ascorbic-acid and Puberty--Precocious

A 2-year-old girl presented with gonadotrophin-independent precocious puberty due to ovarian follicles. Central precocious puberty was excluded by several GnRH-tests and overnight LH sampling. There were no signs of McCune-Albright syndrome. An ovarian tumour was excluded by laparotomy and biopsies. Abdominal sonography demonstrated follicles occurring mostly in the left, sometimes in the right, ovary. Immunoglobulin G (IgG) purified from the patient's serum was capable of stimulating DNA synthesis in granulosa cells of rat ovarian segments kept in organ culture. Since FSH had a similar in-vitro action it is hypothesized that this patient's IgG mimics the action of FSH.

Topics: Animals; Ascorbic Acid; Autoimmune Diseases; Corpus Luteum; Cytotoxicity Tests, Immunologic; DNA; Estradiol; Female; Follicle Stimulating Hormone; Follicular Cyst; Granulosa Cells; Humans; Immunoglobulin G; Infant; Leydig Cells; Luteinizing Hormone; Male; Puberty, Precocious; Rats; Rats, Inbred Strains

Topics: Anabolic Agents; Ascorbic Acid; Child; Erythema Multiforme; Iatrogenic Disease; Methyltestosterone; Niacin; Nicotinic Acids; Puberty; Puberty, Precocious; Sexual Maturation; Steroids; Thyroxine; Toxicology; Vitamin A; Vitamin K; Vitamins