Aggressive Periodontitis

Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.

Synonym
Aggressive Periodontitis
Periodontitis, Circumpubertal
Periodontitis, Juvenile
Periodontosis
Early-Onset Periodontitis
Periodontitis, Aggressive, 1
Juvenile Periodontitis
Prepubertal Periodontitis
Periodontitis, Prepubertal

Excerpt	Reference
"Generalised prepubertal periodontitis is a rare entity that is usually a consequence of severe systemic diseases."	( Aksu, G; Baylas, H; Buduneli, N; Kütükçüler, N, 2001)
"Aggressive periodontitis is a specific form of periodontal disease that is characterized by rapid attachment loss and bone destruction."	( de Oliveira, RR; de Souza, RF; Garlet, GP; Novaes, AB; Ribeiro, FJ; Schwartz-Filho, HO; Scombatti de Souza, SL; Taba, M, 2009)
"Localized aggressive periodontitis is a distinct entity of periodontal disease and is characterized by deep vertical bony defects that typically affect the first molars and incisors of young patients."	( Bernimoulin, JP; Friedmann, A; Kaner, D; Kleber, BM, 2009)
"Aggressive periodontitis is a rare but rapidly progressing form of periodontal disease that usually affects otherwise systemically healthy individuals, at a young age."	( Aukhil, I; Elmariah, T; Gonçalves, PF; Harris, TH; Shaddox, LM; Wallace, MR, 2018)
"Localized aggressive periodontitis is rare periodontitis in clinical practice, which often occurs in young adults under 35 years old, seriously affecting patients' quality of life."	( Cai, Y; Chen, X; He, Z; Song, S; Wang, L; Yu, Q; Zhao, H, 2020)

Excerpt	Reference
"Prepubertal periodontitis affects both primary and permanent dentition."	( Kamma, JJ; Lygidakis, NA; Nakou, M, 1998)

Excerpt	Reference
"The correction of malocclusions in juvenile periodontitis (JP) patients completing periodontal therapy is a problem of increasing clinical concern to orthodontists, since many teeth with severe alveolar bone loss in these patients can now be successfully treated without extraction."	( Folio, J; Keyes, PH; Rams, TE, 1985)
"Sixteen patients diagnosed as having juvenile periodontitis were randomly placed into one of two treatment groups."	( Mabry, TW; Sepe, WW; Yukna, RA, 1985)
"A case of post-juvenile periodontitis in a 28-year-old female patient is described along with new periodontal treatment modalities."	( Hosaka, Y; Nakagawa, T; Okuda, K; Saito, A; Seida, K; Yamada, S, 1994)
"The treatment of localized juvenile periodontitis has been previously described in the literature, utilizing primarily a long-term (2 to 6 week) antibiotic regimen, notably tetracycline."	( Epstein, SR, 1995)
"Twenty-five localized juvenile periodontitis (LJP) patients from a Brazilian population were randomly allocated into an experimental group receiving mechanical treatment and antibiotics, and a control group receiving mechanical treatment and placebo."	( Beldi, MI; Bellini, HT; Campedelli, F; Gjermo, P; Lana, M; Loureiro, CA; Preus, HR; Rams, TE; Tinoco, EM; Tinoco, NM, 1998)
"Thirty-eight patients with untreated generalized aggressive periodontitis participated in the study."	( Aslan, M; Baltacioglu, E; Saraç, Ö; Saybak, A; Yuva, P, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	67 (14.32)	23.3326
1990's	119 (25.43)	12.5806
2000's	77 (16.45)	18.1394
2010's	184 (39.32)	28.8240
2020's	21 (4.49)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
adenine	low	13	0
adipic acid	low	1	0
butyric acid	low	1	0
formic acid	low	1	0
citric acid, anhydrous	medium	1	1
cytosine	low	13	0
lactic acid	low	2	0
glycine	low	2	0
hydrogen carbonate	low	3	0
iodine	low	1	0
inositol	low	1	0
melatonin	low	1	0
nitrates	low	1	0
phosphorylcholine	low	1	0
phosphorylethanolamine	low	1	0
propionic acid	low	2	0
sulfites	low	1	0
succinic acid	low	1	0
thymine	low	12	0
uric acid	low	1	0
1-anilino-8-naphthalenesulfonate	low	2	0
alendronate	medium	2	1
aspirin	low	1	0
verapamil	low	1	0
ciprofloxacin	low	3	0
clonidine	low	1	0
r 59022	low	1	0
erythrosine	low	1	0
ibuprofen	low	1	0
lidocaine	low	1	0
indomethacin	low	1	0
leflunomide	low	1	0
mechlorethamine	low	1	0
metronidazole	medium	76	34
ethylmaleimide	low	1	0
nifedipine	low	1	0
norfloxacin	low	1	0
orphenadrine	medium	1	1
sodium fluoride	medium	2	1
tranexamic acid	low	1	0
2,2',2''-trichlorotriethylamine	low	1	0
triclosan	medium	1	1
thymidine	low	2	0
hydroxyproline	low	1	0
serine	low	3	0
aspartic acid	low	2	0
glutamine	low	1	0
lysine	low	2	0
uridine	low	1	0
kanamycin a	low	1	0
carbostyril	low	1	0
edetic acid	low	1	0
leucine	low	3	0
phenylalanine	low	3	0
ampicillin	low	1	0
histidine	low	1	0
valine	low	1	0
threonine	low	2	0
tryptophan	low	2	0
isoleucine	low	1	0
arginine	low	5	0
isoprene	low	1	0
penicillin v	medium	1	1
n-vinyl-2-pyrrolidinone	low	1	0
xanthenes	low	1	0
phenothiazine	medium	2	2
3-amino-9-ethylcarbazole	low	1	0
quinazolines	low	1	0
acridines	low	1	0
isoxazoles	low	1	0
thiazoles	low	2	0
nitroblue tetrazolium	low	5	0
benzoylarginine-2-naphthylamide	low	1	0
citrulline	low	2	0
emetine	low	1	0
isovaleric acid	low	1	0
luminol	low	6	0
malondialdehyde	low	3	0
gentian violet	low	1	0
allyl sulfide	low	1	0
erythromycin	low	1	0
durapatite	medium	4	3
vancomycin	low	2	0
d-alpha tocopherol	low	1	0
fluorescein-5-isothiocyanate	low	2	0
titanium	low	2	0
chromium	low	1	0
erbium	low	1	0
hypochlorous acid	low	1	0
tricalcium phosphate	medium	3	3
calcium sulfate	medium	2	1
ozone	low	1	0
trolamine salicylate	low	1	0
tetradecanoylphorbol acetate	low	8	0
ornidazole	low	1	0
fluorides	low	2	0
transferrin	low	1	0
calcium oxalate	low	1	0
amoxicillin	medium	70	33
substance p	low	1	0
10-carboxymethyl-9-acridanone	low	1	0
diltiazem	low	1	0
ng-nitroarginine methyl ester	low	2	0
fomesafen	low	1	0
adenosine	low	1	0
glucose, (beta-d)-isomer	low	8	0
2',7'-dichlorofluorescein	low	1	0
iodonitrotetrazolium	low	1	0
thiazolyl blue	low	1	0
allicin	low	1	0
peroxynitric acid	low	1	0
5-bromo-4-chloro-3-indoxyl phosphate	low	1	0
methacycline	low	1	0
2,5-dihydroxybenzaldehyde	low	1	0
clarithromycin	medium	2	1
nicotine	low	2	0
quin2	low	1	0
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole	low	1	0
prolinedithiocarbamate	low	1	0
cv 3988	low	1	0
procyanidin	low	1	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	4	0
methotrexate	low	1	0
proline	low	2	0
peptide elongation factor 2	low	1	0
moxifloxacin	medium	5	5
hydroxyl radical	low	1	0
methyl 4-azidophenylacetimidate	low	1	0
cortisone	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
povidone-iodine	medium	2	1
n-acetylneuraminic acid	low	1	0
inositol 3-phosphate	low	2	0
n-formylmethionine leucyl-phenylalanine	low	30	0
resveratrol	medium	1	1
retinol	low	1	0
clindamycin	low	2	0
zithromax	medium	5	4
texas red	low	1	0
sodium bicarbonate	low	2	0
bromochloroacetic acid	low	3	0
r 59949	low	1	0
cotinine	low	4	0
pica	low	1	0
manool	low	1	0
sodium dodecyl sulfate	low	4	0
alpha-chymotrypsin	low	2	0
osteoprotegerin	low	4	0
cathepsin g	low	1	0
dinoprostone	medium	13	2
calcitriol	low	1	0
leukotriene b4	low	3	0
8,11,14-eicosatrienoic acid	low	1	0
lipoxin a4	low	1	0
clavulanic acid	low	2	0
5,6-epoxy-8,11,14-eicosatrienoic acid	low	1	0
deamino arginine vasopressin	low	1	0
cytochalasin b	low	1	0
12-hydroxy-5,8,10,14-eicosatetraenoic acid	low	1	0
15-hydroxy-5,8,11,13-eicosatetraenoic acid	low	1	0
strontium	low	1	0
cysteine	low	1	0
phosphorus	low	1	0
staurosporine	low	1	0
chlorhexidine	medium	22	10
amoxicillin-potassium clavulanate combination	medium	4	1
mocetinostat	low	9	0
lipid a	low	1	0
sepharose	low	1	0
acid phosphatase	low	1	0
jaw	low	1	0
cytochrome c-t	low	1	0
neuropeptide y	low	1	0
angiotensinogen	low	1	0
phenylmercuric acetate	low	1	0
sodium hypochlorite	low	1	0
sodium bisulfite	low	1	0
chiniofon	low	1	0
mannans	low	1	0
elafin	low	1	0
piperidines	low	1	0
interleukin-8	medium	21	1
leukotoxin	low	38	0
ascorbic acid	low	4	0
tetracycline	medium	34	8
chlortetracycline	low	1	0
minocycline	medium	6	1
epidermal growth factor	low	3	0
calca protein, human	low	1	0
transforming growth factor beta	low	2	0
agar	low	1	0
caseins	low	3	0
lactoferrin	low	14	0
muramidase	low	3	0
chondroitin sulfates	low	1	0
exudates	low	2	0
deoxyguanosine	low	2	0
guanine	low	14	0
guanosine 5'-o-(3-thiotriphosphate)	low	2	0
8-hydroxy-2'-deoxyguanosine	low	2	0
concanavalin a	low	1	0
leptin	low	4	0
pyrimidinones	low	1	0

Protein Targets (1,400)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	15	0	0	15
Chain A, Ferritin light chain	16	0	0	16
TDP1 protein	43	0	0	43
Microtubule-associated protein tau	24	0	0	25
aldehyde dehydrogenase 1 family, member A1	30	0	0	30
regulator of G-protein signaling 4	19	0	0	19
glucocerebrosidase	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	43	0	0	43
vitamin D3 receptor isoform VDRA	17	0	0	17
survival motor neuron protein isoform d	13	0	0	13
Cytochrome P450 3A4	0	18	1	23
Cytochrome P450 2C9	0	14	0	16
Short transient receptor potential channel 6	0	1	0	1
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	7	0	0	7
thioredoxin reductase	30	0	0	30
USP1 protein, partial	21	0	0	21
importin subunit beta-1 isoform 1	9	0	0	9
flap endonuclease 1	17	0	0	17
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	9	0	0	9
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	6	0	0	6
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	19	0	0	19
urokinase-type plasminogen activator precursor	9	0	0	9
plasminogen precursor	9	0	0	9
urokinase plasminogen activator surface receptor precursor	9	0	0	9
geminin	43	0	0	43
DNA polymerase kappa isoform 1	16	0	0	16
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	2	0	2
Transthyretin	0	1	3	4
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	2	3
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	27	0	0	27
Chain A, Cruzipain	13	0	0	13
Platelet-activating factor receptor	0	3	0	4
Inositol monophosphatase 1	10	0	0	10
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
hypoxia-inducible factor 1 alpha subunit	21	0	0	21
SMAD family member 2	15	0	0	15
SMAD family member 3	15	0	0	15
GLI family zinc finger 3	40	0	0	40
AR protein	46	0	0	46
estrogen receptor 2 (ER beta)	19	0	0	19
nuclear receptor subfamily 1, group I, member 3	27	0	0	27
progesterone receptor	24	0	0	24
glucocorticoid receptor [Homo sapiens]	32	0	0	32
retinoic acid nuclear receptor alpha variant 1	40	0	0	40
retinoid X nuclear receptor alpha	31	0	0	31
farnesoid X nuclear receptor	23	0	0	23
estrogen nuclear receptor alpha	57	0	0	57
G	13	0	0	13
peroxisome proliferator-activated receptor delta	22	0	0	22
peroxisome proliferator activated receptor gamma	27	0	0	27
vitamin D (1,25- dihydroxyvitamin D3) receptor	28	0	0	28
alpha-galactosidase	5	0	0	5
activating transcription factor 6	21	0	0	21
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	16	0	0	16
v-jun sarcoma virus 17 oncogene homolog (avian)	19	0	0	19
Stimulator of interferon genes protein	0	0	1	1
chromobox protein homolog 1	25	0	0	25
thyroid hormone receptor beta isoform 2	30	0	0	30
heat shock protein beta-1	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 1	36	0	0	36
peripheral myelin protein 22	16	0	0	16
Trypsin	0	1	0	2
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Cellular tumor antigen p53	34	0	0	34
TAR DNA-binding protein 43	12	0	0	12
Stimulator of interferon genes protein	0	0	1	1
Inositol hexakisphosphate kinase 1	13	0	0	13
cytochrome P450 2C9, partial	13	0	0	13
acetylcholinesterase	18	0	0	18
RAR-related orphan receptor gamma	36	0	0	36
caspase 7, apoptosis-related cysteine protease	9	0	0	9
estrogen-related nuclear receptor alpha	47	0	0	47
cytochrome P450 2D6	17	0	0	17
caspase-3	9	0	0	9
Histone H2A.x	19	0	0	19
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
Chain A, 2-oxoglutarate Oxygenase	18	0	0	18
Luciferase	16	0	0	16
glp-1 receptor, partial	9	0	0	9
ClpP	4	0	0	4
nonstructural protein 1	6	0	0	6
pregnane X nuclear receptor	24	0	0	24
IDH1	17	0	0	17
aryl hydrocarbon receptor	19	0	0	19
thyroid stimulating hormone receptor	19	0	0	19
hemoglobin subunit beta	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	15	0	0	15
histone deacetylase 9 isoform 3	6	0	0	6
huntingtin isoform 2	9	0	0	9
mitogen-activated protein kinase 1	17	0	0	17
rac GTPase-activating protein 1 isoform a	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	10	0	0	10
Voltage-dependent calcium channel gamma-2 subunit	18	0	0	18
Glutamate receptor 2	18	0	0	18
Histamine H2 receptor	14	0	0	14
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Oxoeicosanoid receptor 1	0	1	0	1
Free fatty acid receptor 3	0	0	3	3
Free fatty acid receptor 2	0	2	2	4
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	1	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Smad3	7	0	0	7
DNA topoisomerase 2-alpha	0	1	0	6
Acetylcholinesterase	0	6	0	6
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	25	0	0	25
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	20	0	0	20
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
tumor susceptibility gene 101 protein	1	0	0	1
lamin isoform A-delta10	36	0	0	36
Bile salt export pump	0	34	0	34
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	14	0	0	14
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
NPYLR7B	0	0	1	1
arylsulfatase A	14	0	0	14
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
nuclear receptor ROR-gamma isoform 1	19	0	0	19
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	4	0	4
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	4	0	4
Rap guanine nucleotide exchange factor 3	6	0	0	6
Purine nucleoside phosphorylase	0	3	0	3
Epidermal growth factor receptor	0	6	0	6
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	8	2	11
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	4	1	7
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	2	7
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	2	3
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	2	7
Adenosine receptor A2a	0	5	2	9
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	4	0	4
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	4	0	4
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
thyroid hormone receptor beta isoform a	14	0	0	14
histone acetyltransferase KAT2A isoform 1	12	0	0	12
lethal factor (plasmid)	15	0	0	15
Solute carrier family 22 member 20	0	8	0	8
Solute carrier family 22 member 6	0	8	0	8
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	1	4	6
Procathepsin L	0	2	1	3
Cathepsin B	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	3	3
Transient receptor potential cation channel subfamily V member 1	0	0	0	1
Cysteine protease	0	1	0	1
Mitochondrial 2-oxodicarboxylate carrier	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Chain A, Beta-lactamase	16	0	0	16
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
apical membrane antigen 1, AMA1	3	0	0	3
Beta-lactamase	0	0	0	2
ATP-binding cassette sub-family C member 3	0	25	0	25
Multidrug resistance-associated protein 4	0	25	0	27
Bile salt export pump	0	7	0	7
Beta-lactamase SHV-1	0	1	0	3
Beta-lactamase SHV-1	0	2	0	4
Beta-lactamase	0	1	0	3
Kappa-type opioid receptor	0	1	1	4
Solute carrier family 15 member 1	0	5	0	5
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	9	0	9
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	25	0	25
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Beta-lactamase	0	0	0	2
GLS protein	17	0	0	17
Beta-lactamase	0	2	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	3
DNA polymerase beta	4	0	0	4
Carbonic anhydrase 1	0	13	0	19
Carbonic anhydrase 2	0	13	1	20
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	2
Spike glycoprotein	18	0	1	19
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Thiosulfate sulfurtransferase	0	4	0	4
Metallo-beta-lactamase VIM-13	0	1	0	3
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	1	0	2
60 kDa chaperonin	0	4	0	4
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	4	0	4
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	4
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	3
Beta-lactamase VIM-1	0	1	0	3
ATP-dependent phosphofructokinase	18	0	0	18
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	14	0	0	14
NFKB1 protein, partial	4	0	0	4
thyroid stimulating hormone receptor	16	0	0	16
cytochrome P450 2C19 precursor	8	0	0	8
muscarinic acetylcholine receptor M1	11	0	0	11
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	2	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	3	0	4
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	3	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	6	2	8
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	1	1	3
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Bloom syndrome protein isoform 1	15	0	0	15
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	2	0	2
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	1	4	1	9
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	7
Glutamate receptor ionotropic, NMDA 2B	0	3	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	7
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	3	1	7
Glutamate receptor ionotropic, NMDA 3B	0	3	1	7
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	3	1	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	13	0	0	13
hypothetical protein, conserved	5	0	0	5
EWS/FLI fusion protein	16	0	0	16
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	11	1	0	12
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	6	1	8
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	11	1	0	12
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Substance-P receptor	0	5	0	5
Prostaglandin G/H synthase 2	0	8	1	9
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	13	0	0	13
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	16	3	0	19
Prostaglandin G/H synthase 2	0	6	0	6
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Nitrile Hydratase alpha subunit	0	1	0	1
Chain B, Nitrile Hydratase beta subunit	0	1	0	1
Lysine-specific demethylase 4E	0	2	0	2
Histone deacetylase 3	0	4	0	4
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	3	0	3
Methyl-accepting chemotaxis protein NahY	0	0	2	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	6	0	0	6
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	8	0	9
Androgen receptor	0	1	1	2
Cytochrome P450 2D6	0	6	0	6
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	4	0	4
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Carbonic anhydrase 4	0	8	0	11
Carbonic anhydrase	0	8	0	11
Carbonic anhydrase 15	0	6	0	9
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	2	0	5
Carbonic anhydrase 3	0	2	0	5
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 6	0	2	0	5
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
Carbonic anhydrase 7	0	2	0	5
Carbonic anhydrase 9	0	3	0	6
Carbonic anhydrase 13	0	2	0	4
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	2	0	5
Carbonic anhydrase 5B, mitochondrial	0	3	0	6
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	1	0	2
Albumin	0	2	7	9
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-2	0	0	0	1
Solute carrier family 22 member 6	0	3	0	6
Solute carrier family 22 member 7	0	1	0	3
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	4	0	7
Beta-lactamase	0	1	0	2
Solute carrier family 22 member 11	0	1	0	4
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	3
67.9K protein	13	0	0	13
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	8	0	0	8
thyrotropin-releasing hormone receptor	6	0	0	6
Caspase-2	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
PAX8	0	0	0	1
15-lipoxygenase, partial	7	0	0	7
pregnane X receptor	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
PINK1	4	0	0	4
Parkin	9	0	0	9
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	7	0	0	7
hepatocyte nuclear factor 4-alpha isoform 2	0	2	0	2
cellular tumor antigen p53 isoform a	11	0	0	11
cytochrome P450 2C9 precursor	7	0	0	7
perilipin-5	0	3	0	3
perilipin-1	0	3	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
transcriptional regulator ERG isoform 3	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	4	0	1	5
protein AF-9 isoform a	0	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	3	0	3
cytochrome P450 3A4 isoform 1	16	0	0	16
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	16	2	0	18
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 1	0	8	0	12
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	3	0	3
Glutathione reductase, mitochondrial	0	5	0	6
72 kDa type IV collagenase	0	2	0	2
Matrix metalloproteinase-9	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	16	2	0	18
Gamma-aminobutyric acid receptor subunit delta	16	2	0	18
Gamma-aminobutyric acid receptor subunit gamma-2	16	2	0	18
Gamma-aminobutyric acid receptor subunit alpha-5	16	2	0	18
Gamma-aminobutyric acid receptor subunit alpha-3	16	2	0	18
Gamma-aminobutyric acid receptor subunit gamma-1	16	2	0	18
Gamma-aminobutyric acid receptor subunit alpha-2	16	2	0	18
Gamma-aminobutyric acid receptor subunit alpha-4	16	2	0	18
Gamma-aminobutyric acid receptor subunit gamma-3	16	2	0	18
Trypanothione reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	16	2	0	18
Alpha-synuclein	3	4	0	7
Gamma-aminobutyric acid receptor subunit beta-3	16	2	0	18
Gamma-aminobutyric acid receptor subunit beta-2	16	2	0	18
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Rap guanine nucleotide exchange factor 4	2	0	0	2
GABA theta subunit	16	2	0	18
Multidrug and toxin extrusion protein 1	0	7	0	7
Gamma-aminobutyric acid receptor subunit epsilon	16	2	0	18
Spermine oxidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	11	0	11
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	4	0	7
DNA gyrase subunit B	0	4	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	3	0	4
DNA gyrase subunit A	0	2	0	3
Multidrug resistance protein MdtK	0	0	2	2
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	2	0	3
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	3
Potassium voltage-gated channel subfamily H member 2	0	14	0	16
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
streptokinase A precursor	0	0	3	3
ATP-dependent translocase ABCB1	0	11	1	21
Solute carrier organic anion transporter family member 1B3	0	3	0	4
Solute carrier organic anion transporter family member 1B1	0	6	0	6
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Neutrophil elastase	0	2	0	2
Beta-lactamase OXA-1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Beta-lactamase TEM	0	2	0	3
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	11	1	12
Alpha-1B adrenergic receptor	0	9	0	9
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	6	1	7
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	0	5
Alpha-2B adrenergic receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	5	0	5
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	4	1	5
D(1B) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	3	0	3
5-hydroxytryptamine receptor 1B	0	4	0	4
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	10	1	11
5-hydroxytryptamine receptor 7	0	5	0	5
D(2) dopamine receptor	0	2	1	3
Mu-type opioid receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Nischarin	0	1	0	1
endonuclease IV	2	0	0	2
dopamine D1 receptor	4	0	0	4
peripheral myelin protein 22 isoform 1	9	0	0	9
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
M-phase phosphoprotein 8	8	0	0	8
Glucocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	2	1	3
ATAD5 protein, partial	12	0	0	12
GALC protein	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	5	3	10
Cytochrome P450 2A6	0	3	1	4
Neuronal acetylcholine receptor subunit beta-2	1	5	3	10
Cytochrome P450 2A5	0	2	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
Platelet-activating factor receptor	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
neutrophil cytosol factor 1	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
ras-related protein Rab-9A	6	0	0	6
Solute carrier family 2, facilitated glucose transporter member 1	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Thymidine kinase, cytosolic	0	3	0	6
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
D(1A) dopamine receptor	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	8
Sodium channel protein type 5 subunit alpha	0	5	0	5
Sodium channel protein type 9 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	1	5
Sodium channel protein type 8 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	4	0	4
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Eyes absent homolog 2	0	2	0	2
Amyloid-beta precursor protein	0	4	1	5
Angiotensin-converting enzyme	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
NS5	0	0	1	1
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Serine hydrolase RBBP9	0	1	0	1
Hexose transporter 1	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	4	1	5
Replicase polyprotein 1ab	0	5	1	6
Hypoxia-inducible factor 1-alpha	0	1	0	2
Dihydroorotate dehydrogenase	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	2
Angiotensin-converting enzyme 2	0	0	1	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
ATP-dependent translocase ABCB1	0	3	0	3
60 kDa chaperonin	0	2	0	2
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	4
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
Cytochrome P450 1B1	0	4	0	4
Lanosterol 14-alpha demethylase	0	2	0	2
50S ribosomal protein L36 2	0	3	1	4
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Fumarate hydratase	6	0	0	6
polyprotein	6	0	0	6
eyes absent homolog 2 isoform a	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	2	0	2
Thrombopoietin	3	0	0	3
neuropeptide S receptor isoform A	4	0	0	4
Ghrelin O-acyltransferase	0	1	0	1
Monoglyceride lipase	0	1	0	1
14 kDa phosphohistidine phosphatase	0	1	0	1
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
luciferase	2	0	0	2
Caspase-7	2	0	0	2
tumor necrosis factor	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
caspase-3	2	0	0	2
Muscarinic acetylcholine receptor M2	0	5	0	6
Muscarinic acetylcholine receptor M4	0	4	0	5
Muscarinic acetylcholine receptor M5	0	4	0	5
Muscarinic acetylcholine receptor M1	0	4	0	5
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	4	0	5
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	6	0	6
5-hydroxytryptamine receptor 2A	0	6	0	6
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	4	0	4
Kappa-type opioid receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Fatty-acid amide hydrolase 1	1	1	0	2
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	6	0	6
Leukotriene B4 receptor 1	1	2	0	4
Glutamate receptor ionotropic, kainate 5	1	0	0	1
Leukotriene B4 receptor 2	1	1	0	3
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, Glutamine Binding Protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Neutral amino acid transporter A	0	4	0	4
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	4	0	4
Amino acid transporter	0	4	0	4
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	7	0	8
Proton-coupled amino acid transporter 1	0	6	0	7
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	1	0	2
Chain A, Probable hydrogenase nickel incorporation protein hypB	0	0	1	1
Chain B, Probable hydrogenase nickel incorporation protein hypB	0	0	1	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	3
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	3
muscleblind-like protein 1 isoform 1	6	0	0	6
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Dihydrofolate reductase	0	7	0	8
Albumin	0	0	1	1
Cholinesterase	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	5
UDP-glucuronosyltransferase 2B7	0	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	1	0	2
Prostaglandin G/H synthase 2	0	3	0	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
Prostaglandin G/H synthase 1	0	3	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	3	1	6
Bifunctional epoxide hydrolase 2	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chymotrypsinogen A	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
matrix metalloproteinase 1, partial	0	0	1	1
P53	2	0	0	2
pyruvate kinase	2	0	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Aldo-keto reductase family 1 member B1	0	8	0	8
Endothelin receptor type B	2	0	0	2
Sodium-dependent noradrenaline transporter	0	8	1	9
Endothelin-1 receptor	2	1	0	3
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	5	0	5
Intestinal-type alkaline phosphatase	0	4	0	4
Phospholipase A-2-activating protein	0	4	0	4
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
5'-nucleotidase	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	2	0	2
N-formyl peptide receptor 2	0	1	2	3
Nuclear factor NF-kappa-B p100 subunit	0	2	0	2
Transcription factor p65	0	2	0	2
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
Queuine tRNA-ribosyltransferase	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	3	0	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	4	1	5
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	7	0	7
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	1	3
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
caspase-1 isoform alpha precursor	2	0	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	3
Thymidylate synthase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Thymidylate synthase	0	2	0	3
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	4	2	6
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	0	5
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	5	0	6
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	2	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Stromelysin-1	0	3	0	3
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	2	0	2
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	2	2	4
FML2_HUMAN	0	0	1	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	2	0	2
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Translocator protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	2	1	4
beta-2 adrenergic receptor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
5-hydroxytryptamine receptor 4	0	8	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	8	0	8
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Cannabinoid receptor 1	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	2	0	0	2
5-hydroxytryptamine receptor 2A	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Free fatty acid receptor 2	0	0	1	1
Diacylglycerol kinase alpha	0	2	0	2
Diacylglycerol kinase alpha	0	2	0	2
Diacylglycerol kinase alpha	0	1	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
TPA: protein transporter TIM10	0	1	0	1
TPA: protein transporter TIM23	0	1	0	1
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vif	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
Myc proto-oncogene protein	0	1	0	2
Estrogen receptor	0	1	0	1
Cathepsin D	0	1	0	1
Luciferin 4-monooxygenase	0	1	1	2
DNA polymerase alpha catalytic subunit	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Tyrosinase	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Protein kinase C alpha type	0	1	2	3
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Estrogen receptor	0	0	1	1
Sucrase-isomaltase, intestinal	0	1	0	1
Dipeptidyl peptidase 4	0	2	0	2
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Alpha-glucosidase MAL12	0	1	0	1
Cholinesterase	0	2	0	2
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	0	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	2
Tubulin beta-2B chain	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
Prenyltransferase homolog	0	0	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Zinc finger protein mex-5	0	0	1	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Pyruvate kinase PKM	0	0	1	1
photoreceptor-specific nuclear receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Delta-aminolevulinic acid dehydratase	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 13 member 3	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Protease	0	1	1	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
Neutrophil collagenase	0	1	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Cytidine Deaminase	0	1	0	1
Cytidine deaminase	0	1	0	1
Uridine-cytidine kinase 1	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Cytochrome P450 2C8	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(9)

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Overview

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Treatment

Research

Studies (468)

Protein Targets (1,400)

Aggressive Periodontitis

Synonyms(9)

Research Excerpts

Overview

Actions

Treatment

Research

Studies (468)

Drugs Studied (230)

Protein Targets (1,400)