An EC 2.3.2.* (aminoacyltransferase) inhibitor that interferes with the action of gamma-glutamyltransferase (EC 2.3.2.2).
ChEBI ID: 74570
| Member | Definition | Class |
|---|---|---|
| acivicin | An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria. | acivicin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 141 (34.64) | 18.7374 |
| 1990's | 161 (39.56) | 18.2507 |
| 2000's | 66 (16.22) | 29.6817 |
| 2010's | 35 (8.60) | 24.3611 |
| 2020's | 4 (0.98) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 10 (2.34%) | 5.53% |
| Reviews | 10 (2.34%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 408 (95.33%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 1.7901 | 2 | 2 |
| AR protein | Homo sapiens (human) | Potency | 9.0560 | 3 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 3.7255 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 6.6824 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 19.0047 | 3 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.8962 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 2.9849 | 2 | 2 |