An EC 2.6.1.* (transaminase) inhibitor that interferes with the action of 4-aminobutyrate--2-oxoglutarate transaminase (EC 2.6.1.19).
ChEBI ID: 63674
| Member | Definition | Class |
|---|---|---|
| aminooxyacetic acid | A member of the class of hydroxylamines that is acetic acid substituted at postion 2 by an aminooxy group. It is a compound which inhibits aminobutyrate aminotransferase activity in vivo, resulting in increased levels of gamma-aminobutyric acid in tissues. | (aminooxy)acetic acid |
| gabaculine | The (S)-enantiomer of gabaculine. | (S)-gabaculine |
| vigabatrin | A gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase | vigabatrin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 705 (27.80) | 18.7374 |
| 1990's | 753 (29.69) | 18.2507 |
| 2000's | 554 (21.85) | 29.6817 |
| 2010's | 393 (15.50) | 24.3611 |
| 2020's | 131 (5.17) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 205 (7.49%) | 5.53% |
| Reviews | 267 (9.76%) | 6.00% |
| Case Studies | 175 (6.40%) | 4.05% |
| Observational | 11 (0.40%) | 0.25% |
| Other | 2,078 (75.95%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| arylsulfatase A | Homo sapiens (human) | Potency | 0.4546 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.1694 | 1 | 1 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 0.8492 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 56.2341 | 2 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 0.0053 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.0748 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 5.8048 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 0.2239 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 5.4924 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 0.0063 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 3.6253 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.7512 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 2.3660 | 2 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 22.4089 | 2 | 3 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 33.5875 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 4-aminobutyrate aminotransferase, mitochondrial | Homo sapiens (human) | Ki | 2,025.0000 | 2 | 2 |
| 4-aminobutyrate aminotransferase, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 10,000.0000 | 1 | 1 |
| 4-aminobutyrate aminotransferase, mitochondrial | Sus scrofa (pig) | Ki | 1,745.0000 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cystathionine beta-synthase | Homo sapiens (human) | IC50 | 5.2750 | 4 | 4 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 2.2850 | 2 | 2 |
| Gamma-aminobutyric acid type B receptor subunit 1 | Homo sapiens (human) | Ki | 3,200.0000 | 1 | 2 |
| Gamma-aminobutyric acid type B receptor subunit 2 | Homo sapiens (human) | Ki | 3,200.0000 | 1 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |