| Assay ID | Title | Year | Journal | Article |
|---|
| AID1202470 | Cytotoxicity against human A549 cells by SRB assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents. |
| AID255478 | Minimum inhibitory concentration against bacterial strains | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. |
| AID1684932 | Induction of apoptosis in human HL-60 cells assessed as early apoptotic cells at 2 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 2.9 %) | | | |
| AID1684916 | Induction of apoptosis in human HL-60 cells assessed as cleavage of caspase-8 at 0.5 to 8 uM after 24 hrs Western blot analysis | | | |
| AID1684927 | Induction of apoptosis in human HL-60 cells assessed as late apoptotic cells at 4 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 4.2 %) | | | |
| AID422398 | Antitrypanosomal activity against Trypanosoma brucei | 2009 | Journal of natural products, Feb-27, Volume: 72, Issue:2
| The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness. |
| AID670024 | Growth inhibition of human WI38 cells after 96 hrs by sulphorhodamine B assay | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID381067 | Antiproliferative activity against human MCF7 cells by neutral red method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID1684914 | Inhibition of HDAC1 in human HL-60 cells assessed as increase in Ac-H3 level at 0.5 to 8 uM incubated for 24 hrs by Western blot analysis | | | |
| AID1627667 | Cytotoxicity against human A549 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
| Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents. |
| AID1684935 | Induction of apoptosis in human HL-60 cells assessed as late apoptotic cells at 1 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 4.2 %) | | | |
| AID1684938 | Inhibition of recombinant full length C-terminal FLAG-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence base | | | |
| AID381068 | Antiproliferative activity against human MCF7 cells at 30 uM after 8 hrs by neutral red method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID1684931 | Induction of apoptosis in human HL-60 cells assessed as late apoptotic cells at 2 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 4.2 %) | | | |
| AID1684934 | Induction of apoptosis in human HL-60 cells assessed as necrotic cells at 1 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 0.5 %) | | | |
| AID276474 | Cytotoxicity against Trypanosoma brucei by Alamar blue assay | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22
| Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. |
| AID1709190 | Cytotoxicity against human SK-HEP1 cells assessed as reduction in cell viability by SRB assay | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID670019 | Inhibition of full length N-terminal His6-tagged human DNMT1 at 30 uM after 1 hr by fluorescence analysis | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID1709189 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability by SRB assay | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID1709211 | Antiinvasive activity in human MDA-MB-231 cells assessed as reduction in cell invasion through matrigel-coated chamber at 400 nM after 24 hrs by diff-quik staining based microscopic analysis | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID1709188 | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID1684939 | Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) co-expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins | | | |
| AID1202483 | Antitumor activity against human A549 cells xenografted in athymic BALB/c nu/nu mouse assessed as reduction in tumor weight at 30 mg/kg, ip administered thrice a week measured after 35 days relative to vehicle-treated control | 2015 | European journal of medicinal chemistry, , Volume: 96 | Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents. |
| AID670012 | Inhibition of human recombinant HDAC6 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescence analysis | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID417069 | Activation of mouse Wnt3a signaling expressed in HEK293 STF cells assessed as increase in transcriptional activity after 24 hrs by luciferase reporter gene-based lactate dehydrogenase assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
| Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. |
| AID670013 | Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescence analysis | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID670027 | Inhibition of HDAC1 in human MCF7 cells assessed as up-regulation of acetylated histone H3 protein level at 5 uM after 24 hrs by Western blot analysis | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID356627 | Cytotoxicity against human HCT15 cells | 2003 | Journal of natural products, Nov, Volume: 66, Issue:11
| New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis. |
| AID1202475 | Inhibition of HDAC in human A549 cells at 1.6 uM after 24 hrs by fluorescence assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents. |
| AID670036 | Inhibition of bacterial DNA cytosine-C5 methyltransferase, M.SssI at 50 uM | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID1684917 | Induction of apoptosis in human HL-60 cells assessed as cleavage of caspase-3 at 0.5 to 8 uM after 24 hrs Western blot analysis | | | |
| AID1684933 | Induction of apoptosis in human HL60 cells assessed as viable cells at 2 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 92.05 %) | | | |
| AID1073050 | Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis relative to SAHA-treated control | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells. |
| AID1684880 | Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay | | | |
| AID381071 | Induction of apoptosis in human MCF7 cells assessed as chromosome fragmentation at 10 uM after 8 hrs by fluorescent microscopy | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID1684937 | Induction of apoptosis in human HL-60 cells assessed as viable cells at 1 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 92.5 %) | | | |
| AID1684942 | Growth inhibition of human HL-60 cells after 72 hrs by trypan blue dye based assay | | | |
| AID1684918 | Induction of apoptosis in human HL-60 cells assessed as cleavage of PARP at 0.5 to 8 uM after 24 hrs Western blot analysis | | | |
| AID381066 | Activation of PPARgamma transfected in human MCF7 cells by luciferase reporter gene assay | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID613112 | Inhibition of DNMT in cell-free system | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID670037 | Inhibition of bacterial DNA cytosine-C5 methyltransferase, M.SssI at 5 uM | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID1684925 | Induction of apoptosis in human HL60 cells assessed as necrotic cells at 4 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 0.5 %) | | | |
| AID1684873 | Toxicity in mouse LL/2 cells inoculated C57BL/6J mouse assessed as effect on body weight by measuring initial body weight at 25 mg/kg, ip administered for 12 days measured for every 2 days (Rvb = 18.4 +/- 0.4 g) | | | |
| AID276473 | Inhibition of human GalE by HPAEC assay | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22
| Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. |
| AID379630 | Displacement of [125I]DPCPX from adenosine A1 receptor in rat brain | 2000 | Journal of natural products, Mar, Volume: 63, Issue:3
| Isolation of psammaplin A 11'-sulfate and bisaprasin 11'-sulfate from the marine sponge Aplysinella rhax. |
| AID381074 | Induction of apoptosis in human T47D cells assessed as chromosome fragmentation at 10 uM after 16 hrs by bright field microscopy | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID1709198 | Inhibition of human N-terminal GST-tagged DOT1L (2 to 416 residues) expressed in Escherichia coli at 200 nM using DOT1L substrate measured after 2 hrs in presence of SAM by ELISA | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID1684915 | Induction of apoptosis in human HL-60 cells assessed as cleavage of caspase-9 at 0.5 to 8 uM after 24 hrs Western blot analysis | | | |
| AID1627665 | Inhibition of HDAC in human HeLa cells using Fluor deLys as substrate assessed as deacetylation of substrate by fluorescence assay | 2016 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
| Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents. |
| AID356624 | Cytotoxicity against human SKOV3 cells | 2003 | Journal of natural products, Nov, Volume: 66, Issue:11
| New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis. |
| AID1627666 | Cytotoxicity against human PC3 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
| Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents. |
| AID276475 | Cytotoxicity against CHO-K1 cells by Alamar blue assay | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22
| Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. |
| AID1684929 | Induction of apoptosis in human HL-60 cells assessed as viable cells at 4 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 92.05 %) | | | |
| AID1202477 | Inhibition of HDAC in human A549 cells assessed as increase in acetylated histone 3 expression level at 1.6 uM after 24 hrs by western blotting analysis | 2015 | European journal of medicinal chemistry, , Volume: 96 | Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents. |
| AID90530 | Inhibitory concentration against isolated Histone deacetylase | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Histone deacetylase inhibitors. |
| AID707046 | Induction of apoptosis in AML patient blasts at 5 uM after 26 hrs | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities. |
| AID1627668 | Cytotoxicity against human MCF7 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
| Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents. |
| AID1709191 | Cytotoxicity against human SNU-638 cells assessed as reduction in cell viability by SRB assay | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID360496 | Cytotoxicity against mouse P388 cells | 1995 | Journal of natural products, Nov, Volume: 58, Issue:11
| Cytotoxic compounds from a two-sponge association. |
| AID670030 | Inhibition of Class 1 histone deacetylase in human MCF7 cells assessed as up-regulation of p21 protein level at 5 uM after 24 hrs by Western blot analysis | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID1684930 | Induction of apoptosis in human HL-60 cells assessed as necrotic cells at 2 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 0.5 %) | | | |
| AID417070 | Activation of Neuropeptide S receptor I107 mutant expressed in HEK293 cells assessed as increase in transcriptional activity after 24 hrs by luciferase reporter gene-based lactate dehydrogenase assay | 2009 | Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
| Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. |
| AID1627669 | Cytotoxicity against human HL60 cells assessed as reduction in cell growth inhibition after 72 hrs by trypan blue-staining based hemocytometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
| Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents. |
| AID613114 | Cell cycle arrest in human U937 cells assessed as accumulation at G1 phase at 5 uM after 30 hrs by propidium iodide staining based flow cytometry | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID1709205 | Inhibition of DOT1L in human MDA-MB-231 cells assessed as effect on H3K27 methylation at 200 nM by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID613121 | Induction of human U937 cell differentiation into granulocytes assessed as expression of CD11c marker on cell membrane at 5 uM after 30 to 40 hrs by PI staining based FACS analysis | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID356626 | Cytotoxicity against human XF498 cells | 2003 | Journal of natural products, Nov, Volume: 66, Issue:11
| New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis. |
| AID381054 | Activation of PPARgamma transfected in human MCF7 cells at 10 uM after 48 hrs by luciferase reporter gene assay | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID276472 | Inhibition of Trypanosoma brucei GalE by HPAEC assay | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22
| Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. |
| AID1202471 | Cytotoxicity against human HCT116 cells by SRB assay | 2015 | European journal of medicinal chemistry, , Volume: 96 | Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents. |
| AID1709210 | Antimigratory activity in human MDA-MB-231 cells assessed as suppression of wound closure at 400 nM after 24 hrs by microscopic analysis | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID705856 | Cell cycle arrest in apoptosis in AML patient blasts at 5 uM after 26 hrs | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities. |
| AID356623 | Cytotoxicity against human A549 cells | 2003 | Journal of natural products, Nov, Volume: 66, Issue:11
| New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis. |
| AID1684928 | Induction of apoptosis in human HL-60 cells assessed as early apoptotic cells at 4 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 2.9 %) | | | |
| AID1684941 | Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence | | | |
| AID381075 | Activation of p21 promoter in human H1299 cells by reporter assay | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID670033 | Inhibition of HDAC6 in human MCF7 cells assessed as change in tubulin acetylation level at 5 uM after 24 hrs by Western blot analysis | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID381069 | Antiproliferative activity against human MCF7 cells at 10 uM up to 8 hrs by neutral red method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID1709207 | Inhibition of DOT1L in human MDA-MB-231 cells assessed as effect on histone H3 methylation at 200 nM by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID1684874 | Antitumor activity against mouse LL/2 cells inoculated in C57BL/6J mouse assessed as tumor growth inhibition at 25 mg/kg, ip administered for 12 days | | | |
| AID613113 | Inhibition of human recombinant GST-tagged HDAC1 expressed in Sf9 cells using Fluor de Lys as substrate at 5 uM after 0.5 hrs by fluorimetry | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID1073051 | Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells. |
| AID1684943 | Inhibition of HDAC6 in human HL-60 cells assessed as increase in acetylated alpha tubulin level at 0.5 to 8 uM after 24 hrs by Western blot analysis | | | |
| AID1847755 | Cytotoxicity against mouse P388 cells assessed as cell growth inhibition | 2021 | Bioorganic & medicinal chemistry, 12-15, Volume: 52 | From natural products to HDAC inhibitors: An overview of drug discovery and design strategy. |
| AID381073 | Induction of apoptosis in human T47D cells assessed as chromosome fragmentation at 10 uM after 8 hrs by bright field microscopy | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID1684885 | Inhibition of HDAC2 in human HL-60 cells assessed as increase in Ac-H3 level at 0.5 to 8 uM incubated for 24 hrs by Western blot analysis | | | |
| AID613125 | Inhibition of recombinant human SIRT1 lysine deacetylase activity at 50 uM after 60 mins by fluorimetry relative to control | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID1684936 | Induction of apoptosis in human HL-60 cells assessed as early apoptotic cells at 1 uM incubated for 24 hrs by propidium iodide and annexin-V FITC staining based FACS analysis (Rvb = 2.9 %) | | | |
| AID254938 | Inhibition of Mycobacterium tuberculosis detoxification enzyme mycothiol-S-conjugate amidase (MCA) | 2005 | Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
| Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. |
| AID360257 | Cytotoxicity against human A549 cells | 1995 | Journal of natural products, Nov, Volume: 58, Issue:11
| Cytotoxic compounds from a two-sponge association. |
| AID1627670 | Inhibition of HDAC in human HL60 cells assessed as upregulation of H3 acetylation levels at 2 uM after 18 hrs by SDS-PAGE analysis | 2016 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
| Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents. |
| AID381064 | Activation of PPARgamma transfected in human MCF7 cells at 10 uM by luciferase reporter gene assay | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID360230 | Toxicity in Artemia salina | 1995 | Journal of natural products, Nov, Volume: 58, Issue:11
| Cytotoxic compounds from a two-sponge association. |
| AID1684875 | Antitumor activity against mouse LL/2 cells inoculated in C57BL/6J mouse assessed as reduction of tumor weight at 25 mg/kg, ip administered for 12 days measured at day 14 (Rvb = 0.98 +/- 0.07 g) | | | |
| AID1684877 | Antiproliferative activity against mouse LL/2 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay | | | |
| AID1709204 | Inhibition of DOT1L in human MDA-MB-231 cells assessed as effect on H3K4 methylation at 200 nM by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID1709187 | Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID613126 | Inhibition of recombinant human p300/CBP using [3H]-acetyl CoA at 50 uM after 2 hrs by scintillation counting relative to control | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID356625 | Cytotoxicity against human SK-MEL-2 cells | 2003 | Journal of natural products, Nov, Volume: 66, Issue:11
| New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis. |
| AID670023 | Growth inhibition of human MCF7 cells after 96 hrs by sulphorhodamine B assay | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID670014 | Selectivity index, ratio of IC50 for human recombinant HDAC6 to IC50 for human recombinant HDAC1 | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID143568 | Inhibition of Mycothiol -S-conjugate amidase (MCA) from mycobacterium tuberculosis | 2002 | Bioorganic & medicinal chemistry letters, Sep-02, Volume: 12, Issue:17
| Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. |
| AID381072 | Induction of apoptosis in human MCF7 cells assessed as chromosome fragmentation at 10 uM after 16 hrs by fluorescent microscopy | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID1684867 | Inhibition of HDAC3 in human HL-60 cells assessed as increase in Ac-H3 level at 0.5 to 8 uM incubated for 24 hrs by Western blot analysis | | | |
| AID1684872 | Toxicity in mouse LL/2 cells inoculated C57BL/6J mouse assessed as effect on body weight by measuring end body weight at 25 mg/kg, ip administered for 12 days and measured for every 2 days (Rvb = 18.1 +/- 0.2 g) | | | |
| AID1684940 | Inhibition of recombinant full length C-terminal FLAG-tagged human HDAC2 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence base | | | |
| AID276470 | Inhibition of Trypanosoma brucei GalE at 50 uM | 2006 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22
| Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. |
| AID613119 | Induction of apoptosis in human U937 cells assessed as caspase 3 activation at 5 uM after 30 hrs by FACS analysis | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID670039 | Inhibition of semi-purified DNMT1 | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID613129 | Cell cycle arrest in human U937 cells assessed as accumulation at G1 phase at 5 uM by propidium iodide staining based flow cytometry | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID707029 | Inhibition of HDAC6 in human U937 cells assessed as induction of alpha-tubulin acetylation at 5 uM after 30 hrs by cytofluorimetric analysis | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities. |
| AID707035 | Induction of apoptosis in human U937 cells at 5 uM after 30 hrs | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities. |
| AID670022 | Growth inhibition of human A549 cells after 96 hrs by sulphorhodamine B assay | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID670038 | Inhibition of HDAC in cell extract based assay | 2012 | Journal of medicinal chemistry, Feb-23, Volume: 55, Issue:4
| Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
| AID381053 | Inhibition of HDAC by cell-free enzyme assay | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID613111 | Inhibition of HDAC in cell-free system | 2011 | Bioorganic & medicinal chemistry, Jun-15, Volume: 19, Issue:12
| Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. |
| AID1709206 | Inhibition of DOT1L in human MDA-MB-231 cells assessed as effect on H3K36 methylation at 200 nM by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 04-01, Volume: 35 | Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity. |
| AID1684878 | Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay | | | |
| AID381059 | Antiproliferative activity against human MCF7 cells at 10 uM after 48 hrs by neutral red method | 2006 | Journal of natural products, Apr, Volume: 69, Issue:4
| Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells. |
| AID1684879 | Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 96 hrs by MTT assay | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |