Benzoylarginine Nitroanilide: A chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., papain and trypsin, by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 13494 |
| CHEMBL ID | 1907476 |
| SCHEMBL ID | 701212 |
| SCHEMBL ID | 20471420 |
| MeSH ID | M0002377 |
| PubMed CID | 2724371 |
| CHEMBL ID | 1898160 |
| SCHEMBL ID | 2044745 |
| MeSH ID | M0002377 |
| Synonym |
|---|
| einecs 213-010-7 |
| 911-76-2 |
| (1)-n-(4-((aminoiminomethyl)amino)-1-(((4-nitrophenyl)amino)carbonyl)butyl)benzamide |
| benzamide, n-(4-((aminoiminomethyl)amino)-1-(((4-nitrophenyl)amino)carbonyl)butyl)-, (+-)- |
| SR-01000645497-1 |
| benzoylarginine nitroanilide |
| SCHEMBL701212 |
| RKDYKIHMFYAPMZ-UHFFFAOYSA-N |
| benzamide, n-[4-[(aminoiminomethyl)amino]-1-[[(4-nitrophenyl)amino]carbonyl]butyl]-, (.+/-.)- |
| n-(4-([amino(imino)methyl]amino)-1-[(4-nitroanilino)carbonyl]butyl)benzamide # |
| AKOS024370373 |
| CHEMBL1907476 |
| SCHEMBL20471420 |
| DTXSID40919960 |
| n-[5-carbamimidamido-1-(4-nitroanilino)-1-oxopentan-2-yl]benzenecarboximidic acid |
| 2-benzamido-5-guanidino-4'-nitrovaleranilide |
| n-benzoyl-dl-arginine-4-nitroanilide |
| PD150663 |
| 911-77-3 |
| bapna |
| smr000875358 |
| nalpha-benzoyl-dl-arginine 4-nitroanilide hydrochloride |
| MLS001361402 |
| nalpha-benzoyl-dl-arginine 4-nitroanilide hydrochloride, >=98% |
| n-alpha-benzoyl-dl-arginine 4-nitroanilide monohydrochloride |
| B-0800 |
| n-benzoyl-dl-arginine-4-nitroanilide hydrochloride |
| n-[(2s)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]benzamide hydrochloride |
| FT-0638139 |
| FT-0629935 |
| n-(5-guanidino-1-((4-nitrophenyl)amino)-1-oxopentan-2-yl)benzamide hydrochloride |
| AKOS015902372 |
| 5-carbamimidamido-n-(4-nitrophenyl)-2-(phenylformamido)pentanamide hydrochloride |
| SCHEMBL2044745 |
| 21653-41-8 |
| n-alpha-benzoyl-dl-arginine-4-nitroanilide hydrochloride |
| CHEMBL1898160 |
| bz-d-arg-pna hcl |
| AS-74759 |
| bz-d-arg-pna . hcl |
| bz-arg-pna hcl |
| dl-bapa . hcl;dl-bapna . hcl |
| bz-dl-arg-pna hcl |
| l-bapna . hcl;l-bapa . hcl |
| d-bapa . hcl;d-bapna . hcl |
| mfcd00012846 |
| bz-dl-arg-pna . hcl |
| dl-bapa hcl;dl-bapna hcl |
| A860586 |
| n-(5-guanidino-1-(4-nitrophenylamino)-1-oxopentan-2-yl)benzamide hydrochloride |
| FT-0771053 |
| DEOKFPFLXFNAON-UHFFFAOYSA-N |
| 2-benzamido-5-guanidino-4'-nitrovaleranilide hcl |
| n-benzoyl-dl-arginine-4-nitroanilide hcl |
| AMY22212 |
| d-bapa . hcl;d-bapna . hcl |
| benzamide,n-[4-[(aminoiminomethyl)amino]-1-[[(4-nitrophenyl)amino]carbonyl]butyl]-, monohydrochloride |
| D81794 |
| nalpha-benzoyl-dl-arginine p-nitroanilide hydrochloride |
| n- alpha -benzoyl-dl-arginine 4-nitroanilide monohydrochloride |
| n-[5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]benzamide;hydrochloride |
| DTXSID50883603 |
| CS-W009669 |
| c19h23cln6o4 |
| PD150662 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 2.2387 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 2.2387 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 2.2387 | 0.1585 | 5.2879 | 12.5893 | AID540303 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 5.6234 | 0.5623 | 9.3985 | 25.1189 | AID652106 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 7.0795 | 1.7783 | 16.2081 | 35.4813 | AID652104 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 76 (41.08) | 18.7374 |
| 1990's | 46 (24.86) | 18.2507 |
| 2000's | 42 (22.70) | 29.6817 |
| 2010's | 18 (9.73) | 24.3611 |
| 2020's | 3 (1.62) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 6 (3.09%) | 5.53% |
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (0.52%) | 6.00% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 187 (96.39%) | 84.16% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| Evaluation of the toxicity of ionic liquids on trypsin: A mechanism study. Chemosphere, Volume: 148 | 2016 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |
| Article | Year |
|---|---|
| Single turnover mechanism of a trypsin-reactor with high enzyme concentration. Journal of biotechnology, Feb-05, Volume: 60, Issue: 1-2 | 1998 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |
| Article | Year |
|---|---|
| [Influence of copper in combination with other trace elements on the activity of trypsin (author's transl)]. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, Volume: 50, Issue: 2 | 1980 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |