Compounds > Hircinol
Page last updated: 2024-12-08

Hircinol

Cross-References

ID SourceID
PubMed CID442705
CHEMBL ID475652
CHEBI ID5726

Synonyms (12)

Synonym
hircinol
41060-05-3
C10261 ,
chebi:5726 ,
CHEMBL475652 ,
4-methoxy-9,10-dihydrophenanthrene-2,5-diol
AC1L9D9N ,
DTXSID70331919
2,5-dihydroxy-4-methoxy-9,10-dihydrophenanthrene
bdbm246495
hircinol (13)
Q27106870
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenanthrenesAny benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Pancreatic triacylglycerol lipaseSus scrofa (pig)Ki8.57000.26005.09149.8000AID1803387
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID414771Inhibition of ovine COX1 by colorimetric assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1320961Antifungal activity against Alternaria citri after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1824692Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1320956Antifungal activity against Bipolaris oryzae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320958Antifungal activity against Ceratocystis paradoxa moreau after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320951Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320954Antifungal activity against Phytophthora parasitica var. nicotianae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID414772Inhibition of ovine COX2 by colorimetric assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1320957Antifungal activity against Diaporthe medusaea nitschke after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320952Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1824689Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1824731Inhibition of pyruvate carboxylase in human HCCLM3 cell lysate measured upto 24 hrs by PC assay kit2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1320959Antifungal activity against Exserohilum turcicum after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID484514Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells.
AID1320955Antifungal activity against Colletotrichum capsici after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320953Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320960Antifungal activity against Pestallozzia theae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID414770Antioxidant activity assessed as superoxide radical scavenging activity after 20 mins by NBT reduction assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1320950Antifungal activity against Alternaria brassicicola after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID414769Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1803387In Vitro Pancreatic Lipase Assay from Article 10.3109/14756366.2012.742517: \\Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).\\2014Journal of enzyme inhibition and medicinal chemistry, Feb, Volume: 29, Issue:1
Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oxaloacetic acid
Oxaloacetic Acid: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.. oxaloacetic acid : An oxodicarboxylic acid that is succinic acid bearing a single oxo group.		2.4110C4-dicarboxylic acid;
oxo dicarboxylic acid		geroprotector;
metabolite
catechin
[no description available]		2.0510hydroxyflavan
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.0510guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.0510aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
aspartic acid
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.		2.4110aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
octyl gallate
[no description available]		2.4110gallate esterfood antioxidant;
hypoglycemic agent;
plant metabolite
prochloraz
Mirage: a feldspathic porcelain that can be etched & bonded to the tooth. prochloraz : A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.		2.1310amide fungicide;
aromatic ether;
conazole fungicide;
imidazole fungicide;
imidazoles;
trichlorobenzene;
ureas		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic
dendrophenol
dendrophenol: isolated from Dendrobium loddigesii		2.5320
erianin
Erianin: from Dendrobium chrysotoxum; structure in first source		2.4110
lusianthridin
lusianthridin: from rhizome of Arundina graminifolia		2.9940dihydrophenanthrene
rhapontin
rhapontin: constituent of rhubarb rhizome		2.4110rhaponticinangiogenesis inhibitor;
anti-allergic agent;
anti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
hypoglycemic agent;
neuroprotective agent;
plant metabolite
hydroxyphenethylferulate
hydroxyphenethylferulate: from the roots of Atropa acuminata (Solanaceae); structure in first source		2.110hydroxycinnamic acid
orlistat
Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.. orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.		2.110beta-lactone;
carboxylic ester;
formamides;
L-leucine derivative		anti-obesity agent;
bacterial metabolite;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor
gigantol
gigantol: structure in first source		2.4110
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		2.0510trihydroxyflavoneantineoplastic agent;
metabolite
erianthridin
erianthridin: isolated from an extract of the orchid Maxillaria densa; structure in first source		2.4920
3,7-dihydroxy-2,4-dimethoxyphenanthrene
3,7-dihydroxy-2,4-dimethoxyphenanthrene: from the orchid Scaphyglottis livida; structure in first source		2.0510
1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one
1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one: a macrophage TNF-alpha antagonist; structure in first source		2.4720diarylheptanoid;
enone;
phenols		plant metabolite
batatasin-iii
[no description available]		2.7830stilbenoid
1,7-bis(4-hydroxyphenyl)hepta-4E-6E-dien-3-one
1,7-bis(4-hydroxyphenyl)hepta-4E-6E-dien-3-one : A diarylheptanoid that is 4E-6E-dien-3-one substituted by 4-hydroxyphenyl group at positions 1 and 7. It has been isolated from the rhizomes of Curcuma kwangsiensis.		2.4720diarylheptanoid;
enone;
phenols		plant metabolite
cyclic diadenosine phosphate
cyclic di-AMP : A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of AMP.		2.4110adenyl ribonucleotide;
cyclic purine dinucleotide		Mycoplasma genitalium metabolite
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0510ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatocellular Carcinoma
[description not available]		02.4110
Cancer of Liver
[description not available]		02.4110
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.4110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.4110
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