ascorbic-acid and Stevens-Johnson-Syndrome

Topics: Adult; Aged; Ascorbic Acid; Drug Eruptions; Drug Hypersensitivity; Eczema; Erythema Nodosum; Exanthema; Female; Humans; Lymphocyte Activation; Male; Medical History Taking; Middle Aged; Occupational Diseases; Penicillins; Photosensitivity Disorders; Pyridoxine; Radioallergosorbent Test; Skin Diseases; Stevens-Johnson Syndrome; Sulfonamides; Surveys and Questionnaires

We present the case of a 33-year-old woman with no significant past medical history who was admitted to an outside hospital for the abrupt onset of fevers, malaise and a diffuse mucocutaneous rash. Her constellation of symptoms and presentation were most consistent with a diagnosis of Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome secondary to ibuprofen exposure. Her rash continued to worsen and she was transferred to our medical intensive care unit (ICU), where broad-spectrum antibiotics were discontinued and she was treated with supportive care as well as 'low-dose' intravenous hydrocortisone, ascorbic acid (vitamin C) and thiamine (HAT therapy). After starting this therapy, the patient demonstrated a dramatic response with rapid improvement of her cutaneous and mucosal lesions. She was tolerating a diet provided by the hospital on day 4 and was discharged from the ICU a few days later.

Topics: Administration, Intravenous; Adrenal Cortex Hormones; Adult; Antioxidants; Ascorbic Acid; Drug Therapy, Combination; Female; Humans; Ibuprofen; Stevens-Johnson Syndrome; Thiamine; Vitamin B Complex

Topics: Amino Acids; Ascorbic Acid; Betamethasone; Central Nervous System Stimulants; Child; Female; Glucose; Humans; Stevens-Johnson Syndrome; Tetracycline; Vitamin B Complex

Topics: Adult; Aged; Anti-Bacterial Agents; Ascorbic Acid; Drug Hypersensitivity; Erythema Multiforme; Female; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Infant; Male; Middle Aged; Oxyphenbutazone; Penicillins; Pigmentation Disorders; Prednisolone; Purpura; Rutin; Skin Tests; Stevens-Johnson Syndrome; Surgical Procedures, Operative; Urea