A gout suppressant that acts directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
| Member | Definition | Class |
|---|
| apazone | A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid. | apazone |
| benzbromarone | 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication. | benzbromarone |
| e 3040 | A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by a methylnitrilo group, (pyridin-3-yl)methyl group, methyl group, hydroxy group and methyl group at position 2,4,5,6 and 7, respectively. It is a dual inhibitor of 5-lipoxygenase and thromboxane A2 synthetase and exhibits anti-inflammatory properties. The drug was being developed by Eisai (Tokyo, Japan) for the treatment of bowel disease. | E3040 |
| lesinurad | A member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout. | lesinurad |
| probenecid | A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups. | probenecid |
| sulfinpyrazone | | sulfinpyrazone |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.6898 | 1 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 3.0107 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 20.3025 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 25.5962 | 5 | 5 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 3.0131 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 84.2790 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 5.7857 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 19.8019 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 112.2020 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 11.5098 | 2 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 18.8231 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 11.5765 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 11.5098 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 81.5478 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.1264 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 3.3492 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.4139 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.4494 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.8310 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 23.8055 | 1 | 4 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 22.3373 | 10 | 13 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 18.1966 | 3 | 5 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.7013 | 1 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 28.2036 | 2 | 2 |
| G | Vesicular stomatitis virus | Potency | 2.4139 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 9.2639 | 2 | 7 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 22.4209 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 19.6172 | 2 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 51.2848 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 43.3866 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 4.8680 | 2 | 13 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 28.1170 | 1 | 5 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 4.9194 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.4139 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 11.9856 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.7145 | 2 | 6 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.4139 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 15.5808 | 2 | 3 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 44.6684 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 13.6764 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.8174 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.8677 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 24.9054 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 3.8980 | 1 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 14.5090 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 13.4481 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 24.0353 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 9.9628 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 16.5980 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 14.0879 | 3 | 4 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 8.2852 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 28.2262 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 42.6380 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 26.6930 | 2 | 4 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 6.3096 | 1 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 10.9667 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.5481 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 22.1199 | 2 | 5 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 23.5901 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 70.7946 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 15.1884 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 43.0840 | 2 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 3.0306 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 9.2532 | 3 | 4 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 35.4954 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 51.2848 | 1 | 2 |