An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of fructose-bisphosphatase (EC 3.1.3.11).
ChEBI ID: 65056
| Member | Definition | Class |
|---|---|---|
| adenosine monophosphate | A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase. | adenosine 5'-monophosphate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5,079 (46.36) | 18.7374 |
| 1990's | 1,403 (12.81) | 18.2507 |
| 2000's | 1,533 (13.99) | 29.6817 |
| 2010's | 1,363 (12.44) | 24.3611 |
| 2020's | 1,577 (14.40) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 257 (2.25%) | 5.53% |
| Reviews | 720 (6.30%) | 6.00% |
| Case Studies | 138 (1.21%) | 4.05% |
| Observational | 43 (0.38%) | 0.25% |
| Other | 10,274 (89.87%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 12.2352 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 31.6228 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 18.0719 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.2985 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.8888 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 23.9145 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 2-dehydropantoate 2-reductase | Escherichia coli K-12 | Ki | 6,300.0000 | 1 | 1 |
| 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 40.0000 | 1 | 1 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 80.0000 | 1 | 1 |
| Adenylate kinase isoenzyme 1 | Rattus norvegicus (Norway rat) | Ki | 580.0000 | 1 | 1 |
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 38.0000 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 38.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 0.4400 | 1 | 1 |
| Chain A, ADP-dependent glucokinase | Pyrococcus furiosus | Ki | 60.0000 | 1 | 1 |
| Chain A, phosphodiesterase-nucleotide pyrophosphatase | Xanthomonas citri pv. citri str. 306 | Ki | 260.0000 | 1 | 1 |
| Chain A, Ribonuclease pancreatic | Bos taurus (cattle) | Ki | 46.0000 | 1 | 2 |
| Choline O-acetyltransferase | Homo sapiens (human) | IC50 | 1,800,000,000.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 2.6000 | 1 | 1 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 2.6436 | 11 | 11 |
| Fructose-1,6-bisphosphatase 1 | Sus scrofa (pig) | IC50 | 1.3000 | 2 | 2 |
| Glycine--tRNA ligase | Bombyx mori (domestic silkworm) | Ki | 80.0000 | 1 | 1 |
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8000 | 1 | 2 |
| Inosine-5'-monophosphate dehydrogenase | Escherichia coli K-12 | Ki | 450.0000 | 1 | 1 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | Ki | 0.0002 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 2 | Homo sapiens (human) | IC50 | 70.0000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 2-dehydropantoate 2-reductase | Escherichia coli K-12 | Kd | 5,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens (human) | EC50 | 3.7095 | 2 | 2 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens (human) | Kd | 3.7000 | 1 | 1 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens (human) | EC50 | 3.6500 | 2 | 2 |
| 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens (human) | EC50 | 2.9397 | 3 | 3 |
| 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens (human) | Kd | 3.7000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit beta-2 | Homo sapiens (human) | EC50 | 5.9000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens (human) | EC50 | 2.9397 | 3 | 3 |
| 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens (human) | Kd | 3.7000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-2 | Homo sapiens (human) | EC50 | 5.9000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-3 | Homo sapiens (human) | EC50 | 5.9000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | EC50 | 0.5000 | 1 | 1 |
| Chain A, GLYCOGEN PHOSPHORYLASE B | Oryctolagus cuniculus (rabbit) | Kd | 101.8000 | 1 | 5 |
| Chain B, GLYCOGEN PHOSPHORYLASE B | Oryctolagus cuniculus (rabbit) | Kd | 85.3333 | 1 | 3 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | Kd | 650.0000 | 1 | 1 |
| Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens (human) | Kd | 245.0000 | 2 | 2 |
| P2Y purinoceptor 1 | Homo sapiens (human) | EC50 | 4.3500 | 1 | 2 |
| P2Y purinoceptor 1 | Meleagris gallopavo (turkey) | EC50 | 3.1500 | 1 | 2 |
| P2Y purinoceptor 11 | Homo sapiens (human) | EC50 | 17.2500 | 1 | 1 |
| P2Y purinoceptor 2 | Homo sapiens (human) | EC50 | 1.8925 | 1 | 2 |
| Protease | Human immunodeficiency virus 1 | Kd | 0.0011 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5'-nucleotidase | Homo sapiens (human) | Km | 14.0000 | 1 | 1 |
| Adenosine deaminase-like protein | Homo sapiens (human) | Km | 32.8000 | 1 | 1 |
| Adenylate kinase 2, mitochondrial | Homo sapiens (human) | Km | 380.0000 | 1 | 1 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Km | 85.0000 | 2 | 2 |
| Adenylate kinase isoenzyme 1 | Homo sapiens (human) | Km | 175.0000 | 1 | 1 |
| Adenylate kinase isoenzyme 1 | Rattus norvegicus (Norway rat) | Km | 580.0000 | 1 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | Km | 441.0000 | 1 | 1 |
| GTP:AMP phosphotransferase AK3, mitochondrial | Rattus norvegicus (Norway rat) | Km | 85.0000 | 2 | 2 |