Page last updated: 2024-08-05 15:41:06

EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor

An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase).

ChEBI ID: 86501

Members (1)

MemberDefinitionClass
troleandomycinA semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.troleandomycin

Research

Studies (508)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990257 (50.59)18.7374
1990's140 (27.56)18.2507
2000's81 (15.94)29.6817
2010's28 (5.51)24.3611
2020's2 (0.39)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials26 (4.57%)5.53%
Reviews23 (4.04%)6.00%
Case Studies33 (5.80%)4.05%
Observational0 (0.00%)0.25%
Other487 (85.59%)84.16%

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-dependent translocase ABCB1Homo sapiens (human)IC5077.600033
ATP-dependent translocase ABCB1Homo sapiens (human)Ki285.470022
ATP-dependent translocase ABCB1Mus musculus (house mouse)Ki608.700022
Cytochrome P450 2C9 Homo sapiens (human)IC5050.000011
Cytochrome P450 2J2Homo sapiens (human)IC5050.000011
Cytochrome P450 3A4Homo sapiens (human)IC5027.599755