| Assay ID | Title | Year | Journal | Article |
|---|
| AID26837 | Ionization constant in presence of hydroxyl | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID61135 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain limbic area by po administration | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID170777 | Brain Concentration of 5,6-di-OH-DPAT after 25 (umol/kg) sc administration without tropolone pretreatment in rat cerebellum | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID62466 | Potency to displace the specific in vitro binding of [3H]-N-0437 to calf striatal membrane | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID65149 | In vitro binding affinity is the ability to displace [3H]spiperone from human Dopamine receptor D3 expressed in CHO-K1 cells. | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin. |
| AID61005 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain hemispheral area by sc administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID130901 | Inhibition of locomotor activity(LMA) in mouse after sc administration of the compound. | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin. |
| AID170775 | Brain Concentration of 5,6-di-OH-DPAT after 25 (umol/kg) sc administration with tropolone pretreatment in rat cortex | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177898 | Inhibition of dopamine accumulation in striatum part of rat brain after subcutaneous administration | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID425419 | Activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding relative to dopamine | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
| AID1150433 | Dopaminergic activity in dog assessed as induction of emesis administered intramuscularly measured up to 20 hrs | 1976 | Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
| Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene. |
| AID425416 | Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in HEK293 cells | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
| AID446403 | Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding relative to 100 uM dopamine | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID170776 | Brain Concentration of 5,6-di-OH-DPAT after 25 (umol/kg) sc administration with tropolone pretreatment in rat striatum | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID61140 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain striatal area by po administration | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID195681 | DA-agonist induced motor activity in reserpinized rat was measured; 0.09-0.16 | 1981 | Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
| Monophenolic 2-(dipropylamino)indans and related compounds: central dopamine-receptor stimulating activity. |
| AID425420 | Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
| AID461559 | Displacement of [3H]spiperone from cloned dopamine D2L receptor expressed in HEK cells | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto |
| AID3594 | Effective dose for half-maximal decrease in the accumulation of 5-hydroxytryptophan (5-HTP) in reserpinized rat brain hemispheral area by po administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID61137 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain limbic area by sc administration | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID170918 | Brain Concentration at 25 (umol/kg, sc) with tropolone pretreatment in rat cortex | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID446401 | Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding relative to 1 mM dopamine | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID1150434 | Dopaminergic activity in sc dosed Sprague-Dawley rat assessed as induction of stereotyped behavior administered for 30 to 50 mins | 1976 | Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
| Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene. |
| AID177284 | ED50 value was measured as dose required to produce a half-maximal reduction of Serotonin (5-HTP) accumulation in striatum of reserpinized rat brain; I is Inactive, no significant effect at doses approximately 40 times the ED50 for Dopa accumulation | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID177278 | ED50 value was measured as dose required to produce a half-maximal reduction of Serotonin (5-HTP) accumulation in limbic area of reserpinized rat brain; I is Inactive, no significant effect at doses approximately 40 times the ED50 for Dopa accumulation | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID19222 | Partition coefficient in octanol-buffer at a pH 7.4 | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID177637 | Effect on 5-HTP accumulation in striatum of rat; Inactive | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID170920 | Brain Concentration at 25 (umol/kg, sc) without tropolone pretreatment in rat cerebellum | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID172484 | DA agonist induced behavior was charecterised by increased locomotion, sniffing and licking.++ indicates high intensity of behavioral effect | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID4216 | Binding affinity against 5-hydroxytryptamine 1A receptor in homogenated rat brain tissue, using by [3H]8-OH-DPAT as radioligand | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID177644 | Effect on dopamine accumulation in limbic system of rat. | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID461560 | Displacement of [3H]spiperone from cloned dopamine D3 receptor expressed in HEK cells | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto |
| AID170426 | Motor activity in reserpinized rats at the biochemical ED50 dose level expressed as accumulation counts per 60 min | 1981 | Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
| Monophenolic 2-(dipropylamino)indans and related compounds: central dopamine-receptor stimulating activity. |
| AID184695 | Motor activity was measured in the reserpinized rats as counts/60 min. | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID184433 | Apparent kinetic constant(Km) for the aromatic hydroxylation on crude rat liver microsomes. | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID61143 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain striatal area by sc administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID185916 | Evaluation for contralateral turning in 6-hydroxy-dopamine-lesioned rats administered intraperitoneally at the dose 1 mg/kg Maximum intensity (turnings/min) | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Structure-activity relationships of dopaminergic 5-hydroxy-2-aminotetralin derivatives with functionalized N-alkyl substituents. |
| AID62430 | Dopamine receptor binding affinity by displacing the radioligand [3H]spiroperidol from dopamine receptor. | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Structure-activity relationships of dopaminergic 5-hydroxy-2-aminotetralin derivatives with functionalized N-alkyl substituents. |
| AID425415 | Displacement of [3H]spiperone from rat dopamine D2L receptor expressed in HEK293 cells | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
| AID65080 | Binding affinity against dopamine receptor D2 in homogenated rat brain tissue, using by ([3H]-N00437) as radioligand; Not tested | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID176386 | Estimated dose giving a half-maximal decrease of the DA synthesis rate in the limbic system of rat brain | 1981 | Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
| Monophenolic 2-(dipropylamino)indans and related compounds: central dopamine-receptor stimulating activity. |
| AID61138 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain limbic area by sc administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID446400 | Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID1150435 | Dopaminergic activity in (+)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol-pretreated dog assessed as induction of emesis administered intramuscularly measured up to 20 hrs | 1976 | Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
| Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene. |
| AID26626 | Ionization constant in presence of nitrogen | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID170774 | Brain Concentration of 5,6-di-OH-DPAT after 25 (umol/kg) sc administration with tropolone pretreatment in rat cerebellum | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID173496 | In Vivo effect on concentration of DOPAC in rat striatum at 1 umol/kg | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID197169 | Hypertensive activity (increase in arterial pressure to 60 mmHg)) after i.v. administration to pithed rats. | 1984 | Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
| Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. |
| AID64604 | Potency to displace the specific in vitro binding of [3H]DP-5,6-ADTN to rat striatal membrane | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID36783 | 50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes | 1984 | Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
| Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. |
| AID192618 | post-synaptic agonistic effects by increase in locomotor activity at the dose of 0.08 umol/kg, sc in reserpinized rat | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID65081 | Binding affinity against dopamine receptor D2 in rat brain tissue using [3H]spiperone | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID61142 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain striatal area by sc administration | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID513738 | Displacement of [3H]spiperone from rat D2 receptor expressed in HEK293 cells | 2010 | Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
| Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol. |
| AID62367 | Total dose at which the animal vomits | 1981 | Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
| Monophenolic 2-(dipropylamino)indans and related compounds: central dopamine-receptor stimulating activity. |
| AID177121 | ED50 value was measured as dose required to produce a half-maximal reduction of Dopa accumulation in limbic area of reserpinized rat brain. | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID174605 | Evaluation for contralateral turning in 6-hydroxy-dopamine-lesioned rats administered intraperitoneally at the dose 1 mg/kg duration | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Structure-activity relationships of dopaminergic 5-hydroxy-2-aminotetralin derivatives with functionalized N-alkyl substituents. |
| AID63092 | In vitro binding affinity is the ability to displace [3H]spiperone from human Dopamine receptor D2 expressed in CHO-K1 cells | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin. |
| AID425421 | Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding relative to dopamine | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
| AID177635 | Effect on 5-HTP accumulation in limbic system of rat; Inactive | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177872 | Inhibition of 5-Hydroxy tryptamine accumulation in limbic part of rat brain after subcutaneous administration; I= Inactive | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID170917 | Brain Concentration at 25 (umol/kg, sc) with tropolone pretreatment in rat cerebellum | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177874 | Inhibition of 5-Hydroxy tryptamine accumulation in striatum part of rat brain after subcutaneous administration; I= Inactive | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID62016 | Potency was evaluated for the activity against Dopamine receptor D2 of cat cardioaccelerator nerve preparation; Active | 1986 | Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
| p-Dimethoxy-substituted trans-octahydrobenzo[f]- and -[g]quinolines: synthesis and assessment of dopaminergic agonist effects. |
| AID230026 | Ratio of Km to that Vmax in crude rat liver microsomes was determined | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177646 | Effect on dopamine accumulation in striatum of rat. | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID1630275 | Displacement of [3H]spiperone from rat D2L dopamine receptor expressed in HEK293 cell membranes after 1 hr | | | |
| AID1384577 | Binding affinity to 5-HT7 receptor (unknown origin) | 2018 | Journal of medicinal chemistry, 10-11, Volume: 61, Issue:19
| Structure-Activity Relationships and Therapeutic Potentials of 5-HT |
| AID446397 | Displacement of [3H]spiperone from human dopamine D3 receptor expressed in HEK293 cells | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID3605 | Effective dose for half-maximal decrease in the accumulation of 5-hydroxytryptophan (5-HTP) in reserpinized rat brain striatal area by po administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID446402 | Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID1150436 | Dopaminergic activity in (+)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol-pretreated sc dosed Sprague-Dawley rat assessed as induction of stereotyped behavior administered for 30 to 50 mins | 1976 | Journal of medicinal chemistry, Apr, Volume: 19, Issue:4
| Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene. |
| AID61003 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain hemispheral area by po administration | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID446399 | Selectivity index, ratio of Ki for human dopamine D2L receptor to Ki for human dopamine D3 receptor | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID170779 | Brain Concentration of 5,6-di-OH-DPAT after 25 (umol/kg) sc administration without tropolone pretreatment in rat striatum | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177127 | ED50 value was measured as dose required to produce a half-maximal reduction of Dopa accumulation in the striatum of reserpinized rat brain. | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID425417 | Selectivity ratio of Ki for rat dopamine D2L receptor to Ki rat dopamine D3 receptor | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
| AID191872 | Apparent kinetic constant(Vmax) for the aromatic hydroxylation on crude rat liver microsomes at 1 mg of protein | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID1630276 | Displacement of [3H]spiperone from rat D3 dopamine receptor expressed in HEK293 cell membranes after 1 hr | | | |
| AID425418 | Activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
| AID170921 | Brain Concentration at 25 (umol/kg, sc) without tropolone pretreatment in rat cortex | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID513739 | Displacement of [3H]spiperone from rat D3 receptor expressed in HEK293 cells | 2010 | Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
| Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol. |
| AID63091 | In vitro binding affinity is the ability to displace [3H]N-0437 from human Dopamine receptor D2 expressed in CHO-K1 cells | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177896 | Inhibition of dopamine accumulation in limbic part of rat brain after subcutaneous administration | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID461561 | Selectivity ratio of Ki for dopamine D2L receptor to Ki for dopamine D3 receptor | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in sympto |
| AID36715 | Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.4 nM) to rat isolated brain membranes by 50% was reported. | 1984 | Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
| Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. |
| AID191323 | Evaluation for contralateral turning in 6-hydroxy-dopamine-lesioned rats administered intraperitoneally at the dose 1 mg/kg total turnings | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Structure-activity relationships of dopaminergic 5-hydroxy-2-aminotetralin derivatives with functionalized N-alkyl substituents. |
| AID177497 | Effect on 5-HTP accumulation in hemispheres of rat; Inactive | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID170919 | Brain Concentration at 25 (umol/kg, sc) with tropolone pretreatment in rat striatum | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID170922 | Brain Concentration at 25 (umol/kg, sc) without tropolone pretreatment in rat striatum | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID446398 | Displacement of [3H]spiperone from human dopamine D2L receptor expressed in HEK293 cells | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID170424 | Motor activity in reserpinized rats at the biochemical ED100 dose level expressed as accumulation counts per 60 min | 1981 | Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
| Monophenolic 2-(dipropylamino)indans and related compounds: central dopamine-receptor stimulating activity. |
| AID1630286 | Induction of recombinant alphaSN (unknown origin) fibrillation at 120 uM after 6 days by ThT fluorescence assay | | | |
| AID62310 | Dopamine receptor binding affinity by displacing the radioligand [3H]-dopamine from dopamine receptor. | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Structure-activity relationships of dopaminergic 5-hydroxy-2-aminotetralin derivatives with functionalized N-alkyl substituents. |
| AID173709 | Percent reversal of the increase on DOPA levels in the striatum of GBL-treated rats administered ip with 10 mg/kg of compound. | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177643 | Effect on dopamine accumulation in hemispheres of rat; Inactive | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID173610 | Estimated dose giving an approximately maximal decrease of the DA synthesis rate | 1981 | Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
| Monophenolic 2-(dipropylamino)indans and related compounds: central dopamine-receptor stimulating activity. |
| AID176388 | Estimated dose giving a half-maximal decrease of the DA synthesis rate in the striatum of rat brain | 1981 | Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
| Monophenolic 2-(dipropylamino)indans and related compounds: central dopamine-receptor stimulating activity. |
| AID130900 | Inhibition of locomotor activity(LMA) in mouse after ip administration of the compound. | 1995 | Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
| Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin. |
| AID3600 | Effective dose for half-maximal decrease in the accumulation of 5-hydroxytryptophan (5-HTP) in reserpinized rat brain limbic area by po administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID177870 | Inhibition of 5-Hydroxy tryptamine accumulation in hemispheres of rat brain after subcutaneous administration; I= Inactive | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID173499 | In Vivo effect on concentration of HVA in rat striatum at 1 umol/kg | 1988 | Journal of medicinal chemistry, Nov, Volume: 31, Issue:11
| Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation. |
| AID446404 | Selectivity index, ratio of EC50 for human dopamine D2L receptor to EC50 for human dopamine D3 receptor by [35S]GTPgamma binding assay | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID170778 | Brain Concentration of 5,6-di-OH-DPAT after 25 (umol/kg) sc administration without tropolone pretreatment in rat cortex | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID181024 | Percent reduction of hemispheres in cortex was measured in the brain of reserpinized rats; I is Inactive, no significant effect at doses approximately 40 times the ED50 for Dopa accumulation | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID425422 | Selectivity ratio of EC50 for human dopamine D2L receptor to EC50 human dopamine D3 receptor by [35S]GTPgammaS binding assay | 2009 | Bioorganic & medicinal chemistry, Jun-01, Volume: 17, Issue:11
| Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. |
| AID1630277 | Selectivity ratio of Ki for rat D2L dopamine receptor expressed in HEK293 cells to Ki for rat D3 dopamine receptor expressed in HEK293 cells | | | |
| AID1346302 | Mouse 5-HT1B receptor (5-Hydroxytryptamine receptors) | 1992 | Proceedings of the National Academy of Sciences of the United States of America, Apr-01, Volume: 89, Issue:7
| Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |