A2058G mutant in presence of DMSO | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID554545 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC879 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID554549 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC879-2 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID263390 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4421 | 2006 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7 | Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides. |
| AID558592 | Antimicrobial activity against Streptococcus pneumoniae 4 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID244956 | Minimum inhibitory concentration against Staphylococcus pneumoniae OC9132 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID712424 | Antibacterial activity against Escherichia coli SQ171/2058G harboring 23S rRNA A2058G mutant in presence of ethanol | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID206465 | The compound has been evaluated for the antibacterial activity against Staphylococcus aureus EryS 011UC4 strains | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID300821 | Antimicrobial activity against Haemophilus influenzae 1325 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Novel tethers in ketolide antibiotics. |
| AID1550852 | Bactericidal activity against inducibly erythromycin resistant Streptococcus pyogenes 01-968 expressing i-ermA at 1XMIC incubated for 24 hrs by broth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID423238 | Antibacterial activity against beta lactamase-negative Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID1549376 | Antibacterial activity against MLS-resistant Streptococcus pyogenes 01-968 expressing inducible ermB gene assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | |||
| AID520394 | Antibacterial activity against mef(E)-positive Streptococcus pneumoniae isolate Spain 9V-3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID1550855 | Clearance in Sprague-Dawley rat at 20 mg/kg, po administered as single dose measured for 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID440641 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae 1095 harboring ermB gene by NCCLS method | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID422672 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 19 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1550823 | Antimicrobial activity against constitutively erythromycin resistant Staphylococcus aureus PU20 expressing c-ermC incubated in CAMHB medium for 20 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID85978 | In vitro antibacterial activity against Haemophilus influenzae GYR1435 (fully susceptible strain) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID688519 | Antibacterial activity against MLSB-resistant Streptococcus pneumoniae 205 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19 | Synthesis and structure-activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'. |
| AID528716 | Antibacterial activity against methicillin resistant Staphylococcus epidermidis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID520396 | Antibacterial activity against mef(E) and mef(A)-positive Streptococcus pneumoniae isolate CC-6B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6 | Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). |
| AID728673 | Antimicrobial activity against hldE-deficient Escherichia coli O18:K1:H7 after overnight incubation | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence. |
| AID1459113 | Antibacterial activity against Mef-mediated macrolide efflux resistant Streptococcus pneumoniae by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID1550819 | Antimicrobial activity against constitutively erythromycin resistant Streptococcus pyogenes A2 expressing c-erm incubated in CAMHB medium for 20 to 24 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID475338 | Metabolic stability at human liver S9 fraction assessed as compound remaining after 1 hr | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID528715 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus auricularis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID396041 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pBGS18 plasmid by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID422681 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID261510 | Volume of distribution in Sprague-Dawley rat at 5 mg/kg, iv and 15 mg/kg, po | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID669600 | Antibacterial activity against Staphylococcus aureus UCN14 harboring 23S rRNA A2058T mutant | 2012 | ACS medicinal chemistry letters, Mar-08, Volume: 3, Issue:3 | Desmethyl Macrolides: Synthesis and Evaluation of 4,10-Didesmethyl Telithromycin. |
| AID1550841 | Ratio of MBC to MIC for erythromycin-susceptible Moraxella catarrhalis 13L332 | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID207375 | In vivo antibacterial activity against Staphylococcus aureus strain 10649 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID502235 | Antibacterial activity against constitutive MLS resistance Streptococcus pneumoniae 58 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID1549396 | Half life in Sprague-Dawley rat at 20 mg/kg, po after 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID531459 | Antibacterial activity against Streptococcus pneumoniae serotype 15A assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID977603 | pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID299387 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4051 containing erm(B) by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID638884 | Antibacterial activity against Streptococcus pneumoniae 3579 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID528712 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus hominis subsp. novobiosepticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1474052 | Ratio of drug concentration at steady state in human at 400 mg, po BID for 5 to 10 days after 12 hrs to IC50 for human BSEP overexpressed in Sf9 insect cells | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID300911 | Antibacterial activity against mef containing Streptococcus pneumoniae 1175 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID1278831 | Antibacterial activity against efflux mediated macrolide resistant Streptococcus pyogenes by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID1549384 | Antibacterial activity against MLS-resistant Streptococcus pyogenes 12-206 expressing constitutive ermA gene assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1868046 | Stability in rat liver microsomes assessed as unchanged drug level at 1 uM by LC-MS/MS analysis | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID642856 | Antibacterial activity against efflux mediated macrolide resistant Staphylococcus aureus by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID1550859 | Cmax in Sprague-Dawley rat at 20 mg/kg, po administered as single dose measured for 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID508445 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 3009 harboring mutation in 23S rRNA after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID747248 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID1868044 | Antibacterial activity against Staphylococcus aureus PU32 by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID1550838 | Ratio of MBC to MIC for inducibly erythromycin-resistant and methicillin resistant Staphylococcus aureus PU32 expressing i-ermA | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID423241 | Antibacterial activity against beta lactamase-negative Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID203436 | The compound was tested in vitro for antibacterial activity against 66 strains of inducibly erythromycin resistant Staphylococci; Value is 0.08/0.3 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID206742 | In vitro antibacterial activity against Staphylococcus aureus A5177 strain | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID201260 | In Vitro antibacterial activity against Staphylococcus aureus A5177 (ermA-i strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID581464 | Antimicrobial activity against Escherichia coli TA531 harboring 23S rRNA U2609C mutant after 15 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID201245 | In Vitro antibacterial activity against Staphylococcus aureus 1775 (ermA-c strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID372554 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b with an amino acid substitution in variable mutated locus Asn-526 or Arg-517 of ftsI gene assessed as susceptibility rate by broth microd | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15 | Physicochemical determinants of human renal clearance. |
| AID475098 | Antibacterial activity against Streptococcus pneumoniae 10 expressing mefA efflux pump after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID209607 | In vitro antibacterial activity against Streptococcus pyogenes strain 930. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID423232 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 isolated from respiratory tract infected patients assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID261514 | Oral bioavailability in Sprague-Dawley rat at 15 mg/kg, po | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID244982 | Minimum inhibitory concentration of compound against Ery-R Streptococcus pneumoniae 163 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID508415 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1635 harboring erm(A) gene after 49 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID735601 | Antibacterial activity against MLS-resistant (constitutive), penicillin-resistant Streptococcus pneumoniae PU11 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID483701 | Antimicrobial activity against macrolide-sensitive Staphylococcus aureus PK1 | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1549390 | Antibacterial activity against erythromycin-susceptible Moraxella catarrhalis 13L332 assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1439716 | Bacteriostatic activity against erythromycin-resistant Streptococcus pneumoniae ATCC 49619 after 20 to 24 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID201265 | In Vitro antibacterial activity against Staphylococcus aureus ATCC 6538P (Ery-S resistant strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID518991 | Renal clearance in Sprague-Dawley rat at 50 mg/kg, iv pretreated with Escherichia coli lipopolysaccharide (Rvb=5.29 +/- 0.643 ml/min/kg) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID781252 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 12-8 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID531445 | Antibacterial activity against Streptococcus pneumoniae serotype 6A/C assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID608739 | Antibacterial activity against inducible macrolide-lincosamide-streptogramin B resistant Staphylococcus aureus 90256 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID300910 | Antibacterial activity against erm containing Streptococcus pneumoniae 1095 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID717682 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 09R476 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID475091 | Antibacterial activity against Staphylococcus aureus 209P JC1 after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID475094 | Antibacterial activity against Streptococcus pneumoniae 6 expressing constitutive ermB methylase and mefA after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID502241 | Antibacterial activity against inducible resistance to macrolide, licosamide, and streptogramin Staphylococcus aureus 90265/97 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID567805 | Antibacterial activity against erythromycin-susceptible Haemophilus influenzae 07O114 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID1245707 | Antimicrobial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 incubated for 20 to 24 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID300912 | Antibacterial activity against Haemophilus influenzae 1100 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID1550817 | Antimicrobial activity against mef-encoded erythromycin resistant Streptococcus pneumoniae PU09 incubated in CAMHB medium for 20 to 24 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID261495 | Antibacterial activity against Streptococcus pneumoniae Erm 4589 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID322977 | Half life in mouse serum at 15 mg/kg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID531425 | Antibacterial activity against Streptococcus pneumoniae serotype 22 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1278824 | Antibacterial activity against efflux mediated macrolide resistant Staphylococcus aureus by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID285158 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent resistant isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID1549370 | Bactericidal activity against penicillin-susceptible Streptococcus pneumoniae PU 09 expressing mef gene pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID608735 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 3565 by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID1691395 | Bactericidal activity against MLSB-resistant Streptococcus pneumoniae 07P390 harboring ermB gene assessed as reduction in microbial growth | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID299389 | Antibacterial activity against Haemophilus influenzae OC4882 by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6 | Structure-based identification of OATP1B1/3 inhibitors. |
| AID558599 | Antimicrobial activity against Streptococcus pneumoniae 11 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | |||
| AID1498848 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID323661 | Antimicrobial activity against doxycyclin-resistant Orientia tsutsugamushi in patient of scrub typhus assessed as recovery from infection | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6 | Controlled trial of a 5-day course of telithromycin versus doxycycline for treatment of mild to moderate scrub typhus. |
| AID519328 | Antibacterial activity against Telithromycin resistant Staphylococcus aureus isolate KT02 carrying duplication in the carboxy-terminal region of L22 ribosomal protein | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event. |
| AID508421 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2686 harboring mutation in L4 ribosomal protein after 14 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID246997 | Effective dose against Staphylococcus aureus infected murine was tested after subcutaneous injection | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID539510 | Antibacterial activity against erythromycin A-susceptible Staphylococcus aureus B0329 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID440644 | Antibacterial activity against multidrug-susceptible Haemophilus influenzae 1325 by NCCLS method | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID475093 | Antibacterial activity against Streptococcus pneumoniae 5 expressing constitutive ermB methylase after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID558598 | Antimicrobial activity against Streptococcus pneumoniae 10 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID276842 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4421 containing mef(A) | 2006 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24 | Synthesis and antibacterial activity of C6-carbazate ketolides. |
| AID1498830 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 11X315 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID425968 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 2527 after 14 passages with gemifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID582685 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 infected in human THP1 cells assessed as decrease of CFU after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | |||
| AID261465 | Antibacterial activity against Streptococcus pneumoniae Mef 5654 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID396034 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1549367 | Selectivity ratio of MBC to MIC for erythromycin-susceptible Streptococcus pneumoniae ATCC49619 | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID1474050 | AUC in human at 400 mg, po BID for 5 to 10 days after 12 hrs | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID558594 | Antimicrobial activity against Streptococcus pneumoniae 6 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID502376 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis MRSE-1 by the broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | A new series of macrolide derivatives with 4''-O-saccharide substituents. |
| AID1868048 | Half life in human liver microsomes at 1 uM by LC-MS/MS analysis | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID132628 | The compound was tested in vivo for antibacterial activity against constitutively erythromycin resistant Streptococcus pneumoniae 030MV2 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID209606 | In vitro antibacterial activity against Streptococcus pyogenes PIU 2548 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID608738 | Antibacterial activity against efflux-mediated macrolide-resistance Streptococcus pyogenes 2 Finland by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID428142 | Increase in erm(B) mRNA expression in wild-type Streptococcus pneumoniae PC13 at 0.008 ug/ml by qRT-PCR relative to baseline | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID270433 | Antibacterial activity against Streptococcus pneumoniae 280-962 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID531456 | Antibacterial activity against Streptococcus pneumoniae serotype 19F assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID508440 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 3665 harboring mef(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID208280 | Minimum inhibitory concentration against Streptococcus pneumoniae 6303 (erythromycin susceptible strain) | 2001 | Journal of medicinal chemistry, Nov-22, Volume: 44, Issue:24 | Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. |
| AID1439737 | Bacteriostatic activity against erythromycin-susceptible Moraxella catarrhalis 11B366 after 20 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID245014 | Minimum inhibitory concentration of compound against Ery-S Staphylococcus aureus ATCC 29213 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID637561 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae B739 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID261469 | Antibacterial activity against Streptococcus pneumoniae Mef 5649 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID554552 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC1028 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID1459142 | Protein binding in rat plasma at 1 ug/ml by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID244986 | Minimum inhibitory concentration against Staphylococcus haemolyticus OC3882 | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID261796 | Antibacterial activity against Haemophilus influenzae ATCC 9006 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID747247 | Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID1691427 | Antibacterial activity against azithromycin-susceptible Haemophilus influenzae ATCC 49247 assessed as reduction in microbial growth relative to ciprofloxacin | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID502234 | Antibacterial activity against constitutive MLS resistance Streptococcus pyogenes 166 GR-Micro by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID1459119 | Antibacterial activity against erythromycin susceptible Streptococcus pneumoniae infected in mouse assessed as increase in mouse survival administered orally 1 hr post infection | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | |||
| AID642867 | Inhibition of Escherichia coli DNA gyrase-mediated supercoiling of relaxed pBR322 DNA | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | |||
| AID499556 | Antibacterial activity against erythromycin A-resistant Streptococcus pyogenes B0542 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID781255 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 11-2 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID531417 | Antibacterial activity against Streptococcus pneumoniae serotype 19A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID209865 | In vivo antibacterial activity against Streptococcus pneumoniae strain 5649 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | |||
| AID1459125 | Clearance in Han Wistar rat at 10 mg/kg, iv by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID440649 | Inhibition of human ERG by patch-clamp assay | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID508422 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2686 harboring mutation in L4 ribosomal protein after 25 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID637562 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 3271 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID775004 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 15 by broth microdilution method | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1459114 | Antibacterial activity against erythromycin susceptible Staphylococcus aureus by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID261478 | Antibacterial activity against Streptococcus pneumoniae Mef 2880 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1550826 | Bactericidal activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 assessed as reduction in colony formation incubated in CAMHB medium for 20 to 24 hrs followed by 24 hrs subculturing in the medium without test compound | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID499553 | Antibacterial activity against erythromycin A-resistant Streptococcus pneumoniae B0541 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID518970 | Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZdelta2-4 mutant leader peptide cistrons reporter plasmid at 25 mg/ml after 36 hrs at 37 degC by disc-based beta-galactosidase reporter gene ass | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID1549377 | Bactericidal activity against MLS-resistant Streptococcus pyogenes 01-968 expressing inducible ermB gene pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID535568 | Antibacterial activity against Salmonella enterica subsp. enterica serovar Saintpaul harboring G235A mutation in rlpD gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8 | In vitro activity of azithromycin against nontyphoidal Salmonella enterica. |
| AID1245720 | Bactericidal activity against azithromycin-susceptible and ampicillin-resistant Haemophilus influenzae 11P037 incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID299388 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae OC4438 containing mef(A) by broth microdilution method | 2007 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 17, Issue:14 | Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. |
| AID508417 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2686 harboring mutation in L4 ribosomal protein after 22 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1474053 | Ratio of drug concentration at steady state in human at 400 mg, po BID for 5 to 10 days after 12 hrs to IC50 for human MRP4 overexpressed in Sf9 insect cells | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1498838 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID562608 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID735593 | Antibacterial activity against methicillin-susceptible, MLS-resistant (inducible) Staphylococcus aureus PU 64 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID508458 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2094 harboring erm(A) gene after 43 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID396036 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID588210 | Human drug-induced liver injury (DILI) modelling dataset from Ekins et al | 2010 | Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12 | A predictive ligand-based Bayesian model for human drug-induced liver injury. |
| AID508439 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 3009 harboring mutation in 23S rRNA after 50 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID475099 | Antibacterial activity against Streptococcus pneumoniae 11 expressing mefA efflux pump after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID501299 | Antibacterial activity against inducible resistance to macrolide and constitutive resistance to lincosamide Streptococcus pneumoniae 134 GR M by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID422685 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 37 after 14 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1439720 | Bactericidal activity against penicillin-susceptible Streptococcus pneumoniae PU09 incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID531448 | Antibacterial activity against Streptococcus pneumoniae serotype 35B assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1278832 | Antibacterial activity against Haemophilus influenzae by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID508475 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 237 harboring mutation in L4 ribosomal protein after 43 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID261501 | Antibacterial activity against Streptococcus pneumoniae Erm 8257 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID270437 | Antibacterial activity against Haemophilus influenzae 49247 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID1245718 | Bactericidal activity against Streptococcus pyogenes 01-968 expressing inducible ermA incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID425973 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 2527 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID554534 | Antimicrobial activity against Mycobacterium abscessus isolate MC879 on day 4 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID261471 | Antibacterial activity against Streptococcus pneumoniae Mef 41 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID424328 | Antimicrobial activity against Dialister invisus by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID208620 | The compound was tested in vitro for antibacterial activity against 53 strains of Streptococcus pneumoniae PenR; Value is 0.005/0.15 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID519003 | Drug absorption in Sprague-Dawley rat gastrointestinal tract at 50 mg/kg, po after 24 hrs pretreated with Escherichia coli lipopolysaccharide (Rvb=5.73 +/- 4.57 %) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID501295 | Antibacterial activity against efflux-mediated macrolide-resistance Staphylococcus aureus PK1 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID531458 | Antibacterial activity against Streptococcus pneumoniae serotype 23A assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID426377 | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae 07Z001 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID244964 | Minimum inhibitory concentration of compound against Ery-R Streptococcus pyogenes 3029 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID202100 | In Vitro antibacterial activity against Streptococcus pneumoniae 5979 (ermB strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID781262 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 12-31 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID567793 | Antibacterial activity against methicillin-susceptible Staphylococcus epidermidis 07C134 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID209604 | In vitro antibacterial activity against Streptococcus pyogenes 930 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID1278823 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B resistant Staphylococcus aureus by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID1868041 | Antibacterial activity against Streptococcus pneumoniae PU09 by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID261508 | Lung-to-plasma AUC ratio in Sprague-Dawley rat at 5 mg/kg, iv | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1459122 | Cmax in Han Wistar rat at 10 mg/kg, iv by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID781249 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae 12-5 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID1439744 | Bactericidal activity against azithromycin-susceptible Haemophilus influenzae ATCC 49247 incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID425995 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 after 50 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID209866 | In vivo antibacterial activity against Streptococcus pneumoniae strain 6303 | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID1439741 | Bactericidal activity against erythromycin-susceptible Moraxella catarrhalis 13L332 incubated for 20 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID508467 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2094 harboring erm(A) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1550854 | AUC (0 to t) in Sprague-Dawley rat at 20 mg/kg, po administered as single dose measured for 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID747240 | Antibacterial activity against drug-resistant Salmonella typhi by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID422659 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 after 29 passages with azithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID429076 | Antiplasmodial activity against Plasmodium falciparum 3D7 as delayed maturation in first replication and early second cycle arrest at IC50 | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID428140 | Antimicrobial activity against Streptococcus pneumoniae PC13 transformant harboring 136-bp deletion in erm(B) gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation. |
| AID261509 | Clearance in Sprague-Dawley rat at 5 mg/kg, iv and 15 mg/kg, po | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1550821 | Antimicrobial activity against erythromycin-susceptible Staphylococcus aureus ATCC 29213 incubated in CAMHB medium for 20 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID261459 | Antibacterial activity against Enterococcus faecalis bc11148-2 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID581462 | Antimicrobial activity against chromosomal rrn allele deficient-Escherichia coli TA531 after 15 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID553269 | Antibacterial activity against Staphylococcus aureus UCN14 harboring ribosomal A2058GT mutant | 2011 | ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1 | Desmethyl Macrolide Analogues to Address Antibiotic Resistance: Total Synthesis and Biological Evaluation of 4,8,10-Tridesmethyl Telithromycin. |
| AID554543 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC719 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID483699 | Antimicrobial activity against inducible macrolide and constitutive lincosamide, streptogramin-resistant Streptococcus pneumoniae 58 Spain | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID637565 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae AB14 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID245027 | Minimum inhibitory concentration of compound against Ery-S Streptococcus pyogenes ATCC 19615 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID475100 | Antibacterial activity against Streptococcus pyogenes Cook after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID642861 | Antibacterial activity against Streptococcus pyogenes with inducible resistance to MLS by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID508463 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2094 harboring erm(A) gene after 22 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID735592 | Antibacterial activity against methicillin-resistant, coagulase-negative, MLS-resistant (constitutive) Staphylococcus aureus PU 19 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID539508 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Staphylococcus aureus B0330 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID1549391 | Bactericidal activity against erythromycin-susceptible Moraxella catarrhalis 13L332 pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID508453 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2368 harboring erm(B) gene after 8 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID261461 | Antibacterial activity against Streptococcus pneumoniae 49619 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID422669 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1076 after 14 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID132627 | The compound was tested in vivo for antibacterial activity against constitutively erythromycin resistant Streptococcus pneumoniae 030Cr29 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID261487 | Antibacterial activity against Streptococcus pneumoniae Erm 6396 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID531424 | Antibacterial activity against Streptococcus pneumoniae serotype 33 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID261512 | Plasma half life in Sprague-Dawley rat at 15 mg/kg, po | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID261497 | Antibacterial activity against Streptococcus pneumoniae Erm 5399 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID283556 | Antimicrobial activity against Streptococcus pneumoniae R6 with L4 mutation | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3 | High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. |
| AID518971 | Induction of erm(C) expression in Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid assessed as increase in A2058 dimethylation in 23S rRNA at 0.4 ug/ml at 2 hrs by primer extension assay | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID524550 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bactericidal at 8 times MIC in 24 hrs by time kill study | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5 | CEM-101 activity against Gram-positive organisms. |
| AID717689 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24 | Synthesis and antibacterial activity of novel modified 5-O-desosamine ketolides. |
| AID429075 | Antiplasmodial activity as ED50 against parasite growth after 96 hrs for Plasmodium falciparum 3D7 | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID300915 | Antibacterial activity against Haemophilus influenzae 1218 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID396035 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID637563 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 217 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID781264 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID518989 | Half life in Sprague-Dawley rat at 50 mg/kg, iv pretreated with Escherichia coli lipopolysaccharide (Rvb=159 +/- 56.3 min) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID519002 | Drug absorption in Sprague-Dawley rat gastrointestinal tract at 50 mg/kg, iv after 24 hrs pretreated with Escherichia coli lipopolysaccharide (Rvb=8.53 +/- 4.64 %) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID440645 | Metabolic stability in human liver microsomes assessed as hepatic extraction ratio at 1 uM | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID1617220 | Cytotoxicity in human HEK293 cells assessed as reduction in cell viability at 0.5 uM incubated up to 72 hrs relative to chloramphenicol | 2019 | Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22 | Structure-Activity Relationship of Peptide-Conjugated Chloramphenicol for Inhibiting |
| AID508428 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 7127 harboring S20N mutation in L4 ribosomal protein and A105V mutation in L22 ribosomal protein after 29 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID508402 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 3665 harboring mef(A) gene after 14 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1498842 | Antibacterial activity against methicillin-sensitive Streptococcus pyogenes 12-8 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID426383 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes 07Z016 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID206076 | The compound was tested in vitro for antibacterial activity against 31 strains of erythromycin resistant Streptococci; Value is 0.02/0.08 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID422647 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 after 14 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID781257 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 12-11 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID209608 | In vitro antibacterial activity against Streptococcus pyogenes strain EES 61. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID425972 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 2527 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID424322 | Antimicrobial activity against Dialister micraerophilus assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID518999 | Oral bioavailability in Sprague-Dawley rat at 50 mg/kg, po pretreated with Escherichia coli lipopolysaccharide (Rvb=38.8%) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID1498846 | Antibacterial activity against clarithromycin-resistant Moraxella catarrhalis 12-2 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1 | Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12 | Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID422658 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 after 49 passages with clindamycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1474051 | Drug concentration at steady state in human at 400 mg, po BID for 5 to 10 days after 12 hrs | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID208466 | The compound has been evaluated for the antibacterial activity against Streptococcus pneumoniae Ery Ri 030SJ 5i strains | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID554541 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC879 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID669599 | Antibacterial activity against Escherichia coli DK harboring 23S rRNA A2058G mutant | 2012 | ACS medicinal chemistry letters, Mar-08, Volume: 3, Issue:3 | Desmethyl Macrolides: Synthesis and Evaluation of 4,10-Didesmethyl Telithromycin. |
| AID562404 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID502379 | Antibacterial activity against Streptococcus pyogenes ERSPy-1 expressing mef by the broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | A new series of macrolide derivatives with 4''-O-saccharide substituents. |
| AID1549381 | Antibacterial activity against MLS-resistant Staphylococcus aureus PU 20 expressing constitutive ermC gene assessed as reduction in microbial growth by CLSI based two-fold broth dilution method | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID531453 | Antibacterial activity against Streptococcus pneumoniae serotype 19A assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1459137 | AUC(0 to infinity) in Han Wistar rat at 20 mg/kg, po by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID501282 | Antibacterial activity against inducible resistance to macrolide and constitutive resistance to lincosamide Streptococcus pneumoniae 134 GR M by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID539512 | Antibacterial activity against efflux-resistant Streptococcus pyogenes B0545 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID426376 | Antimicrobial activity against erythromycin-susceptible Streptococcus pneumoniae 07H252 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID372559 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-susceptible Haemophilus influenzae type b without amino acid substitutions in ftsI gene and bla gene assessed as resistance rate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID300822 | Protection against erythromycin-resistant Streptococcus pneumoniae 1095 infection in po dosed mouse after 4 days | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Novel tethers in ketolide antibiotics. |
| AID735591 | Antibacterial activity against methicillin-susceptible, MLS-resistant (inducible) Staphylococcus epidermidis E1 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. |
| AID285157 | Antimicrobial susceptibility of tetracycline-resistant Streptococcus pneumoniae from respiratory tract disease patient assessed as percent susceptible isolates | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4 | Clonal diversity and resistance mechanisms in tetracycline-nonsusceptible Streptococcus pneumoniae isolates in Poland. |
| AID429070 | Cmax in human at 12 mg/kg administered as single oral dose | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID423239 | Antibacterial activity against Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients assessed as susceptible isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID642868 | Inhibition of Escherichia coli topoisomerase 4-mediated relaxation of supercoiled pBR322 DNA | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID411678 | Antibacterial activity against macrolide-susceptible Staphylococcus aureus Smith infected in mouse | 2008 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24 | Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. |
| AID508419 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 24 harboring erm(B) gene after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID261784 | Antibacterial activity against macrolide resistant Streptococcus pneumoniae ATCC 700677 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID554556 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC1082 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID1473740 | Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 10 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID425979 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 after 49 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1550827 | Ratio of MBC to MIC for erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID1164321 | Antimicrobial activity against tolC-negative Escherichia coli DK/2058G harboring ribosome A2058G mutant | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9 | Desmethyl macrolides: synthesis and evaluation of 4-desmethyl telithromycin. |
| AID300907 | Antibacterial activity against erythromycin susceptible Streptococcus pyogenes 203 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID423242 | Antibacterial activity against Haemophilus influenzae ATCC 49247 isolated from respiratory tract infected patients assessed as resistant isolates after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study. |
| AID83640 | The compound has been evaluated for the antibacterial activity against Haemophilus influenzae 351HT3 (beta-lactamase +) | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID554555 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC1028 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID202099 | In Vitro antibacterial activity against Streptococcus pneumoniae 5649 (mefE strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | |||
| AID209925 | The compound was tested in vitro for antibacterial activity against erythromycin susceptible Streptococcus pyogenes 02A1UC1. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID261798 | Antibacterial activity against Haemophilus influenzae EH001 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID1443991 | Induction of mitochondrial dysfunction in Sprague-Dawley rat liver mitochondria assessed as inhibition of mitochondrial respiration per mg mitochondrial protein measured for 20 mins by A65N-1 oxygen probe based fluorescence assay | 2014 | Hepatology (Baltimore, Md.), Sep, Volume: 60, Issue:3 | Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. |
| AID501677 | Antimicrobial activity against Haemophilus influenzae ATCC 49247 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID426375 | Antimicrobial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID637560 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 3489 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID261799 | Antibacterial activity against Haemophilus influenzae EH002 | 2006 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5 | Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. |
| AID261513 | Lung half life in Sprague-Dawley rat at 15 mg/kg, po | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1550818 | Antimicrobial activity against constitutively erythromycin resistant Streptococcus pneumoniae PU27 expressing c-erm incubated in CAMHB medium for 20 to 24 hrs by two-fold microbroth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID518974 | Antimicrobial activity against Escherichia coli ZK796 harboring Staphylococcus aureus erm(C)-containing pERMCT plasmid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID1439717 | Bactericidal activity against erythromycin-resistant Streptococcus pneumoniae ATCC 49619 incubated for 20 to 24 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID1549399 | Cmax in Sprague-Dawley rat at 20 mg/kg, po after 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID422666 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1076 after 35 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID424323 | Antimicrobial activity against Dialister pneumosintes assessed as susceptibility breakpoint by CA-SFM method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID508374 | Antibacterial activity against Streptococcus pneumoniae harboring mutation in 23S rRNA after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID567798 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes 07U086 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID567790 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae 07H252 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID85946 | The compound was tested in vitro for antibacterial activity against 47 strains of Haemophilus influenza AmpS; Value is 0.6/1.2 | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID208479 | The compound was tested in vitro for antibacterial activity against erythromycin susceptible Streptococcus pneumoniae 032UC1. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID501285 | Antibacterial activity against constitutive MLS resistance Streptococcus pyogenes 166 GR-Micro by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID528713 | Antibacterial activity against methicillin resistant coagulase-negative Staphylococcus haemolyticus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID518988 | AUC in Sprague-Dawley rat at 50 mg/kg, iv pretreated with Escherichia coli lipopolysaccharide (Rvb=1570 +/- 240 ug/min/ml) | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. |
| AID1439743 | Bacteriostatic activity against azithromycin-susceptible Haemophilus influenzae ATCC 49247 after 20 to 24 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID1550856 | Half life in Sprague-Dawley rat at 20 mg/kg, po administered as single dose measured for 0.25 to 24 hrs by LC-MS/MS analysis | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID554553 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC1082 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID558591 | Antimicrobial activity against Streptococcus pneumoniae 3 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID429066 | Antiplasmodial activity after 120 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2 | Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. |
| AID1498828 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus 11B122 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID502375 | Antibacterial activity against methicillin-resistant Staphylococcus aureus BK2464 by the broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | A new series of macrolide derivatives with 4''-O-saccharide substituents. |
| AID426381 | Antimicrobial activity against erythromycin-resistant Streptococcus pyogenes 07Z011 by broth microdilution method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. |
| AID209605 | In vitro antibacterial activity against Streptococcus pyogenes EES61 | 2004 | Bioorganic & medicinal chemistry letters, May-17, Volume: 14, Issue:10 | Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. |
| AID261511 | Plasma half life in Sprague-Dawley rat at 5 mg/kg, iv | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID539514 | Antibacterial activity against Haemophilus influenzae B0529 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID553267 | Antibacterial activity against wild type Escherichia coli DK/pKK3535 | 2011 | ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1 | Desmethyl Macrolide Analogues to Address Antibiotic Resistance: Total Synthesis and Biological Evaluation of 4,8,10-Tridesmethyl Telithromycin. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7 | Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID1549388 | Bactericidal activity against Streptococcus pyogenes 12-207 expressing mef gene pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID502237 | Antibacterial activity against efflux-mediated macrolide-resistance Streptococcus pneumoniae Ci137 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID608744 | Antibacterial activity against macrolide, lincosamide, streptogramin-resistant Streptococcus pyogenes 166 GR-Micro by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID501277 | Antibacterial activity against erythromycin-sensitive Staphylococcus aureus ATCC 13709 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit. |
| AID422657 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1459126 | Unbound clearance in Han Wistar rat at 10 mg/kg, iv by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID508431 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 7127 harboring S20N mutation in L4 ribosomal protein and A105V mutation in L22 ribosomal protein after 38 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID396037 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate in presence of 20 ug/ml efflux pump inhibitor Phe-Arg-beta-naphthylamide by standard disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1868052 | Antibacterial activity against erythromycin-resistant Mycoplasma pneumoniae A2059G by microbroth dilution method | 2022 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 68 | Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides. |
| AID502239 | Antibacterial activity against inducible resistance to macrolide, licosamide and streptogramin Streptococcus pyogenes 11 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | Synthesis and properties of macrolones characterized by two ether bonds in the linker. |
| AID637564 | Antibacterial activity against telethromycin-resistant Streptococcus pneumoniae 3488 expressing erm gene by NCCLS method | 2012 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1 | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. |
| AID558600 | Antimicrobial activity against Streptococcus pneumoniae 12 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID781251 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 12-10 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID1439740 | Bacteriostatic activity against erythromycin-susceptible Moraxella catarrhalis 13L332 after 20 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID1550837 | Bactericidal activity against inducibly erythromycin-resistant and methicillin resistant Staphylococcus aureus PU32 expressing i-ermA assessed as reduction in colony formation incubated in CAMHB medium for 20 hrs followed by 24 hrs subculturing in the med | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID558596 | Antimicrobial activity against Streptococcus pneumoniae 8 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6 | Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID642863 | Antibacterial activity against efflux mediated macrolide resistant Streptococcus pyogenes by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | |||
| AID1459135 | Cmax in Han Wistar rat at 20 mg/kg, po by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID425974 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 24 after 50 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID300909 | Antibacterial activity against erythromycin susceptible Streptococcus pneumoniae 1016 | 2007 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18 | Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. |
| AID502377 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae ERSP-2 expressing ermB and mef by the broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | A new series of macrolide derivatives with 4''-O-saccharide substituents. |
| AID1549374 | Bactericidal activity against azithromycin-susceptible Haemophilus influenzae ATCC 49247 pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID132630 | The compound was tested in vivo for antibacterial activity against constitutively erythromycin resistant Streptococcus pneumoniae 030SJ6 in mice after oral administration | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID210388 | In vitro antibacterial activity against Streptococcus pneumoniae strain 5737. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID270424 | Antibacterial activity against Staphylococcus aureus 29213 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID261519 | Efficacy against Haemophilus influenzae in Sprague-Dawley rat lung infection model at 100 mg/kg | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID483702 | Antimicrobial activity against inducible macrolide-resistant Streptococcus pyogenes Finland 3 | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID642857 | Antibacterial activity against erythromycin-susceptible Streptococcus pneumoniae by agar microdilution method | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID581463 | Antimicrobial activity against Escherichia coli TA531 harboring 23S rRNA A2058G mutant after 15 hrs | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. |
| AID425967 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3274 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1549385 | Bactericidal activity against MLS-resistant Streptococcus pyogenes 12-206 expressing constitutive ermA gene pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID531460 | Antibacterial activity against Streptococcus pneumoniae serotype 33 assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID508466 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2094 harboring erm(A) gene after 34 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID781253 | Antibacterial activity against erythromycin-sensitive Streptococcus pneumoniae 12-4 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID245268 | Minimum inhibitory concentration against Staphylococcus aureus OC4172 in presence of mouse serum | 2004 | Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17 | Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. |
| AID324157 | Antibacterial activity against telithromycin-susceptible Streptococcus pneumoniae | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | Clonal spread of mef-positive macrolide-resistant Streptococcus pneumoniae isolates causing invasive disease in adults in Germany. |
| AID210221 | In vitro antibacterial activity against Streptococcus pneumoniae 5979 (MLSB resistant stain bearing an erm (B) gene) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID1691396 | Ratio of MBC to MIC against MLSB-resistant Streptococcus pneumoniae 07P390 harboring ermB | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID1498844 | Antibacterial activity against clarithromycin-sensitive Moraxella catarrhalis 12-1 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID422651 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 after 26 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID260946 | Antibacterial activity against Streptococcus pneumoniae OC9132 | 2006 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 16, Issue:4 | Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives. |
| AID501294 | Antibacterial activity against constitutive MLS resistance sStreptococcus pyogenes 166 GR-Micro by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID244963 | Minimum inhibitory concentration of compound against Ery-R Streptococcus pyogenes 1850 was determined | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5 | Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. |
| AID475101 | Antibacterial activity against Streptococcus pyogenes 2 expressing constitutive ermB methylase after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID1549375 | Selectivity ratio of MBC to MIC for azithromycin-susceptible Haemophilus influenzae ATCC 49247 | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID502374 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by the broth microdilution method | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | A new series of macrolide derivatives with 4''-O-saccharide substituents. |
| AID1164320 | Antimicrobial activity against tolC-negative wild type Escherichia coli DK/pKK3535 | 2014 | ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9 | Desmethyl macrolides: synthesis and evaluation of 4-desmethyl telithromycin. |
| AID567807 | Antibacterial activity against erythromycin-susceptible Haemophilus influenzae 07O394 by broth microdilution method | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1 | Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. |
| AID531447 | Antibacterial activity against Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID440647 | Metabolic stability in human liver cytosol assessed as compound turnover at 1 uM in presence of aldehyde oxidase inhibitor raloxifene | 2009 | Journal of medicinal chemistry, Dec-10, Volume: 52, Issue:23 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. |
| AID499555 | Antibacterial activity against efflux-resistant Streptococcus pneumoniae B0326 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID539503 | Antibacterial activity against erythromycin A-susceptible Streptococcus pyogenes B0542 by agar microdilution method | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24 | Novel hybrids of 15-membered 8a- and 9a-azahomoerythromycin A ketolides and quinolones as potent antibacterials. |
| AID781258 | Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 12-4 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID261458 | Antibacterial activity against Enterococcus faecalis 29212 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1550829 | Ratio of MBC to MIC for mef-encoded erythromycin resistant Streptococcus pneumoniae PU09 | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID208477 | The compound was tested in vitro for antibacterial activity against constitutively erythromycin resistant Streptococcus pneumoniae 030SJ1. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID1459116 | Antibacterial activity against Haemophilus influenzae by agar microdilution method | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID781261 | Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis ATCC 12228 by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 23, Issue:23 | Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities. |
| AID424321 | Antimicrobial activity against Dialister pneumosintes assessed as susceptibility breakpoint by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12 | Antimicrobial susceptibilities and clinical sources of Dialister species. |
| AID210219 | In vitro antibacterial activity against Streptococcus pneumoniae 5649 (efflux-resistant strain bearing a mef (E) gene) | 2004 | Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14 | Synthesis and antibacterial activity of novel bifunctional macrolides. |
| AID1549372 | Bactericidal activity against Streptococcus pneumoniae 07P390 expressing constitutive ermB gene pretreated followed by subculture in absence of compound measured after 24 hrs | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Design, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens. |
| AID747242 | Antibacterial activity against drug-resistant Escherichia coli by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID1550851 | Bactericidal activity against inducibly erythromycin resistant Streptococcus pyogenes 01-968 expressing i-ermA at 1XMIC incubated for 12 hrs by broth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID499554 | Antibacterial activity against constitutive macrolide-lincosamide-streptogramin B-resistant Streptococcus pneumoniae B0627 by agar microdilution method | 2010 | Journal of medicinal chemistry, Aug-12, Volume: 53, Issue:15 | Synthesis and structure-activity relationships of novel 8a-aza-8a-homoerythromycin A ketolides. |
| AID202266 | In Vitro antibacterial ativity against Streptococcus pyogenes PIU2548 (mefA strain) | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10 | Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. |
| AID261488 | Antibacterial activity against Streptococcus pneumoniae Erm 6388 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1459129 | Fraction unbound in Han Wistar rat plasma at 10 mg/kg, iv by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID508385 | Antibacterial activity against Streptococcus pyogenes harboring mutation in L4 ribosomal protein after overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID747239 | Antibacterial activity against drug-resistant Pseudomonas aeruginosa by broth microdilution method | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11 | Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives. |
| AID425983 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1691391 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae PU09 harboring mef gene assessed as reduction in microbial growth | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID261485 | Antibacterial activity against Streptococcus pneumoniae Mef 9959 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1169032 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID554547 | Antimicrobial activity against Mycobacterium smegmatis transformed with erm allele Mycobacterium abscessus isolate MC719 preincubated with 2 ug/ml erythromycin for 20 to 24 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. |
| AID261484 | Antibacterial activity against Streptococcus pneumoniae Mef 9142 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID508456 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2368 harboring erm(B) gene after 6 passages and 10 compound-free subculturing by retest method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID553268 | Antibacterial activity against Escherichia coli DK/2058G harboring ribosomal A2058G mutant | 2011 | ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1 | Desmethyl Macrolide Analogues to Address Antibiotic Resistance: Total Synthesis and Biological Evaluation of 4,8,10-Tridesmethyl Telithromycin. |
| AID531421 | Antibacterial activity against Streptococcus pneumoniae serotype 35B by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1473741 | Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay | 2013 | Toxicological sciences : an official journal of the Society of Toxicology, Nov, Volume: 136, Issue:1 | A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. |
| AID1498836 | Antibacterial activity against azithromycin-sensitive Haemophilus influenzae 11P042 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID475092 | Antibacterial activity against Streptococcus pneumoniae DP1 type 1 after 20 hrs by agar dilution method | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7 | Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities. |
| AID508416 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 1635 harboring erm(A) gene after 50 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1459124 | Terminal half life in Han Wistar rat at 10 mg/kg, iv by LC-MS/MS analysis | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Synthesis of novel 15-membered 8a-azahomoerythromycin A acylides: Consequences of structural modification at the C-3 and C-6 position on antibacterial activity. |
| AID1245714 | Antimicrobial activity against Streptococcus pyogenes 12-207 expressing mef incubated for 20 to 24 hrs by two-fold microbroth dilution method | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID422667 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1076 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID483694 | Antimicrobial activity against macrolide-resistant Streptococcus pneumoniae Ci137 | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Novel 8a-aza-8a-homoerythromycin--4''-(3-substituted-amino)propionates with broad spectrum antibacterial activity. |
| AID208473 | The compound was tested in vitro for antibacterial activity against constitutively erythromycin resistant Streptococcus pneumoniae 030CR18c. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID501298 | Antibacterial activity against inducible resistance to macrolide, licosamide and streptogramin Staphylococcus aureus 90256 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID1439719 | Bacteriostatic activity against penicillin-susceptible Streptococcus pneumoniae PU09 after 20 to 24 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID210389 | In vitro antibacterial activity against Streptococcus pneumoniae strain ATCC 6303. | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6 | Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. |
| AID208475 | The compound was tested in vitro for antibacterial activity against constitutively erythromycin resistant Streptococcus pneumoniae 030PW23c. | 1999 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 9, Issue:21 | Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. |
| AID1550848 | Bactericidal activity against mef-encoded erythromycin resistant Streptococcus pneumoniae PU09 at 1 to 16xMIC incubated for 1 to 24 hrs by broth dilution method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. |
| AID669601 | Antibacterial activity against Staphylococcus aureus ATCC 33591 harboring ermA gene | 2012 | ACS medicinal chemistry letters, Mar-08, Volume: 3, Issue:3 | Desmethyl Macrolides: Synthesis and Evaluation of 4,10-Didesmethyl Telithromycin. |
| AID508395 | Antibacterial activity against macrolide-susceptible Streptococcus pneumoniae 1077 after 15 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1169035 | Antibacterial activity against Haemophilus influenzae by agar microdilution method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10 | Synthesis and Structure-Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics. |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4 | DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID642866 | Inhibition of protein synthesis using Escherichia coli S30 extracts preincubated for 10 mins measured after 50 mins by luciferase reporter gene assay | 2011 | ACS medicinal chemistry letters, May-12, Volume: 2, Issue:5 | Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. |
| AID261454 | Antibacterial activity against Staphylococcus aureus 29213 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID261490 | Antibacterial activity against Streptococcus pneumoniae Erm S 4085 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID508455 | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae 2368 harboring erm(B) gene after 6 passages following overnight incubation by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1 | In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. |
| AID1617197 | Antibacterial activity against Escherichia coli K-12 assessed as reduction in bacterial growth incubated for 16 hrs | 2019 | Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22 | Structure-Activity Relationship of Peptide-Conjugated Chloramphenicol for Inhibiting |
| AID1439735 | Bactericidal activity against methicillin-resistant Staphylococcus aureus PU32 expressing inducible ermA incubated for 20 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID369230 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent sensitive isolates by CLSI breakpoint method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9 | Serotypes, Clones, and Mechanisms of Resistance of Erythromycin-Resistant Streptococcus pneumoniae Isolates Collected in Spain. |
| AID582686 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 infected in human THP1 cells assessed as concentration required to no apparent bacterial growth after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9 | Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages. |
| AID1439728 | Bacteriostatic activity against azithromycin-susceptible/ampicillin-resistant Haemophilus influenzae 11P307 after 20 to 24 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID261507 | Plasma AUC in Sprague-Dawley rat at 5 mg/kg, iv | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID270432 | Antibacterial activity against Streptococcus pneumoniae 297-749 by broth microdilution method | 2006 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 16, Issue:17 | Synthesis and antibacterial activity of C12 des-methyl ketolides. |
| AID562606 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11 | Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID1439725 | Bacteriostatic activity against Streptococcus pyogenes 12-207 expressing mef after 20 to 24 hrs by two-fold microbroth dilution method | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID1278828 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by agar microdilution method | 2016 | Bioorganic & medicinal chemistry, Mar-15, Volume: 24, Issue:6 | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. |
| AID501670 | Antimicrobial activity against Staphylococcus aureus ATCC 13709 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. |
| AID1691393 | Ratio of MBC to MIC against penicillin-susceptible Streptococcus pneumoniae PU09 | 2020 | European journal of medicinal chemistry, May-01, Volume: 193 | Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides. |
| AID518973 | Antimicrobial activity against Escherichia coli ZK796 harboring empty plasmid | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3 | Induction of erm(C) expression by noninducing antibiotics. |
| AID208468 | The compound has been evaluated for the antibacterial activity against Streptococcus pneumoniae EryRc 030SJ1 strains | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID501293 | Antibacterial activity against Haemophilus influenzae ATCC 49247 by broth microdilution method | 2010 | Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17 | 4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. |
| AID531457 | Antibacterial activity against Streptococcus pneumoniae serotype 35B assessed as percent resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID1498835 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 11 N369 by broth microdilution method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14 | Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. |
| AID531423 | Antibacterial activity against Streptococcus pneumoniae serotype 15A by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7 | Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. |
| AID209919 | The compound has been evaluated for the antibacterial activity against Streptococcus pyogenes EryS 02A1UC1. | 2000 | Bioorganic & medicinal chemistry letters, Sep-04, Volume: 10, Issue:17 | Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides. |
| AID1439738 | Bactericidal activity against erythromycin-susceptible Moraxella catarrhalis 11B366 incubated for 20 hrs followed by sub-culturing for 24 hrs in absence of compound | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7 | Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. |
| AID422663 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 after 15 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID608743 | Antibacterial activity against constitutive macrolide, lincosamide, streptogramin-resistant Streptococcus pneumoniae 58 spain by broth microdilution method | 2011 | European journal of medicinal chemistry, Aug, Volume: 46, Issue:8 | Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. |
| AID712417 | Antibacterial activity against Escherichia coli DK/2058G harboring 23S rRNA A2058G mutant in presence of DMSO | 2012 | ACS medicinal chemistry letters, Dec-12, Volume: 3, Issue:12 | Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin. |
| AID261473 | Antibacterial activity against Streptococcus pneumoniae Mef 983 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID1245722 | Bactericidal activity against methicillin-resistant Staphylococcus aureus PU20 expressing constitutive ermC incubated for 20 hrs followed by sub-culturing for 24 hrs in absence of compound | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19 | Synthesis and structure-activity relationships of novel 9-oxime acylides with improved bactericidal activity. |
| AID261506 | Antibacterial activity against Streptococcus pneumoniae Erm 5590 | 2006 | Journal of medicinal chemistry, Mar-09, Volume: 49, Issue:5 | Synthesis and antibacterial activity of novel C12 vinyl ketolides. |
| AID372561 | Antibacterial activity against genetically beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b with an amino acid substitution in highly mutated locus Ser-385 of ftsI gene assessed as resistance rate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11 | Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11 | 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.87) | 18.2507 |
| 2000's | 56 (48.70) | 29.6817 |
| 2010's | 54 (46.96) | 24.3611 |
| 2020's | 4 (3.48) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.33) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (2.59%) | 5.53% |
| Reviews | 2 (1.72%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 111 (95.69%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||