ferroptosis inducer

Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.

ChEBI ID: 173085

Members (18)

Member	Definition	Class
acetaminophen	A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.	paracetamol
ammonium ferric sulfate	A compound of ammonium, iron and sulfate in which the ratio of ammonium to iron(2+) to sulfate ions is 2:1:2.	ferrous ammonium sulfate (anhydrous)
artesunate	An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.	artesunate
bay 11-7085	A sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB.	BAY11-7085
buthionine sulfoximine	A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.	2-amino-4-(S-butylsulfonimidoyl)butanoic acid; S-butyl-DL-homocysteine (S,R)-sulfoximine
buthionine sulfoximine	A 2-amino-4-(S-butylsulfonimidoyl)butanoic acid which has S-configuration. It is a inhibitor of gamma-glutamylcysteine synthetase and glutathione (GSH) biosynthesis and is capable of enhancing the apoptotic effects of several chemotherapeutic agents.	L-buthionine-(S,R)-sulfoximine
cisplatin	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).	cisplatin; transplatin
disulfiram	An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.	disulfiram
DPI2	A thiazolidinone that is 2-sulfanylidene-1,3-thiazolidin-4-one substituted by 3-{[3-(morpholin-4-yl)propyl]amino}-3-oxopropyl and 4-ethylbenzylidene groups at positions 3 and 5, respectively. It is a ferroptosis inducer.	DPI2
erastin	A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.	erastin
glutamic acid	An optically active form of glutamic acid having L-configuration.	L-glutamic acid
iFSP1	A member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1.	iFSP1
jq1 compound	A member of the class of thienotriazolodiazepines that is the tert-butyl ester of [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid. An inhibitor of bromodomain-containing protein 4 that exhibits anti-cancer and cardioprotective properties.	JQ1
lanperisone	A 2-methyl-3-(pyrrolidin-1-yl)-1-[4-(trifluoromethyl)phenyl]propan-1-one in which the methyl group at position 2 adopts R-configuration. It is a muscle relaxant and induces ferroptosis in cancer cells.	lanperisone
ML-210	An N-acylpiperazine that is piperazine substituted by 5-methyl-4-nitro-1,2-oxazole-3-carbonyl and bis(4-chlorophenyl)methyl groups at positions 1 and 4, respectively. It is a glutathione peroxidase 4 (GPX4) inhibitor which induces ferroptosis in cancer cells expressing the RAS oncogene.	ML-210
ML162	A monochlorobenzene that is benzene substituted by (chloroacetyl){2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl}amino, chloro and methoxy groups at positions 1, 3 and 4, respectively. It is a covalent inhibitor of glutathione peroxidase 4 (GPX4) that induces ferroptosis in cells.	ML162
simvastatin	A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.	simvastatin
sorafenib	A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.	sorafenib

Research

Studies (80,600)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	10,062 (12.48)	18.7374
1990's	14,000 (17.37)	18.2507
2000's	22,387 (27.78)	29.6817
2010's	25,867 (32.09)	24.3611
2020's	8,284 (10.28)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	5,944 (7.04%)	5.53%
Reviews	7,471 (8.85%)	6.00%
Case Studies	3,398 (4.02%)	4.05%
Observational	305 (0.36%)	0.25%
Other	67,329 (79.73%)	84.16%

Protein Targets (920)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	6.4356	1	8
15-lipoxygenase, partial	Homo sapiens (human)	Potency	0.4392	1	4
67.9K protein	Vaccinia virus	Potency	13.4834	2	5
acetylcholinesterase	Homo sapiens (human)	Potency	61.4534	4	6
acid sphingomyelinase	Homo sapiens (human)	Potency	409.7234	1	2
activating transcription factor 6	Homo sapiens (human)	Potency	0.6270	1	3
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	7.0959	1	9
Alpha-synuclein	Homo sapiens (human)	Potency	6.3786	1	4
Amyloid-beta precursor protein	Homo sapiens (human)	Potency	8.9760	1	3
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	14.1254	1	1
AR protein	Homo sapiens (human)	Potency	6.0059	9	30
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	45.0976	3	4
arylsulfatase A	Homo sapiens (human)	Potency	3.7873	1	2
ATAD5 protein, partial	Homo sapiens (human)	Potency	19.6075	4	11
Ataxin-2	Homo sapiens (human)	Potency	27.6172	2	6
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	18.0936	3	6
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	29.7223	2	7
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	7.1944	1	2
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	6.2870	1	2
beta-2 adrenergic receptor	Homo sapiens (human)	Potency	10.6238	2	2
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	9.3981	2	6
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	57.4570	1	2
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	11.4264	1	3
caspase-3	Cricetulus griseus (Chinese hamster)	Potency	10.5590	1	2
caspase-3	Homo sapiens (human)	Potency	11.4264	1	3
Caspase-7	Cricetulus griseus (Chinese hamster)	Potency	10.5590	1	2
Cellular tumor antigen p53	Homo sapiens (human)	Potency	17.0033	2	6
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	22.5358	2	2
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	21.9640	1	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	25.1189	1	1
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	41.0680	2	5
Chain A, Cruzipain	Trypanosoma cruzi	Potency	11.6698	2	7
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	31.9261	2	4
Chain A, HADH2 protein	Homo sapiens (human)	Potency	13.7626	2	6
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	64.1931	1	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	24.2432	2	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	18.8231	1	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	23.8385	1	4
Chain B, HADH2 protein	Homo sapiens (human)	Potency	13.7626	2	6
chromobox protein homolog 1	Homo sapiens (human)	Potency	24.1636	2	6
core-binding factor subunit beta isoform 2	Homo sapiens (human)	Potency	0.5380	2	2
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	6.1318	1	3
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	2.0241	1	3
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	7.3915	1	6
cytochrome P450 2D6	Homo sapiens (human)	Potency	15.3360	1	3
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	39.8107	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	17.8913	2	12
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	9.8355	2	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	6.3087	1	6
D(1A) dopamine receptor	Homo sapiens (human)	Potency	5.6706	2	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	8.0687	1	2
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	11.2202	1	1
DNA polymerase III, partial	Bacillus subtilis	Potency	18.8876	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	54.7678	1	6
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	63.4054	1	2
endonuclease IV	Escherichia coli	Potency	1.4125	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	14.9350	9	38
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	12.2478	2	8
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	6.2675	10	39
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	11.7340	1	12
EWS/FLI fusion protein	Homo sapiens (human)	Potency	9.0637	4	19
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	2.4045	2	7
flap endonuclease 1	Homo sapiens (human)	Potency	62.5721	2	6
Fumarate hydratase	Homo sapiens (human)	Potency	26.8389	1	7
G	Vesicular stomatitis virus	Potency	7.3915	1	6
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	17.8913	1	6
geminin	Homo sapiens (human)	Potency	13.0354	4	19
GLI family zinc finger 3	Homo sapiens (human)	Potency	7.6879	3	11
glp-1 receptor, partial	Homo sapiens (human)	Potency	7.8608	2	3
GLS protein	Homo sapiens (human)	Potency	20.8837	2	11
glucocerebrosidase	Homo sapiens (human)	Potency	8.9125	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	17.0797	3	6
glucokinase regulatory protein	Homo sapiens (human)	Potency	31.6228	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	17.0242	1	5
Glycoprotein hormones alpha chain	Homo sapiens (human)	Potency	0.5012	1	1
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	31.6228	1	1
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	50.1187	1	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	Homo sapiens (human)	Potency	1.9953	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	2.9309	2	2
heat shock protein beta-1	Homo sapiens (human)	Potency	18.2331	2	10
hexokinase-4 isoform 1	Homo sapiens (human)	Potency	31.6228	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	5.2533	2	17
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	19.5277	1	4
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	11.1255	1	1
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	6.6896	2	7
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	44.9647	1	2
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	7.3915	1	6
huntingtin isoform 2	Homo sapiens (human)	Potency	5.3972	1	2
hypothetical protein, conserved	Trypanosoma brucei	Potency	8.3608	2	6
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	5.6915	2	5
IDH1	Homo sapiens (human)	Potency	14.6253	1	5
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	35.7168	2	2
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	7.3915	1	12
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	15.8489	1	1
Integrin alpha-IIb	Homo sapiens (human)	Potency	25.1189	1	1
Integrin beta-3	Homo sapiens (human)	Potency	25.1189	1	1
Interferon beta	Homo sapiens (human)	Potency	9.2865	2	15
lamin isoform A-delta10	Homo sapiens (human)	Potency	9.2779	2	9
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	3.9811	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	9.6772	3	7
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	28.1838	2	2
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	8.7960	1	4
Microtubule-associated protein tau	Homo sapiens (human)	Potency	11.4799	2	15
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	25.1189	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	6.3653	1	2
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	11.6618	1	4
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	28.1838	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	28.1838	1	1
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	19.4454	1	5
NFKB1 protein, partial	Homo sapiens (human)	Potency	7.0795	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	3.3905	1	3
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	36.9846	1	2
Nrf2	Homo sapiens (human)	Potency	7.5651	2	2
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	15.4797	3	12
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	23.2626	1	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	11.3347	2	5
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	21.1317	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	4.3345	2	15
nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus (Norway rat)	Potency	6.3096	1	1
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	10.9786	3	12
Ornithine decarboxylase	Rattus norvegicus (Norway rat)	Potency	25.1189	1	1
P53	Homo sapiens (human)	Potency	70.7946	1	1
Parkin	Homo sapiens (human)	Potency	26.2332	2	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	39.5502	2	4
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	11.6631	2	5
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	47.5826	1	4
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	26.3226	3	12
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	5.4108	2	6
phosphoglycerate kinase	Trypanosoma brucei brucei TREU927	Potency	26.8545	1	1
phosphopantetheinyl transferase	Bacillus subtilis	Potency	12.5282	1	5
PINK1	Homo sapiens (human)	Potency	24.8033	1	2
plasminogen precursor	Mus musculus (house mouse)	Potency	6.5776	1	3
polyprotein	Zika virus	Potency	26.8389	1	7
polypyrimidine tract-binding protein 1 isoform a	Homo sapiens (human)	Potency	14.5500	2	2
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	2.9019	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	8.8861	1	4
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	19.1498	1	2
PPM1D protein	Homo sapiens (human)	Potency	10.5498	1	6
pregnane X nuclear receptor	Homo sapiens (human)	Potency	26.2800	2	5
progesterone receptor	Homo sapiens (human)	Potency	4.4369	2	5
pyruvate kinase	Leishmania mexicana mexicana	Potency	15.8489	2	2
pyruvate kinase PKM isoform b	Homo sapiens (human)	Potency	25.1189	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	4.1842	2	11
ras-related protein Rab-9A	Homo sapiens (human)	Potency	38.7823	1	3
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	19.1818	1	7
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	10.4677	3	15
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	23.3307	3	14
RGS12	Homo sapiens (human)	Potency	1.9953	1	1
runt-related transcription factor 1 isoform AML1b	Homo sapiens (human)	Potency	0.5380	2	2
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	0.7360	3	3
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	15.3893	1	2
SMAD family member 2	Homo sapiens (human)	Potency	15.1530	2	2
SMAD family member 3	Homo sapiens (human)	Potency	15.1530	2	2
Smad3	Homo sapiens (human)	Potency	7.5768	4	10
snurportin-1	Homo sapiens (human)	Potency	35.7168	2	2
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	5.4705	2	5
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	28.3627	1	3
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	9.0532	1	2
TDP1 protein	Homo sapiens (human)	Potency	8.0677	2	25
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	10.0000	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	8.4405	3	14
Thrombopoietin	Homo sapiens (human)	Potency	6.4937	2	4
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	18.8277	3	12
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	36.3762	4	11
thyrotropin-releasing hormone receptor	Homo sapiens (human)	Potency	23.5267	2	3
transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	Potency	11.2202	1	1
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	30.9516	1	2
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	6.5776	1	3
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	6.5776	1	3
USP1 protein, partial	Homo sapiens (human)	Potency	26.1116	1	4
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	5.3076	2	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	17.4373	5	13
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	22.7570	1	8
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	17.0242	1	5
Vpr	Human immunodeficiency virus 1	Potency	12.5893	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	Homo sapiens (human)	IC50	4.2905	2	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Homo sapiens (human)	IC50	0.7843	8	8
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Schizosaccharomyces pombe 972h-	IC50	95.2000	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Homo sapiens (human)	Ki	34.0013	2	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Rattus norvegicus (Norway rat)	IC50	0.0112	2	2
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Ki	1.1810	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Ki	1.9590	1	1
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	IC50	34.5470	1	1
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	Ki	11.0200	2	2
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	Ki	0.4170	1	1
5-hydroxytryptamine receptor 5A	Homo sapiens (human)	Ki	3.2960	1	1
5-hydroxytryptamine receptor 6	Homo sapiens (human)	IC50	16.0010	1	1
5-hydroxytryptamine receptor 6	Homo sapiens (human)	Ki	6.8210	2	2
5-hydroxytryptamine receptor 7	Homo sapiens (human)	Ki	7.0710	1	1
Adenosine receptor A3	Homo sapiens (human)	IC50	0.3560	1	1
Adenosine receptor A3	Homo sapiens (human)	Ki	0.2010	1	1
Aldehyde dehydrogenase, mitochondrial	Homo sapiens (human)	IC50	3.4000	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	70.3700	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	Ki	69.8120	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.3560	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.2010	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.3560	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	0.2010	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	IC50	4.9040	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	Ki	1.8390	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	IC50	3.2180	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	Ki	1.4690	1	1
Alpha-ketoglutarate-dependent dioxygenase FTO	Homo sapiens (human)	IC50	1,000.0000	1	1
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	13.7340	1	1
Angiopoietin-1 receptor	Homo sapiens (human)	IC50	0.0032	5	5
Angiotensin-converting enzyme 2	Homo sapiens (human)	IC50	9.3500	1	1
apelin receptor	Homo sapiens (human)	IC50	2.6300	1	1
Arachidonate 5-lipoxygenase-activating protein	Homo sapiens (human)	IC50	44.0000	1	1
Aromatase	Homo sapiens (human)	IC50	0.1269	1	7
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	4
ATP-citrate synthase	Rattus norvegicus (Norway rat)	Ki	300.0000	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	29.5800	5	5
Aurora kinase A	Homo sapiens (human)	IC50	3.8000	4	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	Escherichia coli K-12	Ki	38,000.0000	1	2
Bifunctional epoxide hydrolase 2	Homo sapiens (human)	IC50	0.0120	1	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	Mycobacterium tuberculosis H37Rv	IC50	85.0300	1	1
Bile salt export pump	Homo sapiens (human)	IC50	189.5786	5	14
Bile salt export pump	Rattus norvegicus (Norway rat)	IC50	1,000.0000	1	1
Breakpoint cluster region protein	Homo sapiens (human)	GI50	7.3000	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	3.1000	1	1
Bromodomain testis-specific protein	Homo sapiens (human)	IC50	0.1902	13	13
Bromodomain-containing protein 1	Homo sapiens (human)	IC50	44.5000	1	1
Bromodomain-containing protein 2	Homo sapiens (human)	IC50	0.0959	22	22
Bromodomain-containing protein 2	Homo sapiens (human)	Ki	0.0128	4	4
Bromodomain-containing protein 3	Homo sapiens (human)	IC50	0.0573	18	18
Bromodomain-containing protein 3	Homo sapiens (human)	Ki	0.0078	4	4
Bromodomain-containing protein 4	Homo sapiens (human)	IC50	0.8257	119	119
Bromodomain-containing protein 4	Homo sapiens (human)	Ki	0.0193	8	8
C-C chemokine receptor type 2	Homo sapiens (human)	IC50	3.3225	1	2
C-C chemokine receptor type 2	Homo sapiens (human)	Ki	1.2840	1	2
C-C chemokine receptor type 4	Homo sapiens (human)	IC50	8.3950	1	1
C-C chemokine receptor type 4	Homo sapiens (human)	Ki	4.3970	1	1
C-C chemokine receptor type 5	Homo sapiens (human)	IC50	23.6610	1	1
C-C chemokine receptor type 5	Homo sapiens (human)	Ki	18.2840	1	1
C-X-C chemokine receptor type 2	Homo sapiens (human)	IC50	6.0130	1	1
C-X-C chemokine receptor type 2	Homo sapiens (human)	Ki	4.2090	1	1
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	111.4000	2	5
Carbamate kinase	Giardia intestinalis	IC50	0.6000	1	1
Carbonic anhydrase 1	Homo sapiens (human)	Ki	122.2188	5	16
Carbonic anhydrase 12	Homo sapiens (human)	Ki	147.6615	2	13
Carbonic anhydrase 13	Mus musculus (house mouse)	Ki	149.6769	2	13
Carbonic anhydrase 14	Homo sapiens (human)	Ki	148.1615	2	13
Carbonic anhydrase 15	Mus musculus (house mouse)	Ki	9.2300	1	1
Carbonic anhydrase 2	Homo sapiens (human)	Ki	121.5062	5	16
Carbonic anhydrase 3	Homo sapiens (human)	Ki	147.8923	2	13
Carbonic anhydrase 4	Homo sapiens (human)	Ki	148.2231	2	13
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	209.0385	2	13
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Ki	170.1154	2	13
Carbonic anhydrase 6	Homo sapiens (human)	Ki	197.9615	2	13
Carbonic anhydrase 7	Homo sapiens (human)	Ki	138.0526	3	14
Carbonic anhydrase 9	Homo sapiens (human)	Ki	137.7933	4	15
Casein kinase I isoform alpha	Homo sapiens (human)	IC50	0.2500	1	1
Caspase-1	Homo sapiens (human)	IC50	1.8000	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	Escherichia coli	Ki	15.0000	1	1
Chain A, Glutamate Receptor Subunit 2	Rattus norvegicus (Norway rat)	IC50	0.8210	1	2
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	Homo sapiens (human)	Ki	0.0005	1	5
Chain B, Glutamate Receptor Subunit 2	Rattus norvegicus (Norway rat)	IC50	0.8210	1	1
CREB-binding protein	Homo sapiens (human)	IC50	9.7153	3	3
Cyclin-C	Homo sapiens (human)	IC50	0.0662	2	2
Cyclin-dependent kinase 19	Homo sapiens (human)	IC50	0.2060	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	IC50	150.0000	1	1
Cyclin-dependent kinase 4	Homo sapiens (human)	IC50	3.0000	2	2
Cyclin-dependent kinase 6	Homo sapiens (human)	IC50	0.1300	1	1
Cyclin-dependent kinase 8	Homo sapiens (human)	IC50	2.0165	10	10
Cystine/glutamate transporter	Homo sapiens (human)	IC50	0.1800	3	3
Cytochrome P450 1A2	Homo sapiens (human)	IC50	2.4100	2	2
Cytochrome P450 2C9	Homo sapiens (human)	IC50	50.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	IC50	10.0000	1	1
Cytochrome P450 2J2	Homo sapiens (human)	IC50	50.0000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	5.0264	4	4
D(1A) dopamine receptor	Homo sapiens (human)	IC50	3.2850	1	2
D(1A) dopamine receptor	Homo sapiens (human)	Ki	1.6425	1	2
D(2) dopamine receptor	Homo sapiens (human)	IC50	23.0180	1	1
D(2) dopamine receptor	Homo sapiens (human)	Ki	7.6730	1	1
D(3) dopamine receptor	Homo sapiens (human)	IC50	2.2720	1	2
D(3) dopamine receptor	Homo sapiens (human)	Ki	0.7715	1	2
D(4) dopamine receptor	Homo sapiens (human)	IC50	3.1500	1	1
D(4) dopamine receptor	Homo sapiens (human)	Ki	1.1050	1	1
Discoidin domain-containing receptor 2	Homo sapiens (human)	IC50	0.0215	2	2
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)	IC50	50.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	IC50	3.3000	1	1
Ephrin type-B receptor 4	Homo sapiens (human)	IC50	0.5442	6	7
Epidermal growth factor receptor	Homo sapiens (human)	IC50	6.4377	8	8
Excitatory amino acid transporter 1	Homo sapiens (human)	IC50	76.4503	4	6
Excitatory amino acid transporter 1	Homo sapiens (human)	Ki	33.3114	1	2
Excitatory amino acid transporter 2	Homo sapiens (human)	IC50	65.9784	2	4
Excitatory amino acid transporter 2	Homo sapiens (human)	Ki	62.5478	1	2
Excitatory amino acid transporter 3	Homo sapiens (human)	IC50	41.1195	2	4
Excitatory amino acid transporter 3	Homo sapiens (human)	Ki	25.0848	1	2
Excitatory amino acid transporter 4	Rattus norvegicus (Norway rat)	IC50	12.6930	2	4
fatty acid synthase	Homo sapiens (human)	IC50	10.4000	2	2
Fatty-acid amide hydrolase 1	Homo sapiens (human)	IC50	363.0780	1	1
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	IC50	6.1000	1	1
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	Ki	0.3900	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	0.2827	6	12
Fructose-1,6-bisphosphatase 1	Homo sapiens (human)	IC50	101.2380	10	10
G1/S-specific cyclin-D1	Homo sapiens (human)	IC50	3.0000	1	1
Gasdermin-D	Homo sapiens (human)	IC50	0.4000	1	1
Gasdermin-D	Mus musculus (house mouse)	IC50	0.4000	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	Homo sapiens (human)	IC50	80.0000	1	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	Plasmodium berghei	IC50	56.7000	3	3
Glutamate carboxypeptidase 2	Homo sapiens (human)	IC50	428.0000	2	2
Glutamate receptor 1	Homo sapiens (human)	IC50	0.6130	1	1
Glutamate receptor 1	Rattus norvegicus (Norway rat)	IC50	0.5885	4	4
Glutamate receptor 1	Homo sapiens (human)	Ki	1.3607	3	3
Glutamate receptor 1	Rattus norvegicus (Norway rat)	Ki	0.6345	2	2
Glutamate receptor 2	Homo sapiens (human)	IC50	0.6130	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	IC50	0.5885	4	4
Glutamate receptor 2	Homo sapiens (human)	Ki	0.9400	3	3
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Ki	0.4452	4	5
Glutamate receptor 3	Homo sapiens (human)	IC50	0.6130	1	1
Glutamate receptor 3	Rattus norvegicus (Norway rat)	IC50	0.5885	4	4
Glutamate receptor 3	Rattus norvegicus (Norway rat)	Ki	2.3122	4	4
Glutamate receptor 4	Homo sapiens (human)	IC50	0.6130	1	1
Glutamate receptor 4	Rattus norvegicus (Norway rat)	IC50	0.5885	4	4
Glutamate receptor 4	Homo sapiens (human)	Ki	0.8680	3	3
Glutamate receptor 4	Rattus norvegicus (Norway rat)	Ki	0.7270	2	2
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 1	Homo sapiens (human)	Ki	0.7010	2	2
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	Ki	0.1284	5	7
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 2	Homo sapiens (human)	Ki	1.1060	2	2
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	Ki	0.9566	7	9
Glutamate receptor ionotropic, kainate 3	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 3	Homo sapiens (human)	Ki	0.7890	2	2
Glutamate receptor ionotropic, kainate 3	Rattus norvegicus (Norway rat)	Ki	0.4201	4	6
Glutamate receptor ionotropic, kainate 4	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 4	Rattus norvegicus (Norway rat)	Ki	0.0630	1	1
Glutamate receptor ionotropic, kainate 5	Rattus norvegicus (Norway rat)	IC50	0.3800	3	5
Glutamate receptor ionotropic, kainate 5	Homo sapiens (human)	Ki	0.7337	3	3
Glutamate receptor ionotropic, kainate 5	Rattus norvegicus (Norway rat)	Ki	0.0630	1	1
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	IC50	0.1532	4	4
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	Ki	8.4950	5	6
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	IC50	0.1532	4	4
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	Ki	8.4950	5	6
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	IC50	0.1532	4	4
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	Ki	8.4950	5	6
Glutamate receptor ionotropic, NMDA 2C	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	IC50	0.1532	4	4
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	Ki	8.4950	5	6
Glutamate receptor ionotropic, NMDA 2D	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	IC50	0.1532	4	4
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	Ki	8.4950	5	6
Glutamate receptor ionotropic, NMDA 3A	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	IC50	0.1532	4	4
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	Ki	8.4950	5	6
Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (human)	IC50	0.0700	2	2
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	IC50	0.1532	4	4
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	Ki	8.4950	5	6
Glutathione reductase, mitochondrial	Homo sapiens (human)	IC50	53.7000	1	1
Glutathione reductase, mitochondrial	Homo sapiens (human)	Ki	42.7000	1	1
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	12.4875	3	4
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50	5.7500	1	1
Histone acetyltransferase p300	Homo sapiens (human)	IC50	19.4000	1	1
Histone deacetylase 1	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 11	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 2	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 3	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 4	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 5	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 6	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 7	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 8	Homo sapiens (human)	IC50	0.2910	1	1
Histone deacetylase 9	Homo sapiens (human)	IC50	0.2910	1	1
Histone-lysine N-methyltransferase EHMT1	Homo sapiens (human)	IC50	1.6000	1	1
Histone-lysine N-methyltransferase EHMT2	Homo sapiens (human)	IC50	0.6000	1	1
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	IC50	0.1000	1	1
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	IC50	0.1000	1	1
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	IC50	0.1000	1	1
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	IC50	0.0515	2	2
Insulin receptor	Homo sapiens (human)	IC50	5.3000	1	1
Insulin receptor	Rattus norvegicus (Norway rat)	IC50	0.0034	1	1
Kappa-type opioid receptor	Homo sapiens (human)	IC50	6.1030	1	1
Kappa-type opioid receptor	Homo sapiens (human)	Ki	2.4410	1	1
large T antigen	Betapolyomavirus macacae	IC50	10.7300	1	1
Lysine-specific demethylase 5A	Homo sapiens (human)	IC50	10.0000	1	1
Lysyl oxidase homolog 2	Homo sapiens (human)	IC50	0.1500	1	1
Lysyl oxidase homolog 3	Homo sapiens (human)	IC50	0.0930	1	1
Lysyl oxidase homolog 4	Homo sapiens (human)	IC50	0.0590	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	IC50	0.0385	2	2
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	0.2620	1	1
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	IC50	0.1937	9	15
melanocortin receptor 4	Homo sapiens (human)	IC50	66.2617	3	3
Metabotropic glutamate receptor 1	Homo sapiens (human)	Ki	3.6067	3	3
Metabotropic glutamate receptor 1	Rattus norvegicus (Norway rat)	Ki	0.3400	1	1
Metabotropic glutamate receptor 2	Homo sapiens (human)	Ki	7.6500	4	4
Metabotropic glutamate receptor 3	Homo sapiens (human)	Ki	9.0000	1	1
Metabotropic glutamate receptor 4	Homo sapiens (human)	Ki	5.6000	4	4
Metabotropic glutamate receptor 4	Rattus norvegicus (Norway rat)	Ki	3.4000	2	2
Metabotropic glutamate receptor 5	Homo sapiens (human)	Ki	4.3167	3	3
Metabotropic glutamate receptor 6	Homo sapiens (human)	Ki	38.0000	1	1
Metabotropic glutamate receptor 7	Homo sapiens (human)	Ki	5,400.0000	1	1
Metabotropic glutamate receptor 8	Homo sapiens (human)	IC50	0.0057	1	1
Metabotropic glutamate receptor 8	Homo sapiens (human)	Ki	9.5000	1	1
Metabotropic glutamate receptor 8	Rattus norvegicus (Norway rat)	Ki	3.4000	2	2
Mitogen-activated protein kinase 1	Homo sapiens (human)	IC50	0.1095	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	0.6228	8	8
Mitogen-activated protein kinase 3	Homo sapiens (human)	IC50	0.7640	2	2
Monoglyceride lipase	Homo sapiens (human)	IC50	0.8095	2	2
Mu-type opioid receptor	Homo sapiens (human)	IC50	3.5110	1	1
Mu-type opioid receptor	Homo sapiens (human)	Ki	1.4250	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	133.0000	1	4
Myoglobin	Homo sapiens (human)	IC50	2.3000	1	1
NACHT, LRR and PYD domains-containing protein 3	Mus musculus (house mouse)	IC50	3.0000	1	1
nucleotide-binding oligomerization domain-containing protein 2 isoform 1	Homo sapiens (human)	IC50	6.2250	1	1
perilipin-1	Homo sapiens (human)	IC50	6.9590	1	1
perilipin-5	Homo sapiens (human)	IC50	1.6220	1	1
Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)	IC50	0.0215	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	IC50	50.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	IC50	50.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	IC50	50.0000	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	IC50	50.0000	1	1
photoreceptor-specific nuclear receptor	Homo sapiens (human)	IC50	1.1640	1	1
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	IC50	0.4270	1	1
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	0.1164	9	9
Platelet-derived growth factor receptor beta	Mus musculus (house mouse)	IC50	0.1235	2	8
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50	0.2910	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	IC50	22.2230	1	2
Procathepsin L	Homo sapiens (human)	IC50	9.3500	1	1
Prolyl 4-hydroxylase	Paramecium bursaria Chlorella virus 1	IC50	1,000.0000	1	1
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	200.0000	1	1
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	372.0000	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	0.0034	1	1
Protein-lysine 6-oxidase	Homo sapiens (human)	IC50	0.3200	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	GI50	0.1013	3	3
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	IC50	0.0260	8	8
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	0.3900	1	1
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	IC50	0.1333	29	32
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Ki	0.0060	1	1
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	0.1310	1	1
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	IC50	1.5000	2	2
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	3.6000	1	1
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	IC50	14.5200	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	GI50	3.1330	3	3
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	0.0348	21	21
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	IC50	9.3500	1	1
Replicase polyprotein 1ab	Betacoronavirus England 1	IC50	15.3833	2	3
Replicase polyprotein 1ab	Human coronavirus 229E	IC50	9.3500	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	6.3094	9	10
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	9.3500	2	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Ki	3.7100	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	Ki	3.7100	1	1
Retinal dehydrogenase 1	Homo sapiens (human)	IC50	0.1300	1	1
RuvB-like 1	Homo sapiens (human)	IC50	66.0000	1	1
RuvB-like 2	Homo sapiens (human)	IC50	66.0000	1	1
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	IC50	0.0087	3	3
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	GI50	1.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	IC50	0.3699	58	62
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Ki	0.0327	3	3
Serine/threonine-protein kinase B-raf	Mus musculus (house mouse)	IC50	0.1300	1	1
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50	50.0000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Ki	17.5600	1	4
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Ki	17.5600	1	4
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Ki	17.5600	1	4
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Ki	17.5600	1	4
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	IC50	0.1750	2	2
Sigma non-opioid intracellular receptor 1	Cavia porcellus (domestic guinea pig)	IC50	0.0490	1	1
Sodium-dependent dopamine transporter	Homo sapiens (human)	IC50	4.6370	1	1
Sodium-dependent dopamine transporter	Homo sapiens (human)	Ki	3.6840	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	IC50	70.3700	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Ki	69.8120	1	1
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50	0.0011	1	1
Solute carrier family 22 member 6	Rattus norvegicus (Norway rat)	Ki	2,099.0000	1	1
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	IC50	7.7750	4	4
Spike glycoprotein	Betacoronavirus England 1	IC50	9.3500	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	IC50	9.3500	1	1
transactivating tegument protein VP16 [Human herpesvirus 1]	Human alphaherpesvirus 1 (Herpes simplex virus type 1)	IC50	4.4260	1	1
Transmembrane protease serine 2	Homo sapiens (human)	IC50	9.3500	1	1
tumor necrosis factor	Homo sapiens (human)	IC50	6.0585	1	1
type-1 angiotensin II receptor	Homo sapiens (human)	IC50	6.6370	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	GI50	7.3000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	0.1000	2	2
Tyrosine-protein kinase ABL1	Mus musculus (house mouse)	IC50	0.2259	1	1
Tyrosine-protein kinase HCK	Homo sapiens (human)	IC50	0.5300	1	2
Tyrosine-protein kinase Lck	Homo sapiens (human)	IC50	0.0600	1	1
Tyrosine-protein kinase Mer	Homo sapiens (human)	IC50	1.3700	1	1
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	IC50	0.0600	4	4
Vascular endothelial growth factor receptor 2	Danio rerio (zebrafish)	IC50	2.6000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	0.1000	79	85
Vascular endothelial growth factor receptor 2	Mus musculus (house mouse)	IC50	0.1129	2	8
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Ki	0.0074	3	3
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	IC50	0.0191	5	5
Vascular endothelial growth factor receptor 3	Mus musculus (house mouse)	IC50	0.1269	1	7

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	1
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	15.0000	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	3	3
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	1
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	1
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	1
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	1
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
Activin receptor type-1	Homo sapiens (human)	Kd	15.0000	4	4
Activin receptor type-1B	Homo sapiens (human)	Kd	15.0000	4	4
Activin receptor type-2A	Homo sapiens (human)	Kd	10.0000	3	3
Activin receptor type-2B	Homo sapiens (human)	Kd	15.0000	4	4
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	1
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	1
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	1
Adenosine kinase	Homo sapiens (human)	Kd	30.0000	1	1
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	1
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	3	3
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	2.3250	4	4
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	3	3
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	15.0000	4	4
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	1
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	15.0000	4	4
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	10.0000	3	3
Aurora kinase A	Homo sapiens (human)	Kd	15.0000	4	4
Aurora kinase B	Homo sapiens (human)	Kd	7.8300	4	4
Aurora kinase C	Homo sapiens (human)	Kd	0.2100	3	3
bcl-2-like protein 11 isoform 1	Homo sapiens (human)	EC50	70.6000	1	1
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	2.1000	3	3
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	15.0000	4	4
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	18.0000	4	5
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	16.6667	3	3
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	15.0000	4	4
Breakpoint cluster region protein	Homo sapiens (human)	Kd	30.0000	1	1
Bromodomain testis-specific protein	Homo sapiens (human)	Kd	0.1786	7	7
Bromodomain-containing protein 2	Homo sapiens (human)	Kd	0.0827	12	12
Bromodomain-containing protein 3	Homo sapiens (human)	Kd	0.0599	10	10
Bromodomain-containing protein 4	Homo sapiens (human)	EC50	0.1203	3	3
Bromodomain-containing protein 4	Homo sapiens (human)	Kd	0.0912	31	57
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	0.2200	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	3	3
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	15.0000	4	4
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	10.0000	3	3
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	10.0000	3	3
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	10.0000	3	3
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	3	3
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	15.0000	4	4
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	14.0000	5	5
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	15.0000	4	4
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	16.6667	3	3
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	15.0000	4	4
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	3	3
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	16.6667	3	3
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	10.0000	2	2
Casein kinase I isoform delta	Homo sapiens (human)	Kd	15.0000	4	4
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	15.0000	4	4
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	15.0000	4	4
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	15.0000	4	4
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	15.0000	4	4
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	3	3
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	15.0000	4	4
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	10.0000	1	1
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	15.0000	4	4
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	3	3
Chain A, BCL-2-RELATED PROTEIN A1	Homo sapiens (human)	EC50	70.6000	1	1
Chain A, Bromodomain testis-specific protein	Homo sapiens (human)	Kd	0.1901	1	1
Chain A, Bromodomain-containing protein 4	Homo sapiens (human)	Kd	0.0490	1	1
Chain A, Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	0.0914	1	7
Chain A, Slr1257 protein	Synechocystis sp. PCC 6803 substr. Kazusa	Kd	0.2400	1	1
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	1
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	12.1500	4	4
CREB-binding protein	Homo sapiens (human)	Kd	9.6000	1	1
Cyclin-C	Homo sapiens (human)	Kd	0.3100	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	10.0000	3	3
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	10.0000	3	3
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	20.0000	2	2
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	2.9000	3	3
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	2.9000	2	2
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	15.0000	4	4
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	8.7000	4	4
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	10.0000	3	3
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	0.2500	3	3
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	14.6750	4	4
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	13.4500	4	4
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	7.6050	4	4
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	0.3100	4	4
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	15.0000	4	4
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	0.1300	2	2
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	0.4900	2	2
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	12.9000	5	5
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	15.0000	4	4
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	1
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Cytochrome P450 1A1	Homo sapiens (human)	Kd	19.1000	1	1
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	3	3
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	1
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	3	3
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	3	3
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	4	4
Delta-type opioid receptor	Mus musculus (house mouse)	EC50	0.0030	1	2
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	1
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	1
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	0.3281	7	7
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	1
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	1
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	1
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	1
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	15.0000	4	4
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	15.0000	4	4
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	15.0000	4	4
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	10.0000	3	3
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	15.0950	2	2
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	15.0000	4	4
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	14.3750	4	4
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	10.0000	3	3
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	15.0000	4	4
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	10.0000	3	3
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	10.1250	4	4
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	15.0000	4	4
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	16.6667	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	15.0000	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	10.0000	3	3
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	1
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	1
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	9.8250	4	4
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	8.1600	5	5
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	3.0250	4	4
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	8.0600	5	5
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	9.0367	6	6
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	0.3180	5	5
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	7.8733	6	6
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	1.8240	5	5
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	2.6750	4	4
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	8.9250	4	4
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	18.0000	4	5
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	7.8600	5	5
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	10.1600	3	3
Epidermal growth factor receptor	Homo sapiens (human)	Kd	10.6897	29	29
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	0.3294	5	5
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	20.0000	2	2
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	1
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	8.1800	5	5
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	2.7000	3	3
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	6.9833	6	6
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	10.0000	3	3
Focal adhesion kinase 1	Homo sapiens (human)	Kd	15.0000	4	4
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	1
Glutamate receptor 1	Homo sapiens (human)	EC50	792,445,056.0762	12	20
Glutamate receptor 1	Rattus norvegicus (Norway rat)	EC50	27.3799	6	7
Glutamate receptor 2	Homo sapiens (human)	EC50	722,116,393.1444	8	11
Glutamate receptor 2	Rattus norvegicus (Norway rat)	EC50	1,482,620,106.9400	4	5
Glutamate receptor 3	Homo sapiens (human)	EC50	2,264,128,594.8718	5	7
Glutamate receptor 3	Rattus norvegicus (Norway rat)	EC50	54.8048	5	6
Glutamate receptor 4	Homo sapiens (human)	EC50	9,952,675,009.4244	2	4
Glutamate receptor 4	Rattus norvegicus (Norway rat)	EC50	18.6392	4	5
Glutamate receptor ionotropic, kainate 1	Homo sapiens (human)	EC50	57.3333	3	3
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	EC50	129.1633	2	3
Glutamate receptor ionotropic, kainate 2	Homo sapiens (human)	EC50	25.0000	2	2
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	EC50	65.9615	2	3
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	EC50	1.4069	6	7
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	EC50	1.6496	3	4
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	EC50	0.9600	2	2
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	EC50	0.5600	2	2
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	EC50	0.2850	2	2
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	EC50	0.1200	1	1
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	EC50	0.1200	1	1
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	15.0000	4	4
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	15.0000	4	4
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	2
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	1
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	10.0000	7	7
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	10.5000	5	5
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	2.2000	2	2
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	1.7000	2	2
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	0.4150	2	2
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	0.0030	2	2
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	2	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	2	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	15.0000	4	4
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	1
Insulin receptor	Homo sapiens (human)	Kd	15.0000	4	4
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	3	3
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	18.0000	4	5
Integrin alpha-IIb	Homo sapiens (human)	EC50	7.4000	1	1
Integrin beta-3	Homo sapiens (human)	EC50	7.4000	1	1
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	10.0000	3	3
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	15.0000	4	4
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	20.0000	2	2
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
LacZ protein (plasmid)	Escherichia coli	EC50	40.0000	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	3	3
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	10.0000	1	1
LIM domain kinase 1	Homo sapiens (human)	Kd	7.4000	5	5
LIM domain kinase 2	Homo sapiens (human)	Kd	14.9000	4	4
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	0.0280	4	4
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	16.6667	3	3
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	15.0000	4	4
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	15.0000	4	4
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	0.2300	3	3
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	0.1600	4	4
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	15.0000	4	4
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	15.0000	4	4
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	0.1804	23	23
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	15.0000	4	4
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
melanocortin receptor 4	Homo sapiens (human)	EC50	50.0000	1	1
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	15.0000	4	4
Metabotropic glutamate receptor 1	Homo sapiens (human)	EC50	45.2375	4	4
Metabotropic glutamate receptor 1	Rattus norvegicus (Norway rat)	EC50	13.1512	10	12
Metabotropic glutamate receptor 2	Homo sapiens (human)	EC50	7.3849	12	13
Metabotropic glutamate receptor 2	Rattus norvegicus (Norway rat)	EC50	8.7450	8	10
Metabotropic glutamate receptor 3	Homo sapiens (human)	EC50	2.8572	5	5
Metabotropic glutamate receptor 3	Rattus norvegicus (Norway rat)	EC50	1.6294	3	4
Metabotropic glutamate receptor 4	Homo sapiens (human)	EC50	14.9333	3	3
Metabotropic glutamate receptor 4	Rattus norvegicus (Norway rat)	EC50	6.3776	8	10
Metabotropic glutamate receptor 5	Homo sapiens (human)	EC50	163.5500	4	4
Metabotropic glutamate receptor 5	Rattus norvegicus (Norway rat)	EC50	6.4817	8	10
Metabotropic glutamate receptor 6	Homo sapiens (human)	EC50	98.3000	3	3
Metabotropic glutamate receptor 6	Rattus norvegicus (Norway rat)	EC50	35.7000	5	5
Metabotropic glutamate receptor 7	Homo sapiens (human)	EC50	625.2950	4	4
Metabotropic glutamate receptor 7	Rattus norvegicus (Norway rat)	EC50	800.0000	2	3
Metabotropic glutamate receptor 8	Mus musculus (house mouse)	EC50	0.0220	1	1
Metabotropic glutamate receptor 8	Rattus norvegicus (Norway rat)	EC50	14.4933	3	3
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Midasin	Homo sapiens (human)	Kd	30.0000	1	1
Misshapen-like kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	15.0000	4	4
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	15.0000	4	4
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	5.1817	6	6
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	8.1750	4	4
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	6.6000	2	2
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	5.2717	6	6
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	7.5345	4	4
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	15.0000	4	4
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	10.0000	3	3
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	10.0000	3	3
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	10.0000	3	3
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	15.0000	4	4
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	12.2000	5	5
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	7.9277	3	3
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	10.0000	3	3
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	15.0000	4	4
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	0.0990	2	2
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	0.1870	4	4
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	15.0000	4	4
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	15.0000	4	4
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	0.8200	4	4
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	10.0000	3	3
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	13.7000	4	4
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	18.0000	4	5
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	14.8800	4	5
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	7.3000	5	5
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	1
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	1
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	0.1300	3	3
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	6.6750	4	4
Myosin light chain kinase 3	Homo sapiens (human)	Kd	19.8000	2	2
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	3	3
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	10.0000	1	1
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	14.0000	5	5
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	1
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	1
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	3	3
Myosin-IIIb	Homo sapiens (human)	Kd	9.0333	3	3
Myotonin-protein kinase	Homo sapiens (human)	Kd	10.0000	3	3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	1
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	9.2250	4	4
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	13.3333	6	6
NT-3 growth factor receptor	Homo sapiens (human)	Kd	0.6000	3	3
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	3	3
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	10.0000	3	3
Nuclear receptor subfamily 4 group A member 2	Homo sapiens (human)	EC50	5.1000	1	1
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	1
nucleotide-binding oligomerization domain-containing protein 1 isoform 1	Homo sapiens (human)	EC50	2.1100	1	1
nucleotide-binding oligomerization domain-containing protein 2 isoform 1	Homo sapiens (human)	EC50	20.0000	1	2
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	1
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	10.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	1
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	3	3
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	21	21
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	20.0000	2	2
Phospholipid hydroperoxide glutathione peroxidase	Homo sapiens (human)	EC50	8.8180	2	4
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	15.0000	4	4
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	10.0000	3	3
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	0.0620	4	4
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	5.0322	6	6
Poly [ADP-ribose] polymerase tankyrase-2	Homo sapiens (human)	Kd	10.0000	1	1
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	1
Protein delta homolog 1	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C alpha type	Homo sapiens (human)	Kd	20.0000	2	2
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	1
Protein kinase C delta type	Homo sapiens (human)	Kd	15.0000	4	4
Protein kinase C epsilon type	Homo sapiens (human)	Kd	10.0000	3	3
Protein kinase C eta type	Homo sapiens (human)	Kd	10.0000	3	3
Protein kinase C iota type	Homo sapiens (human)	Kd	20.0000	2	2
Protein kinase C theta type	Homo sapiens (human)	Kd	15.0000	4	4
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	1
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	15.0000	4	4
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	15.0000	4	4
Prothrombin	Homo sapiens (human)	EC50	7.4000	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	0.0302	12	12
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	10.0000	3	3
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	15.0000	4	4
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	1
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	1
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	1
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	15.0000	4	4
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	15.0000	4	4
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	15.0000	4	4
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	0.2300	3	3
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	1
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	1
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	1
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	10.0000	3	3
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	10.0000	2	2
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	10.0000	2	2
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	3	3
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	7.3600	5	5
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	0.1466	28	28
recombinase A	Mycobacterium tuberculosis H37Rv	EC50	0.5976	2	2
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	16.6667	3	3
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	10.0000	2	2
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	10.0000	2	2
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	12.8571	7	7
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	10.0000	6	6
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	15.0000	4	4
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	12.8571	7	7
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	12.8571	7	7
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	11.7857	7	7
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	16.6667	3	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	30.0000	1	1
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	1
RuvB-like 2	Homo sapiens (human)	Kd	22.0000	1	1
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	1
Septin-9	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	5.1217	6	6
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	2.4000	3	3
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	4.2000	4	4
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	EC50	0.0030	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	4.0855	8	8
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	7.9800	4	4
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	18.0000	4	5
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	9.3800	5	5
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	15.0000	4	4
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	18.0000	4	5
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	10.9100	4	4
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	15.2700	2	2
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	11.8000	3	3
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	20.0000	3	4
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	0.2800	4	4
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	3	3
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	16.6667	3	3
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	3	3
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	3	3
SRSF protein kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	6.9200	5	5
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	1
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	3	3
TGF-beta receptor type-1	Homo sapiens (human)	Kd	15.0000	4	4
TGF-beta receptor type-2	Homo sapiens (human)	Kd	14.2250	4	4
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	1
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	14.4750	4	4
Transient receptor potential cation channel subfamily A member 1	Homo sapiens (human)	EC50	3.0000	1	1
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	1
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	10.0000	1	1
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	2.1288	40	40
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	11.6667	5	6
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	10.0000	3	3
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	15.0000	4	4
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	13.2250	4	4
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	15.0000	4	4
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	15.0000	4	4
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	9.2667	3	3
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	4.6929	7	7
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	14.6000	4	4
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	14.6250	4	4
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	3	3
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	13.3333	6	6
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	10.0000	3	3
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	9.1000	3	3
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	9.0000	5	5
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	9.7500	4	4
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	10.2000	4	4
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	0.0680	3	3
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	3	3
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	4.5000	3	3
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	9.8000	3	3
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	15.0000	4	4
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	15.0000	4	4
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	10.0000	3	3
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	15.0000	4	4
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	3	3
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	1
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	1	1
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	2	2
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	0.0310	4	4
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	EC50	0.5000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	0.0660	6	6
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	0.0634	5	5
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Voltage-dependent anion-selective channel protein 2	Homo sapiens (human)	Kd	0.1000	1	1
Wee1-like protein kinase	Homo sapiens (human)	Kd	18.0000	4	5
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Bcl-2-like protein 11	Homo sapiens (human)	AC50	41.9100	1	1
Bromodomain-containing protein 4	Homo sapiens (human)	DC50	5.0000	1	1
Carbonic anhydrase 1	Homo sapiens (human)	KA	6.4300	1	1
Carbonic anhydrase 2	Homo sapiens (human)	KA	100.0000	1	1
Carbonic anhydrase-like protein, putative	Trypanosoma cruzi strain CL Brener	KA	100.0000	1	1
Chain A, BCL-2-RELATED PROTEIN A1	Homo sapiens (human)	AC50	82.4533	6	6
Cytochrome P450 1A1	Homo sapiens (human)	Km	803.0000	1	1
Cytochrome P450 1A1	Rattus norvegicus (Norway rat)	Ks	870.0000	1	1
Cytochrome P450 1A2	Homo sapiens (human)	Km	120.0000	1	1
Cytochrome P450 2B1	Rattus norvegicus (Norway rat)	Ks	800.0000	1	1
DNA damage-binding protein 1	Homo sapiens (human)	DC50	5.0000	1	1
Excitatory amino acid transporter 1	Homo sapiens (human)	Km	8.5500	2	2
Excitatory amino acid transporter 2	Homo sapiens (human)	Km	21.0000	2	2
Excitatory amino acid transporter 3	Homo sapiens (human)	Km	17.4500	2	2
Excitatory amino acid transporter 3	Rattus norvegicus (Norway rat)	Ks	5.1000	1	1
Glutamate racemase	Enterococcus faecalis V583	Km	1,200.0000	1	1
Glutamate racemase	Helicobacter pylori 26695	Km	5,176.6667	3	3
H3 histone acetyltransferase	Candida albicans SC5314	AC50	3.2600	1	1
heat shock protein 90, putative	Plasmodium falciparum 3D7	AC50	4.5540	1	1
heat shock protein HSP 90-alpha isoform 2	Homo sapiens (human)	AC50	5.1780	1	1
HRAS, partial	Homo sapiens (human)	AC50	13.9035	3	6
hypothetical protein CAALFM_CR05890CA	Candida albicans SC5314	AC50	3.2600	1	1
interferon gamma precursor	Homo sapiens (human)	AC50	7.7500	1	1
Metabotropic glutamate receptor 1	Homo sapiens (human)	Activity	1.0000	1	1
Metabotropic glutamate receptor 2	Homo sapiens (human)	Activity	4.0000	1	1
Metabotropic glutamate receptor 3	Homo sapiens (human)	Activity	9.0000	1	1
Metabotropic glutamate receptor 4	Homo sapiens (human)	Activity	12.0000	1	1
Metabotropic glutamate receptor 5	Homo sapiens (human)	Activity	4.0000	1	1
Metabotropic glutamate receptor 6	Homo sapiens (human)	Activity	20.0000	1	1
Metabotropic glutamate receptor 7	Homo sapiens (human)	Activity	5,400.0000	1	1
PAX8	Homo sapiens (human)	AC50	0.3230	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	INH	26.0000	1	1
Protein cereblon	Homo sapiens (human)	DC50	5.0000	1	1
replicative DNA helicase	Mycobacterium tuberculosis H37Rv	AC50	1.2485	2	2
Sulfotransferase 1A1	Rattus norvegicus (Norway rat)	Km	92.0000	1	1
toxin B	Clostridioides difficile 630	AC50	20.8700	1	1
UDP-glucuronosyltransferase 1-6	Homo sapiens (human)	Km	2,200.0000	1	1
UDP-glucuronosyltransferase 1A1	Homo sapiens (human)	Km	9,400.0000	1	1
UDP-glucuronosyltransferase 1A9	Homo sapiens (human)	Km	20,900.0000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	INH	100.0000	1	1

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ferroptosis inducer

Members (18)

Research

Studies (80,600)

Study Types

Protein Targets (920)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements