A cyclodepsipeptide consisting of eight hydroxy- or amino-acids joined in sequence to give a macrocycle. They form the basis of a relatively new class of anthelmintic agents with a novel mechanism of action.
ChEBI ID: 78740
| Member | Definition | Role |
|---|---|---|
| bassianolide | A cyclodepsipeptide consisting of a cyclic tetramer of the depsipeptide D-Hiv-N-methyl-L-leucine (where D-Hiv = D-alpha-hydroxyisovaleric acid). Found in the fungal species Beauveria bassiana and Verticillium lecanii, it has insecticidal properties and is used as a commercial biopesticide to control of insects of agricultural, veterinary and medical significance. For elucidation of the structure, see Suzuki et al., Tetrahedron Lett. 1977 v25, 2167-2170. | bassianolide |
| bay 44-4400 | A cyclooctadepsipeptide consisting of D-lactoyl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, N-methyl-L-leucyl, D-lactoyl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, and N-methyl-L-leucyl residues joined in sequence to give a 24-membered macrocycle. An anthelmintic, it is used with praziquantel for the treatment and control of hookworm, roundworm and tapeworm infections in cats. | emodepside |
| pf 1022a | PF1022A |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 89 (2.29) | 18.7374 |
| 1990's | 307 (7.89) | 18.2507 |
| 2000's | 869 (22.34) | 29.6817 |
| 2010's | 1,663 (42.75) | 24.3611 |
| 2020's | 962 (24.73) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 69 (1.72%) | 5.53% |
| Reviews | 51 (1.27%) | 6.00% |
| Case Studies | 16 (0.40%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 3,877 (96.61%) | 84.16% |