Page last updated: 2024-08-05 15:12:37
uricosuric drug
A gout suppressant that acts directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.
ChEBI ID: 35841
Members (6)
| Member | Definition | Class |
|---|---|---|
| apazone | A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid. | apazone |
| benzbromarone | 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication. | benzbromarone |
| e 3040 | A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by a methylnitrilo group, (pyridin-3-yl)methyl group, methyl group, hydroxy group and methyl group at position 2,4,5,6 and 7, respectively. It is a dual inhibitor of 5-lipoxygenase and thromboxane A2 synthetase and exhibits anti-inflammatory properties. The drug was being developed by Eisai (Tokyo, Japan) for the treatment of bowel disease. | E3040 |
| lesinurad | A member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout. | lesinurad |
| probenecid | A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups. | probenecid |
| sulfinpyrazone | sulfinpyrazone |
Research
Studies (5,008)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3,242 (64.74) | 18.7374 |
| 1990's | 613 (12.24) | 18.2507 |
| 2000's | 466 (9.31) | 29.6817 |
| 2010's | 528 (10.54) | 24.3611 |
| 2020's | 159 (3.17) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 578 (10.41%) | 5.53% |
| Reviews | 377 (6.79%) | 6.00% |
| Case Studies | 237 (4.27%) | 4.05% |
| Observational | 6 (0.11%) | 0.25% |
| Other | 4,353 (78.42%) | 84.16% |
Protein Targets (198)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.6898 | 1 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 3.0107 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 20.3025 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 25.5962 | 5 | 5 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 3.0131 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 84.2790 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 5.7857 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 19.8019 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 112.2020 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 11.5098 | 2 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 18.8231 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 11.5765 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 11.5098 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 81.5478 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.1264 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 3.3492 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.4139 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.4494 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.8310 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 23.8055 | 1 | 4 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 22.3373 | 10 | 13 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 18.1966 | 3 | 5 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.7013 | 1 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 28.2036 | 2 | 2 |
| G | Vesicular stomatitis virus | Potency | 2.4139 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.4494 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 9.2639 | 2 | 7 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 22.4209 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 19.6172 | 2 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 51.2848 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 43.3866 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 4.8680 | 2 | 13 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 28.1170 | 1 | 5 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 4.9194 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.4139 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 11.9856 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.7145 | 2 | 6 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.4139 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 15.5808 | 2 | 3 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 44.6684 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 13.6764 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.8174 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.8677 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 24.9054 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 3.8980 | 1 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 14.5090 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 13.4481 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 24.0353 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 9.9628 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 16.5980 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 14.0879 | 3 | 4 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 8.2852 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 28.2262 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 42.6380 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 26.6930 | 2 | 4 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 6.3096 | 1 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 10.9667 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.5481 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 22.1199 | 2 | 5 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 23.5901 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 70.7946 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 15.1884 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 43.0840 | 2 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 3.0306 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 9.2532 | 3 | 4 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 35.4954 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 51.2848 | 1 | 2 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 16.8980 | 2 | 2 |
| 10 kDa chaperonin | Escherichia coli | IC50 | 33.5000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.8040 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 1.1480 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 33.5000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 5.2220 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 2.9520 | 1 | 1 |
| Aldo-keto reductase family 1 member C1 | Homo sapiens (human) | IC50 | 0.0480 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2220 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.9520 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2220 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.9520 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 192.3571 | 5 | 7 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 509.9000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| calpain II, partial | Sus scrofa (pig) | IC50 | 6.4260 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 87.3000 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | Ki | 42.2000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 44.6000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 10.0000 | 3 | 3 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 1.2450 | 3 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.4310 | 3 | 3 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.3600 | 3 | 3 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 26.1667 | 1 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 27.7000 | 1 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 3.7000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 39.6735 | 8 | 28 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 0.0190 | 3 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 74.9000 | 1 | 3 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 4.2600 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 45.9333 | 1 | 3 |
| envelope glycoprotein | Human immunodeficiency virus 1 | IC50 | 12.8000 | 1 | 1 |
| Eyes absent homolog 2 | Homo sapiens (human) | IC50 | 10.3000 | 2 | 2 |
| Eyes absent homolog 3 | Homo sapiens (human) | IC50 | 22.6500 | 4 | 4 |
| Eyes absent homolog 3 | Mus musculus (house mouse) | IC50 | 11.0000 | 2 | 2 |
| fMet-Leu-Phe receptor | Homo sapiens (human) | IC50 | 12.2000 | 2 | 2 |
| Inosine-5'-monophosphate dehydrogenase | Pseudomonas aeruginosa PAO1 | IC50 | 55.0000 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | IC50 | 0.2100 | 1 | 1 |
| M1-family alanyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 62.7800 | 1 | 1 |
| M17 leucyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 81.8900 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 1.9460 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 1.2350 | 1 | 1 |
| Monocarboxylate transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 22.0000 | 1 | 1 |
| Monocarboxylate transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Ki | 0.1900 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 75.0000 | 1 | 2 |
| Multidrug resistance-associated protein 5 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0005 | 1 | 1 |
| nuclear receptor corepressor 2 isoform 2 | Homo sapiens (human) | IC50 | 4.8110 | 1 | 1 |
| Pannexin-1 | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Pannexin-1 | Mus musculus (house mouse) | IC50 | 150.0000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 14.9880 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 18.8080 | 1 | 1 |
| peroxisome proliferator-activated receptor gamma isoform 2 | Homo sapiens (human) | IC50 | 4.8110 | 1 | 1 |
| photoreceptor-specific nuclear receptor | Homo sapiens (human) | IC50 | 39.8410 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 0.1650 | 2 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 304.5500 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 1,640.0000 | 1 | 1 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | IC50 | 22.4075 | 3 | 4 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | Ki | 49.6500 | 2 | 2 |
| Solute carrier family 22 member 12 | Homo sapiens (human) | IC50 | 14.8331 | 15 | 21 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 1,700.0000 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 8.4557 | 1 | 2 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 9.2000 | 5 | 6 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | Ki | 6.9367 | 3 | 3 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 6.3548 | 1 | 2 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 23.4000 | 2 | 2 |
| Solute carrier family 22 member 7 | Homo sapiens (human) | IC50 | 668.0000 | 1 | 1 |
| Solute carrier family 22 member 7 | Rattus norvegicus (Norway rat) | IC50 | 977.0000 | 1 | 1 |
| Solute carrier family 22 member 7 | Homo sapiens (human) | Ki | 766.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | IC50 | 6.9650 | 2 | 2 |
| Solute carrier family 22 member 8 | Mus musculus (house mouse) | IC50 | 3.0200 | 1 | 1 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | IC50 | 6.0300 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 14.4033 | 3 | 3 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | Ki | 12.2150 | 2 | 2 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 74.4000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 72.9000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1C1 | Mus musculus (house mouse) | Ki | 293.0000 | 1 | 1 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Thromboxane-A synthase | Rattus norvegicus (Norway rat) | IC50 | 0.0900 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 0.0495 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 53.8000 | 2 | 2 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | Ki | 1,429.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | Ki | 221.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A10 | Homo sapiens (human) | Ki | 231.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A7 | Homo sapiens (human) | Ki | 96.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A9 | Homo sapiens (human) | Ki | 2,452.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bile acid receptor | Homo sapiens (human) | EC50 | 24.5000 | 1 | 1 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | EC50 | 17.1820 | 1 | 2 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | EC50 | 17.1820 | 1 | 2 |
| Polymerase acidic protein | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Kd | 48.2000 | 1 | 1 |
| recombinase A | Mycobacterium tuberculosis H37Rv | EC50 | 14.9950 | 2 | 2 |
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 | 11.8660 | 2 | 2 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 4,200.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| HSP40, subfamily A [Plasmodium falciparum 3D7] | Plasmodium falciparum 3D7 | AbsAC1000_uM | 3.2810 | 1 | 1 |
| replicative DNA helicase | Mycobacterium tuberculosis H37Rv | AC50 | 6.1070 | 2 | 2 |
| Skn7p | Saccharomyces cerevisiae (brewer's yeast) | AbsAC40_uM | 0.9120 | 1 | 1 |