A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified.
| Member | Definition | Class |
|---|
| 1-cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide | A carbodiimide having cyclcohexyl and 2-(4-morpholinyl)ethyl as the two N-substituents. | N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide |
| 1,3-dichloro-2-propanol | A secondary alcohol that is isopropanol in which one hydrogen of each methyl group is substituted by a chlorine. A liquid at room temperature (melting point -4degreeC, boiling point 174degreeC at 760 mm Hg), it is used as a solvent for hard resins and nitrocellulose. | 1,3-dichloropropan-2-ol |
| cisplatin | A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups). | cisplatin; transplatin |
| cyanuric chloride | A chloro-1,3,5-triazine in which the triazine ring is substituted on each carbon by chlorine. Its main use is in the preparation of the triazine-class pesticides. | cyanuric chloride |
| dicyclohexylcarbodiimide | A carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms. | 1,3-dicyclohexylcarbodiimide |
| divinyl sulfone | A sulfone compound having two S-vinyl substituents. | divinyl sulfone |
| ethylene dimethacrylate | The enoate ester that is the 1,2-bis(methacryloyl) derivative of ethylene glycol. | ethylene glycol dimethacrylate |
| genipin | | Genipin |
| glutaral | A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5. | glutaraldehyde |
| methoxsalen | A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis. | methoxsalen |
| pentosidine | An imidazopyridine having norleucine and ornithine residues attached via their side-chains at the 4- and 2-positions respectively. | pentosidine |
| tetrachlorophthalic anhydride | A cyclic dicarboxylic anhydride that is phthalic anhydride chlorinated at the 4-, 5-, 6- and 7-positions. | tetrachlorophthalic anhydride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 16.2086 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 1.3534 | 2 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 52.0101 | 2 | 5 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 33.3185 | 2 | 7 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 19.2994 | 1 | 3 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 18.2605 | 8 | 25 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 0.3118 | 2 | 5 |
| arylsulfatase A | Homo sapiens (human) | Potency | 21.3313 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 60.0459 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 3.7933 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 59.6843 | 2 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 75.6303 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 75.6303 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 33.0618 | 3 | 13 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 12.7585 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 12.7585 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 49.0188 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 8.8006 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 3.8902 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 4.3649 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 22.4113 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.8247 | 2 | 8 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 19.4971 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 43.8355 | 1 | 6 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 18.8876 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 57.1220 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 63.4054 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 1.4125 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 28.0538 | 11 | 36 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 18.8467 | 3 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 14.2609 | 6 | 16 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.3824 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 3.3173 | 2 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 22.5135 | 3 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 36.0192 | 2 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 3.8902 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.8247 | 1 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 37.6570 | 2 | 9 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 27.6952 | 2 | 4 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 35.3749 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 61.6524 | 2 | 2 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.1623 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 21.1699 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 113.0040 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 3.8902 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 1.9012 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 42.7640 | 1 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 59.6218 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 3.8902 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 3.8902 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 64.0292 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 17.8020 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 48.1381 | 1 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 2.6157 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 15.0654 | 1 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.1413 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 26.2098 | 4 | 11 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 53.9197 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 21.8861 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.6253 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 17.4493 | 3 | 14 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 26.8545 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 31.7179 | 5 | 17 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 32.8568 | 3 | 5 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 26.8545 | 1 | 1 |
| polyprotein | Zika virus | Potency | 15.8489 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 42.4600 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 49.2290 | 2 | 9 |
| progesterone receptor | Homo sapiens (human) | Potency | 12.1972 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 34.2390 | 2 | 10 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.5003 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 42.1483 | 3 | 9 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 22.9955 | 4 | 10 |
| RGS12 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 55.4772 | 1 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 55.4772 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 18.2563 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 8.9124 | 4 | 7 |
| Thrombopoietin | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 37.1006 | 3 | 7 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0028 | 2 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 36.1444 | 3 | 7 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 43.9284 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 29.7951 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 28.5195 | 4 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 35.3749 | 1 | 2 |