An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.
ChEBI ID: 29256
| Member | Definition | Role |
|---|---|---|
| 1-azepanyl-[2-methoxy-4-(methylthio)phenyl]methanone | 1-azepanyl-[2-methoxy-4-(methylthio)phenyl]methanone | |
| 2-methoxy-4-(methylthio)-N-pyridin-4-ylbenzamide | 2-methoxy-4-(methylthio)-N-pyridin-4-ylbenzamide | |
| 3-mercaptopyruvic acid | A 2-oxo monocarboxylic acid that is pyruvic acid substituted by a sulfanyl group at position 3. | 3-mercaptopyruvic acid |
| 9-mercaptodethiobiotin | A member of the class of imidazolidinones that is dethiobiotin carrying a mercapto substituent at position 9. An intermediate in the biosynthesis of biotin. | 9-mercaptodethiobiotin |
| bacillithiol | A thiol that is the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. | bacillithiol |
| cysteamine | An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2. | cysteamine |
| dithiothreitol | A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group. | 1,4-dimercaptobutane-2,3-diol; 1,4-dithiothreitol |
| l 744832 | A secondary carboxamide resulting from the formal condensation of the carboxy group of 2-{[(2S,3S)-2-{[(2R)-2-amino-3-sulfanylpropyl]amino}-3-methylpentyl]oxy}-3-phenylpropanoic acid with the amino group of propan-2-yl (2S)-2-amino-4-(methylsulfonyl)butanoate. It is a farnesyltransferase inhibitor that exhibits anticancer properties. | L-744,832 |
| mecysteine | An L-cysteinyl ester resulting from the formal condensation of the carboxylic acid group of L-cysteine with methanol. It is used (as the hydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough. | methyl L-cysteinate |
| molybdopterin cytosine dinucleotide | molybdopterin cytosine dinucleotide | |
| N-(3,5-dichloro-2-pyridinyl)-2-methoxy-4-(methylthio)benzamide | N-(3,5-dichloro-2-pyridinyl)-2-methoxy-4-(methylthio)benzamide | |
| pantetheine | An amide obtained by formal condensation of the carboxy group of pantothenic acid and the amino group of cysteamine. | pantetheine |
| penicillamine | An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group. | penicillamine |
| thioglycerol | A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group. | monothioglycerol |
| zofenoprilate | A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-2-methyl-3-sulfanylpropanoyl group. The active metabolite of zofenopril. | zofenoprilat |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4,979 (44.80) | 18.7374 |
| 1990's | 2,463 (22.16) | 18.2507 |
| 2000's | 1,876 (16.88) | 29.6817 |
| 2010's | 1,472 (13.24) | 24.3611 |
| 2020's | 325 (2.92) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 92 (0.79%) | 5.53% |
| Reviews | 193 (1.65%) | 6.00% |
| Case Studies | 114 (0.98%) | 4.05% |
| Observational | 5 (0.04%) | 0.25% |
| Other | 11,278 (96.54%) | 84.16% |