Page last updated: 2024-12-08

Hircinol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID442705
CHEMBL ID475652
CHEBI ID5726

Synonyms (12)

Synonym
hircinol
41060-05-3
C10261 ,
chebi:5726 ,
CHEMBL475652 ,
4-methoxy-9,10-dihydrophenanthrene-2,5-diol
AC1L9D9N ,
DTXSID70331919
2,5-dihydroxy-4-methoxy-9,10-dihydrophenanthrene
bdbm246495
hircinol (13)
Q27106870
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenanthrenesAny benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Pancreatic triacylglycerol lipaseSus scrofa (pig)Ki8.57000.26005.09149.8000AID1803387
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID414771Inhibition of ovine COX1 by colorimetric assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1320961Antifungal activity against Alternaria citri after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1824692Antiproliferative activity against human HCCLM3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1320956Antifungal activity against Bipolaris oryzae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320958Antifungal activity against Ceratocystis paradoxa moreau after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320951Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320954Antifungal activity against Phytophthora parasitica var. nicotianae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID414772Inhibition of ovine COX2 by colorimetric assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1320957Antifungal activity against Diaporthe medusaea nitschke after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320952Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1824689Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1824731Inhibition of pyruvate carboxylase in human HCCLM3 cell lysate measured upto 24 hrs by PC assay kit2022Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1320959Antifungal activity against Exserohilum turcicum after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID484514Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells.
AID1320955Antifungal activity against Colletotrichum capsici after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320953Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID1320960Antifungal activity against Pestallozzia theae after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID414770Antioxidant activity assessed as superoxide radical scavenging activity after 20 mins by NBT reduction assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1320950Antifungal activity against Alternaria brassicicola after 4 to 14 days by serial dilution method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile.
AID414769Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
AID1803387In Vitro Pancreatic Lipase Assay from Article 10.3109/14756366.2012.742517: \\Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).\\2014Journal of enzyme inhibition and medicinal chemistry, Feb, Volume: 29, Issue:1
Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]