A proteinogenic amino acid derivative resulting from reaction of L-tryptophan at the amino group or the carboxy group, or from the replacement of any hydrogen of L-tryptophan by a heteroatom.
ChEBI ID: 47994
| Member | Definition | Role |
|---|---|---|
| 2-methyltryptophan | An L-tryptophan derivative in which the hydrogen at position 2 on the indole ring is replaced by a methyl group. | 2-methyl-L-tryptophan zwitterion; 2-methyl-L-tryptophan |
| 5-methoxytryptophan | An L-tryptophan derivative that is L-tryptophan with a methoxy substituent at position 5. | 5-methoxy-L-tryptophan zwitterion; 5-methoxytryptophan |
| 6-bromotryptophan | A bromoamino acid that is L-tryptophan in which the hydrogen at position 6 of the indole ring is substituted by bromine. | L-6'-bromotryptophan zwitterion; L-6'-bromotryptophan |
| 6-chlorotryptophan | A non-proteinogenic L-alpha-amino acid that is L-tryptophan in which the hydrogen at position 6 on the indole ring has been replaced by a chlorine. | 6-chloro-L-tryptophan zwitterion; 6-chloro-L-tryptophan |
| 7-chlorotryptophan | An L-tryptophan derivative having a chloro substituent at the 7-position. | 7-chloro-L-tryptophan zwitterion; 7-chloro-L-tryptophan |
| abrine | A N-methyl-L-alpha-amino acid that is the N(alpha)-methyl derivative of L-tryptophan. | N(alpha)-methyl-L-tryptophan zwitterion; N(alpha)-methyl-L-tryptophan |
| cysteine tryptophylquinone | An L-tryptophan derivative that is L-tryptophan-6,7-dione in which a cysteine unit is attached at position 4 via its side-chain thiol group. | cysteine tryptophylquinone |
| ilomastat | An N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor | ilomastat |
| lenticin | An amino acid betaine obtaine by exhaustive methylation of the alpha-amino group of L-tryptophan with concomitant deprotonation of the carboxy group. | hypaphorine |
| n-acetyltryptophan | A N-acetyl-L-amino acid that is the N-acetyl derivative of L-tryptophan. | N-acetyl-L-tryptophan |
| n-acetyltryptophanamide | (2S)-2-acetamido-3-(1H-indol-3-yl)propanamide | |
| sid 26681509 | A carbohydrazide that is L-tryptophan in which the amino and carboxy groups are substituted by tert-butoxycarbonyl and 2-({[2-(2-ethylanilino)-2-oxoethyl]sulfanyl}carbonyl)hydrazinyl groups, respectively. It is a potent and reversible inhibitor of human cathepsin L (IC50 = 56 nM). | SID 26681509 |
| tryptophyl adenylate | An L-tryptophan derivative that is the ester obtained by formal condensation of the carboxy group of L-tryptophan with the 3'-hydroxy group of AMP. | 3'-L-tryptophyl-AMP |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 43 (13.15) | 18.7374 |
| 1990's | 36 (11.01) | 18.2507 |
| 2000's | 97 (29.66) | 29.6817 |
| 2010's | 110 (33.64) | 24.3611 |
| 2020's | 41 (12.54) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.29%) | 5.53% |
| Reviews | 14 (4.13%) | 6.00% |
| Case Studies | 1 (0.29%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 323 (95.28%) | 84.16% |