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dicarboximide

An imide in which the two acyl substituents on nitrogen are carboacyl groups.

ChEBI ID: 35356

Members (31)

MemberDefinitionRole
4-(5-amino-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-amine4-(5-amino-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-amine
4-[5-(4-methyl-1,2,5-oxadiazol-3-yl)-1H-1,2,4-triazol-3-yl]-1,2,5-oxadiazol-3-amine4-[5-(4-methyl-1,2,5-oxadiazol-3-yl)-1H-1,2,4-triazol-3-yl]-1,2,5-oxadiazol-3-amine
4-amino-1,8-naphthalimide4-amino-1,8-naphthalimide
4-maleimido-2,2,6,6-tetramethylpiperidinooxylA member of the class of piperidines that is TEMPO carrying a maleimido group at position 4.4-maleimido-TEMPO
aminoglutethimideA dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.aminoglutethimide
aspartimideA pyrrolidinone that is succinimide substituted by an amino group at position 3.3-aminosuccinimide
asperparaline aAn alkaloid isolated from Aspergillus aculeatus.asperparaline A
bromosuccinimideA five-membered cyclic dicarboximide compound having a bromo substituent on the nitrogen atom.N-bromosuccinimide
cycloheximideA dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.cycloheximide
dichlozolinateThe ethyl ester of 3-(3,5-dichlorophenyl)-5-methyl-2,4-dioxo-1,3-oxazolidine-5-carboxylic acid.ethyl 3-(3,5-dichlorophenyl)-5-methyl-2,4-dioxo-1,3-oxazolidine-5-carboxylate
ethosuximideA dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.ethosuximide
formothionFormothion
glutarimideA dicarboximide that is piperidine which is substituted by oxo groups at positions 2 and 6.piperidine-2,6-dione
iwr-1 endoA dicarboximide having an endo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group.IWR-1-endo
iwr-1 exoA dicarboximide having an exo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. It is a weak axin stabilizer, an analogue of IWR-1-endo.IWR-1-exo
lenalidomideA dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.lenalidomide
lurasidoneAn N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizophrenia.lurasidone
maleimideA cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure.maleimide
malyngamide Amalyngamide A
n-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide3-maleimido-PROXYL
N-(3,4-dihydro-2H-pyrrol-5-yl)-5-(2-furanyl)-1,3,4-oxadiazol-2-amineN-(3,4-dihydro-2H-pyrrol-5-yl)-5-(2-furanyl)-1,3,4-oxadiazol-2-amine
n-chlorosuccinimideA five-membered cyclic dicarboximide compound having a chloro substituent on the nitrogen atom.N-chlorosuccinimide
n-iodosuccinimideA five-membered cyclic dicarboximide compound having an iodo substituent on the nitrogen atom.N-iodosuccinimide
perylenediimideThe 3,4,9,10-tetracarboxylic diimide derivative of perylene.perylenediimide
piplartinePiplartine
pomalidomideAn aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.pomalidomide
s 23121A dicarboximide that is 4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione in which the nitrogen has been substituted by a 5-(but-3-yn-2-yloxy)-4-chloro-2-fluorophenyl group.2-[5-(but-3-yn-2-yloxy)-4-chloro-2-fluorophenyl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione
s 53482A benzoxazine that is N-(prop-2-yn-1-yl)-2H-1,4-benzoxazin-3(4H)-one which is substituted at position 6 by a 1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl group and at position 7 by a fluorine. A protoporphyrinogen oxidase inhibitor, it is used for the control of weeds in soya, peanuts, and a variety of vegetable and fruit crops.flumioxazin
succinimideA dicarboximide that is pyrrolidine which is substituted by oxo groups at positions 2 and 5.succinimide
tandospironeA dicarboximide that is (3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione which is substituted by a 4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl group at position 2. It is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM).tandospirone
vinclozolinA member of the class of oxazolidinones that is 5-ethenyl-5-methyl-2,4-oxazolidinedione in which the imide hydrogen is replaced by a 3,5-dichlorophenyl group.3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione

Research

Studies (27,573)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199011,394 (41.32)18.7374
1990's5,989 (21.72)18.2507
2000's4,048 (14.68)29.6817
2010's4,636 (16.81)24.3611
2020's1,506 (5.46)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials1,064 (3.68%)5.53%
Reviews1,380 (4.78%)6.00%
Case Studies823 (2.85%)4.05%
Observational37 (0.13%)0.25%
Other25,587 (88.56%)84.16%